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Research Output 1999 2019

  • 2285 Citations
  • 26 h-Index
  • 108 Article
  • 1 Review article
3 Citations (Scopus)

A common regulatory variant in SLC35B4 influences the recurrence and survival of prostate cancer

Huang, E. Y., Chang, Y. J., Huang, S. P., Lin, V. C., Yu, C. C., Huang, C. Y., Yin, H. L., Chang, T. Y., Lu, T. L. & Bao, B. Y., Jul 1 2018, In : Journal of Cellular and Molecular Medicine. 22, 7, p. 3661-3670 10 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Single Nucleotide Polymorphism
Recurrence
Survival
Glycosyltransferases
Dipeptidyl-Peptidase IV Inhibitors
Keratinocytes
Wound Healing
Adiponectin
Medical problems
9 Citations (Scopus)

Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil

Chen, W-Y., Huang, C. Y., Cheng, W. L., Hung, C-S., Huang, M-T., Tai, C-J., Liu, Y-N., Chen, C-L. & Chang, Y-J., Jul 3 2015, (Accepted/In press) In : Tumor Biology. 36, 12, p. 9537-9544

Research output: Contribution to journalArticle

Nicotinic Receptors
Fluorouracil
Stomach Neoplasms
In Situ Nick-End Labeling
Cell Cycle
13 Citations (Scopus)

Alterations in histone deacetylase 8 lead to cell migration and poor prognosis in breast cancer

Hsieh, C. L., Ma, H. P., Su, C-M., Chang, Y. J., Hung, W. Y., Ho, Y. S., Huang, W. J. & Lin, R. K., Apr 15 2016, In : Life Sciences. 151, p. 7-14 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cell Movement
Breast Neoplasms
Atlases
Assays
5 Citations (Scopus)

A novel microtubule-disrupting agent induces endoplasmic reticular stress-mediated cell death in human hepatocellular carcinoma cells

Ho, C. T., Chang, Y. J., Yang, L. X., Wei, P. L., Liu, T. Z. & Liu, J. J., Sep 10 2015, In : PLoS One. 10, 9, e0136340.

Research output: Contribution to journalArticle

Cell death
hepatoma
Microtubules
microtubules
cell death
9 Citations (Scopus)
Camptotheca
Camptothecin
Endometrial Neoplasms
Fruit
Cisplatin
26 Citations (Scopus)

Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential

Wang, S. C., Li, Z-H., Hsu, C. H., Chang, Y. J., Chang, M. S., Wang, Y. C., Ho, Y. S., Wen, W. C. & Lin, R. K., Jun 18 2014, In : Journal of Agricultural and Food Chemistry. 62, 24, p. 5625-5635 11 p.

Research output: Contribution to journalArticle

Antrodia
Taiwanofungus camphoratus
methyltransferases
Methyltransferases
breast neoplasms
14 Citations (Scopus)
docetaxel
Solanum nigrum
Autophagy
Endometrial Neoplasms
Neoplasms
35 Citations (Scopus)
docetaxel
Solanum nigrum
Autophagy
Fluorouracil
Doxorubicin
17 Citations (Scopus)

Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation

Yu, C. C., Wu, P. J., Hsu, J. L., Ho, Y. F., Hsu, L. C., Chang, Y. J., Chang, H. S., Chen, I. S. & Guh, J. H., Jan 2013, In : Prostate. 73, 2, p. 133-145 13 p.

Research output: Contribution to journalArticle

Caspases
70-kDa Ribosomal Protein S6 Kinases
Prostatic Neoplasms
Mitochondria
Down-Regulation
118 Citations (Scopus)

ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor

Yang, Z., Chang, Y. J., Yu, I. C., Yeh, S., Wu, C. C., Miyamoto, H., Merry, D. E., Sobue, G., Chen, L. M., Chang, S. S. & Chang, C., Mar 2007, In : Nature Medicine. 13, 3, p. 348-353 6 p.

Research output: Contribution to journalArticle

Atrophic Muscular Disorders
Androgen Receptors
Phenotype
Degradation
Agglomeration
7 Citations (Scopus)
gemcitabine
Chemotherapy
Tumor Burden
Pancreatic Neoplasms
Heterografts
3 Citations (Scopus)

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy

Chang, T. C., Wei, P. L., Makondi, P. T., Chen, W. T., Huang, C. Y. & Chang, Y. J., Jan 1 2019, In : PLoS One. 14, 1, e0210274.

Research output: Contribution to journalArticle

bromelains
Bromelains
autophagy
Autophagy
colorectal neoplasms
24 Citations (Scopus)
Rectal Neoplasms
Biopsy
Magnetic Resonance Spectroscopy
Survival Rate
Therapeutics
5 Citations (Scopus)
Colorectal Neoplasms
Epidemiology
Smoking
Microsatellite Instability
Neoplasms
10 Citations (Scopus)

Cisplatin-, Doxorubicin-, and Docetaxel-Induced Cell Death Promoted by the Aqueous Extract of Solanum nigrum in Human Ovarian Carcinoma Cells

Tai, C. J., Wang, C. W., Chen, C. L., Wang, C. K., Chang, Y. J., Jian, J. Y., Lin, C. S. & Tai, C. J., Nov 1 2015, In : Integrative Cancer Therapies. 14, 6, p. 546-555 10 p.

Research output: Contribution to journalArticle

docetaxel
Solanum nigrum
Doxorubicin
Cisplatin
Ovarian Neoplasms
7 Citations (Scopus)
Circulating Neoplastic Cells
carbopol 940
Tumors
Colorectal Neoplasms
Assays
7 Citations (Scopus)
gemcitabine
Pancreatic Neoplasms
Nausea
Vomiting
Fluorouracil
8 Citations (Scopus)
Hepatocellular Carcinoma
Tomography
PubMed
Libraries
Therapeutics
1 Citation (Scopus)

Coupling dichloroacetate treatment with curcumin significantly enhances anticancer potential

Kan, P. C., Chang, Y. J., Chien, C. S., Su, C. Y. & Fang, H. W., Nov 1 2018, In : Anticancer Research. 38, 11, p. 6253-6261 9 p.

Research output: Contribution to journalArticle

Curcumin
Alprostadil
Apoptosis
Annexin A5
Volatile Oils
43 Citations (Scopus)

Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces α9-nicotinic acetylcholine receptor expression in human breast cancer cells

Lee, C. H., Chang, Y. C., Chen, C. S., Tu, S. H., Wang, Y. J., Chen, L. C., Chang, Y. J., Wei, P. L., Chang, H. W., Chang, C. H., Huang, C. S., Wu, C. H. & Ho, Y. S., Sep 2011, In : Breast Cancer Research and Treatment. 129, 2, p. 331-345 15 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Nicotine
Estrogen Receptors
Estrogens
Breast Neoplasms
1 Citation (Scopus)
Bioinformatics
Computational Biology
colorectal neoplasms
MicroRNAs
microRNA
7 Citations (Scopus)

Discontinuous residues of factor IX constitute a surface for binding the anti-factor IX monoclonal antibody A-5

Chang, Y. J., Wu, H. L., Hsu, Y. C., Hamaguchi, N., Shi, G. Y., Shen, M. C. & Lin, S. W., 2003, In : Thrombosis Research. 111, 4-5, p. 293-299 7 p.

Research output: Contribution to journalArticle

Factor IX
Monoclonal Antibodies
Alanine
Factor VIIIa
Factor VIII
15 Citations (Scopus)

Engineered recombinant factor VII Q217 variants with altered inhibitor specificities

Chang, Y. J., Hamaguchi, N., Chang, S. C., Ruf, W., Shen, M. C. & Lin, S. W., Aug 24 1999, In : Biochemistry. 38, 34, p. 10940-10948 9 p.

Research output: Contribution to journalArticle

Factor VII
Antithrombin III
Glycine
benzoyl-Ile-Glu-Gly-Arg-p-nitroanilide
Chymotrypsinogen
38 Citations (Scopus)

Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through redox regulation

Chen, C. H., Chang, Y. J., Ku, M. S. B., Chung, K. T. & Yang, J. T., Mar 2011, In : Journal of Molecular Medicine. 89, 3, p. 303-315 13 p.

Research output: Contribution to journalArticle

temozolomide
Valproic Acid
Glioma
Oxidation-Reduction
Apoptosis
57 Citations (Scopus)

Evidence of human thrombomodulin domain as a novel angiogenic factor

Shi, C. S., Shi, G. Y., Chang, Y. S., Han, H. S., Kuo, C. H., Liu, C., Huang, H. C., Chang, Y. J., Chen, P. S. & Wu, H. L., Apr 5 2005, In : Circulation. 111, 13, p. 1627-1636 10 p.

Research output: Contribution to journalArticle

Thrombomodulin
Angiogenesis Inducing Agents
Endothelial Cells
Human Umbilical Vein Endothelial Cells
Epidermal Growth Factor
13 Citations (Scopus)
Fluorouracil
Cisplatin
Hepatocellular Carcinoma
Cell Death
Neoplasms
1 Citation (Scopus)

GeneGazer: A toolkit integrating two pipelines for personalized profiling and biosignature identification

Luo, J. D., Chang, Y. J., Chang, C. M., You, J. F., Wei, P. L. & Chiou, C. C., Mar 1 2016, In : Cancer Genomics and Proteomics. 13, 2, p. 141-150 10 p.

Research output: Contribution to journalArticle

MicroRNAs
Epigenomics
Gene expression
Pipelines
Genes

Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression

Yu, C. C., Chen, L. C., Chiou, C. Y., Chang, Y. J., Lin, V. C., Huang, C. Y., Lin, I. L., Chang, T. Y., Lu, T. L., Lee, C. H., Huang, S. P. & Bao, B. Y., Apr 5 2019, In : Cancer Cell International. 19, 1, 87.

Research output: Contribution to journalArticle

Open Access
Circadian Rhythm
Prostatic Neoplasms
Alleles
Computer Simulation
Disease-Free Survival
29 Citations (Scopus)

Glucose-regulated protein 78 (GRP78) mediated the efficacy to curcumin treatment on hepatocellular carcinoma

Chang, Y. J., Tai, C. J., Kuo, L. J., Wei, P. L., Liang, H. H., Liu, T. Z., Wang, W., Tai, C. J., Ho, Y. S., Wu, C. H. & Huang, M. T., Aug 2011, In : Annals of Surgical Oncology. 18, 8, p. 2395-2403 9 p.

Research output: Contribution to journalArticle

Curcumin
Hepatocellular Carcinoma
In Situ Nick-End Labeling
Small Interfering RNA
Cell Cycle
20 Citations (Scopus)
Colonic Neoplasms
Biomarkers
Neoplasm Metastasis
Vimentin
Cadherins
37 Citations (Scopus)

Glucose-Regulated protein 78 (GRP78) silencing enhances cell migration but does not influence cell proliferation in hepatocellular carcinoma

Chang, Y-J., Chiu, C. C., Wu, C-H., An, J., Wu, C. C., Liu, T. Z., Wei, P-L. & Huang, M-T., Jun 2010, In : Annals of Surgical Oncology. 17, 6, p. 1703-1709 7 p.

Research output: Contribution to journalArticle

Cell Movement
Hepatocellular Carcinoma
Cell Proliferation
Small Interfering RNA
glucose-regulated proteins
60 Citations (Scopus)

Glucose-regulated protein 78 Is a novel contributor to acquisition of resistance to sorafenib in hepatocellular carcinoma

Chiou, J-F., Tai, C-J., Huang, M-T., Wei, P-L., Wang, Y. H., An, J., Wu, C-H., Liu, T. Z. & Chang, Y-J., Feb 2010, In : Annals of Surgical Oncology. 17, 2, p. 603-612 10 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Hep G2 Cells
sorafenib
glucose-regulated proteins
Neoplasms
13 Citations (Scopus)

Glucose-regulated protein 78 mediates hormone-independent prostate cancer progression and metastasis through maspin and COX-2 expression

Wu, C. T., Wang, W. C., Chen, M. F., Su, H. Y., Chen, W. Y., Wu, C. H., Chang, Y. J. & Liu, H. H., Jan 2014, In : Tumor Biology. 35, 1, p. 195-204 10 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Hormones
Neoplasm Metastasis
Cell Movement
SERPIN-B5
10 Citations (Scopus)

Glucose-regulated protein 78 mediates the anticancer efficacy of shikonin in hormone-refractory prostate cancer cells

Kuo, L. J., Huang, C. Y., Cheng, W. L., Hung, C. S., Wu, C. T., Lin, F. Y., Chang, Y. J. & Huang, M. T., Jul 29 2015, In : Tumor Biology. 36, 7, p. 5063-5070 8 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Hormones
Small Interfering RNA
Therapeutics
shikonin
6 Citations (Scopus)

Glucose-regulated protein 78 mediates the therapeutic efficacy of 17-DMAG in colon cancer cells

Chang, Y. J., Huang, C. Y., Hung, C. S., Liu, H. H. & Wei, P. L., Jun 11 2015, In : Tumor Biology. 36, 6, p. 4367-4376 10 p.

Research output: Contribution to journalArticle

17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
Colonic Neoplasms
Therapeutics
HT29 Cells
Propidium
19 Citations (Scopus)
Vascular Endothelial Growth Factor Receptor-2
Colonic Neoplasms
Vascular Endothelial Growth Factor A
Down-Regulation
Growth
12 Citations (Scopus)

Glucose-regulated protein 94 mediates cancer progression via AKT and eNOS in hepatocellular carcinoma

Huang, C. Y., Batzorig, U., Cheng, W. L., Huang, M. T., Chen, W. Y., Wei, P. L. & Chang, Y. J., Apr 1 2016, In : Tumor Biology. 37, 4, p. 4295-4304

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Neoplasms
glucose-regulated proteins
AMP-Activated Protein Kinases
Heterografts
6 Citations (Scopus)

Glucose-regulated protein 94 mediates metastasis by CCT8 and the JNK pathway in hepatocellular carcinoma

Wei, P-L., Huang, C. Y., Tai, C-J., Batzorig, U., Cheng, W. L., Hunag, M. T. & Chang, Y-J., Jun 1 2016, In : Tumor Biology. 37, 6, p. 8219-8227 9 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Hepatocellular Carcinoma
Neoplasm Metastasis
Neoplasms
Wound Healing
4 Citations (Scopus)
NF-kappa B
Cyclooxygenase 2
Vascular Endothelial Growth Factor A
Neoplasm Metastasis
Proteins

Glucose-Regulated Protein 94 Modulates the Response of Osteosarcoma to Chemotherapy

Huang, C. Y., Wei, P. L., Wang, J. W., Makondi, P. T., Huang, M. T., Chen, H. A. & Chang, Y. J., Jan 1 2019, In : Disease Markers. 2019, 1 p.

Research output: Contribution to journalArticle

Chemotherapy
Osteosarcoma
gemcitabine
Drug Therapy
Epirubicin
8 Citations (Scopus)

Glucose-regulated protein 94 modulates the therapeutic efficacy to taxane in cervical cancer cells

Tai, C. J., Wang, J. W., Su, H. Y., Tai, C. J., Wang, C. K., Wu, C. T., Lien, Y. C. & Chang, Y. J., Jan 2014, In : Tumor Biology. 35, 1, p. 403-410 8 p.

Research output: Contribution to journalArticle

Uterine Cervical Neoplasms
Therapeutics
Apoptosis
bcl-Associated Death Protein
glucose-regulated proteins
29 Citations (Scopus)
Class E Scavenger Receptors
Chaperonin 60
Chlamydophila pneumoniae
Atherosclerosis
Endothelial Cells
9 Citations (Scopus)

GroEL1, from chlamydia pneumoniae, induces vascular adhesion molecule 1 expression by p37AUF1 in endothelial cells and hypercholesterolemic rabbit

Huang, C. Y., Shih, C. M., Tsao, N. W., Chen, Y. H., Li, C. Y., Chang, Y. J., Chang, N. C., Ou, K. L., Lin, C. Y., Lin, Y. W., Nien, C. H. & Lin, F. Y., Aug 10 2012, In : PLoS One. 7, 8, e42808.

Research output: Contribution to journalArticle

Chlamydophila pneumoniae
Endothelial cells
blood vessels
endothelial cells
Blood Vessels
45 Citations (Scopus)

GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and akt pathway after epirubicin treatment in colon cancer DLD-1 cells

Chang, Y. J., Huang, Y. P., Li, Z. L. & Chen, C. H., Apr 18 2012, In : PLoS One. 7, 4, e35123.

Research output: Contribution to journalArticle

epirubicin
Epirubicin
Oxidative stress
colorectal neoplasms
Colonic Neoplasms
12 Citations (Scopus)

GRP78 mediates the therapeutic efficacy of curcumin on colon cancer

Chang, Y-J., Huang, C. Y., Hung, C-S., Chen, W-Y. & Wei, P-L., 2015, In : Tumor Biology. 36, 2, p. 633-641 9 p.

Research output: Contribution to journalArticle

Curcumin
Colonic Neoplasms
HT29 Cells
Therapeutics
In Situ Nick-End Labeling
8 Citations (Scopus)

Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation

Liang, H. H., Huang, C. Y., Chou, C. W., Makondi, P. T., Huang, M. T., Wei, P. L. & Chang, Y. J., Sep 15 2018, In : Life Sciences. 209, p. 43-51 9 p.

Research output: Contribution to journalArticle

HSP27 Heat-Shock Proteins
Curcumin
Autophagy
Colonic Neoplasms
Reactive Oxygen Species
14 Citations (Scopus)

High-level expression of CXCR4 in breast cancer is associated with early distant and bone metastases

Hung, C-S., Su, H. Y., Liang, H-H., Lai, C. W., Chang, Y-C., Ho, Y-S., Wu, C-H., Ho, J-D., Wei, P-L. & Chang, Y-J., 2014, In : Tumor Biology. 35, 2, p. 1581-1588 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Bone and Bones
Chemokine Receptors
Incidence

HSPB1 rs2070804 polymorphism is associated with the depth of primary tumor

Hung, C. S., Huang, C. Y., Hsu, Y. W., Makondi, P. T., Chang, W. C., Chang, Y. J., Wang, J. Y. & Wei, P. L., Jan 1 2019, In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

Polymorphism
Tumors
Colorectal Neoplasms
Single Nucleotide Polymorphism
Neoplasms