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Yuan-Chii Gladys Lee

Associate Professor

 https://orcid.org/0000-0002-5074-7941
  • 1046 Citations
  • 17 h-Index
20012020

Research output per year

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Personal profile

Education

  • 2000 Ph.D., Biochemistry, University of Cambridge, (Pembroke College), U.K.
  • 1991 MSc., Biology, Tunghai University, Taiwan
  • 1987 BA, Literature and Foreign Languages, Tunghai University, Taiwan

Experience

  • 2009- Associate Professor, Graduate Institute of Biomedical Informatics, Taipei Medical University
  • 2003-2009 Assistant Professor, Graduate Institute of Biomedical Informatics, Taipei Medical University
  • 2000-2003 Postdoctoral Fellow, National Health Research Institute

Awards

  • 2015 Best University Tutor in Taipei Medical University
  • 2015 Award, NIH/NINDS Summer Internship Program Research Poster Competition
  • 2015 Award, MoE Internship Abroad
  • 2015-2017 MOST Award, Multivariate bioinformatics analysis of Taiwanese cancer RNA-seq.
  • 2014 MOST Award, Association between human endogenous retrovirus and cancers using RNA-seq data
  • 2011 MOST Award, A Revolutionary Approach for Disease-associated Pathways Identification: From Genome-wide Network Construction, Pathway Discovery, to Pathway-based Analysis and Validation
  • 2000 MOHW Translation Research Award, Translational research: from systems biology to drug target for cancer metastasis.

Research Interests

  • Bioinformatics
  • Next Generation Sequence data analysis
  • Gene Expression Microarray data analysis
  • Human Endogenous Retroviruses
  • Cancer Genome Biology

URL

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Projects

以RNA-seq分析來探討HIV提高non-AIDS-defining malignancies罹患率之分子機制

Lee, Y. G.

7/1/17 → 2/28/18

Project: A - Government Institution › b - Ministry of Science and Technology

Multivariate Bioinformatics Analysis of Taiwanese Cancer RNA-seq data to Study Human Endogenous Retroviruses as Carcinogens(2/2)

Lee, Y. G.

8/1/16 → 7/31/17

Project: A - Government Institution › b - Ministry of Science and Technology

Multivariate Bioinformatics Analysis of Taiwanese Cancer RNA-Seq Data to Study Human Endogenous Retroviruses as Carcinogens

Lee, Y. G. & Lin, J.

8/1/15 → 7/31/16

Project: A - Government Institution › b - Ministry of Science and Technology

Association between Human Endogenous Retrovirus and Cancers Using RNA-Seq Data

Lee, Y. G.

8/1/14 → 7/31/15

Project: A - Government Institution › b - Ministry of Science and Technology

A Revolutionary Approach for Disease-Associated Pathways Identification: from Genome-Wide Network Construction, Pathway Discovery, to Pathway-Based Analysis and Validation

Lee, Y. G.

8/1/11 → 7/31/12

Project: A - Government Institution › b - Ministry of Science and Technology

Research Output

  • 1046 Citations
  • 17 h-Index
  • 31 Article

Altered expressions and splicing profiles of Acin1 transcripts differentially modulate brown adipogenesis through an alternative splicing mechanism

Lin, Y. C., Lu, Y. H., Lee, Y. C., Hung, C. S. & Lin, J. C., Sep 2020, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1863, 9, 194601.

Research output: Contribution to journal › Article

    • Berberine Promotes Beige Adipogenic Signatures of 3T3-L1 Cells by Regulating Post-transcriptional Events

    Lin, Y-C., Lee, Y-C., Lin, Y-J. & Lin, J-C., Jun 23 2019, In : Cells. 8, 6

    Research output: Contribution to journal › Article

    • Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation

    Chang, C. C., Huang, K. H., Hsu, S. P., Lee, Y. C. G., Sue, Y. M. & Juan, S. H., Dec 1 2019, In : Scientific Reports. 9, 1, 4606.

    Research output: Contribution to journal › Article

    Open Access

    • Synergistic effects of cAMP–dependent protein kinase A and AMP-activated protein kinase on lipolysis in kinsenoside-treated C3H10T1/2 adipocytes

    Lee, Y. C. G., Sue, Y. M., Lee, C. K., Huang, H. M., He, J. J., Wang, Y. S. & Juan, S. H., Mar 1 2019, In : Phytomedicine. 55, p. 255-263 9 p.

    Research output: Contribution to journal › Article

    • 1 Citation (Scopus)

    RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell

    Lin, J. C., Lee, Y. C., Tan, T. H., Liang, Y. C., Chuang, H. C., Fann, Y. C., Johnson, K. R. & Lin, Y. J., Feb 1 2018, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 2, p. 259-272 14 p.

    Research output: Contribution to journal › Article

    • 14 Citations (Scopus)