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Research Output

  • 1117 Citations
  • 14 h-Index
  • 30 Article
  • 1 Editorial
2020
Open Access
2018
9 Citations (Scopus)

A synergistic anti-cancer effect of troglitazone and lovastatin in a human anaplastic thyroid cancer cell line and in a mouse xenograft model

Zhong, W. B., Tsai, Y. C., Chin, L. H., Tseng, J. H., Tang, L. W., Horng, S., Fan, Y. C. & Hsu, S. P., Jul 1 2018, In : International Journal of Molecular Sciences. 19, 7, 1834.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2 Citations (Scopus)
2017

Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6

Tsai, Y. C., Chen, W. Y., Siu, M. K., Tsai, H. Y., Yin, J. J., Huang, J. & Liu, Y. N., Jan 1 2017, In : Cancer Letters. 384, p. 1-8 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis

Chen, W-Y., Tsai, Y-C., Siu, M. K., Yeh, H-L., Chen, C-L., Yin, J. J., Huang, J. & Liu, Y-N., Jul 10 2017, In : Oncogene. p. 6213-6224

Research output: Contribution to journalArticle

11 Citations (Scopus)

Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer

Chen, W. Y., Tsai, Y. C., Yeh, H. L., Suau, F., Jiang, K. C., Shao, A. N., Huang, J. & Liu, Y. N., Aug 15 2017, In : Science Signaling. 10, 492, eaam6826.

Research output: Contribution to journalArticle

25 Citations (Scopus)

New ideas in preventing castration-resistant prostate cancer

Tsai, Y. C. & Liu, Y. N., Oct 17 2017, In : Oncotarget. 8, 49, p. 84628-84629 2 p.

Research output: Contribution to journalEditorial

Simvastatin inhibits cell proliferation and migration in human anaplastic thyroid cancer

Chen, M. C., Tsai, Y. C., Tseng, J. H., Liou, J. J., Horng, S., Wen, H. C., Fan, Y. C., Zhong, W. B. & Hsu, S. P., Dec 13 2017, In : International Journal of Molecular Sciences. 18, 12, 2690.

Research output: Contribution to journalArticle

9 Citations (Scopus)
11 Citations (Scopus)
2016

KLF4 functions as an activator of the androgen receptor through reciprocal feedback

Siu, M-K., Suau, F., Chen, W-Y., Tsai, Y-C., Tsai, H-Y., Yeh, H-L. & Liu, Y-N., Dec 2016, In : Oncogenesis. 5, 12, p. e282

Research output: Contribution to journalArticle

2015

DNA methyltransferase DNMT3A associates with viral proteins and impacts HSV-1 infection

Rowles, D. L., Tsai, Y. C., Greco, T. M., Lin, A. E., Li, M., Yeh, J. & Cristea, I. M., Jun 1 2015, In : Proteomics. 15, 12, p. 1968-1982 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Transforming growth factor-β promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway

Siu, M. K., Tsai, Y. C., Chang, Y. S., Yin, J. J., Suau, F., Chen, W. Y. & Liu, Y. N., Sep 3 2015, In : Oncogene. 34, 36, p. 4767-4776 10 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
2014

Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis

Tsai, Y. C., Greco, T. M. & Cristea, I. M., 2014, In : Molecular and Cellular Proteomics. 13, 1, p. 73-83 11 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2012

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription

Tsai, Y. C., Greco, T. M., Boonmee, A., Miteva, Y. & Cristea, I. M., May 2012, In : Molecular and Cellular Proteomics. 11, 5, p. 60-76 17 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
2011

Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα

Lin, R. K., Zhou, N., Lyu, Y. L., Tsai, Y. C., Lu, C. H., Kerrigan, J., Chen, Y. T., Guan, Z., Hsieh, T. S. & Liu, L. F., Sep 23 2011, In : Journal of Biological Chemistry. 286, 38, p. 33591-33600 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2010

Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia

Azarova, A. M., Lin, R. K., Tsai, Y. C., Liu, L. F., Lin, C. P. & Lyu, Y. L., Aug 2010, In : Biochemical and Biophysical Research Communications. 399, 1, p. 66-71 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2009

12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents

Feng, W., Satyanarayana, M., Tsai, Y. C., Liu, A. A., Liu, L. F. & LaVoie, E. J., Apr 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 7, p. 2877-2885 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

A G-quadruplex stabilizer induces M-phase cell cycle arrest

Tsai, Y. C., Qi, H., Lin, C. P., Lin, R. K., Kerrigan, J. E., Rzuczek, S. G., LaVoie, E. J., Rice, J. E., Pilch, D. S., Lyu, Y. L. & Liu, L. F., Aug 21 2009, In : Journal of Biological Chemistry. 284, 34, p. 22535-22543 9 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
8 Citations (Scopus)
17 Citations (Scopus)
2008

11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents

Feng, W., Satyanarayana, M., Tsai, Y. C., Liu, A. A., Liu, L. F. & LaVoie, E. J., Sep 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 18, p. 8598-8606 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

A novel peroxisome proliferator-activated receptor α/γ agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells

Kao, Y. H., Hsieh, H. P., Chitlimalla, S. K., Pan, W. Y., Kuo, C. C., Tsai, Y. C., Lin, W. H., Chuang, S. E. & Chang, J. Y., Feb 2008, In : Anti-Cancer Drugs. 19, 2, p. 151-158 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
9 Citations (Scopus)

Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31)

Satyanarayana, M., Feng, W., Cheng, L., Liu, A. A., Tsai, Y. C., Liu, L. F. & LaVoie, E. J., Aug 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 16, p. 7824-7831 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents

Feng, W., Satyanarayana, M., Cheng, L., Liu, A., Tsai, Y. C., Liu, L. F. & LaVoie, E. J., Oct 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 20, p. 9295-9301 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2007

Protection of DNA ends by telomeric 3′ G-tail sequences

Tsai, Y. C., Qi, H. & Liu, L. F., Jun 29 2007, In : Journal of Biological Chemistry. 282, 26, p. 18786-18792 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies

Azarova, A. M., Lyu, Y. L., Lin, C. P., Tsai, Y. C., Lau, J. Y. N., Wang, J. C. & Liu, L. F., Jun 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 26, p. 11014-11019 6 p.

Research output: Contribution to journalArticle

190 Citations (Scopus)

Topoisomerase IIβ-mediated DNA double-strand breaks: Implications in doxorubicin cardiotoxicity and prevention by dexrazoxane

Yi, L. L., Kerrigan, J. E., Lin, C. P., Azarova, A. M., Tsai, Y. C., Ban, Y. & Liu, L. F., Sep 15 2007, In : Cancer Research. 67, 18, p. 8839-8846 8 p.

Research output: Contribution to journalArticle

338 Citations (Scopus)
2006

G-quadruplexes induce apoptosis in tumor cells

Qi, H., Lin, C. P., Fu, X., Wood, L. M., Liu, A. A., Tsai, Y. C., Chen, Y., Barbieri, C. M., Pilch, D. S. & Liu, L. F., Dec 15 2006, In : Cancer Research. 66, 24, p. 11808-11816 9 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
2004

Inhibition of hepatitis C virus replication by arsenic trioxide

Hwang, D. R., Tsai, Y. C., Lee, J. C., Huang, K. K., Lin, R. K., Ho, C. H., Chiou, J. M., Lin, Y. T., Hsu, J. T. A. & Yeh, C. T., Aug 2004, In : Antimicrobial Agents and Chemotherapy. 48, 8, p. 2876-2882 7 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)