Yuan-Soon Ho

Projects

Projects per year 2010 2022

• 3 Active
• 37 Finished

Projects per year

Search results

• Active

  乳癌細胞α9尼古丁受體作為新穎靶向RNA奈米藥物與T細胞療法之臨床轉譯 研究-乳癌細胞α9尼古丁受體/HER2複合體作為RNA奈米藥物治療HerceptinR抗藥 性之機制探討(2/3)

  Ho, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 組織胺甲基化轉換酵素(HNMT)輔助臨床醫師鑑別乳癌病患作為Herceptin療效評估之新穎分子標記(3/3)

  Ho, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以玻尿酸合成酶為平台探討RNA適體奈米質粒抑制乳癌之機制

  Ho, Y.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Finished

  組織胺甲基化轉換酵素(HNMT)輔助臨床醫師鑑別乳癌病患作為Herceptin療效評估之新穎分子標記(2/3)

  Ho, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌細胞α9尼古丁受體作為新穎靶向RNA奈米藥物與T細胞療法之臨床轉譯 研究-乳癌細胞α9尼古丁受體/HER2複合體作為RNA奈米藥物治療HerceptinR抗藥 性之機制探討(1/3)

  Ho, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Oncogenic Roles of A9-Nicotinic Acetylcholine Receptor Variants on Breast Cancer( III )

  Ho, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Mechanisms of Histamine N-Methyl-Transferase (Hnmt) as a Novel Molecular Marker to Help Clinician for Identifying of Herceptin Responder in Breast Cancer Patients(1/3)

  Ho, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Oncogenic Roles of A9-Nicotinic Acetylcholine Receptor Variants on Breast Cancer(II)(2/3)

  Ho, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Mechanisms of Histamine N-Methyltransferase (Hnmt)-Mediated Herceptinr Drug-Resistance in Breast Cancer Cells(3/3)

  Ho, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Trastuzumab 89%
  • Breast Neoplasms 16%
  • Tissue Array Analysis 9%
  • Gene Expression Profiling 8%

• Investigating the Oncogenic Roles of A9-Nicotinic Acetylcholine Receptor Variants on Breast Cancer( I )

  Ho, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Mechanisms of Histamine N-Methyltransferase (Hnmt)-Mediated Herceptinr Drug-Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Trastuzumab 89%
  • Breast Neoplasms 17%
  • Tissue Array Analysis 9%
  • Gene Expression Profiling 8%

• 組織胺甲基化轉換酵素參與第第二型人類表皮因子受體蛋白穩定性之探討

  Ho, Y.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Mechanisms of Histamine N-Methyltransferase (Hnmt)-Mediated Herceptinr Drug-Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Trastuzumab 89%
  • Breast Neoplasms 17%
  • Tissue Array Analysis 9%
  • Gene Expression Profiling 8%

• 轉譯醫學研究法探討茶緩解菸害之機轉:乳癌和動脈粥狀硬化為例(3/3)

  Ho, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Tea 100%
  • Nicotine 28%
  • Capsules 25%
  • Breast Neoplasms 21%
  • MicroRNAs 19%

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Trastuzumab 88%
  • Neoplastic Stem Cells 39%
  • Drug Resistance 27%
  • Luciferases 20%

• Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation---The Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example

  Ho, Y. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Gene Expression 46%
  • Tumor Microenvironment 40%
  • Hyaluronan Synthases 30%
  • Fibroblasts 29%

• Gene Knock out Mice Model for Studying the Molecular Mechanisms of Early Onset Breast Tumor Microenvironment Regulation.

  Wu, C., Ho, Y. & Tu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • breast 100%
  • cancer 97%
  • tumors 59%
  • fibroblasts 33%
  • genes 31%

• Translational Investigation for Tea Attenuate Smoking-Induced Disease---Breast Cancer and Atherosclerosis as a Mechanistic Study

  Ho, Y. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Tea 100%
  • Nicotine 26%
  • Capsules 23%
  • Breast Neoplasms 23%
  • Smoking 19%

• Study of Novel Genes Regulated by Aberrant DNA Methylation and Application in Colon Cancer Treatment

  Lin, R. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasm Genes 100%
  • Methylation 83%
  • Taiwan 82%
  • DNA Methylation 81%
  • Colonic Neoplasms 66%

• Design and Preclinical Translation Study of Mixed-Bispecific/Trispecific Antibody for Enhancing Therapeutic Effectiveness of Anticancer Drug-Loaded Pegylated Nanocarriers by Simultaneously Targeting to Tumor Cells and Cancer/Tumor Associated Fibrobla (I)

  Sheu, M., Chuang, K. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanocarrier 100%
  • Antigen 77%
  • Tumor Marker 61%
  • Modification 51%
  • Liposome 42%

• Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

  Wu, C., Ho, Y. & Lee, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Resistance 100%
  • Nicotine 97%
  • Acute Toxicity 95%
  • Acetylcholine 85%
  • Drug 83%

• Study of Expression and Functional Mechanisms of Histamine N-Methyltransferase (HNMT) in Tumorigenesis and Correlation with Progression in Lung Cancer

  Wang, L., Lee, W., Ho, Y. & Wu, T. A.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Lung Neoplasms 43%
  • Carcinogenesis 18%
  • Neoplasms 10%
  • Genes 9%

• Activation Autophagy by the Combination of a Histone Deacetylase Inhibitor and Radiation Limits BNIP3 Regulation in Triple-Negative Breast Cancer Cells and Orthotopic Mouse Model

  Chiu, H. & Ho, Y.

  8/1/15 → 6/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Triple Negative Breast Neoplasms 100%
  • Histone Deacetylase Inhibitors 97%
  • Ionizing Radiation 42%
  • Autophagy 39%
  • human ERBB2 protein 25%

• 104年度「空中救護審核機制計畫」

  Tsai, S., Whang-Peng, J., Liu, L., Chang, W., Ho, Y., Cheng, Y., Yeh, S., Chen, K., Sung, S., Hung, K., Chen, R., Chiou, H., Chen, C. & Li, Y.

  1/1/15 → 3/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation: the Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example.

  Ho, Y. & Wu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Gene Expression 46%
  • Tumor Microenvironment 40%
  • Hyaluronan Synthases 30%
  • Fibroblasts 29%

• Translational Investigation for Tea Attenuate Smoking-Induced Disease---Breast Cancer and Atherosclerosis as a Mechanistic Study

  Ho, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Tea 100%
  • Nicotine 26%
  • Capsules 23%
  • Breast Neoplasms 23%
  • Smoking 19%

• Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

  Wu, C., Ho, Y. & Lee, C.

  5/1/14 → 7/30/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Resistance 100%
  • Nicotine 97%
  • Acute Toxicity 95%
  • Acetylcholine 85%
  • Drug 83%

• Molecular mechanisms of alpha9-nicotinic acetylcholine receptor (alpha 9-nAChR)-mediated Trastuzumab (HerceptinR) drug resistance in breast cancer cells

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Liposomes 66%
  • MicroRNAs 56%
  • Trastuzumab 53%
  • Nicotinic Receptors 49%

• 三陰性乳癌周邊微環境之研究平台建立：以玻尿酸合成酉每Ⅲ抑癌作用為例(1/3)

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 晚期乳癌組織中尼古丁受體(α9-nAChR)表現與Trastuzumab (Herceptin®)產生抗藥性之分子機制探討

  Ho, Y.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 晚期乳癌組織中尼古丁受體(α9-nAChR)表現與Trastuzumab (Herceptin®)產生抗藥性之分子機制探討

  Ho, Y.

  8/1/12 → 7/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Molecular Mechanisms of Alpha 9-Nicotinic Acetylcholine Receptor (Alpha 9-Nachr)-Mediated Trastuzumab (Herceptinr) Drug Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Liposomes 66%
  • MicroRNAs 56%
  • Trastuzumab 53%
  • Nicotinic Receptors 49%

• Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

  Wu, C., Ho, Y. & Lee, C.

  5/1/12 → 4/30/13

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Resistance 100%
  • Nicotine 97%
  • Acute Toxicity 95%
  • Acetylcholine 85%
  • Drug 83%

• a9-尼古丁乙醯膽鹼受體拮抗劑應用於緩解乳癌病人Herceptin®治療抗藥性之研究

  Ho, Y.

  3/1/12 → 2/28/13

  Project: C - Project of Alliance › q - Cathay General Hospital

• Studies on the Carcinogenic Mechanisms of Histamine N-Methyltransferase-Mediated Breast Cancer Formation

  Wu, C. & Ho, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Breast Neoplasms 18%
  • Neoplasms 6%
  • Carcinogenesis 6%

• Molecular Mechanisms of Alpha 9-Nicotinic Acetylcholine Receptor (Alpha 9-nAChRs)-Mediated Trastuzumab (Herceptin R) Drug Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Trastuzumab 79%
  • Liposomes 66%
  • MicroRNAs 56%
  • Nicotinic Receptors 49%

• Studies on the Mechanisms of a9-Nicotinic Acetylcholine Receptor Confers Tamoxifen-Induced Drug Resistance in Human Breast Cancer Cells

  Ho, Y. & Wu, C.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • tamoxifen 100%
  • phosphopyruvate hydratase 94%
  • breast neoplasms 68%
  • nicotinic receptors 48%
  • drug resistance 35%

• Studies on the Mechanisms of Apple Polyphenol (Phloretin)-Induced Apoptosis in Human Breast Cancer Cells

  Wu, C. & Ho, Y.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glucose 100%
  • Antitumor 17%
  • Laser Capture Microdissection 12%
  • Phloretin 7%
  • Apoptosis Induction 7%

• Studies on the Mechanisms of A9-Nicotinic Acetylcholine Receptor Confers Tamoxifen-Induced Drug Resistance in Human Breast Cancer Cells

  Ho, Y. & Wu, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • tamoxifen 100%
  • phosphopyruvate hydratase 94%
  • breast neoplasms 68%
  • nicotinic receptors 48%
  • drug resistance 35%

• Cell Behaviors and Its Gene Analysis of Nerve-Like Cell on Three-Dimensional Fibrous Matrix

  Tseng, H. & Ho, Y.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • membranes 100%
  • nerves 70%
  • cells 60%
  • gene expression 50%
  • tissue engineering 32%