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2020

Astragalus membranaceus-Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors

Chang, F. L., Tsai, K. C., Lin, T. Y., Yang, T. W., Lo, Y. N., Chen, W. C., Chang, J. H., Lu, M. K., Chiou, C. T., Chen, P. H., Yen, Y., Pan, S. L. & Lee, Y. C., Jan 1 2020, In : BioMed Research International. 2020, 3415471.

Research output: Contribution to journalArticle

Open Access

Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats

Yang, Y. C. S. H., Chang, H. W., Lin, I. H., Chien, L. N., Wu, M. J., Liu, Y. R., Chu, P. G., Xie, G., Dong, F., Jia, W., Chang, V. H. S. & Yen, Y., Dec 1 2020, In : Scientific Reports. 10, 1, 866.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Upregulation of protein synthesis and proteasome degradation confers sensitivity to proteasome inhibitor bortezomib in myc-atypical teratoid/rhabdoid tumors

Tran, H. M., Wu, K. S., Sung, S. Y., Changou, C. A., Hsieh, T. H., Liu, Y. R., Liu, Y. L., Tsai, M. L., Lee, H. L., Hsieh, K. L. C., Huang, W. C., Liang, M. L., Chen, H. H., Lee, Y. Y., Lin, S. C., Ho, D. M. T., Chang, F. C., Chao, M. E., Chen, W., Chu, S. S. & 4 others, Yu, A. L., Yen, Y., Chang, C. C. & Wong, T. T., Mar 22 2020, In : Cancers. 12, 3, 752.

Research output: Contribution to journalArticle

Open Access
2019
Open Access

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., Jan 31 2019, In : ACS Omega. 4, 1, p. 2387-2397 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Design and Evaluation of PEGylated Liposomal Formulation of a Novel Multikinase Inhibitor for Enhanced Chemosensitivity and Inhibition of Metastatic Pancreatic Ductal Adenocarcinoma

Madamsetty, V. S., Pal, K., Dutta, S. K., Wang, E., Thompson, J. R., Banerjee, R. K., Caulfield, T. R., Mody, K., Yen, Y., Mukhopadhyay, D. & Huang, H-S., Oct 4 2019, In : Bioconjugate Chemistry.

Research output: Contribution to journalArticle

1 Citation (Scopus)

DHS (trans−4,4′-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2)

Chen, C. W., Li, Y., Hu, S., Zhou, W., Meng, Y., Li, Z., Zhang, Y., Sun, J., Bo, Z., DePamphilis, M. L., Yen, Y., Han, Z. & Zhu, W., Mar 2019, In : Oncogene.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Does long-term use of antidiabetic drugs changes cancer risk?

Liu, Y. C., Nguyen, P. A., Humayun, A., Chien, S. C., Yang, H. C., Asdary, R. N., Syed-Abdul, S., Hsu, M. H., Moldovan, M., Yen, Y., Li, Y. C., Jian, W. S. & Iqbal, U., Oct 1 2019, In : Medicine (United States). 98, 40, p. e17461 e17461.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Human Mitotic Centromere-Associated Kinesin Is Targeted by MicroRNA 485-5p/181c and Prognosticates Poor Survivability of Breast Cancer

Lu, H., Wang, C., Xue, L., Zhang, Q., Luh, F., Wang, J., Lin, T. G., Yen, Y. & Liu, X., Jan 1 2019, In : Journal of Oncology. 2019, 2316237.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Chen, H. Y., Lang, Y. D., Lin, H. N., Liu, Y. R., Liao, C. C., Nana, A. W., Yen, Y. & Chen, R. H., Dec 1 2019, In : Scientific Reports. 9, 1, 9687.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Novel Common Genetic Susceptibility Loci for Colorectal Cancer

Schmit, S. L., Edlund, C. K., Schumacher, F. R., Gong, J., Harrison, T. A., Huyghe, J. R., Qu, C., Melas, M., Van Den Berg, D. J., Wang, H., Tring, S., Plummer, S. J., Albanes, D., Alonso, M. H., Amos, C. I., Anton, K., Aragaki, A. K., Arndt, V., Barry, E. L., Berndt, S. I. & 30 others, Bezieau, S., Bien, S., Bloomer, A., Boehm, J., Boutron-Ruault, M. C., Brenner, H., Brezina, S., Buchanan, D. D., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castelao, J. E., Chan, A. T., Chang-Claude, J., Chanock, S. J., Cheng, I., Cheng, Y. W., Chin, L. S., Church, J. M., Church, T., Coetzee, G. A., Cotterchio, M., Cruz Correa, M., Curtis, K. R., Duggan, D., Lin, Y., Liu, Y. R., Yen, Y. & Hsu, L., Feb 1 2019, In : Journal of the National Cancer Institute. 111, 2, p. 146-157 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Randomized trial of oral cyclophosphamide versus oral cyclophosphamide with celecoxib for recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer

Gupta, R., Cristea, M., Frankel, P., Ruel, C., Chen, C., Wang, Y., Morgan, R., Leong, L., Chow, W., Koczywas, M., Koehler, S., Lim, D., Luu, T., Martel, C., McNamara, M., Somlo, G., Twardowski, P., Yen, Y., Idorenyi, A., Raechelle, T. & 2 others, Carroll, M. & Chung, V., Jan 1 2019, In : Cancer Treatment and Research Communications. 21, 100155.

Research output: Contribution to journalArticle

Rrm2b deletion causes mitochondrial metabolic defects in renal tubules

Chen, Y. F., Lin, I. H., Guo, Y. R., Chiu, W. J., Wu, M. S., Jia, W. & Yen, Y., Dec 1 2019, In : Scientific Reports. 9, 1, 1 p., 13238.

Research output: Contribution to journalArticle

Open Access
Open Access
2 Citations (Scopus)

The Ambivalent Role of lncRNA Xist in Carcinogenesis

Chen, Y. K. & Yen, Y., Apr 15 2019, In : Stem Cell Reviews and Reports. 15, 2, p. 314-323 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2018

A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death

Penque, B. A., Su, L., Wang, J., Ji, W., Bale, A., Luh, F., Fulbright, R. K., Sarmast, U., Sega, A. G., Konstantino, M., Spencer-Manzon, M., Pierce, R., Yen, Y. & Lakhani, S. A., Jan 1 2018, (Accepted/In press) In : European Journal of Medical Genetics.

Research output: Contribution to journalArticle

A phase I trial of escalating doses of cixutumumab (IMC-A12) and sorafenib in the treatment of advanced hepatocellular carcinoma

El-Khoueiry, A. B., O’Donnell, R., Semrad, T. J., Mack, P., Blanchard, S., Bahary, N., Jiang, Y., Yen, Y., Wright, J., Chen, H., Lenz, H. J. & Gandara, D. R., May 1 2018, In : Cancer Chemotherapy and Pharmacology. 81, 5, p. 957-963 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43

Dai, Y., Wang, C., Chiu, L. Y., Abbasi, K., Tolbert, B. S., Sauvé, G., Yen, Y. & Liu, C. C., Oct 15 2018, In : Biosensors and Bioelectronics. 117, p. 60-67 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Cheng, C. T., Qi, Y., Wang, Y. C., Chi, K. K., Chung, Y., Ouyang, C., Chen, Y. R., Oh, M. E., Sheng, X., Tang, Y., Liu, Y. R., Lin, H. H., Kuo, C. Y., Schones, D., Vidal, C. M., Chu, J. C. Y., Wang, H. J., Chen, Y. H., Miller, K. M., Chu, P. & 4 others, Yen, Y., Jiang, L., Kung, H. J. & Ann, D. K., Dec 1 2018, In : Communications Biology. 1, 1, 178.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Differences in silencing of mismatched targets by sliced versus diced siRNAs

Sun, G., Wang, J., Huang, Y., Yuan, C. W. Y., Zhang, K., Hu, S., Chen, L., Lin, R. J., Yen, Y. & Riggs, A. D., Jan 1 2018, In : Nucleic Acids Research. 46, 13, p. 6806-6822 17 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Global DNA methylation analysis reveals miR-214-3p contributes to cisplatin resistance in pediatric intracranial nongerminomatous malignant germ cell tumors

Hsieh, T. H., Liu, Y. R., Chang, T. Y., Liang, M. L., Chen, H. H., Wang, H. W., Yen, Y. & Wong, T-T., Mar 27 2018, In : Neuro-Oncology. 20, 4, p. 519-530 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Machine learning–based radiomics for molecular subtyping of gliomas

Lu, C-F., Hsu, F-T., Hsieh, KL-C., Kao, Y-CJ., Cheng, S-J., Hsu, JB-K., Tsai, P-H., Chen, R-J., Huang, C-C., Yen, Y. & Chen, C-Y., Sep 15 2018, In : Clinical Cancer Research. 24, 18, p. 4429-4436 8 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer

Luu, T., Kim, K. P., Blanchard, S., Anyang, B., Hurria, A., Yang, L., Beumer, J. H., Somlo, G. & Yen, Y., Jan 1 2018, In : Breast Cancer Research and Treatment. 167, 2, p. 469-478 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer

Xue, L., Liu, X., Wang, Q., Liu, C. Q., Chen, Y., Jia, W., Hsie, R., Chen, Y., Luh, F., Zheng, S. & Yen, Y., Jan 1 2018, In : American Journal of Translational Research. 10, 11, p. 3635-3649 15 p., AJTR0084684.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Significance of cyclin D1 overexpression in progression and radio-resistance of pediatric ependymomas

Liang, M. L., Hsieh, T. H., Liu, Y. R., Chen, Y. W., Lee, Y. Y., Chang, F. C., Lin, S. C., Huang, M. C., Ho, D. M. T., Wong, T-T., Yen, Y. & Yang, M. H., Jan 1 2018, In : Oncotarget. 9, 2, p. 2527-2542 16 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes

Wang, Y. C., Chang, K. C., Lin, B. W., Lee, J. C., Lai, C. H., Lin, L. J., Yen, Y., Lin, C. S., Yang, S. J., Lin, P. C., Lee, C. T. & Hung, L. Y., Jun 1 2018, In : Experimental and Molecular Medicine. 50, 6, p. 70 70.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Tyrosine kinase inhibitors for advanced or metastatic thyroid cancer: a meta-analysis of randomized controlled trials

Liu, J. W., Chen, C., Loh, E. W., Chu, C. C., Wang, M. Y., Ouyang, H. J., Chang, Y. T., Zhuang, W. Z., Chou, C. W., Huang, D. J., Lee, C. H., Yen, Y. & Tam, K. W., 2018, In : Current Medical Research and Opinion. p. 1-9 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2017

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., Nov 10 2017, In : European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2 Citations (Scopus)

Does aspirin use reduce the risk for cancer?

Usman, I., Yang, H. C., Jian, W. S., Yen, Y. & Li, Y. C., Feb 1 2017, In : Journal of Investigative Medicine. 65, 2, p. 391-392 2 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers

Ding, J., Kuo, M. L., Su, L., Xue, L., Luh, F., Zhang, H., Wang, J., Lin, T. G., Zhang, K., Chu, P., Zheng, S., Liu, X. & Yen, Y., May 1 2017, In : Carcinogenesis. 38, 5, p. 519-531 13 p., bgx022.

Research output: Contribution to journalArticle

26 Citations (Scopus)
7 Citations (Scopus)

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Shih, J. W., Chiang, W. F., Wu, A. T. H., Wu, M. H., Wang, L. Y., Yu, Y. L., Hung, Y. W., Wang, W. C., Chu, C. Y., Hung, C. L., Changou, C. A., Yen, Y. & Kung, H. J., Jun 22 2017, In : Nature Communications. 8, 15874.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Mechanism and clinical properties of stembios cell therapy: Induction of early osseointegration in novel dental implants

Weng, C. C., Ou, K. L., Wu, C. Y., Huang, Y. H., Wang, J., Yen, Y., Cheng, H. Y. & Lin, Y. H., 2017, In : International Journal of Oral and Maxillofacial Implants. 32, 1, p. e47-e54

Research output: Contribution to journalArticle

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Huang, Y. J., Yang, C. K., Wei, P. L., Huynh, T. T., Whang-Peng, J., Meng, T. C., Hsiao, M., Tzeng, Y. M., Wu, A. T. & Yen, Y., Feb 28 2017, In : Journal of hematology & oncology. 10, 1, p. 60 1 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Overexpression of uridine-cytidine kinase 2 correlates with breast cancer progression and poor prognosis

Shen, G., He, P., Mao, Y., Li, P., Luh, F., Ding, G., Liu, X. & Yen, Y., Jun 1 2017, In : Journal of Breast Cancer. 20, 2, p. 132-141 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Pilot trial of CRLX101 in patients with advanced, chemotherapyrefractory gastroesophageal cancer

Chao, J., Lin, J., Frankel, P., Clark, A. J., Wiley, D. T., Garmey, E., Fakih, M., Lim, D., Chung, V., Luevanos, E., Eliasof, S., Davis, M. E. & Yen, Y., Dec 1 2017, In : Journal of Gastrointestinal Oncology. 8, 6, p. 962-969 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

A phase I pharmacodynamic study of GTI-2040, an antisense oligonucleotide against ribonuclotide reductase, in acute leukemias: a California Cancer Consortium study

Kirschbaum, M. H., Frankel, P., Synold, T. W., Xie, Z., Yen, Y., Popplewell, L., Chen, R., Aljitawi, O., Tuscano, J. M., Chan, K. K. & Newman, E. M., Oct 2 2016, In : Leukemia and Lymphoma. 57, 10, p. 2307-2314 8 p.

Research output: Contribution to journalArticle

Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells

Chen, Y. R., Tsou, B., Hu, S., Ma, H., Liu, X., Yen, Y. & Ann, D. K., Jan 1 2016, In : Oncotarget. 7, 2, p. 1984-1999 16 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Chemotherapy for advanced biliary tract carcinoma: A meta-analysis of randomized controlled trials

Chen, L., Chen, C., Yen, Y. & Tam, K. W., Aug 1 2016, In : Medicine (United States). 95, 33, 385.

Research output: Contribution to journalArticle

8 Citations (Scopus)

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

Clark, A. J., Wiley, D. T., Zuckerman, J. E., Webster, P., Chao, J., Lin, J., Yen, Y. & Davis, M. E., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. 3850-3854 5 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer

Wu, J., Zhang, S., Shan, J., Hu, Z., Liu, X., Chen, L., Ren, X., Yao, L., Sheng, H., Li, L., Ann, D., Yen, Y., Wang, J. & Wang, X., Jul 1 2016, In : Cancer Letters. 376, 2, p. 284-292 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation

Chang, L. C., Chen, T. C., Chen, S. J., Chen, C. L., Lee, C. C., Wu, S. H., Yen, Y., Huang, H. S. & Lin, J. J., Oct 18 2016, In : Oncotarget. 7, 42, p. 67986-68001 16 p.

Research output: Contribution to journalArticle

Integrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma

Yang, S. H., Lin, H. Y., Changou, C. A., Chen, C. H., Liu, Y. R., Wang, J., Jiang, X., Luh, F. & Yen, Y., Jan 1 2016, In : Oncotarget. 7, 1, p. 362-373 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Novel regulators and molecular mechanisms of p53R2 and its disease relevance

Cho, E. C. & Yen, Y., Apr 1 2016, In : Biochimie. 123, p. 81-84 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Observation of polarization and thickness dependent third-harmonic generation in multilayer black phosphorus

Wu, H. Y., Yen, Y. & Liu, C. H., Dec 26 2016, In : Applied Physics Letters. 109, 26, 261902.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Precision Medicine and Pancreatic Cancer

Farrell, J. J., Moughan, J., Wong, J. L., Regine, W. F., Schaefer, P., Benson, A. B., Macdonald, J. S., Liu, X., Yen, Y., Lai, R., Zheng, Z., Bepler, G., Guha, C. & Elsaleh, H., Nov 1 2016, In : Pancreas. 45, 10, p. 1485-1493 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
22 Citations (Scopus)