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Research Output 1992 2019

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2019
2 Citations (Scopus)

DNA primase polypeptide 1 (PRIM1) involves in estrogen-induced breast cancer formation through activation of the G2/M cell cycle checkpoint

Lee, W-H., Chen, L-C., Lee, C-J., Huang, C-C., Ho, Y-S., Yang, P-S., Ho, C-T., Chang, H-L., Lin, I-H., Chang, H-W., Liu, Y-R., Wu, C-H. & Tu, S-H., Feb 1 2019, In : International Journal of Cancer. 144, 3, p. 615-630 16 p.

Research output: Contribution to journalArticle

DNA Primase
G2 Phase Cell Cycle Checkpoints
Estrogens
Breast Neoplasms
Peptides

Membrane protein-regulated networks across human cancers

Lin, C. Y., Lee, C. H., Chuang, Y. H., Lee, J. Y., Chiu, Y. Y., Wu Lee, Y. H., Jong, Y. J., Hwang, J. K., Huang, S. H., Chen, L. C., Wu, C. H., Tu, S. H., Ho, Y. S. & Yang, J. M., Dec 1 2019, In : Nature Communications. 10, 1, 3131.

Research output: Contribution to journalArticle

Open Access
Membrane Proteins
cancer
membranes
proteins
Neoplasms

Proteasome 26s subunit, non-atpase 3 (Psmd3) regulates breast cancer by stabilizing her2 from degradation

Fararjeh, A. S., Chen, L. C., Ho, Y. S., Cheng, T. C., Liu, Y. R., Chang, H. L., Chang, H. W., Wu, C. H. & Tu, S. H., Apr 1 2019, In : Cancers. 11, 4, 527.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
human ERBB2 protein
ATP dependent 26S protease
Ubiquitination
Proteasome Endopeptidase Complex

Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin

Lin, J. H., Lee, W. J., Wu, H. C., Wu, C. H., Chen, L. C., Huang, C. C., Chang, H. L., Cheng, T. C., Chang, H. W., Ho, C. T., Tu, S. H. & Ho, Y. S., Jan 1 2019, In : Cell Adhesion and Migration.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Cadherins
Cell Adhesion
Estrogen Receptors
Breast Neoplasms
Open Access
Petroselinum
G1 Phase Cell Cycle Checkpoints
Cell Cycle Resting Phase
G1 Phase
Nude Mice
2018
3 Citations (Scopus)
docetaxel
Bispecific Antibodies
Lecithins
Drug Delivery Systems
Neoplasms
7 Citations (Scopus)
docetaxel
Lecithins
Drug Delivery Systems
Therapeutics
Neoplasms
5 Citations (Scopus)
Myeloid Progenitor Cells
Histone Deacetylases
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmaceutical Preparations
Neoplastic Stem Cells
Nicotinic Receptors
Nicotine
Tobacco Smoke Pollution
Smoke
smoke
1 Citation (Scopus)

Oestrogen receptor-regulated glutathione S-transferase mu 3 expression attenuates hydrogen peroxide-induced cytotoxicity, which confers tamoxifen resistance on breast cancer cells

Lin, J. H., Tu, S. H., Chen, L. C., Huang, C. C., Chang, H. L., Cheng, T. C., Chang, H. W., Wu, C. H., Wu, H. C. & Ho, Y. S., Jan 1 2018, (Accepted/In press) In : Breast Cancer Research and Treatment.

Research output: Contribution to journalArticle

Tamoxifen
Glutathione Transferase
Estrogen Receptors
Hydrogen Peroxide
Breast Neoplasms
10 Citations (Scopus)
Glucose Transporter Type 2
Phloretin
glucose transporters
Malus
Polyphenols
1 Citation (Scopus)

The impact of the effectiveness of GATA3 as a prognostic factor in breast cancer

Fararjeh, A-FS., Tu, S-H., Chen, L-C., Liu, Y-R., Lin, Y-K., Chang, H-L., Chang, H-W., Wu, C-H., Hwang-Verslues, W. W. & Ho, Y-S., 2018, In : Human Pathology. 80, p. 219-230 12 p.

Research output: Contribution to journalArticle

Breast Neoplasms
GATA3 Transcription Factor
Cell Line
Neoplasms
Curcumin
1 Citation (Scopus)

α-Tocopherol succinate enhances pterostilbene anti-tumor activity in human breast cancer cells in vivo and in vitro

Tam, K. W., Ho, C. T., Tu, S. H., Lee, W. J., Huang, C. S., Chen, C. S., Wu, C. H., Lee, C. H. & Ho, Y. S., Jan 1 2018, In : Oncotarget. 9, 4, p. 4593-4606 14 p.

Research output: Contribution to journalArticle

alpha-Tocopherol
Vitamin E
Human Activities
Breast Neoplasms
Neoplasms
2017
3 Citations (Scopus)
Taiwan
Breast Neoplasms
DNA Mismatch Repair
Single Nucleotide Polymorphism
Luciferases
7 Citations (Scopus)

P53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene treatment

Chen, R. J., Wu, P. H., Ho, C. T., Way, T. D., Pan, M. H., Chen, H. M., Ho, Y. S. & Wang, Y. J., Aug 10 2017, In : Cell death & disease. 8, 8, p. e2985

Research output: Contribution to journalArticle

Telomerase
Lung Neoplasms
Down-Regulation
Proteins
Cell Aging
2016
11 Citations (Scopus)

Alterations in histone deacetylase 8 lead to cell migration and poor prognosis in breast cancer

Hsieh, C. L., Ma, H. P., Su, C-M., Chang, Y. J., Hung, W. Y., Ho, Y. S., Huang, W. J. & Lin, R. K., Apr 15 2016, In : Life Sciences. 151, p. 7-14 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cell Movement
Breast Neoplasms
Atlases
Assays
5 Citations (Scopus)

Protein phosphatase Mg2+/Mn2+ dependent 1F promotes smoking-induced breast cancer by inactivating phosphorylatedp53- induced signals

Tu, S-H., Lin, Y. C., Huang, C-C., Yang, P. S., Chang, H. W., Chang, C. H., Wu, C-H., Chen, L-C. & Ho, Y-S., 2016, In : Oncotarget. 7, 47, p. 77516-77531 16 p.

Research output: Contribution to journalArticle

Phosphoprotein Phosphatases
Smoking
Breast Neoplasms
Nicotine
Western Blotting
1 Citation (Scopus)

Pu-erh tea attenuates smoking-induced foam cell formation through inhibition of the α9-nicotinic-acetylcholine receptor expression in monocytes: An ex vivo study

Chen, L. C., Chen, M. Y., Tu, S. H., Pan, M. H., Lo, C. Y., Ho, C. T., Wu, C. H. & Ho, Y. S., Apr 1 2016, In : Journal of Functional Foods. 22, p. 132-144 13 p.

Research output: Contribution to journalArticle

foam cells
Foam Cells
cholinergic receptors
Nicotinic Receptors
Tea
4 Citations (Scopus)

Pu-erh Tea Extract Attenuates Nicotine-Induced Foam Cell Formation in Primary Cultured Monocytes: An in Vitro Mechanistic Study

Tu, S. H., Chen, M. Y., Chen, L. C., Mao, Y. T., Ho, C. H., Lee, W. J., Lin, Y-K., Pan, M. H., Lo, C. Y., Chen, C. L., Yen, Y., Whang-Peng, J., Ho, C. T., Wu, C. H. & Ho, Y. S., Apr 27 2016, In : Journal of Agricultural and Food Chemistry. 64, 16, p. 3186-3195 10 p.

Research output: Contribution to journalArticle

foam cells
Foam Cells
nicotine
Tea
Nicotine
2015
14 Citations (Scopus)

Down-regulation of α-L-fucosidase 1 expression confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surface

Cheng, T. C., Tu, S. H., Chen, L. C., Chen, M. Y., Chen, W. Y., Lin, Y-K., Ho, C. T., Lin, S. Y., Wu, C. H. & Ho, Y. S., 2015, In : Oncotarget. 6, 25, p. 21283-21300 18 p.

Research output: Contribution to journalArticle

alpha-L-Fucosidase
Triple Negative Breast Neoplasms
Glycosylation
Down-Regulation
Survival
14 Citations (Scopus)
Bupivacaine
Analgesia
Meta-Analysis
Randomized Controlled Trials
Breast Neoplasms
14 Citations (Scopus)

Novel Link of Anti-apoptotic ATF3 with Pro-apoptotic CTMP in the Ischemic Brain

Huang, C. Y., Chen, J. J., Wu, J. S., Tsai, H. D., Lin, H., Yan, Y. T., Hsu, C-Y., Ho, Y-S. & Lin, T. N., 2015, In : Molecular Neurobiology. 51, 2, p. 543-557 15 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Brain
Proteins
Apoptosis
Activating Transcription Factor 1
38 Citations (Scopus)

Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1

Jin, G., Lee, S. W., Zhang, X., Cai, Z., Gao, Y., Chou, P. C., Rezaeian, A. H., Han, F., Wang, C. Y., Yao, J. C., Gong, Z., Chan, C. H., Huang, C. Y., Tsai, F. J., Tsai, C. H., Tu, S. H., Wu, C. H., Sarbassov, D. D., Ho, Y. S. & Lin, H. K., Jun 18 2015, In : Molecular Cell. 58, 6, p. 989-1000 12 p.

Research output: Contribution to journalArticle

Ubiquitination
Amino Acids
Cell Enlargement
mechanistic target of rapamycin complex 1
Ubiquitin-Protein Ligases
2014
25 Citations (Scopus)

Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential

Wang, S. C., Li, Z-H., Hsu, C. H., Chang, Y. J., Chang, M. S., Wang, Y. C., Ho, Y. S., Wen, W. C. & Lin, R. K., Jun 18 2014, In : Journal of Agricultural and Food Chemistry. 62, 24, p. 5625-5635 11 p.

Research output: Contribution to journalArticle

Antrodia
Taiwanofungus camphoratus
methyltransferases
Methyltransferases
breast neoplasms
5 Citations (Scopus)

CHRNA9 polymorphisms and smoking exposure synergize to increase the risk of breast cancer in Taiwan

Hsieh, Y. C., Lee, C. H., Tu, S. H., Wu, C. H., Hung, C. S., Hsieh, M. C., Chuang, C. W., Ho, Y. S. & Chiou, H. Y., Nov 1 2014, In : Carcinogenesis. 35, 11, p. 2520-2525 6 p.

Research output: Contribution to journalArticle

Taiwan
Smoking
Single Nucleotide Polymorphism
Breast Neoplasms
Cholinergic Receptors
13 Citations (Scopus)

High-level expression of CXCR4 in breast cancer is associated with early distant and bone metastases

Hung, C-S., Su, H. Y., Liang, H-H., Lai, C. W., Chang, Y-C., Ho, Y-S., Wu, C-H., Ho, J-D., Wei, P-L. & Chang, Y-J., 2014, In : Tumor Biology. 35, 2, p. 1581-1588 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Bone and Bones
Chemokine Receptors
Incidence
16 Citations (Scopus)

Novel peptides suppress VEGFR-3 activity and antagonize VEGFR-3-mediated oncogenic effects

Chang, Y. W., Su, C. M., Su, Y-H., Ho, Y. S., Lai, H. H., Chen, H. A., Kuo, M. L., Hung, W. C., Chen, Y. W., Wu, C. H., Chen, P. S. & Su, J. L., 2014, In : Oncotarget. 5, 11, p. 3823-3835 13 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-3
Peptides
Vascular Endothelial Growth Factor C
Neoplasms
Lymphangiogenesis
21 Citations (Scopus)

Potent anti-cancer effect of 39-hydroxypterostilbene in human colon xenograft tumors

Cheng, T. C., Lai, C. S., Chung, M. C., Kalyanam, N., Majeed, M., Ho, C. T., Ho, Y. S. & Pan, M. H., Nov 12 2014, In : PLoS One. 9, 11, e111814.

Research output: Contribution to journalArticle

human growth
autophagy
colorectal neoplasms
Heterografts
colon
5 Citations (Scopus)

Protective effect of non-ionizing radiation from ceramic far infrared (cFIR)-emitting material against oxidative stress on human breast epithelial cells

Leung, T-K., Lee, C-M., Lin, S. L., Wu, C. H., Chiou, J. F., Huang, P. J., Shen, L. K., Hung, C. S., Ho, Y. S., Wang, H. J., Kung, C. H., Lin, Y. H. & Yeh, H. M., 2014, In : Journal of Medical and Biological Engineering. 34, 1, p. 69-75 7 p.

Research output: Contribution to journalArticle

Nonionizing Radiation
Oxidative stress
Ceramics
Oxidative Stress
Breast
2 Citations (Scopus)

The regulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumor promotion by estradiol in female A/J mice

Chen, R. J., Chang, C. Y., Chang, L. W., Siao, S. H., Ho, Y. S., Wu, C. H., Foo, N. P., Lin, P. & Wang, Y. J., Mar 28 2014, In : PLoS One. 9, 3, e93152.

Research output: Contribution to journalArticle

tetrachlorodibenzo-p-dioxin
lung neoplasms
estradiol
Tumors
Estradiol
12 Citations (Scopus)

Vascular Endothelial Growth Factor-C Upregulates Cortactin and Promotes Metastasis of Esophageal Squamous Cell Carcinoma

Su, C-M., Su, Y-H., Chiu, C. F., Chang, Y. W., Hong, C. C., Yu, Y. H., Ho, Y. S., Wu, C. H., Yen, C. S. & Su, J. L., 2014, In : Annals of Surgical Oncology. 21, 4, p. 767-775 9 p.

Research output: Contribution to journalArticle

Cortactin
Vascular Endothelial Growth Factor C
Up-Regulation
Neoplasm Metastasis
Neoplasms
2013
13 Citations (Scopus)

Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development

Tam, K-W., Ho, C. T., Lee, W. J., Tu, S-H., Huang, C. S., Chen, C. S., Lee, C-H., Wu, C-H. & Ho, Y-S., Jun 1 2013, In : Food Chemistry. 138, 2-3, p. 1015-1021 7 p.

Research output: Contribution to journalArticle

Tocopherols
tocopherols
breast neoplasms
breasts
Breast
23 Citations (Scopus)

Areca nut-induced buccal mucosa fibroblast contraction and its signaling: A potential role in oral submucous fibrosis-a precancer condition

Chang, M. C., Lin, L. D., Wu, H. L., Ho, Y. S., Hsien, H. C., Wang, T. M., Jeng, P. Y., Cheng, R. H., Hahn, L. J. & Jeng, J. H., May 2013, In : Carcinogenesis. 34, 5, p. 1096-1104 9 p.

Research output: Contribution to journalArticle

Oral Submucous Fibrosis
Areca
Nuts
Mouth Mucosa
Fibroblasts
14 Citations (Scopus)

Hexahydro-β-acids potently inhibit 12- O -tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice

Hsu, C-H., Ho, Y-S., Lai, C. S., Hsieh, S. C., Chen, L. H., Lin, E., Ho, C. T. & Pan, M. H., Nov 27 2013, In : Journal of Agricultural and Food Chemistry. 61, 47, p. 11541-11549 9 p.

Research output: Contribution to journalArticle

beta acids
Tetradecanoylphorbol Acetate
Tumors
Skin
Acetates
11 Citations (Scopus)

Long-term ethanol exposure-induced hepatocellular carcinoma cell migration and invasion through lysyl oxidase activation are attenuated by combined treatment with pterostilbene and curcumin analogues

Huang, C. S., Ho, C. T., Tu, S. H., Pan, M. H., Chuang, C. H., Chang, H. W., Chang, C. H., Wu, C. H. & Ho, Y. S., May 8 2013, In : Journal of Agricultural and Food Chemistry. 61, 18, p. 4326-4335 10 p.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Curcumin
cell invasion
curcumin
hepatoma
18 Citations (Scopus)

Luteolin sensitises drug-resistant human breast cancer cells to tamoxifen via the inhibition of cyclin E2 expression

Tu, S. H., Ho, C. T., Liu, M. F., Huang, C. S., Chang, H. W., Chang, C. H., Wu, C. H. & Ho, Y. S., 2013, In : Food Chemistry. 141, 2, p. 1553-1561 9 p.

Research output: Contribution to journalArticle

Luteolin
tamoxifen
Cyclins
luteolin
cyclins
34 Citations (Scopus)
Epithelial-Mesenchymal Transition
MicroRNAs
Cell Movement
Hepatocellular Carcinoma
Cadherins
22 Citations (Scopus)

Shikonin suppresses the migratory ability of hepatocellular carcinoma cells

Wei, P. L., Tu, C. C., Chen, C. H., Ho, Y. S., Wu, C. T., Su, H. Y., Chen, W. Y., Liu, J. J. & Chang, Y. J., Aug 28 2013, In : Journal of Agricultural and Food Chemistry. 61, 34, p. 8191-8197 7 p.

Research output: Contribution to journalArticle

hepatoma
Hepatocellular Carcinoma
Cells
gelatinase A
cells
2012
34 Citations (Scopus)

Chemopreventive effects of pterostilbene on urethane-induced lung carcinogenesis in mice via the inhibition of EGFR-mediated pathways and the induction of apoptosis and autophagy

Chen, R. J., Tsai, S. J., Ho, C. T., Pan, M. H., Ho, Y-S., Wu, C-H. & Wang, Y. J., Nov 21 2012, In : Journal of Agricultural and Food Chemistry. 60, 46, p. 11533-11541 9 p.

Research output: Contribution to journalArticle

urethane
autophagy
Urethane
Autophagy
Epidermal Growth Factor Receptor
35 Citations (Scopus)

Human breast cancer cell metastasis is attenuated by lysyl oxidase inhibitors through down-regulation of focal adhesion kinase and the paxillin-signaling pathway

Chen, L. C., Tu, S. H., Huang, C. S., Chen, C. S., Ho, C. T., Lin, H. W., Lee, C. H., Chang, H. W., Chang, C. H., Wu, C. H., Lee, W. S. & Ho, Y. S., Aug 2012, In : Breast Cancer Research and Treatment. 134, 3, p. 989-1004 16 p.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Paxillin
Focal Adhesion Protein-Tyrosine Kinases
Down-Regulation
Breast Neoplasms
17 Citations (Scopus)
Antrodia
Taiwanofungus camphoratus
fruiting bodies
Tumors
Chemical activation
10 Citations (Scopus)

Knockdown survivin expression reduces the efficacy of curcumin treatment in hepatocellular carcinoma cells

Hung, C. S., Liu, H. H., Huang, M. T., Cheng, C. W., Kuo, L. J., Ho, Y. S., Wu, C. H., Chen, C. M., Wei, P. L. & Chang, Y. J., Oct 2012, In : Annals of Surgical Oncology. 19, 11, p. 3547-3555 9 p.

Research output: Contribution to journalArticle

Curcumin
Hepatocellular Carcinoma
Small Interfering RNA
In Situ Nick-End Labeling
Cell Cycle
17 Citations (Scopus)
Nicotinic Receptors
Fibronectins
Stomach Neoplasms
Cell Movement
alpha7 Nicotinic Acetylcholine Receptor
24 Citations (Scopus)
Vimentin
Cell Movement
Hepatocellular Carcinoma
Up-Regulation
Biosensing Techniques
22 Citations (Scopus)
Epithelial-Mesenchymal Transition
Cell Movement
Hepatocellular Carcinoma
Neoplasms
Vimentin
11 Citations (Scopus)
Antrodia
Neoplasms
Heterografts
Cell Cycle Resting Phase
G1 Phase
2011
34 Citations (Scopus)

Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways

Ho, S. Y., Wu, W., Chiu, H. W., Chen, Y. A., Ho, Y. S., Guo, H. R. & Wang, Y. J., Sep 5 2011, In : Chemico-Biological Interactions. 193, 2, p. 162-171 10 p.

Research output: Contribution to journalArticle

HL-60 Cells
p38 Mitogen-Activated Protein Kinases
Reactive Oxygen Species
Cells
Radiation
48 Citations (Scopus)
Autophagy
Glioma
Down-Regulation
Apoptosis
Phosphatidylinositol 3-Kinases
41 Citations (Scopus)

Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces α9-nicotinic acetylcholine receptor expression in human breast cancer cells

Lee, C. H., Chang, Y. C., Chen, C. S., Tu, S. H., Wang, Y. J., Chen, L. C., Chang, Y. J., Wei, P. L., Chang, H. W., Chang, C. H., Huang, C. S., Wu, C. H. & Ho, Y. S., Sep 2011, In : Breast Cancer Research and Treatment. 129, 2, p. 331-345 15 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Nicotine
Estrogen Receptors
Estrogens
Breast Neoplasms
29 Citations (Scopus)

Glucose-regulated protein 78 (GRP78) mediated the efficacy to curcumin treatment on hepatocellular carcinoma

Chang, Y. J., Tai, C. J., Kuo, L. J., Wei, P. L., Liang, H. H., Liu, T. Z., Wang, W., Tai, C. J., Ho, Y. S., Wu, C. H. & Huang, M. T., Aug 2011, In : Annals of Surgical Oncology. 18, 8, p. 2395-2403 9 p.

Research output: Contribution to journalArticle

Curcumin
Hepatocellular Carcinoma
In Situ Nick-End Labeling
Small Interfering RNA
Cell Cycle