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Personal profile


  • 1988 Ph.D. (Pathology and Cell Biology), Thomas Jefferson University, Philadelphia
  • 1982 M.D., Taipei Medical College, Taipei, Taiwan


  • 2011- Professor, Taipei Medical University
  • 2011-2017 President, Taipei Medical University
  • Affiliate Professor, California Institute of Technology, Pasadena, CA
  • Chair, The Chinese Oncology Society
  • Chair, ASCO International Affair Community
  • Chair, Molecular Pharmacology Department, City of Hope
  • Associate Director for Translational Research, City of Hope Comprehensive Cancer Center
  • Adjunct Professor, School of Pharmacy, University of Southern California
  • Adjunct Professor, Graduate Institute of Oncology, College of Medicine, National Taiwan University


  • Academician, International Academy of Engineering, Russia
  • Fellow, American Association for the Advancement of Science(AAAS)
  • Tang Prize Board Member
  • Board of Trustees, NHRI (Taiwan NIH), Taiwan
  • Kuong-Chi Scholar, Zhejiang University, Hangzhou, China
  • Steering Committee of Ming Hsieh Institute, USA
  • Who’s Who International and Professional Member (life member)
  • America’s Top Doctor (life member)
  • Hedvig Foundation Award
  • Cooper Portrait for Scientific Achievement Award in Cooper Auditorium, City of Hope
  • Distinguished Alumnus Award, Thomas Jefferson University, Philadelphia

Research Interests

  • Cancer Research
  • Translational Medicine


Fingerprint Dive into the research topics where Yun Yen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 97 Similar Profiles
Ribonucleotide Reductases Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
gemcitabine Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
Hepatocellular Carcinoma Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Hydroxyurea Medicine & Life Sciences
KB Cells Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2018


Yen, Y.


Project: A - Government Institutiona - National Health Research Institutes


Yen, Y.


Project: A - Government Institutionb - Ministry of Science and Technology

"First-in-Class"新穎性抗癌藥物ITCH E3 ubiquitinligase 抑制劑之新藥開發

Yen, Y.


Project: A - Government Institutionb - Ministry of Science and Technology


Yen, Y.


Project: A - Government Institutionb - Ministry of Science and Technology

Research Output 1994 2019

DHS (trans−4,4′-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2)

Chen, C. W., Li, Y., Hu, S., Zhou, W., Meng, Y., Li, Z., Zhang, Y., Sun, J., Bo, Z., DePamphilis, M. L., Yen, Y., Han, Z. & Zhu, W., Mar 2019, In : Oncogene.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
DNA Replication

Human Mitotic Centromere-Associated Kinesin Is Targeted by MicroRNA 485-5p/181c and Prognosticates Poor Survivability of Breast Cancer

Lu, H., Wang, C., Xue, L., Zhang, Q., Luh, F., Wang, J., Lin, T. G., Yen, Y. & Liu, X., Jan 1 2019, In : Journal of Oncology. 2019, 2316237.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
Survival Analysis
9 Citations (Scopus)

Novel Common Genetic Susceptibility Loci for Colorectal Cancer

Schmit, S. L., Edlund, C. K., Schumacher, F. R., Gong, J., Harrison, T. A., Huyghe, J. R., Qu, C., Melas, M., Van Den Berg, D. J., Wang, H., Tring, S., Plummer, S. J., Albanes, D., Alonso, M. H., Amos, C. I., Anton, K., Aragaki, A. K., Arndt, V., Barry, E. L., Berndt, S. I. & 30 othersBezieau, S., Bien, S., Bloomer, A., Boehm, J., Boutron-Ruault, M. C., Brenner, H., Brezina, S., Buchanan, D. D., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castelao, J. E., Chan, A. T., Chang-Claude, J., Chanock, S. J., Cheng, I., Cheng, Y. W., Chin, L. S., Church, J. M., Church, T., Coetzee, G. A., Cotterchio, M., Cruz Correa, M., Curtis, K. R., Duggan, D., Lin, Y., Liu, Y. R., Yen, Y. & Hsu, L., Feb 1 2019, In : Journal of the National Cancer Institute. 111, 2, p. 146-157 12 p.

Research output: Contribution to journalArticle

Genetic Loci
Genetic Predisposition to Disease
Colorectal Neoplasms
Genome-Wide Association Study
Confidence Intervals

A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death

Penque, B. A., Su, L., Wang, J., Ji, W., Bale, A., Luh, F., Fulbright, R. K., Sarmast, U., Sega, A. G., Konstantino, M., Spencer-Manzon, M., Pierce, R., Yen, Y. & Lakhani, S. A., Jan 1 2018, (Accepted/In press) In : European Journal of Medical Genetics.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Lactic Acidosis
Failure to Thrive
2 Citations (Scopus)

A phase I trial of escalating doses of cixutumumab (IMC-A12) and sorafenib in the treatment of advanced hepatocellular carcinoma

El-Khoueiry, A. B., O’Donnell, R., Semrad, T. J., Mack, P., Blanchard, S., Bahary, N., Jiang, Y., Yen, Y., Wright, J., Chen, H., Lenz, H. J. & Gandara, D. R., May 1 2018, In : Cancer Chemotherapy and Pharmacology. 81, 5, p. 957-963 7 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Liver Neoplasms