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Research Output 2002 2019

  • 280 Citations
  • 9 h-Index
  • 30 Article
  • 1 Comment/debate
  • 1 Review article
2019

Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model

Kurniawan, A. L., Lee, Y. C., Shih, C. K., Hsieh, R. H., Chen, S. H. & Chang, J. S., Jul 1 2019, In : Food and Function. 10, 7, p. 4113-4123 11 p.

Research output: Contribution to journalArticle

sex hormones
Gonadal Steroid Hormones
testosterone
Testosterone
Iron
Single-Chain Antibodies
Epitopes
Escherichia coli
Amino Acids
OMPA outer membrane proteins

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., Jan 31 2019, In : ACS Omega. 4, 1, p. 2387-2397 11 p.

Research output: Contribution to journalArticle

Open Access
Receptor, Fibroblast Growth Factor, Type 2
Epitopes
Antibodies, Monoclonal, Humanized
Fibroblast Growth Factor Receptors
Fibroblasts
1 Citation (Scopus)
Endometriosis
Estrogen Receptors
Apoptosis
Mitochondria
Mitochondrial DNA
2018
1 Citation (Scopus)

Characterization of chicken-derived single chain antibody fragments against venom of Naja naja atra

Lee, C. H., Leu, S. J., Lee, Y. C., Liu, C. I., Lin, L. T., Mwale, P. F., Chiang, J. R., Tsai, B. Y., Chen, C. C., Hung, C. S. & Yang, Y. Y., Oct 1 2018, In : Toxins. 10, 10, 383.

Research output: Contribution to journalArticle

Cobra Venoms
Elapidae
Single-Chain Antibodies
Immunoglobulin Fragments
Venoms
9 Citations (Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

Autophagy
Urinary Bladder Neoplasms
Cell Death
Therapeutics
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

Generation and characterization of avian-derived anti-human CD19 single chain fragment antibodies

Tsai, K. C., Chiang, C. W., Lo, Y. N., Chang, F. L., Lin, T. Y., Chang, C. Y., Chen, W. C. & Lee, Y. C., Jan 1 2018, (Accepted/In press) In : Animal Biotechnology.

Research output: Contribution to journalArticle

Complementarity Determining Regions
Single-Chain Antibodies
Immunoglobulin Fragments
Antibodies
Chickens

Interaction of S17 antibody with the functional binding region of the hepatitis B virus pre-S2 epitope

Chang, C. Y., Chang, F. L., Chiang, C. W., Lo, Y. N., Lin, T. Y., Chen, W. C., Tsai, K. C. & Lee, Y. C., Sep 1 2018, In : Viral Immunology. 31, 7, p. 492-499 8 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Epitopes
Single-Chain Antibodies
Virus Diseases
Surface Antigens
2017
Bungarus
Environmental Microbiology
venom
Snake Venoms
venoms
2016
2 Citations (Scopus)

A new era for cancer target therapies: Applying systems biology and computer-aided drug design to cancer therapies

Wong, Y. H., Chiu, C. C., Lin, C. L., Chen, T. S., Jheng, B. R., Lee, Y. C., Chen, J. & Chen, B. S., Nov 1 2016, In : Current Pharmaceutical Biotechnology. 17, 14, p. 1246-1267 22 p.

Research output: Contribution to journalReview article

Computer-Aided Design
Systems Biology
Drug Design
Neoplasms
Ligands
4 Citations (Scopus)

Cellular nuclear export factors TAP and Aly are required for HDAg-L-mediated assembly of hepatitis delta virus

Huang, H. C., Lee, C. P., Liu, H. K., Chang, M. F., Lai, Y. H., Lee, Y. C. & Huang, C., Dec 9 2016, In : Journal of Biological Chemistry. 291, 50, p. 26226-26238 13 p.

Research output: Contribution to journalArticle

Hepatitis delta Antigens
Hepatitis Delta Virus
Cell Nucleus Active Transport
Viruses
Virion
3 Citations (Scopus)
Quantitative Structure-Activity Relationship
Plasmodium falciparum
Malaria
Parasites
Parasitic Diseases
1 Citation (Scopus)

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., Jan 1 2016, In : Molecular BioSystems. 12, 8, p. 2541-2551 11 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2 Inhibitors
Anti-Inflammatory Agents
Molecular Docking Simulation
Non-Steroidal Anti-Inflammatory Agents
Prostaglandin-Endoperoxide Synthases
1 Citation (Scopus)

Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays

Chang, C. C., Yuan, W., Lin, Y. L., Liu, R. S., Juan, Y. C., Sun, W. H., Tsay, H. J., Huang, H. C., Lee, Y. C. & Liu, H. K., Jan 1 2016, In : Evidence-based Complementary and Alternative Medicine. 2016, 3262790.

Research output: Contribution to journalArticle

Paeonia
Therapeutic Uses
Hypoglycemic Agents
Ethanol
Polyphenols
10 Citations (Scopus)

Production and characterization of neutralizing antibodies against Bungarus multicinctus snake venom

Lee, C. H., Lee, Y-C., Leu, S-J., Lin, L-T., Chiang, J. R., Hsu, W. J. & Yang, Y-Y., 2016, In : Applied and Environmental Microbiology. 82, 23, p. 6973-6982 10 p.

Research output: Contribution to journalArticle

Bungarus
venom
Single-Chain Antibodies
Snake Venoms
venoms
7 Citations (Scopus)

The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity

Chang, C. C., Yuan, W., Roan, H. Y., Chang, J. L., Huang, H. C., Lee, Y. C., Tsay, H. J. & Liu, H. K., Nov 3 2016, In : BMC Complementary and Alternative Medicine. 16, 1, 432.

Research output: Contribution to journalArticle

Silk
Insulin-Secreting Cells
Zea mays
Antioxidants
Insulin
2015
9 Citations (Scopus)

Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries

Tung, C. P., Chen, I. C., Yu, C. M., Peng, H. P., Jian, J. W., Ma, S. H., Lee, Y. C., Jan, J. T. & Yang, A. S., Oct 12 2015, In : Scientific Reports. 5, 15053.

Research output: Contribution to journalArticle

Hemagglutinins
Neutralizing Antibodies
Bacteriophages
Human Influenza
Epitopes
66 Citations (Scopus)

Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling

Chen, W-C., Tseng, T-S., Hsiao, N-W., Lin, Y-L., Wen, Z-H., Tsai, C-C., Lee, Y-C., Lin, H-H. & Tsai, K-C., 2015, In : Scientific Reports. 5

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Melanins
Zebrafish
Gastrodia
Agaricales
7 Citations (Scopus)

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation

Tseng, T-S., Tsai, K-C., Chen, W-C., Wang, Y-T., Lee, Y-C., Lu, C-K., Don, M-J., Chang, C-Y., Lee, C-H., Lin, H-H., Hsu, H-J. & Hsiao, N-W., 2015, In : Journal of Agricultural and Food Chemistry. 63, 27, p. 6181-6188 8 p.

Research output: Contribution to journalArticle

dipeptides
Monophenol Monooxygenase
Dipeptides
Cysteine
cysteine
8 Citations (Scopus)

Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens

Chen, H. S., Hou, S. C., Jian, J. W., Goh, K. S., Shen, S. T., Lee, Y. C., You, J. J., Peng, H. P., Kuo, W. C., Chen, S. T., Peng, M. C., Wang, A. H. J., Yu, C. M., Chen, I. C., Tung, C. P., Chen, T. H., Ping Chiu, K., Ma, C., Yuan Wu, C., Lin, S. W. & 1 others, Yang, A. S., Jul 23 2015, In : Scientific Reports. 5, 12411.

Research output: Contribution to journalArticle

Antibody Formation
Antigens
Antibodies
Proteins
Bacteriophages
2014
12 Citations (Scopus)

Antibody variable domain interface and framework sequence requirements for stability and function by high-throughput experiments

Hsu, H. J., Lee, K. H., Jian, J. W., Chang, H. J., Yu, C. M., Lee, Y. C., Chen, I. C., Peng, H. P., Wu, C. Y., Huang, Y. F., Shao, C. Y., Chiu, K. P. & Yang, A. S., Jan 7 2014, In : Structure. 22, 1, p. 22-34 13 p.

Research output: Contribution to journalArticle

Antigens
Antibodies
Protein Stability
Mutagenesis
Proteins
16 Citations (Scopus)

Loop-sequence features and stability determinants in antibody variable domains by high-throughput experiments

Chang, H. J., Jian, J. W., Hsu, H. J., Lee, Y. C., Chen, H. S., You, J. J., Hou, S. C., Shao, C. Y., Chen, Y. J., Chiu, K. P., Peng, H. P., Lee, K. H. & Yang, A. S., Jan 7 2014, In : Structure. 22, 1, p. 9-21 13 p.

Research output: Contribution to journalArticle

Antibodies
Complementarity Determining Regions
Antigens
High-Throughput Nucleotide Sequencing
Single-Chain Antibodies
18 Citations (Scopus)

Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors

Hsiao, N-W., Tseng, T-S., Lee, Y-C., Chen, W-C., Lin, H-H., Chen, Y-R., Wang, Y-T., Hsu, H-J. & Tsai, K-C., 2014, In : Journal of Chemical Information and Modeling. 54, 11, p. 3099-3111 13 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Melanin
Monophenol Monooxygenase
Cosmetics
Biological Products
2012
28 Citations (Scopus)

Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface

Yu, C. M., Peng, H. P., Chen, I. C., Lee, Y. C., Chen, J. B., Tsai, K. C., Chen, C. T., Chang, J. Y., Yang, E. W., Hsu, P. C., Jian, J. W., Hsu, H. J., Chang, H. J., Hsu, W. L., Huang, K. F., Ma, A. C. & Yang, A. S., Mar 22 2012, In : PLoS One. 7, 3, e33340.

Research output: Contribution to journalArticle

Complementarity Determining Regions
antigens
Antigens
antibodies
Antibodies
2011

Effects of signal sequence on phage-displayed disulfide-stabilized single chain antibody variable fragment (sc-dsFv) libraries

Lee, Y. C., Chen, I. C., Yu, C. M., Huang, Y. J., Hsu, H. J. & Yang, A. S., Jul 29 2011, In : Biochemical and Biophysical Research Communications. 411, 2, p. 348-353 6 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Bacteriophages
Protein Sorting Signals
Disulfides
Libraries
2010
34 Citations (Scopus)

A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies

Tsai, K. C., Chen, Y. C., Hsiao, N. W., Wang, C. L., Lin, C. L., Lee, Y. C., Li, M. & Wang, B., Apr 1 2010, In : European Journal of Medicinal Chemistry. 45, 4, p. 1544-1551 8 p.

Research output: Contribution to journalArticle

Static Electricity
Electrostatics
Quantitative Structure-Activity Relationship
Computational chemistry
Atoms
14 Citations (Scopus)

Engineering anti-vascular endothelial growth factor single chain disulfide-stabilized antibody variable fragments (sc-dsFv) with phage-displayed sc-dsFv libraries

Huang, Y. J., Chen, I. C., Yu, C. M., Lee, Y. C., Hsu, H. J., Ching, A. T. C., Chang, H. J. & Yang, A. S., Mar 12 2010, In : Journal of Biological Chemistry. 285, 11, p. 7880-7891 12 p.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Bacteriophages
Disulfides
Vascular Endothelial Growth Factor A
Libraries
2 Citations (Scopus)

Signal sequence as a determinant in expressing disulfide-stabilized single chain antibody variable fragments (sc-dsFv) against human VEGF

Chen, I. C., Yu, C. M., Lee, Y. C., Huang, Y. J., Hsu, H. J. & Yang, A. S., Jun 21 2010, In : Molecular BioSystems. 6, 7, p. 1307-1315 9 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Protein Sorting Signals
Disulfides
Bacteriophages
Vascular Endothelial Growth Factor A
2009
5 Citations (Scopus)

The first pharmacophore model for potent NF-κB inhibitors

Tsai, K-C., Teng, L-W., Shao, Y-M., Chen, Y-C., Lee, Y-C., Li, M-Y. & Hsiao, N-W., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 19, p. 5665-5669 5 p.

Research output: Contribution to journalArticle

NF-kappa B
Molecules
Quantitative Structure-Activity Relationship
Bioactivity
Hydrogen
2007
13 Citations (Scopus)

A dominant antigenic epitope on SARS-CoV spike protein identified by an avian single-chain variable fragment (scFv)-expressing phage

Lee, Y. C., Leu, S. J. C., Hung, H. C., Wu, H. H., Huang, I. J., Hsieh, W. S., Chiu, W. T., Hsieh, M. S., Cheng, T. F. & Yang, Y. Y., May 15 2007, In : Veterinary Immunology and Immunopathology. 117, 1-2, p. 75-85 11 p.

Research output: Contribution to journalArticle

Avian Proteins
Severe Acute Respiratory Syndrome
Single-Chain Antibodies
bacteriophages
Bacteriophages
8 Citations (Scopus)

Chicken single-chain variable fragments against the SARS-CoV spike protein

Lee, Y. C., Leu, S. J. C., Hu, C. J., Shih, N. Y., Huang, I. J., Wu, H. H., Hsieh, W. S., Chiang, B. L., Chiu, W. T. & Yang, Y. Y., Dec 2007, In : Journal of Virological Methods. 146, 1-2, p. 104-111 8 p.

Research output: Contribution to journalArticle

Severe Acute Respiratory Syndrome
Single-Chain Antibodies
Chickens
Proteins
Bacteriophages
2002

Contribution of heavy chain genes on the binding property of a recombinant human IgG rheumatoid factor

Lee, Y-C., Leu, S-J., Hsieh, M-S., Huang, I. J. & Yang, Y-Y., 2002, In : J. Biomedical and Laboratory Sciences. 14, p. 89-94 6 p.

Research output: Contribution to journalArticle