Yu-Chu Chang

Personal profile

Education

2003-2009 Ph.D., Department of Biochemistry, Duke University, USA
1997-2001 B.S., Department of Physics, National Taiwan University

Experience

Assistant Professor, Department of Biochemistry and Molecular Cell Biology, Taipei Medical University
2018.08- Assistant Professor, International Ph.D. Program for Cell Therapy and Regeneration Medicine, Taipei Medical University
2016.03-2017.07 Assistant Professor, Ph.D. Program for Cancer Molecular Biology and drug Discovery, Taipei Medical University
2015.08-2016.03 Assistant Researcher, Ph.D. Program for Cancer Molecular Biology and drug Discovery, Taipei Medical University

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Ribonuclease P Medicine & Life Sciences

Protein folding Chemical Compounds

Protein Folding Medicine & Life Sciences

Bacilli Chemical Compounds

Bacillus subtilis Medicine & Life Sciences

Ligands Medicine & Life Sciences

Intrinsically Disordered Proteins Medicine & Life Sciences

Proteins Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

108大專生計畫獎-張語曲

Chang, Y.

8/1/19 → 7/1/20

Project: A - Government Institution › b - Ministry of Science and Technology

建立探討膜蛋白折疊的研究平台(1/3)

Chang, Y.

8/1/19 → 7/1/20

Project: A - Government Institution › b - Ministry of Science and Technology

利用蛋白質交互作用探討沙門氏菌 YqiC蛋白質的功能

Chang, Y.

7/1/19 → 2/1/20

Project: A - Government Institution › b - Ministry of Science and Technology

張語曲-107研究計畫績效獎

Chang, Y.

8/1/18 → 7/31/20

Project: B - Project of TMU › h - Other (Funded by TMU)

發展迎戰抗生素抗藥性沙門氏桿菌的新策略-新發現沙門氏桿菌蛋白質YqiC之生物化學與生物物理學特性研究

Chang, Y.

1/1/19 → 12/1/19

Project: A - Government Institution › d - Ministry of Education

Research Output 2007 2019

438 Citations
6 h-Index
7 Article
1 Chapter

ATP Synthase Subunit Epsilon Overexpression Promotes Metastasis by Modulating AMPK Signaling to Induce Epithelial-to-Mesenchymal Transition and Is a Poor Prognostic Marker in Colorectal Cancer Patients

Huang, Y-J., Jan, Y-H., Chang, Y-C., Tsai, H-F., Wu, A. T., Chen, C-L. & Hsiao, M., Jul 21 2019, In : Journal of Clinical Medicine. 8, 7

Research output: Contribution to journal › Article

AMP-Activated Protein Kinases

Epithelial-Mesenchymal Transition

Hypoxia-Inducible Factor 1

Colonic Neoplasms

Colorectal Neoplasms

37 Citations (Scopus)

Ligand concentration regulates the pathways of coupled protein folding and binding

Daniels, K. G., Tonthat, N. K., McClure, D. R., Chang, Y. C., Liu, X., Schumacher, M. A., Fierke, C. A., Schmidler, S. C. & Oas, T. G., Jan 22 2014, In : Journal of the American Chemical Society. 136, 3, p. 822-825 4 p.

Research output: Contribution to journal › Article

Protein folding

Protein Folding

Protein Binding

Ligands

Proteins

30 Citations (Scopus)

Measuring membrane protein stability under native conditions

Chang, Y. C. & Bowie, J. U., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 1, p. 219-224 6 p.

Research output: Contribution to journal › Article

Protein Stability

Thermodynamics

Bacteriorhodopsins

Membrane Proteins

Membranes

15 Citations (Scopus)

Measuring transmembrane helix interaction strengths in lipid bilayers using steric trapping

Hong, H., Chang, Y-C. & Bowie, J. U., 2013, Methods in Molecular Biology. Vol. 1063. p. 37-56 20 p. (Methods in Molecular Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Lipid Bilayers

Streptavidin

Competitive Binding

Biotin

Membrane Proteins

35 Citations (Scopus)

Osmolyte-induced folding of an intrinsically disordered protein: Folding mechanism in the absence of ligand

Chang, Y. C. & Oas, T. G., Jun 29 2010, In : Biochemistry. 49, 25, p. 5086-5096 11 p.

Research output: Contribution to journal › Article

Intrinsically Disordered Proteins

Protein folding

Protein Folding

Ligands

Proteins