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Research Output 1999 2019

  • 2281 Citations
  • 26 h-Index
  • 108 Article
  • 1 Review article
1999
15 Citations (Scopus)

Engineered recombinant factor VII Q217 variants with altered inhibitor specificities

Chang, Y. J., Hamaguchi, N., Chang, S. C., Ruf, W., Shen, M. C. & Lin, S. W., Aug 24 1999, In : Biochemistry. 38, 34, p. 10940-10948 9 p.

Research output: Contribution to journalArticle

Factor VII
Antithrombin III
Glycine
benzoyl-Ile-Glu-Gly-Arg-p-nitroanilide
Chymotrypsinogen
2001
9 Citations (Scopus)

The distinct roles that Gln-192 and Glu-217 of factor IX play in selectivity for macromolecular substrates and inhibitors

Hsu, Y. C., Hamaguchi, N., Chang, Y. J. & Lin, S. W., Sep 18 2001, In : Biochemistry. 40, 37, p. 11261-11269 9 p.

Research output: Contribution to journalArticle

Factor IX
Factor VIIIa
Factor IXa
Antithrombin III
Substrates
2002
31 Citations (Scopus)
Factor VIIIa
Mutagenesis
Factor IX
Epidermal Growth Factor
Alanine
2003
7 Citations (Scopus)

Discontinuous residues of factor IX constitute a surface for binding the anti-factor IX monoclonal antibody A-5

Chang, Y. J., Wu, H. L., Hsu, Y. C., Hamaguchi, N., Shi, G. Y., Shen, M. C. & Lin, S. W., 2003, In : Thrombosis Research. 111, 4-5, p. 293-299 7 p.

Research output: Contribution to journalArticle

Factor IX
Monoclonal Antibodies
Alanine
Factor VIIIa
Factor VIII
2004
10 Citations (Scopus)
Factor IXa
Factor X
Platelets
Application programs
Epidermal Growth Factor
2005
57 Citations (Scopus)

Evidence of human thrombomodulin domain as a novel angiogenic factor

Shi, C. S., Shi, G. Y., Chang, Y. S., Han, H. S., Kuo, C. H., Liu, C., Huang, H. C., Chang, Y. J., Chen, P. S. & Wu, H. L., Apr 5 2005, In : Circulation. 111, 13, p. 1627-1636 10 p.

Research output: Contribution to journalArticle

Thrombomodulin
Angiogenesis Inducing Agents
Endothelial Cells
Human Umbilical Vein Endothelial Cells
Epidermal Growth Factor
2006
94 Citations (Scopus)

Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells

Zhang, C., Yeh, S., Chen, Y. T., Wu, C. C., Chuang, K. H., Lin, H. Y., Wang, R. S., Chang, Y. J., Mendis-Handagama, C., Hu, L., Lardy, H. & Chang, C., Nov 21 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 47, p. 17718-17723 6 p.

Research output: Contribution to journalArticle

Oligospermia
Fertility
Testis
Androgen Receptors
Germ Cells
2007
118 Citations (Scopus)

ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor

Yang, Z., Chang, Y. J., Yu, I. C., Yeh, S., Wu, C. C., Miyamoto, H., Merry, D. E., Sobue, G., Chen, L. M., Chang, S. S. & Chang, C., Mar 2007, In : Nature Medicine. 13, 3, p. 348-353 6 p.

Research output: Contribution to journalArticle

Atrophic Muscular Disorders
Androgen Receptors
Phenotype
Degradation
Agglomeration
246 Citations (Scopus)

Promotion of bladder cancer development and progression by androgen receptor signals

Miyamoto, H., Yang, Z., Chen, Y. T., Ishiguro, H., Uemura, H., Kubota, Y., Nagashima, Y., Chang, Y. J., Hu, Y. C., Tsai, M. Y., Yeh, S., Messing, E. M. & Chang, C., Apr 4 2007, In : Journal of the National Cancer Institute. 99, 7, p. 558-568 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Urinary Bladder Neoplasms
Androgens
Androgen Antagonists
Dihydrotestosterone
13 Citations (Scopus)

Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54

Yang, Z., Chang, Y. J., Miyamoto, H., Yeh, S., Yao, J. L., Di Sant'Agnese, P. A., Tsai, M. Y. & Chang, C., Mar 2007, In : Endocrinology. 148, 3, p. 1340-1349 10 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoproteins
Androgen Receptors
Transcriptional Activation
Prostatic Neoplasms
Growth
70 Citations (Scopus)

Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth

Yang, Z., Chang, Y. J., Miyamoto, H., Ni, J., Niu, Y., Chen, Z., Chen, Y. L., Yao, J. L., Di Sant'Agnese, P. A. & Chang, C., Feb 2007, In : Molecular Endocrinology. 21, 2, p. 343-358 16 p.

Research output: Contribution to journalArticle

Androgen Receptors
Transcriptional Activation
Prostatic Neoplasms
Growth
transgelin
2008
6 Citations (Scopus)

Mutation of human plasminogen kringle 1-5 enhances anti-angiogenic action via increased interaction with integrin αvβ3

Chang, P. C., Chang, Y. J., Wu, H. L., Chang, C. W., Lin, C. I., Wang, W. C. & Shi, G. Y., Apr 2008, In : Thrombosis and Haemostasis. 99, 4, p. 729-738 10 p.

Research output: Contribution to journalArticle

Kringles
Integrins
Mutation
Endothelial Cells
Angiostatins
28 Citations (Scopus)

Subfertility with defective folliculogenesis in female mice lacking testicular orphan nuclear receptor 4

Chen, L. M., Wang, R. S., Lee, Y. F., Liu, N. C., Chang, Y. J., Wu, C. C., Xie, S., Hung, Y. C. & Chang, C., Apr 2008, In : Molecular Endocrinology. 22, 4, p. 858-867 10 p.

Research output: Contribution to journalArticle

Orphan Nuclear Receptors
Infertility
LH Receptors
Corpus Luteum
Nuclear Receptor Subfamily 2, Group C, Member 2
2009
59 Citations (Scopus)
Nicotinic Receptors
Carcinogens
Colonic Neoplasms
Tobacco
Cell Movement
2010
37 Citations (Scopus)

Glucose-Regulated protein 78 (GRP78) silencing enhances cell migration but does not influence cell proliferation in hepatocellular carcinoma

Chang, Y-J., Chiu, C. C., Wu, C-H., An, J., Wu, C. C., Liu, T. Z., Wei, P-L. & Huang, M-T., Jun 2010, In : Annals of Surgical Oncology. 17, 6, p. 1703-1709 7 p.

Research output: Contribution to journalArticle

Cell Movement
Hepatocellular Carcinoma
Cell Proliferation
Small Interfering RNA
glucose-regulated proteins
60 Citations (Scopus)

Glucose-regulated protein 78 Is a novel contributor to acquisition of resistance to sorafenib in hepatocellular carcinoma

Chiou, J-F., Tai, C-J., Huang, M-T., Wei, P-L., Wang, Y. H., An, J., Wu, C-H., Liu, T. Z. & Chang, Y-J., Feb 2010, In : Annals of Surgical Oncology. 17, 2, p. 603-612 10 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Hep G2 Cells
sorafenib
glucose-regulated proteins
Neoplasms
24 Citations (Scopus)

Knockdown of thrombomodulin enhances HCC cell migration through increase of ZEB1 and decrease of E-cadherin gene expression

Huang, M. T., Wei, P. L., Liu, J. J., Liu, D. Z., Huang, H. C., An, J., Wu, C. C., Wu, C. H., Ho, Y. S., Yang, Y. Y. & Chang, Y. J., Dec 2010, In : Annals of Surgical Oncology. 17, 12, p. 3379-3385 7 p.

Research output: Contribution to journalArticle

Thrombomodulin
Cadherins
Cell Movement
Hepatocellular Carcinoma
Gene Expression
97 Citations (Scopus)

Overexpression and activation of the α9-nicotinic receptor during tumorigenesis in human breast epithelial cells

Lee, C. H., Huang, C. S., Chen, C. S., Tu, S. H., Wang, Y. J., Chang, Y. J., Tam, K. W., Wei, P. L., Cheng, T. C., Chu, J. S., Chen, L. C., Wu, C. H. & Ho, Y. S., Sep 8 2010, In : Journal of the National Cancer Institute. 102, 17, p. 1322-1335 14 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Nicotine
Carcinogenesis
Breast
Epithelial Cells
19 Citations (Scopus)

Role of DNA methyltransferase 1 in hormone-resistant prostate cancer

Chen, M. F., Chen, W. C., Chang, Y. J., Wu, C. F. & Wu, C. T., Sep 2010, In : Journal of Molecular Medicine. 88, 9, p. 953-962 10 p.

Research output: Contribution to journalArticle

Methyltransferases
Prostatic Neoplasms
Hormones
DNA
Androgen Receptors
2011
5 Citations (Scopus)
Colorectal Neoplasms
Epidemiology
Smoking
Microsatellite Instability
Neoplasms
43 Citations (Scopus)

Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces α9-nicotinic acetylcholine receptor expression in human breast cancer cells

Lee, C. H., Chang, Y. C., Chen, C. S., Tu, S. H., Wang, Y. J., Chen, L. C., Chang, Y. J., Wei, P. L., Chang, H. W., Chang, C. H., Huang, C. S., Wu, C. H. & Ho, Y. S., Sep 2011, In : Breast Cancer Research and Treatment. 129, 2, p. 331-345 15 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Nicotine
Estrogen Receptors
Estrogens
Breast Neoplasms
38 Citations (Scopus)

Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through redox regulation

Chen, C. H., Chang, Y. J., Ku, M. S. B., Chung, K. T. & Yang, J. T., Mar 2011, In : Journal of Molecular Medicine. 89, 3, p. 303-315 13 p.

Research output: Contribution to journalArticle

temozolomide
Valproic Acid
Glioma
Oxidation-Reduction
Apoptosis
29 Citations (Scopus)

Glucose-regulated protein 78 (GRP78) mediated the efficacy to curcumin treatment on hepatocellular carcinoma

Chang, Y. J., Tai, C. J., Kuo, L. J., Wei, P. L., Liang, H. H., Liu, T. Z., Wang, W., Tai, C. J., Ho, Y. S., Wu, C. H. & Huang, M. T., Aug 2011, In : Annals of Surgical Oncology. 18, 8, p. 2395-2403 9 p.

Research output: Contribution to journalArticle

Curcumin
Hepatocellular Carcinoma
In Situ Nick-End Labeling
Small Interfering RNA
Cell Cycle
29 Citations (Scopus)
Class E Scavenger Receptors
Chaperonin 60
Chlamydophila pneumoniae
Atherosclerosis
Endothelial Cells
48 Citations (Scopus)

Nicotine enhances colon cancer cell migration by induction of fibronectin

Wei, P. L., Kuo, L. J., Huang, M. T., Ting, W. C., Ho, Y. S., Wang, W., An, J. & Chang, Y. J., Jun 2011, In : Annals of Surgical Oncology. 18, 6, p. 1782-1790 9 p.

Research output: Contribution to journalArticle

Nicotine
Fibronectins
Colonic Neoplasms
Cell Movement
Epithelial-Mesenchymal Transition
77 Citations (Scopus)

Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins

Chen, C. S., Lee, C-H., Hsieh, C. D., Ho, C. T., Pan, M. H., Huang, C. S., Tu, S-H., Wang, Y. J., Chen, L-C., Chang, Y-J., Wei, P-L., Yang, Y-Y., Wu, C-H. & Ho, Y-S., Jan 2011, In : Breast Cancer Research and Treatment. 125, 1, p. 73-87 15 p.

Research output: Contribution to journalArticle

Cyclin D3
Nicotinic Receptors
Nicotine
Down-Regulation
Cell Proliferation
43 Citations (Scopus)

Nicotine promotes cell migration through alpha7 nicotinic acetylcholine receptor in gastric cancer cells

Lien, Y. C., Wang, W., Kuo, L. J., Liu, J. J., Wei, P. L., Ho, Y. S., Ting, W. C., Wu, C. H. & Chang, Y. J., Sep 2011, In : Annals of Surgical Oncology. 18, 9, p. 2671-2679 9 p.

Research output: Contribution to journalArticle

alpha7 Nicotinic Acetylcholine Receptor
Nicotine
Stomach Neoplasms
Cell Movement
Cadherins
14 Citations (Scopus)

Normoxically overexpressed hypoxia inducible factor 1-alpha is involved in arsenic trioxide resistance acquisition in hepatocellular carcinoma

Tung, J. N., Cheng, Y. W., Hsu, C. H., Liu, T. Z., Hsieh, P. Y., Ting, L. L., Ko, H. L., Chang, Y. J., Chiou, J. F. & Wu, A. T. H., May 2011, In : Annals of Surgical Oncology. 18, 5, p. 1492-1500 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Hepatocellular Carcinoma
Apoptosis
Carcinoma
arsenic trioxide
26 Citations (Scopus)

Oncological and functional outcomes of intersphincteric resection for low rectal cancer

Kuo, L. J., Hung, C. S., Wu, C. H., Wang, W., Tam, K. W., Liang, H. H., Chang, Y. J. & Wei, P. L., Sep 2011, In : Journal of Surgical Research. 170, 1, p. e93-e98

Research output: Contribution to journalArticle

Rectal Neoplasms
Disease-Free Survival
Antidiarrheals
Defecation
Radiotherapy
58 Citations (Scopus)

Tea polyphenol (-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced α9-nicotinic acetylcholine receptor upregulation in human breast cancer cells

Tu, S. H., Ku, C. Y., Ho, C. T., Chen, C. S., Huang, C. S., Lee, C. H., Chen, L. C., Pan, M. H., Chang, H. W., Chang, C. H., Chang, Y. J., Wei, P. L., Wu, C. H. & Ho, Y. S., Mar 2011, In : Molecular Nutrition and Food Research. 55, 3, p. 455-466 12 p.

Research output: Contribution to journalArticle

cholinergic receptors
nicotine
epigallocatechin
Nicotinic Receptors
Polyphenols
9 Citations (Scopus)
Nicotinic Receptors
Nicotine
Breast Neoplasms
Neoplasm Metastasis
Cell Movement
2012
14 Citations (Scopus)
docetaxel
Solanum nigrum
Autophagy
Endometrial Neoplasms
Neoplasms
24 Citations (Scopus)
Rectal Neoplasms
Biopsy
Magnetic Resonance Spectroscopy
Survival Rate
Therapeutics
9 Citations (Scopus)

GroEL1, from chlamydia pneumoniae, induces vascular adhesion molecule 1 expression by p37AUF1 in endothelial cells and hypercholesterolemic rabbit

Huang, C. Y., Shih, C. M., Tsao, N. W., Chen, Y. H., Li, C. Y., Chang, Y. J., Chang, N. C., Ou, K. L., Lin, C. Y., Lin, Y. W., Nien, C. H. & Lin, F. Y., Aug 10 2012, In : PLoS One. 7, 8, e42808.

Research output: Contribution to journalArticle

Chlamydophila pneumoniae
Endothelial cells
blood vessels
endothelial cells
Blood Vessels
45 Citations (Scopus)

GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and akt pathway after epirubicin treatment in colon cancer DLD-1 cells

Chang, Y. J., Huang, Y. P., Li, Z. L. & Chen, C. H., Apr 18 2012, In : PLoS One. 7, 4, e35123.

Research output: Contribution to journalArticle

epirubicin
Epirubicin
Oxidative stress
colorectal neoplasms
Colonic Neoplasms
10 Citations (Scopus)

Knockdown survivin expression reduces the efficacy of curcumin treatment in hepatocellular carcinoma cells

Hung, C. S., Liu, H. H., Huang, M. T., Cheng, C. W., Kuo, L. J., Ho, Y. S., Wu, C. H., Chen, C. M., Wei, P. L. & Chang, Y. J., Oct 2012, In : Annals of Surgical Oncology. 19, 11, p. 3547-3555 9 p.

Research output: Contribution to journalArticle

Curcumin
Hepatocellular Carcinoma
Small Interfering RNA
In Situ Nick-End Labeling
Cell Cycle
33 Citations (Scopus)
rho-Associated Kinases
HDL Lipoproteins
Healthy Volunteers
Phosphatidylinositol 3-Kinase
Cell Aging
21 Citations (Scopus)
Nicotinic Receptors
Fibronectins
Stomach Neoplasms
Cell Movement
alpha7 Nicotinic Acetylcholine Receptor
24 Citations (Scopus)
Vimentin
Cell Movement
Hepatocellular Carcinoma
Up-Regulation
Biosensing Techniques
22 Citations (Scopus)
Epithelial-Mesenchymal Transition
Cell Movement
Hepatocellular Carcinoma
Neoplasms
Vimentin
9 Citations (Scopus)

Survivin-mediated therapeutic efficacy of gemcitabine through glucose-regulated protein 78 in hepatocellular carcinoma

Hung, C. S., Lin, S. F., Liu, H. H., Kuo, L. J., Li, L. T., Su, H. Y., Liew, P. L., Lin, F. Y., Wei, P. L., Liu, D. Z. & Chang, Y. J., Aug 2012, In : Annals of Surgical Oncology. 19, 8, p. 2744-2752 9 p.

Research output: Contribution to journalArticle

gemcitabine
Hepatocellular Carcinoma
Therapeutics
DNA Nucleotidylexotransferase
glucose-regulated proteins
Atherosclerosis
Endothelial Cells
Scavenger Receptors
Coronary Vessels
Oxidized LDL Receptors
2013
35 Citations (Scopus)
docetaxel
Solanum nigrum
Autophagy
Fluorouracil
Doxorubicin
17 Citations (Scopus)

Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation

Yu, C. C., Wu, P. J., Hsu, J. L., Ho, Y. F., Hsu, L. C., Chang, Y. J., Chang, H. S., Chen, I. S. & Guh, J. H., Jan 2013, In : Prostate. 73, 2, p. 133-145 13 p.

Research output: Contribution to journalArticle

Caspases
70-kDa Ribosomal Protein S6 Kinases
Prostatic Neoplasms
Mitochondria
Down-Regulation
13 Citations (Scopus)
Fluorouracil
Cisplatin
Hepatocellular Carcinoma
Cell Death
Neoplasms
19 Citations (Scopus)
Vascular Endothelial Growth Factor Receptor-2
Colonic Neoplasms
Vascular Endothelial Growth Factor A
Down-Regulation
Growth
16 Citations (Scopus)
Learning Curve
Rectal Neoplasms
Laparoscopy
Surgical Blood Loss
Dissection
29 Citations (Scopus)

MicroRNA-200a/b influenced the therapeutic effects of curcumin in hepatocellular carcinoma (HCC) cells

Liang, H. H., Wei, P. L., Hung, C. S., Wu, C. T., Wang, W., Huang, M. T. & Chang, Y. J., 2013, In : Tumor Biology. 34, 5, p. 3209-3218 10 p.

Research output: Contribution to journalArticle

Curcumin
Therapeutic Uses
MicroRNAs
Hepatocellular Carcinoma
In Situ Nick-End Labeling
36 Citations (Scopus)
Epithelial-Mesenchymal Transition
MicroRNAs
Cell Movement
Hepatocellular Carcinoma
Cadherins
54 Citations (Scopus)

New therapeutic approach to suppress castration-resistant prostate cancer using ASC-J9 via targeting androgen receptor in selective prostate cells

Lai, K. P., Huang, C. K., Chang, Y. J., Chung, C. Y., Yamashita, S., Li, L., Lee, S. O., Yeh, S. & Chang, C., Feb 2013, In : American Journal of Pathology. 182, 2, p. 460-473 14 p.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostate
Prostatic Neoplasms
Androgens