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Yuan-Chii Gladys Lee

Associate Professor

 https://orcid.org/0000-0002-5074-7941
  • 985 Citations
  • 16 h-Index
20012019
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Personal profile

Education

  • 2000 Ph.D., Biochemistry, University of Cambridge, (Pembroke College), U.K.
  • 1991 MSc., Biology, Tunghai University, Taiwan
  • 1987 BA, Literature and Foreign Languages, Tunghai University, Taiwan

Experience

  • 2009- Associate Professor, Graduate Institute of Biomedical Informatics, Taipei Medical University
  • 2003-2009 Assistant Professor, Graduate Institute of Biomedical Informatics, Taipei Medical University
  • 2000-2003 Postdoctoral Fellow, National Health Research Institute

Awards

  • 2015 Best University Tutor in Taipei Medical University
  • 2015 Award, NIH/NINDS Summer Internship Program Research Poster Competition
  • 2015 Award, MoE Internship Abroad
  • 2015-2017 MOST Award, Multivariate bioinformatics analysis of Taiwanese cancer RNA-seq.
  • 2014 MOST Award, Association between human endogenous retrovirus and cancers using RNA-seq data
  • 2011 MOST Award, A Revolutionary Approach for Disease-associated Pathways Identification: From Genome-wide Network Construction, Pathway Discovery, to Pathway-based Analysis and Validation
  • 2000 MOHW Translation Research Award, Translational research: from systems biology to drug target for cancer metastasis.

Research Interests

  • Bioinformatics
  • Next Generation Sequence data analysis
  • Gene Expression Microarray data analysis
  • Human Endogenous Retroviruses
  • Cancer Genome Biology

URL

Fingerprint Dive into the research topics where Yuan-Chii Gladys Lee is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Lung Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Hepatocellular Carcinoma Medicine & Life Sciences
Genes Medicine & Life Sciences
Methylcholanthrene Medicine & Life Sciences
Protein Kinases Medicine & Life Sciences
Databases Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2010 2018

使用RNA-seq數據研究人類免疫缺乏病毒相關癌症的分子機轉

Lee, Y. G.

8/1/17 → 7/31/18

Project: B - Project of TMU › h - Other (Funded by TMU)

以RNA-seq分析來探討HIV提高non-AIDS-defining malignancies罹患率之分子機制

Lee, Y. G.

7/1/17 → 2/28/18

Project: A - Government Institution › b - Ministry of Science and Technology

Multivariate Bioinformatics Analysis of Taiwanese Cancer RNA-seq data to Study Human Endogenous Retroviruses as Carcinogens

Lee, Y. G.

8/1/16 → 7/31/17

Project: A - Government Institution › b - Ministry of Science and Technology

Multivariate Bioinformatics Analysis of Taiwanese Cancer RNA-Seq Data to Study Human Endogenous Retroviruses as Carcinogens

Lee, Y. G. & Lin, J.

8/1/15 → 7/31/16

Project: A - Government Institution › b - Ministry of Science and Technology

Association between Human Endogenous Retrovirus and Cancers Using RNA-Seq Data

Lee, Y. G.

8/1/14 → 7/31/15

Project: A - Government Institution › b - Ministry of Science and Technology

Research Output 2001 2019

  • 985 Citations
  • 16 h-Index
  • 29 Article

Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation

Chang, C. C., Huang, K. H., Hsu, S. P., Lee, Y. C. G., Sue, Y. M. & Juan, S. H., Dec 1 2019, In : Scientific Reports. 9, 1, 4606.

Research output: Contribution to journal › Article

Open Access
Histone Deacetylase 1
Methylcholanthrene
Simvastatin
Renal Cell Carcinoma
Epithelial Cells

Synergistic effects of cAMP–dependent protein kinase A and AMP-activated protein kinase on lipolysis in kinsenoside-treated C3H10T1/2 adipocytes

Lee, Y. C. G., Sue, Y. M., Lee, C. K., Huang, H. M., He, J. J., Wang, Y. S. & Juan, S. H., Mar 1 2019, In : Phytomedicine. 55, p. 255-263 9 p.

Research output: Contribution to journal › Article

Lipolysis
Cyclic AMP-Dependent Protein Kinases
Adipocytes
Protein Kinases
Lipase
6 Citations (Scopus)

RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell

Lin, J. C., Lee, Y. C., Tan, T. H., Liang, Y. C., Chuang, H. C., Fann, Y. C., Johnson, K. R. & Lin, Y. J., Feb 1 2018, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 2, p. 259-272 14 p.

Research output: Contribution to journal › Article

RNA-Binding Proteins
Colorectal Neoplasms
Mitogen-Activated Protein Kinase 8
Cadherins
Alternative Splicing
7 Citations (Scopus)

3-Methylcholanthrene/Aryl-Hydrocarbon Receptor-Mediated Hypertension Through eNOS Inactivation

Chang, C-C., Hsu, Y-H., Chou, H-C., Lee, Y-C. G. & Juan, S-H., May 1 2017, In : Journal of Cellular Physiology. 232, 5, p. 1020-1029

Research output: Contribution to journal › Article

Aryl Hydrocarbon Receptors
Methylcholanthrene
Nitric Oxide Synthase Type III
Hypertension
Blood pressure
3 Citations (Scopus)

The impact of the RBM4-initiated splicing cascade on modulating the carcinogenic signature of colorectal cancer cells

Lin, J. C., Lee, Y. C., Liang, Y. C., Fann, Y. C., Johnson, K. R. & Lin, Y. J., Mar 9 2017, In : Scientific Reports. 7, 44204.

Research output: Contribution to journal › Article

Colorectal Neoplasms
Introns
Alternative Splicing
RNA
RNA Sequence Analysis