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Research Output

  • 1486 Citations
  • 21 h-Index
  • 83 Article
  • 1 Poster
  • 1 Comment/debate
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Article
2020

Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric-cancer cell migration via PKCα-mediated AHR-HDAC interactions

Tsai, C. H., Li, C. H., Liao, P. L., Chang, Y. W., Cheng, Y. W. & Kang, J. J., Feb 2020, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1867, 2, 118564.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2019

Chloramphenicol induces autophagy and inhibits the hypoxia inducible factor-1 alpha pathway in non-small cell lung cancer cells

Hsu, H. L., Liao, P. L., Cheng, Y. W., Huang, S. H., Wu, C. H., Li, C. H. & Kang, J. J., Jan 1 2019, In : International Journal of Molecular Sciences. 20, 1, 157.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling

Tsai, C. H., Lee, Y., Li, C. H., Cheng, Y. W. & Kang, J. J., Jan 1 2019, (Accepted/In press) In : Cell Biology and Toxicology.

Research output: Contribution to journalArticle

Efficacy of azatyrosine-phenylbutyric hydroxamides, a histone deacetylase inhibitor, on chemotherapy-induced gastrointestinal mucositis

Liao, P. L., Huang, S. H., Hung, C. H., Huang, W. K., Tsai, C. H., Kang, J. J., Wang, H. P. & Cheng, Y. W., Jan 1 2019, In : International Journal of Molecular Sciences. 20, 2, 249.

Research output: Contribution to journalArticle

Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in Diabetic Rodent Models

Tse, L. S., Liao, P. L., Tsai, C. H., Li, C. H., Liao, J. W., Kang, J. J. & Cheng, Y. W., Mar 14 2019, In : Nutrients. 11, 3

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

HDAC8 inhibitor WK2-16 therapeutically targets lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation

Lin, F. L., Yen, J. L., Kuo, Y. C., Kang, J. J., Cheng, Y. W., Huang, W. J. & Hsiao, G., Jan 2 2019, In : International Journal of Molecular Sciences. 20, 2, p. 410 410.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access

Low-luminance blue light-enhanced phototoxicity in A2E-Laden RPE cell cultures and rats

Lin, C. H., Wu, M. R., Huang, W. J., Chow, D. S. L., Hsiao, G. & Cheng, Y. W., Apr 11 2019, In : International Journal of Molecular Sciences. 20, 7, 1799.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition

Lin, F. L., Cheng, Y. W., Yu, M., Ho, J. D., Kuo, Y. C., Chiou, G. C. Y., Chang, H. M., Lee, T. H. & Hsiao, G., Mar 15 2019, In : Phytomedicine. 56, p. 207-214 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018
1 Citation (Scopus)

Safety assessment of the Cistanche tubulosa health food product Memoregain®: Genotoxicity and 28-day repeated dose toxicity test

Liao, P. L., Li, C. H., Tse, L. S., Kang, J. J. & Cheng, Y. W., Aug 1 2018, In : Food and Chemical Toxicology. 118, p. 581-588 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Theissenolactone C exhibited ocular protection of endotoxin-induced uveitis by attenuating ocular inflammatory responses and glial activation

Lin, F. L., Ho, J. D., Cheng, Y. W., Chiou, G. C. Y., Yen, J. L., Chang, H. M., Lee, T. H. & Hsiao, G., Apr 9 2018, In : Frontiers in Pharmacology. 9, APR, 326.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2017

Anti-inflammatory properties of shikonin contribute to improved early-stage diabetic retinopathy

Liao, P. L., Lin, C. H., Li, C. H., Tsai, C. H., Ho, J. D., Chiou, G. C. Y., Kang, J. J. & Cheng, Y. W., Mar 21 2017, In : Scientific Reports. 7, 44985.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta, accelerates vimentin degradation, and suppresses epithelial–mesenchymal transition in non-small cell lung cancer cells

Li, C. H., Liu, C. W., Tsai, C. H., Peng, Y. J., Yang, Y. H., Liao, P. L., Lee, C. C., Cheng, Y. W. & Kang, J. J., May 1 2017, In : Archives of Toxicology. 91, 5, p. 2165-2178 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Periodic exposure to smartphone-mimic low-luminance blue light induces retina damage through Bcl-2/BAX-dependent apoptosis

Lin, C. H., Wu, M. R., Li, C. H., Cheng, H. W., Huang, S. H., Tsai, C. H., Lin, F. L., Ho, J. D., Kang, J. J., Hsiao, G. & Cheng, Y. W., May 1 2017, In : Toxicological Sciences. 157, 1, p. 196-210 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The inhibition of lung cancer cell migration by AhR-regulated autophagy

Tsai, C. H., Li, C. H., Cheng, Y. W., Lee, C. C., Liao, P. L., Lin, C. H., Huang, S. H. & Kang, J. J., Feb 14 2017, In : Scientific Reports. 7, 41927.

Research output: Contribution to journalArticle

17 Citations (Scopus)
18 Citations (Scopus)
6 Citations (Scopus)
2016

Ligand independent aryl hydrocarbon receptor inhibits lung cancer cell invasion by degradation of Smad4

Lee, C. C., Yang, W. H., Li, C. H., Cheng, Y. W., Tsai, C. H. & Kang, J. J., Jul 1 2016, In : Cancer Letters. 376, 2, p. 211-217 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2015

Gold nanoparticles increase endothelial paracellular permeability by altering components of endothelial tight junctions, and increase blood-brain barrier permeability in mice

Li, C. H., Shyu, M. K., Jhan, C., Cheng, Y. W., Tsai, C. H., Liu, C. W., Lee, C. C., Chen, R. M. & Kang, J. J., Nov 1 2015, In : Toxicological Sciences. 148, 1, p. 192-203 12 p., kfv176.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Long-term Fluorometholone Topical Use Induces Ganglion Cell Damage in Rats Analyzed With Optical Coherence Tomography

Lin, C. H., Liao, P. L., Hsiao, G., Li, C. H., Huang, S. H., Tsai, C. H., Wu, M. R., Lin, F. L., Ho, J. D., Cheng, H. W. & Cheng, Y. W., Oct 1 2015, In : Toxicological Sciences. 147, 2, p. 317-325 9 p., kfv132.

Research output: Contribution to journalArticle

5 Citations (Scopus)

NcoA2-dependent inhibition of HIF-1α activation is regulated via AhR

Tsai, C. H., Li, C. H., Liao, P. L., Cheng, Y. W., Lin, C. H., Huang, S. H. & Kang, J. J., Dec 1 2015, In : Toxicological Sciences. 148, 2, p. 517-530 14 p., kfv199.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2014

In search of the active metabolites of an anticancer piperazinedione, TW01003, in rats

Wang, C. L., Chen, C. K., Wang, Y. H. & Cheng, Y. W., 2014, In : BioMed Research International. 2014, 793504.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Minocycline accelerates hypoxia-inducible factor-1 alpha degradation and inhibits hypoxia-induced neovasculogenesis through prolyl hydroxylase, von Hippel-Lindau-dependent pathway

Li, C. H., Liao, P. L., Yang, Y. T., Huang, S. H., Lin, C. H., Cheng, Y. W. & Kang, J. J., Mar 2014, In : Archives of Toxicology. 88, 3, p. 659-671 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Novel piperazinediones as antitumor agents

Wang, C. L., Lee, O., Hsiao, G., Lian, J. F. & Cheng, Y. W., Aug 1 2014, In : Anticancer Research. 34, 8, p. 4013-4020 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Quality of life among patients with abdominal aortic aneurysm undergoing endografting in Taiwan

Tung, H. H., Cheng, Y., Shih, C. C., Chen, L. K., Lee, J. Y. & Wang, T. J., Jan 1 2014, In : European Journal of Cardiovascular Nursing. 13, 4, p. 369-377 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Snail regulates Nanog status during the epithelial-mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer

Liu, C. W., Li, C. H., Peng, Y. J., Cheng, Y. W., Chen, H. W., Liao, P. L., Kang, J. J. & Yeng, M. H., 2014, In : Oncotarget. 5, 11, p. 3880-3894 15 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Zinc oxide nanoparticles impair bacterial clearance by macrophages

Lin, C. D., Kou, Y. Y., Liao, C. Y., Li, C. H., Huang, S. P., Cheng, Y. W., Liao, W. C., Chen, H. X., Wu, P. L., Kang, J. J., Lee, C. C. & Lai, C. H., Jul 1 2014, In : Nanomedicine. 9, 9, p. 1327-1339 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2013

Evaluation of acute 13-week subchronic toxicity and genotoxicity of the powdered root of Tongkat Ali (Eurycoma Longifolia Jack)

Li, C. H., Liao, J. W., Liao, P. L., Huang, W. K., Tse, L. S., Lin, C. H., Kang, J. J. & Cheng, Y. W., 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 102987.

Research output: Contribution to journalArticle

19 Citations (Scopus)
42 Citations (Scopus)
2012

Anti-ageing effects of alpha-naphthoflavone on normal and UVB-irradiated human skin fibroblasts

Liao, P. L., Li, C. H., Chang, C. Y., Lu, S. R., Lin, C. H., Tse, L. S. & Cheng, Y. W., Jul 2012, In : Experimental Dermatology. 21, 7, p. 546-548 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
8 Citations (Scopus)

Motorcycle exhaust particles up-regulate expression of vascular adhesion molecule-1 and intercellular adhesion molecule-1 in human umbilical vein endothelial cells

Lee, C. C., Huang, S. H., Yang, Y. T., Cheng, Y. W., Li, C. H. & Kang, J. J., Jun 2012, In : Toxicology in Vitro. 26, 4, p. 552-560 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice

Li, C. H., Shen, C. C., Cheng, Y. W., Huang, S. H., Wu, C. C., Kao, C. C., Liao, J. W. & Kang, J. J., Nov 2012, In : Nanotoxicology. 6, 7, p. 746-756 11 p.

Research output: Contribution to journalArticle

142 Citations (Scopus)

Suppression of matrix metalloproteinase-9 expression by andrographolide in human monocytic THP-1 cells via inhibition of NF-κB activation

Lee, W. R., Chung, C. L., Hsiao, C. J., Chou, Y. C., Hsueh, P. J., Yang, P. C., Jan, J. S., Cheng, Y. W. & Hsiao, G., Feb 15 2012, In : Phytomedicine. 19, 3-4, p. 270-277 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Zinc oxide nanoparticles-induced intercellular adhesion molecule 1 expression requires Rac1/Cdc42, mixed lineage kinase 3, and c-Jun N-terminal kinase activation in endothelial cells

Li, C. H., Liao, P. L., Shyu, M. K., Liu, C. W., Kao, C. C., Huang, S. H., Cheng, Y. W. & Kang, J. J., 2012, In : Toxicological Sciences. 126, 1, p. 162-172 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2011

(Journal of Food and Drug Analysis 18, 6, (380))

Cheng, Y. W. & Lou, H. Y., Jun 2011, In : Journal of Food and Drug Analysis. 19, 2, p. 243 1 p.

Research output: Contribution to journalArticle

Aristolochic acid downregulates monocytic matrix metalloproteinase-9 by inhibiting nuclear factor-κB activation

Wu, C. J., Chou, Y. C., Cheng, Y. W., Hsiao, C. J., Wang, C. H., Wang, H. Y., Sheu, J. R. & Hsiao, G., Jul 15 2011, In : Chemico-Biological Interactions. 192, 3, p. 209-219 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Myrrh mediates haem oxygenase-1 expression to suppress the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages

Cheng, Y. W., Cheah, K. P., Lin, C-W., Li, J. S., Yu, W. Y., Chang, M. L., Yeh, G. C., Chen, S-H., Choy, C-S. & Hu, C-M., Sep 2011, In : Journal of Pharmacy and Pharmacology. 63, 9, p. 1211-1218 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Shikonin inhibited mitogen-activated IL-4 and IL-5 production on EL-4 cells through downregulation of GATA-3 and c-Maf induction

Lee, C. C., Kang, J. J., Chiang, B. L., Wang, C. N. & Cheng, Y. W., Sep 12 2011, In : Life Sciences. 89, 11-12, p. 364-370 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2010
15 Citations (Scopus)

Benzo[a]pyrene inhibits angiogenic factors-induced αvβ3 integrin expression, neovasculogenesis, and angiogenesis in human umbilical vein endothelial cells

Li, C. H., Cheng, Y. W., Hsu, Y. T., Hsu, Y. J., Liao, P. L. & Kang, J. J., Dec 2010, In : Toxicological Sciences. 118, 2, p. 544-553 10 p., kfq279.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion

Li, C. H., Cheng, Y. W., Liao, P. L., Yang, Y. T. & Kang, J. J., Mar 25 2010, In : Toxicological Sciences. 116, 1, p. 140-150 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Safety assessment of musk substitute from nutria of Myocastor coypus in mice

Yu, W. C., Horng, Y. L., Shoei, S. L., Jun, W. L., Hui, W. C., Ching, H. L., Po, L. L. & Jaw, J. K., Dec 2010, In : Journal of Food and Drug Analysis. 18, 6, p. 380-390 11 p.

Research output: Contribution to journalArticle

Shikonin inhibits maturation of bone marrow-derived dendritic cells and suppresses allergic airway inflammation in a murine model of asthma

Lee, C. C., Wang, C. N., Lai, Y. T., Kang, J. J., Liao, J. W., Chiang, B. L., Chen, H. C. & Cheng, Y. W., Dec 2010, In : British Journal of Pharmacology. 161, 7, p. 1496-1511 16 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
15 Citations (Scopus)
2009

Cholesterol-3-beta, 5-alpha, 6-beta-triol induced PI3K-Akt-eNOS-dependent cyclooxygenase-2 expression in endothelial cells

Liao, P. L., Cheng, Y. W., Li, C. H., Lo, Y. L. & Kang, J. J., Oct 28 2009, In : Toxicology Letters. 190, 2, p. 172-178 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Podophyllin, but not the constituents quercetin or kaempferol, induced genotoxicity in vitro and in vivo through ROS production

Lin, M. C., Cheng, H. W., Tsai, Y. C., Liao, P. L., Kang, J. J. & Cheng, Y. W., 2009, In : Drug and Chemical Toxicology. 32, 1, p. 68-76 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Proliferation of retinal pigment epithelial cells induced by (R, R)-XY-10 and (S, S)-XY-10 and their action mechanisms

Cheng, Y. W., Wang, Y. L., Zhang, Y. H., Peng, S. X. & Chiou, G. C. Y., Oct 22 2009, In : International Journal of Ophthalmology. 9, 9, p. 1641-1645 5 p.

Research output: Contribution to journalArticle

Vasorelaxation effects of 2-chloroethanol and chloroacetaldehyde in the isolated rat aortic rings

Chen, Y. T., Hung, D. Z., Chou, C. C., Kang, J. J., Cheng, Y. W., Hu, C-M. & Liao, J. W., Aug 2009, In : Journal of Health Science. 55, 4, p. 525-531 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)