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Personal profile


  • PGY-I-III, Department of Internal Medicine St. Luke's Hospital,Temple University, Bethlehem, PA
  • Fellow, Department of Internal Medicine, Hematology and Bone Marrow Transplantation and Oncology Section, Yale University School of Medicine
  • Ph.D. in Pathology and Cell Biology, Thomas Jefferson University, Philadelphia
  • M.D., Taipei Medical College, Taipei, Taiwan


  • President and Chair Professor, Taipei Medical University
  • Affiliate Professor, California Institute of Technology, Pasadena, CA
  • Chair, The Chinese Oncology Society
  • Chair, ASCO International Affair Community
  • Chair, Molecular Pharmacology Department, City of Hope
  • Associate Director for Translational Research, City of Hope Comprehensive Cancer Center
  • Adjunct Professor, School of Pharmacy, University of Southern California
  • Adjunct Professor, Graduate Institute of Oncology, College of Medicine, National Taiwan University


  • Academician, International Academy of Engineering, Russia
  • Fellow, American Association for the Advancement of Science(AAAS)
  • Tang Prize Board Member
  • Board of Trustees, NHRI (Taiwan NIH), Taiwan
  • Kuong-Chi Scholar, Zhejiang University, Hangzhou, China
  • Steering Committee of Ming Hsieh Institute, USA
  • Who’s Who International and Professional Member (life member)
  • America’s Top Doctor (life member)
  • Hedvig Foundation Award
  • Cooper Portrait for Scientific Achievement Award in Cooper Auditorium, City of Hope
  • Distinguished Alumnus Award, Thomas Jefferson University, Philadelphia

Research Interests

  • Cancer Research
  • Translational Medicine


Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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gemcitabine Medicine & Life Sciences
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Hepatocellular Carcinoma Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Hydroxyurea Medicine & Life Sciences
KB Cells Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2018


Yen, Y.


Project: A - Government Institutiona - National Health Research Institutes


Yen, Y.


Project: A - Government Institutionb - Ministry of Science and Technology

"First-in-Class"新穎性抗癌藥物ITCH E3 ubiquitinligase 抑制劑之新藥開發

Yen, Y.


Project: A - Government Institutionb - Ministry of Science and Technology


Yen, Y.


Project: A - Government Institutionb - Ministry of Science and Technology

Research Output 1994 2018

2 Citations (Scopus)

A phase I trial of escalating doses of cixutumumab (IMC-A12) and sorafenib in the treatment of advanced hepatocellular carcinoma

El-Khoueiry, A. B., O’Donnell, R., Semrad, T. J., Mack, P., Blanchard, S., Bahary, N., Jiang, Y., Yen, Y., Wright, J., Chen, H., Lenz, H. J. & Gandara, D. R., May 1 2018, In : Cancer Chemotherapy and Pharmacology. 81, 5, p. 957-963 7 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Liver Neoplasms
5 Citations (Scopus)

Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43

Dai, Y., Wang, C., Chiu, L. Y., Abbasi, K., Tolbert, B. S., Sauvé, G., Yen, Y. & Liu, C. C., Oct 15 2018, In : Biosensors and Bioelectronics. 117, p. 60-67 8 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Biosensing Techniques

Benefits and harms of the centers for medicare & medicaid services ruling on next-generation sequencing

Luh, F. & Yen, Y., Sep 1 2018, In : JAMA oncology. 4, 9, p. 1171-1172 2 p.

Research output: Contribution to journalShort survey

1 Citation (Scopus)

DHS (trans−4,4′-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2)

Chen, C. W., Li, Y., Hu, S., Zhou, W., Meng, Y., Li, Z., Zhang, Y., Sun, J., Bo, Z., DePamphilis, M. L., Yen, Y., Han, Z. & Zhu, W., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
DNA Replication
3 Citations (Scopus)

Differences in silencing of mismatched targets by sliced versus diced siRNAs

Sun, G., Wang, J., Huang, Y., Yuan, C. W. Y., Zhang, K., Hu, S., Chen, L., Lin, R. J., Yen, Y. & Riggs, A. D., Jan 1 2018, In : Nucleic Acids Research. 46, 13, p. 6806-6822 17 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Argonaute Proteins
Guide RNA
RNA Interference

Press / Media