Research Output per year
Research Output 2002 2019
2019
Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model
Kurniawan, A. L., Lee, Y. C., Shih, C. K., Hsieh, R. H., Chen, S. H. & Chang, J. S., Jul 17 2019, In : Food and Function. 10, 7, p. 4113-4123 11 p.Research output: Contribution to journal › Article
sex hormones
Gonadal Steroid Hormones
testosterone
Testosterone
Iron
Antigenic epitopes on the outer membrane protein A of Escherichia coli identified with single-chain variable fragment (scFv) antibodies
Mwale, P. F., Lee, C-H., Leu, S-J., Lee, Y-C., Wu, H-H., Lin, L-T., Lin, T. E., Huang, Y-J. & Yang, Y-Y., Apr 26 2019, In : Applied Microbiology and Biotechnology.Research output: Contribution to journal › Article
Single-Chain Antibodies
Epitopes
Escherichia coli
Amino Acids
OMPA outer membrane proteins
Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent
Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., Jan 31 2019, In : ACS Omega. 4, 1, p. 2387-2397 11 p.Research output: Contribution to journal › Article
Open Access
Receptor, Fibroblast Growth Factor, Type 2
Epitopes
Antibodies, Monoclonal, Humanized
Fibroblast Growth Factor Receptors
Fibroblasts
Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway
Wakabayashi, G., Lee, Y. C., Luh, F., Kuo, C. N., Chang, W. C. & Yen, Y., Dec 5 2019, In : Journal of Biomedical Science. 26, 1, 96.Research output: Contribution to journal › Review article
Open Access
Programmed Cell Death 1 Receptor
CTLA-4 Antigen
Chemotherapy
Radiotherapy
Biomarkers
2
Citations
(Scopus)
Mitochondrial translocation of estrogen receptor β affords resistance to oxidative insult-induced apoptosis and contributes to the pathogenesis of endometriosis
Liao, T. L., Lee, Y. C., Tzeng, C. R., Wang, Y. P., Chang, H. Y., Lin, Y. F. & Kao, S. H., Apr 1 2019, In : Free Radical Biology and Medicine. 134, p. 359-373 15 p.Research output: Contribution to journal › Article
Endometriosis
Estrogen Receptors
Apoptosis
Mitochondria
Mitochondrial DNA
PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
Lang, Y. D., Chen, H. Y., Ho, C. M., Shih, J. H., Hsu, E. C., Shen, R., Lee, Y. C., Chen, J. W., Wu, C. Y., Yeh, H. W., Chen, R. H. & Jou, Y. S., Dec 1 2019, In : Nature Communications. 10, 1, 5716.Research output: Contribution to journal › Article
Open Access
Catenins
progressions
Tumors
tumors
Neoplasm Metastasis
2018
1
Citation
(Scopus)
Characterization of chicken-derived single chain antibody fragments against venom of Naja naja atra
Lee, C. H., Leu, S. J., Lee, Y. C., Liu, C. I., Lin, L. T., Mwale, P. F., Chiang, J. R., Tsai, B. Y., Chen, C. C., Hung, C. S. & Yang, Y. Y., Oct 1 2018, In : Toxins. 10, 10, 383.Research output: Contribution to journal › Article
Cobra Venoms
Elapidae
Single-Chain Antibodies
Immunoglobulin Fragments
Venoms
10
Citations
(Scopus)
Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer
Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.Research output: Contribution to journal › Article
Autophagy
Urinary Bladder Neoplasms
Cell Death
Therapeutics
Clustered Regularly Interspaced Short Palindromic Repeats
1
Citation
(Scopus)
Generation and characterization of avian-derived anti-human CD19 single chain fragment antibodies
Tsai, K. C., Chiang, C. W., Lo, Y. N., Chang, F. L., Lin, T. Y., Chang, C. Y., Chen, W. C. & Lee, Y. C., Jan 1 2018, (Accepted/In press) In : Animal Biotechnology.Research output: Contribution to journal › Article
Complementarity Determining Regions
Single-Chain Antibodies
Immunoglobulin Fragments
Antibodies
Chickens
Interaction of S17 antibody with the functional binding region of the hepatitis B virus pre-S2 epitope
Chang, C. Y., Chang, F. L., Chiang, C. W., Lo, Y. N., Lin, T. Y., Chen, W. C., Tsai, K. C. & Lee, Y. C., Sep 1 2018, In : Viral Immunology. 31, 7, p. 492-499 8 p.Research output: Contribution to journal › Article
Hepatitis B virus
Epitopes
Single-Chain Antibodies
Virus Diseases
Surface Antigens
2017
2
Citations
(Scopus)
Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo
Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., Feb 9 2017, In : Scientific Reports. 7, 42291.Research output: Contribution to journal › Article
Tubulin
Leukemia
Apoptosis
Caspase 7
Drug Therapy
Correction: Production and characterization of neutralizing antibodies against Bungarus multicinctus snake venom [Applied and Environmental Microbiology, 82, 23, (2016), (6973-6982)] DOI:10.1128/AEM.01876-16
Lee, C. H., Lee, Y. C., Leu, S. J., Lin, L. T., Chiang, J. R., Hsu, W. J. & Yangd, Y. Y., Nov 1 2017, In : Applied and Environmental Microbiology. 83, 22, e01949-17.Research output: Contribution to journal › Comment/debate
Bungarus
Environmental Microbiology
venom
Snake Venoms
venoms
12
Citations
(Scopus)
Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells
Chao, M. W., Chen, T. H., Huang, H. L., Chang, Y. W., HuangFu, W. C., Lee, Y. C., Teng, C. M. & Pan, S. L., Apr 7 2017, In : Scientific Reports. 7, 46134.Research output: Contribution to journal › Article
Cardiac Glycosides
Protein Kinase C
Hepatocellular Carcinoma
Apoptosis
Digitalis
5
Citations
(Scopus)
Single chain antibody fragment against venom from the snake Daboia russelii formosensis
Lee, C. H., Lee, Y. C., Lee, Y. L., Leu, S. J., Lin, L. T., Chen, C. C., Chiang, J. R., Fellow, P., Tsai, B. Y., Hung, C. S. & Yang, Y. Y., Nov 1 2017, In : Toxins. 9, 11, 347.Research output: Contribution to journal › Article
Single-Chain Antibodies
Immunoglobulin Fragments
Snake Venoms
Venoms
Bacteriophages
2016
2
Citations
(Scopus)
A new era for cancer target therapies: Applying systems biology and computer-aided drug design to cancer therapies
Wong, Y. H., Chiu, C. C., Lin, C. L., Chen, T. S., Jheng, B. R., Lee, Y. C., Chen, J. & Chen, B. S., Nov 1 2016, In : Current Pharmaceutical Biotechnology. 17, 14, p. 1246-1267 22 p.Research output: Contribution to journal › Review article
Computer-Aided Design
Systems Biology
Drug Design
Neoplasms
Ligands
4
Citations
(Scopus)
Cellular nuclear export factors TAP and Aly are required for HDAg-L-mediated assembly of hepatitis delta virus
Huang, H. C., Lee, C. P., Liu, H. K., Chang, M. F., Lai, Y. H., Lee, Y. C. & Huang, C., Dec 9 2016, In : Journal of Biological Chemistry. 291, 50, p. 26226-26238 13 p.Research output: Contribution to journal › Article
Hepatitis delta Antigens
Hepatitis Delta Virus
Cell Nucleus Active Transport
Viruses
Virion
3
Citations
(Scopus)
Comparative study between 3D-QSAR and Docking-Based Pharmacophore models for potent Plasomodium falciparum dihydroorotate dehydrogenase inhibitors
Tseng, T-S., Lee, Y-C., Hsiao, N-W., Liu, Y-R. & Tsai, K-C., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 2, p. 265-271 7 p.Research output: Contribution to journal › Article
Quantitative Structure-Activity Relationship
Plasmodium falciparum
Malaria
Parasites
Parasitic Diseases
1
Citation
(Scopus)
Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations
Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., Jan 1 2016, In : Molecular BioSystems. 12, 8, p. 2541-2551 11 p.Research output: Contribution to journal › Article
Cyclooxygenase 2 Inhibitors
Anti-Inflammatory Agents
Molecular Docking Simulation
Non-Steroidal Anti-Inflammatory Agents
Prostaglandin-Endoperoxide Synthases
1
Citation
(Scopus)
Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays
Chang, C. C., Yuan, W., Lin, Y. L., Liu, R. S., Juan, Y. C., Sun, W. H., Tsay, H. J., Huang, H. C., Lee, Y. C. & Liu, H. K., Jan 1 2016, In : Evidence-based Complementary and Alternative Medicine. 2016, 3262790.Research output: Contribution to journal › Article
Paeonia
Therapeutic Uses
Hypoglycemic Agents
Ethanol
Polyphenols
10
Citations
(Scopus)
Production and characterization of neutralizing antibodies against Bungarus multicinctus snake venom
Lee, C. H., Lee, Y-C., Leu, S-J., Lin, L-T., Chiang, J. R., Hsu, W. J. & Yang, Y-Y., 2016, In : Applied and Environmental Microbiology. 82, 23, p. 6973-6982 10 p.Research output: Contribution to journal › Article
Bungarus
venom
Single-Chain Antibodies
Snake Venoms
venoms
7
Citations
(Scopus)
The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity
Chang, C. C., Yuan, W., Roan, H. Y., Chang, J. L., Huang, H. C., Lee, Y. C., Tsay, H. J. & Liu, H. K., Nov 3 2016, In : BMC Complementary and Alternative Medicine. 16, 1, 432.Research output: Contribution to journal › Article
Silk
Insulin-Secreting Cells
Zea mays
Antioxidants
Insulin
2015
9
Citations
(Scopus)
Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries
Tung, C. P., Chen, I. C., Yu, C. M., Peng, H. P., Jian, J. W., Ma, S. H., Lee, Y. C., Jan, J. T. & Yang, A. S., Oct 12 2015, In : Scientific Reports. 5, 15053.Research output: Contribution to journal › Article
Hemagglutinins
Neutralizing Antibodies
Bacteriophages
Human Influenza
Epitopes
68
Citations
(Scopus)
Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling
Chen, W-C., Tseng, T-S., Hsiao, N-W., Lin, Y-L., Wen, Z-H., Tsai, C-C., Lee, Y-C., Lin, H-H. & Tsai, K-C., 2015, In : Scientific Reports. 5Research output: Contribution to journal › Article
Monophenol Monooxygenase
Melanins
Zebrafish
Gastrodia
Agaricales
7
Citations
(Scopus)
Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation
Tseng, T-S., Tsai, K-C., Chen, W-C., Wang, Y-T., Lee, Y-C., Lu, C-K., Don, M-J., Chang, C-Y., Lee, C-H., Lin, H-H., Hsu, H-J. & Hsiao, N-W., 2015, In : Journal of Agricultural and Food Chemistry. 63, 27, p. 6181-6188 8 p.Research output: Contribution to journal › Article
dipeptides
Monophenol Monooxygenase
Dipeptides
Cysteine
cysteine
8
Citations
(Scopus)
Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Chen, H. S., Hou, S. C., Jian, J. W., Goh, K. S., Shen, S. T., Lee, Y. C., You, J. J., Peng, H. P., Kuo, W. C., Chen, S. T., Peng, M. C., Wang, A. H. J., Yu, C. M., Chen, I. C., Tung, C. P., Chen, T. H., Ping Chiu, K., Ma, C., Yuan Wu, C., Lin, S. W. & 1 others, , Jul 23 2015, In : Scientific Reports. 5, 12411.Research output: Contribution to journal › Article
Antibody Formation
Antigens
Antibodies
Proteins
Bacteriophages
2014
12
Citations
(Scopus)
Antibody variable domain interface and framework sequence requirements for stability and function by high-throughput experiments
Hsu, H. J., Lee, K. H., Jian, J. W., Chang, H. J., Yu, C. M., Lee, Y. C., Chen, I. C., Peng, H. P., Wu, C. Y., Huang, Y. F., Shao, C. Y., Chiu, K. P. & Yang, A. S., Jan 7 2014, In : Structure. 22, 1, p. 22-34 13 p.Research output: Contribution to journal › Article
Antigens
Antibodies
Protein Stability
Mutagenesis
Proteins
16
Citations
(Scopus)
Loop-sequence features and stability determinants in antibody variable domains by high-throughput experiments
Chang, H. J., Jian, J. W., Hsu, H. J., Lee, Y. C., Chen, H. S., You, J. J., Hou, S. C., Shao, C. Y., Chen, Y. J., Chiu, K. P., Peng, H. P., Lee, K. H. & Yang, A. S., Jan 7 2014, In : Structure. 22, 1, p. 9-21 13 p.Research output: Contribution to journal › Article
Antibodies
Complementarity Determining Regions
Antigens
High-Throughput Nucleotide Sequencing
Single-Chain Antibodies
18
Citations
(Scopus)
Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors
Hsiao, N-W., Tseng, T-S., Lee, Y-C., Chen, W-C., Lin, H-H., Chen, Y-R., Wang, Y-T., Hsu, H-J. & Tsai, K-C., 2014, In : Journal of Chemical Information and Modeling. 54, 11, p. 3099-3111 13 p.Research output: Contribution to journal › Article
Neurodegenerative diseases
Melanin
Monophenol Monooxygenase
Cosmetics
Biological Products
2012
28
Citations
(Scopus)
Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface
Yu, C. M., Peng, H. P., Chen, I. C., Lee, Y. C., Chen, J. B., Tsai, K. C., Chen, C. T., Chang, J. Y., Yang, E. W., Hsu, P. C., Jian, J. W., Hsu, H. J., Chang, H. J., Hsu, W. L., Huang, K. F., Ma, A. C. & Yang, A. S., Mar 22 2012, In : PLoS One. 7, 3, e33340.Research output: Contribution to journal › Article
Complementarity Determining Regions
antigens
Antigens
antibodies
Antibodies
2011
Effects of signal sequence on phage-displayed disulfide-stabilized single chain antibody variable fragment (sc-dsFv) libraries
Lee, Y. C., Chen, I. C., Yu, C. M., Huang, Y. J., Hsu, H. J. & Yang, A. S., Jul 29 2011, In : Biochemical and Biophysical Research Communications. 411, 2, p. 348-353 6 p.Research output: Contribution to journal › Article
Single-Chain Antibodies
Bacteriophages
Protein Sorting Signals
Disulfides
Libraries
2010
34
Citations
(Scopus)
A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies
Tsai, K. C., Chen, Y. C., Hsiao, N. W., Wang, C. L., Lin, C. L., Lee, Y. C., Li, M. & Wang, B., Apr 1 2010, In : European Journal of Medicinal Chemistry. 45, 4, p. 1544-1551 8 p.Research output: Contribution to journal › Article
Static Electricity
Electrostatics
Quantitative Structure-Activity Relationship
Computational chemistry
Atoms
14
Citations
(Scopus)
Engineering anti-vascular endothelial growth factor single chain disulfide-stabilized antibody variable fragments (sc-dsFv) with phage-displayed sc-dsFv libraries
Huang, Y. J., Chen, I. C., Yu, C. M., Lee, Y. C., Hsu, H. J., Ching, A. T. C., Chang, H. J. & Yang, A. S., Mar 12 2010, In : Journal of Biological Chemistry. 285, 11, p. 7880-7891 12 p.Research output: Contribution to journal › Article
Immunoglobulin Fragments
Bacteriophages
Disulfides
Vascular Endothelial Growth Factor A
Libraries
2
Citations
(Scopus)
Signal sequence as a determinant in expressing disulfide-stabilized single chain antibody variable fragments (sc-dsFv) against human VEGF
Chen, I. C., Yu, C. M., Lee, Y. C., Huang, Y. J., Hsu, H. J. & Yang, A. S., Jun 21 2010, In : Molecular BioSystems. 6, 7, p. 1307-1315 9 p.Research output: Contribution to journal › Article
Single-Chain Antibodies
Protein Sorting Signals
Disulfides
Bacteriophages
Vascular Endothelial Growth Factor A
2009
5
Citations
(Scopus)
The first pharmacophore model for potent NF-κB inhibitors
Tsai, K-C., Teng, L-W., Shao, Y-M., Chen, Y-C., Lee, Y-C., Li, M-Y. & Hsiao, N-W., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 19, p. 5665-5669 5 p.Research output: Contribution to journal › Article
NF-kappa B
Molecules
Quantitative Structure-Activity Relationship
Bioactivity
Hydrogen
2007
13
Citations
(Scopus)
A dominant antigenic epitope on SARS-CoV spike protein identified by an avian single-chain variable fragment (scFv)-expressing phage
Lee, Y. C., Leu, S. J. C., Hung, H. C., Wu, H. H., Huang, I. J., Hsieh, W. S., Chiu, W. T., Hsieh, M. S., Cheng, T. F. & Yang, Y. Y., May 15 2007, In : Veterinary Immunology and Immunopathology. 117, 1-2, p. 75-85 11 p.Research output: Contribution to journal › Article
Avian Proteins
Severe Acute Respiratory Syndrome
Single-Chain Antibodies
bacteriophages
Bacteriophages
8
Citations
(Scopus)
Chicken single-chain variable fragments against the SARS-CoV spike protein
Lee, Y. C., Leu, S. J. C., Hu, C. J., Shih, N. Y., Huang, I. J., Wu, H. H., Hsieh, W. S., Chiang, B. L., Chiu, W. T. & Yang, Y. Y., Dec 2007, In : Journal of Virological Methods. 146, 1-2, p. 104-111 8 p.Research output: Contribution to journal › Article
Severe Acute Respiratory Syndrome
Single-Chain Antibodies
Chickens
Proteins
Bacteriophages
2002
Contribution of heavy chain genes on the binding property of a recombinant human IgG rheumatoid factor
Lee, Y-C., Leu, S-J., Hsieh, M-S., Huang, I. J. & Yang, Y-Y., 2002, In : J. Biomedical and Laboratory Sciences. 14, p. 89-94 6 p.Research output: Contribution to journal › Article