Research Output per year
Research Output
2020
Astragalus membranaceus-Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors
Chang, F. L., Tsai, K. C., Lin, T. Y., Yang, T. W., Lo, Y. N., Chen, W. C., Chang, J. H., Lu, M. K., Chiou, C. T., Chen, P. H., Yen, Y., Pan, S. L. & Lee, Y. C., Jan 1 2020, In : BioMed Research International. 2020, 3415471.Research output: Contribution to journal › Article
Open Access
4
Citations
(Scopus)
Corrigendum to: TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis “Toxicol Appl Pharmacol. 2016;305:194–202” (Toxicology and Applied Pharmacology (2016) 305 (194–202)(S0041008X16301478)(10.1016/j.taap.2016.06.013))
Lin, C. F., Huang, H. L., Peng, C. Y., Lee, Y. C., Wang, H. P., Teng, C. M. & Pan, S. L., Jan 15 2020, In : Toxicology and Applied Pharmacology. 387, 114858.Research output: Contribution to journal › Comment/debate
Open Access
Generation and Characterization of Single Chain Variable Fragment against Alpha-Enolase of Candida albicans
Leu, S. J., Lee, Y. C., Lee, C. H., Liao, P. Y., Chiang, C. W., Yang, C. M., Su, C. H., Ou, T. Y., Liu, K. J., Lo, H. J., Tsai, B. Y. & Yang, Y. Y., Apr 2 2020, In : International journal of molecular sciences. 21, 8, 2903.Research output: Contribution to journal › Article
Open Access
Isolation of anti-VEGF monoclonal antibodies with neutralizing effects from an Astragalus-induced immune antibody library
Lee, Y. C., Huang, H. T., Chang, C. D., Chen, C. T., Lin, T. Y., Yang, T. W., Chang, F. L., Lu, M. K., Chiou, C. T., Chen, W. C., Pan, S. L. & Tsai, K. C., Nov 2020, In : International Immunopharmacology. 88, 107007.Research output: Contribution to journal › Article
2019
Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model
Kurniawan, A. L., Lee, Y. C., Shih, C. K., Hsieh, R. H., Chen, S. H. & Chang, J. S., Jul 17 2019, In : Food and Function. 10, 7, p. 4113-4123 11 p.Research output: Contribution to journal › Article
3
Citations
(Scopus)
Antigenic epitopes on the outer membrane protein A of Escherichia coli identified with single-chain variable fragment (scFv) antibodies
Mwale, P. F., Lee, C-H., Leu, S-J., Lee, Y-C., Wu, H-H., Lin, L-T., Lin, T. E., Huang, Y-J. & Yang, Y-Y., Apr 26 2019, In : Applied Microbiology and Biotechnology.Research output: Contribution to journal › Article
Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent
Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., Jan 31 2019, In : ACS Omega. 4, 1, p. 2387-2397 11 p.Research output: Contribution to journal › Article
Open Access
1
Citation
(Scopus)
Correction to: Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway (Journal of Biomedical Science (2019) 26 (96) DOI: 10.1186/s12929-019-0588-8)
Wakabayashi, G., Lee, Y. C., Luh, F., Kuo, C. N., Chang, W. C. & Yen, Y., Dec 23 2019, In : Journal of Biomedical Science. 26, 1, 98.Research output: Contribution to journal › Comment/debate
Open Access
Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway
Wakabayashi, G., Lee, Y. C., Luh, F., Kuo, C. N., Chang, W. C. & Yen, Y., Dec 5 2019, In : Journal of Biomedical Science. 26, 1, 96.Research output: Contribution to journal › Review article
Open Access
4
Citations
(Scopus)
Mitochondrial translocation of estrogen receptor β affords resistance to oxidative insult-induced apoptosis and contributes to the pathogenesis of endometriosis
Liao, T. L., Lee, Y. C., Tzeng, C. R., Wang, Y. P., Chang, H. Y., Lin, Y. F. & Kao, S. H., Apr 1 2019, In : Free Radical Biology and Medicine. 134, p. 359-373 15 p.Research output: Contribution to journal › Article
5
Citations
(Scopus)
PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
Lang, Y. D., Chen, H. Y., Ho, C. M., Shih, J. H., Hsu, E. C., Shen, R., Lee, Y. C., Chen, J. W., Wu, C. Y., Yeh, H. W., Chen, R. H. & Jou, Y. S., Dec 1 2019, In : Nature Communications. 10, 1, 5716.Research output: Contribution to journal › Article
Open Access
2
Citations
(Scopus)
2018
Characterization of chicken-derived single chain antibody fragments against venom of Naja naja atra
Lee, C. H., Leu, S. J., Lee, Y. C., Liu, C. I., Lin, L. T., Mwale, P. F., Chiang, J. R., Tsai, B. Y., Chen, C. C., Hung, C. S. & Yang, Y. Y., Oct 1 2018, In : Toxins. 10, 10, 383.Research output: Contribution to journal › Article
3
Citations
(Scopus)
Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer
Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.Research output: Contribution to journal › Article
15
Citations
(Scopus)
Generation and characterization of avian-derived anti-human CD19 single chain fragment antibodies
Tsai, K. C., Chiang, C. W., Lo, Y. N., Chang, F. L., Lin, T. Y., Chang, C. Y., Chen, W. C. & Lee, Y. C., Jan 1 2018, (Accepted/In press) In : Animal Biotechnology. 30, 4, p. 293-301 9 p.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Iatrogenic Teratoma Rupture during TVOR Complicated with Peritonitis, Pleuritis, and Septic Shock
Wang, P-Y., Chang, Y-E., Lee, Y-C. & Tzeng, C. R., 2018, In : Case reports in obstetrics and gynecology. 2018, p. 3126436Research output: Contribution to journal › Article
Interaction of S17 antibody with the functional binding region of the hepatitis B virus pre-S2 epitope
Chang, C. Y., Chang, F. L., Chiang, C. W., Lo, Y. N., Lin, T. Y., Chen, W. C., Tsai, K. C. & Lee, Y. C., Sep 1 2018, In : Viral Immunology. 31, 7, p. 492-499 8 p.Research output: Contribution to journal › Article
2
Citations
(Scopus)
2017
Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo
Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., Feb 9 2017, In : Scientific Reports. 7, 42291.Research output: Contribution to journal › Article
2
Citations
(Scopus)
Correction: Production and characterization of neutralizing antibodies against Bungarus multicinctus snake venom [Applied and Environmental Microbiology, 82, 23, (2016), (6973-6982)] DOI:10.1128/AEM.01876-16
Lee, C. H., Lee, Y. C., Leu, S. J., Lin, L. T., Chiang, J. R., Hsu, W. J. & Yangd, Y. Y., Nov 1 2017, In : Applied and Environmental Microbiology. 83, 22, e01949-17.Research output: Contribution to journal › Comment/debate
Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells
Chao, M. W., Chen, T. H., Huang, H. L., Chang, Y. W., HuangFu, W. C., Lee, Y. C., Teng, C. M. & Pan, S. L., Apr 7 2017, In : Scientific Reports. 7, 46134.Research output: Contribution to journal › Article
14
Citations
(Scopus)
Single chain antibody fragment against venom from the snake Daboia russelii formosensis
Lee, C. H., Lee, Y. C., Lee, Y. L., Leu, S. J., Lin, L. T., Chen, C. C., Chiang, J. R., Fellow, P., Tsai, B. Y., Hung, C. S. & Yang, Y. Y., Nov 1 2017, In : Toxins. 9, 11, 347.Research output: Contribution to journal › Article
9
Citations
(Scopus)
2016
A new era for cancer target therapies: Applying systems biology and computer-aided drug design to cancer therapies
Wong, Y. H., Chiu, C. C., Lin, C. L., Chen, T. S., Jheng, B. R., Lee, Y. C., Chen, J. & Chen, B. S., Nov 1 2016, In : Current Pharmaceutical Biotechnology. 17, 14, p. 1246-1267 22 p.Research output: Contribution to journal › Review article
3
Citations
(Scopus)
Antibodies against venom of the snake Deinagkistrodon acutus
Lee, C. H., Lee, Y. C., Liang, M. H., Leu, S. J., Lin, L. T., Chiang, J. R. & Yang, Y. Y., 2016, In : Applied and Environmental Microbiology. 82, 1, p. 71-80 10 p.Research output: Contribution to journal › Article
15
Citations
(Scopus)
Cellular nuclear export factors TAP and Aly are required for HDAg-L-mediated assembly of hepatitis delta virus
Huang, H. C., Lee, C. P., Liu, H. K., Chang, M. F., Lai, Y. H., Lee, Y. C. & Huang, C., Dec 9 2016, In : Journal of Biological Chemistry. 291, 50, p. 26226-26238 13 p.Research output: Contribution to journal › Article
6
Citations
(Scopus)
Comparative study between 3D-QSAR and Docking-Based Pharmacophore models for potent Plasomodium falciparum dihydroorotate dehydrogenase inhibitors
Tseng, T-S., Lee, Y-C., Hsiao, N-W., Liu, Y-R. & Tsai, K-C., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 2, p. 265-271 7 p.Research output: Contribution to journal › Article
4
Citations
(Scopus)
Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations
Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., Jan 1 2016, In : Molecular BioSystems. 12, 8, p. 2541-2551 11 p.Research output: Contribution to journal › Article
2
Citations
(Scopus)
Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays
Chang, C. C., Yuan, W., Lin, Y. L., Liu, R. S., Juan, Y. C., Sun, W. H., Tsay, H. J., Huang, H. C., Lee, Y. C. & Liu, H. K., Jan 1 2016, In : Evidence-based Complementary and Alternative Medicine. 2016, 3262790.Research output: Contribution to journal › Article
5
Citations
(Scopus)
Production and characterization of neutralizing antibodies against Bungarus multicinctus snake venom
Lee, C. H., Lee, Y-C., Leu, S-J., Lin, L-T., Chiang, J. R., Hsu, W. J. & Yang, Y-Y., 2016, In : Applied and Environmental Microbiology. 82, 23, p. 6973-6982 10 p.Research output: Contribution to journal › Article
13
Citations
(Scopus)
The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity
Chang, C. C., Yuan, W., Roan, H. Y., Chang, J. L., Huang, H. C., Lee, Y. C., Tsay, H. J. & Liu, H. K., Nov 3 2016, In : BMC Complementary and Alternative Medicine. 16, 1, 432.Research output: Contribution to journal › Article
10
Citations
(Scopus)
2015
Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries
Tung, C. P., Chen, I. C., Yu, C. M., Peng, H. P., Jian, J. W., Ma, S. H., Lee, Y. C., Jan, J. T. & Yang, A. S., Oct 12 2015, In : Scientific Reports. 5, 15053.Research output: Contribution to journal › Article
11
Citations
(Scopus)
Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling
Chen, W-C., Tseng, T-S., Hsiao, N-W., Lin, Y-L., Wen, Z-H., Tsai, C-C., Lee, Y-C., Lin, H-H. & Tsai, K-C., 2015, In : Scientific Reports. 5Research output: Contribution to journal › Article
76
Citations
(Scopus)
Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation
Tseng, T-S., Tsai, K-C., Chen, W-C., Wang, Y-T., Lee, Y-C., Lu, C-K., Don, M-J., Chang, C-Y., Lee, C-H., Lin, H-H., Hsu, H-J. & Hsiao, N-W., 2015, In : Journal of Agricultural and Food Chemistry. 63, 27, p. 6181-6188 8 p.Research output: Contribution to journal › Article
11
Citations
(Scopus)
Phage display - Mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom
Lee, Y-C., Hsiao, N-W., Tseng, T-S., Chen, W-C., Lin, H-H., Leu, S. J., Yang, E-W. & Tsai, K-C., Jan 1 2015, In : Molecular Pharmacology. 87, 2, p. 218-230 13 p., A8.Research output: Contribution to journal › Article
14
Citations
(Scopus)
Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Chen, H. S., Hou, S. C., Jian, J. W., Goh, K. S., Shen, S. T., Lee, Y. C., You, J. J., Peng, H. P., Kuo, W. C., Chen, S. T., Peng, M. C., Wang, A. H. J., Yu, C. M., Chen, I. C., Tung, C. P., Chen, T. H., Ping Chiu, K., Ma, C., Yuan Wu, C., Lin, S. W. & 1 others, , Jul 23 2015, In : Scientific Reports. 5, 12411.Research output: Contribution to journal › Article
10
Citations
(Scopus)
Single chain antibody fragment with serine protease inhibitory property capable of neutralizing toxicity of Trimeresurus mucrosquamatus venom
Lee, Y. C., Chen, W. C., Liang, M. H., Lee, C. H., Tsai, K. C., Chiang, J. R., Chiang, L. C., Chen, C. C., Chang, C. Y., Lee, C. H., Leu, S. J. & Yang, Y. Y., May 1 2015, In : Biochemical and Biophysical Research Communications. 460, 2, p. 170-176 7 p.Research output: Contribution to journal › Article
2
Citations
(Scopus)
2014
Antibody variable domain interface and framework sequence requirements for stability and function by high-throughput experiments
Hsu, H. J., Lee, K. H., Jian, J. W., Chang, H. J., Yu, C. M., Lee, Y. C., Chen, I. C., Peng, H. P., Wu, C. Y., Huang, Y. F., Shao, C. Y., Chiu, K. P. & Yang, A. S., Jan 7 2014, In : Structure. 22, 1, p. 22-34 13 p.Research output: Contribution to journal › Article
16
Citations
(Scopus)
Loop-sequence features and stability determinants in antibody variable domains by high-throughput experiments
Chang, H. J., Jian, J. W., Hsu, H. J., Lee, Y. C., Chen, H. S., You, J. J., Hou, S. C., Shao, C. Y., Chen, Y. J., Chiu, K. P., Peng, H. P., Lee, K. H. & Yang, A. S., Jan 7 2014, In : Structure. 22, 1, p. 9-21 13 p.Research output: Contribution to journal › Article
19
Citations
(Scopus)
Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors
Hsiao, N-W., Tseng, T-S., Lee, Y-C., Chen, W-C., Lin, H-H., Chen, Y-R., Wang, Y-T., Hsu, H-J. & Tsai, K-C., 2014, In : Journal of Chemical Information and Modeling. 54, 11, p. 3099-3111 13 p.Research output: Contribution to journal › Article
23
Citations
(Scopus)
2013
Isolation, characterization, and molecular modeling of a rheumatoid factor from a hepatitis C virus infected patient with sjögren's syndrome
Lee, Y. C., Tsai, K. C., Leu, S. J., Wang, T. J., Liu, C. Y. & Yang, Y. Y., 2013, In : Scientific World Journal. 2013, 516516.Research output: Contribution to journal › Article
4
Citations
(Scopus)
2012
Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface
Yu, C. M., Peng, H. P., Chen, I. C., Lee, Y. C., Chen, J. B., Tsai, K. C., Chen, C. T., Chang, J. Y., Yang, E. W., Hsu, P. C., Jian, J. W., Hsu, H. J., Chang, H. J., Hsu, W. L., Huang, K. F., Ma, A. C. & Yang, A. S., Mar 22 2012, In : PLoS One. 7, 3, e33340.Research output: Contribution to journal › Article
29
Citations
(Scopus)
2011
Effects of signal sequence on phage-displayed disulfide-stabilized single chain antibody variable fragment (sc-dsFv) libraries
Lee, Y. C., Chen, I. C., Yu, C. M., Huang, Y. J., Hsu, H. J. & Yang, A. S., Jul 29 2011, In : Biochemical and Biophysical Research Communications. 411, 2, p. 348-353 6 p.Research output: Contribution to journal › Article
2010
A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies
Tsai, K. C., Chen, Y. C., Hsiao, N. W., Wang, C. L., Lin, C. L., Lee, Y. C., Li, M. & Wang, B., Apr 1 2010, In : European Journal of Medicinal Chemistry. 45, 4, p. 1544-1551 8 p.Research output: Contribution to journal › Article
39
Citations
(Scopus)
Engineering anti-vascular endothelial growth factor single chain disulfide-stabilized antibody variable fragments (sc-dsFv) with phage-displayed sc-dsFv libraries
Huang, Y. J., Chen, I. C., Yu, C. M., Lee, Y. C., Hsu, H. J., Ching, A. T. C., Chang, H. J. & Yang, A. S., Mar 12 2010, In : Journal of Biological Chemistry. 285, 11, p. 7880-7891 12 p.Research output: Contribution to journal › Article
16
Citations
(Scopus)
Signal sequence as a determinant in expressing disulfide-stabilized single chain antibody variable fragments (sc-dsFv) against human VEGF
Chen, I. C., Yu, C. M., Lee, Y. C., Huang, Y. J., Hsu, H. J. & Yang, A. S., Jun 21 2010, In : Molecular BioSystems. 6, 7, p. 1307-1315 9 p.Research output: Contribution to journal › Article
2
Citations
(Scopus)
2009
The first pharmacophore model for potent NF-κB inhibitors
Tsai, K-C., Teng, L-W., Shao, Y-M., Chen, Y-C., Lee, Y-C., Li, M-Y. & Hsiao, N-W., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 19, p. 5665-5669 5 p.Research output: Contribution to journal › Article
6
Citations
(Scopus)
2007
A dominant antigenic epitope on SARS-CoV spike protein identified by an avian single-chain variable fragment (scFv)-expressing phage
Lee, Y. C., Leu, S. J. C., Hung, H. C., Wu, H. H., Huang, I. J., Hsieh, W. S., Chiu, W. T., Hsieh, M. S., Cheng, T. F. & Yang, Y. Y., May 15 2007, In : Veterinary Immunology and Immunopathology. 117, 1-2, p. 75-85 11 p.Research output: Contribution to journal › Article
13
Citations
(Scopus)
Chicken single-chain variable fragments against the SARS-CoV spike protein
Lee, Y. C., Leu, S. J. C., Hu, C. J., Shih, N. Y., Huang, I. J., Wu, H. H., Hsieh, W. S., Chiang, B. L., Chiu, W. T. & Yang, Y. Y., Dec 2007, In : Journal of Virological Methods. 146, 1-2, p. 104-111 8 p.Research output: Contribution to journal › Article
9
Citations
(Scopus)
2002
Contribution of heavy chain genes on the binding property of a recombinant human IgG rheumatoid factor
Lee, Y-C., Leu, S-J., Hsieh, M-S., Huang, I. J. & Yang, Y-Y., 2002, In : J. Biomedical and Laboratory Sciences. 14, p. 89-94 6 p.Research output: Contribution to journal › Article