• 423 Citations
  • 13 h-Index
20022020

Research output per year

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Research Output

  • 423 Citations
  • 13 h-Index
  • 42 Article
  • 3 Comment/debate
  • 2 Review article
2020

Astragalus membranaceus-Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors

Chang, F. L., Tsai, K. C., Lin, T. Y., Yang, T. W., Lo, Y. N., Chen, W. C., Chang, J. H., Lu, M. K., Chiou, C. T., Chen, P. H., Yen, Y., Pan, S. L. & Lee, Y. C., Jan 1 2020, In : BioMed Research International. 2020, 3415471.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
Open Access

Generation and Characterization of Single Chain Variable Fragment against Alpha-Enolase of Candida albicans

Leu, S. J., Lee, Y. C., Lee, C. H., Liao, P. Y., Chiang, C. W., Yang, C. M., Su, C. H., Ou, T. Y., Liu, K. J., Lo, H. J., Tsai, B. Y. & Yang, Y. Y., Apr 2 2020, In : International journal of molecular sciences. 21, 8, 2903.

Research output: Contribution to journalArticle

Open Access

Isolation of anti-VEGF monoclonal antibodies with neutralizing effects from an Astragalus-induced immune antibody library

Lee, Y. C., Huang, H. T., Chang, C. D., Chen, C. T., Lin, T. Y., Yang, T. W., Chang, F. L., Lu, M. K., Chiou, C. T., Chen, W. C., Pan, S. L. & Tsai, K. C., Nov 2020, In : International Immunopharmacology. 88, 107007.

Research output: Contribution to journalArticle

2019

Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model

Kurniawan, A. L., Lee, Y. C., Shih, C. K., Hsieh, R. H., Chen, S. H. & Chang, J. S., Jul 17 2019, In : Food and Function. 10, 7, p. 4113-4123 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., Jan 31 2019, In : ACS Omega. 4, 1, p. 2387-2397 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access

Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway

Wakabayashi, G., Lee, Y. C., Luh, F., Kuo, C. N., Chang, W. C. & Yen, Y., Dec 5 2019, In : Journal of Biomedical Science. 26, 1, 96.

Research output: Contribution to journalReview article

Open Access
4 Citations (Scopus)
5 Citations (Scopus)

PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

Lang, Y. D., Chen, H. Y., Ho, C. M., Shih, J. H., Hsu, E. C., Shen, R., Lee, Y. C., Chen, J. W., Wu, C. Y., Yeh, H. W., Chen, R. H. & Jou, Y. S., Dec 1 2019, In : Nature Communications. 10, 1, 5716.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2018

Characterization of chicken-derived single chain antibody fragments against venom of Naja naja atra

Lee, C. H., Leu, S. J., Lee, Y. C., Liu, C. I., Lin, L. T., Mwale, P. F., Chiang, J. R., Tsai, B. Y., Chen, C. C., Hung, C. S. & Yang, Y. Y., Oct 1 2018, In : Toxins. 10, 10, 383.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Generation and characterization of avian-derived anti-human CD19 single chain fragment antibodies

Tsai, K. C., Chiang, C. W., Lo, Y. N., Chang, F. L., Lin, T. Y., Chang, C. Y., Chen, W. C. & Lee, Y. C., Jan 1 2018, (Accepted/In press) In : Animal Biotechnology. 30, 4, p. 293-301 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Interaction of S17 antibody with the functional binding region of the hepatitis B virus pre-S2 epitope

Chang, C. Y., Chang, F. L., Chiang, C. W., Lo, Y. N., Lin, T. Y., Chen, W. C., Tsai, K. C. & Lee, Y. C., Sep 1 2018, In : Viral Immunology. 31, 7, p. 492-499 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., Feb 9 2017, In : Scientific Reports. 7, 42291.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells

Chao, M. W., Chen, T. H., Huang, H. L., Chang, Y. W., HuangFu, W. C., Lee, Y. C., Teng, C. M. & Pan, S. L., Apr 7 2017, In : Scientific Reports. 7, 46134.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Single chain antibody fragment against venom from the snake Daboia russelii formosensis

Lee, C. H., Lee, Y. C., Lee, Y. L., Leu, S. J., Lin, L. T., Chen, C. C., Chiang, J. R., Fellow, P., Tsai, B. Y., Hung, C. S. & Yang, Y. Y., Nov 1 2017, In : Toxins. 9, 11, 347.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2016

A new era for cancer target therapies: Applying systems biology and computer-aided drug design to cancer therapies

Wong, Y. H., Chiu, C. C., Lin, C. L., Chen, T. S., Jheng, B. R., Lee, Y. C., Chen, J. & Chen, B. S., Nov 1 2016, In : Current Pharmaceutical Biotechnology. 17, 14, p. 1246-1267 22 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Antibodies against venom of the snake Deinagkistrodon acutus

Lee, C. H., Lee, Y. C., Liang, M. H., Leu, S. J., Lin, L. T., Chiang, J. R. & Yang, Y. Y., 2016, In : Applied and Environmental Microbiology. 82, 1, p. 71-80 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Cellular nuclear export factors TAP and Aly are required for HDAg-L-mediated assembly of hepatitis delta virus

Huang, H. C., Lee, C. P., Liu, H. K., Chang, M. F., Lai, Y. H., Lee, Y. C. & Huang, C., Dec 9 2016, In : Journal of Biological Chemistry. 291, 50, p. 26226-26238 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
4 Citations (Scopus)

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., Jan 1 2016, In : Molecular BioSystems. 12, 8, p. 2541-2551 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays

Chang, C. C., Yuan, W., Lin, Y. L., Liu, R. S., Juan, Y. C., Sun, W. H., Tsay, H. J., Huang, H. C., Lee, Y. C. & Liu, H. K., Jan 1 2016, In : Evidence-based Complementary and Alternative Medicine. 2016, 3262790.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Production and characterization of neutralizing antibodies against Bungarus multicinctus snake venom

Lee, C. H., Lee, Y-C., Leu, S-J., Lin, L-T., Chiang, J. R., Hsu, W. J. & Yang, Y-Y., 2016, In : Applied and Environmental Microbiology. 82, 23, p. 6973-6982 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity

Chang, C. C., Yuan, W., Roan, H. Y., Chang, J. L., Huang, H. C., Lee, Y. C., Tsay, H. J. & Liu, H. K., Nov 3 2016, In : BMC Complementary and Alternative Medicine. 16, 1, 432.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2015

Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries

Tung, C. P., Chen, I. C., Yu, C. M., Peng, H. P., Jian, J. W., Ma, S. H., Lee, Y. C., Jan, J. T. & Yang, A. S., Oct 12 2015, In : Scientific Reports. 5, 15053.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling

Chen, W-C., Tseng, T-S., Hsiao, N-W., Lin, Y-L., Wen, Z-H., Tsai, C-C., Lee, Y-C., Lin, H-H. & Tsai, K-C., 2015, In : Scientific Reports. 5

Research output: Contribution to journalArticle

76 Citations (Scopus)

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation

Tseng, T-S., Tsai, K-C., Chen, W-C., Wang, Y-T., Lee, Y-C., Lu, C-K., Don, M-J., Chang, C-Y., Lee, C-H., Lin, H-H., Hsu, H-J. & Hsiao, N-W., 2015, In : Journal of Agricultural and Food Chemistry. 63, 27, p. 6181-6188 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Phage display - Mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom

Lee, Y-C., Hsiao, N-W., Tseng, T-S., Chen, W-C., Lin, H-H., Leu, S. J., Yang, E-W. & Tsai, K-C., Jan 1 2015, In : Molecular Pharmacology. 87, 2, p. 218-230 13 p., A8.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens

Chen, H. S., Hou, S. C., Jian, J. W., Goh, K. S., Shen, S. T., Lee, Y. C., You, J. J., Peng, H. P., Kuo, W. C., Chen, S. T., Peng, M. C., Wang, A. H. J., Yu, C. M., Chen, I. C., Tung, C. P., Chen, T. H., Ping Chiu, K., Ma, C., Yuan Wu, C., Lin, S. W. & 1 others, Yang, A. S., Jul 23 2015, In : Scientific Reports. 5, 12411.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Single chain antibody fragment with serine protease inhibitory property capable of neutralizing toxicity of Trimeresurus mucrosquamatus venom

Lee, Y. C., Chen, W. C., Liang, M. H., Lee, C. H., Tsai, K. C., Chiang, J. R., Chiang, L. C., Chen, C. C., Chang, C. Y., Lee, C. H., Leu, S. J. & Yang, Y. Y., May 1 2015, In : Biochemical and Biophysical Research Communications. 460, 2, p. 170-176 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2014

Antibody variable domain interface and framework sequence requirements for stability and function by high-throughput experiments

Hsu, H. J., Lee, K. H., Jian, J. W., Chang, H. J., Yu, C. M., Lee, Y. C., Chen, I. C., Peng, H. P., Wu, C. Y., Huang, Y. F., Shao, C. Y., Chiu, K. P. & Yang, A. S., Jan 7 2014, In : Structure. 22, 1, p. 22-34 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Loop-sequence features and stability determinants in antibody variable domains by high-throughput experiments

Chang, H. J., Jian, J. W., Hsu, H. J., Lee, Y. C., Chen, H. S., You, J. J., Hou, S. C., Shao, C. Y., Chen, Y. J., Chiu, K. P., Peng, H. P., Lee, K. H. & Yang, A. S., Jan 7 2014, In : Structure. 22, 1, p. 9-21 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors

Hsiao, N-W., Tseng, T-S., Lee, Y-C., Chen, W-C., Lin, H-H., Chen, Y-R., Wang, Y-T., Hsu, H-J. & Tsai, K-C., 2014, In : Journal of Chemical Information and Modeling. 54, 11, p. 3099-3111 13 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2013
4 Citations (Scopus)
2012

Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface

Yu, C. M., Peng, H. P., Chen, I. C., Lee, Y. C., Chen, J. B., Tsai, K. C., Chen, C. T., Chang, J. Y., Yang, E. W., Hsu, P. C., Jian, J. W., Hsu, H. J., Chang, H. J., Hsu, W. L., Huang, K. F., Ma, A. C. & Yang, A. S., Mar 22 2012, In : PLoS One. 7, 3, e33340.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2011

Effects of signal sequence on phage-displayed disulfide-stabilized single chain antibody variable fragment (sc-dsFv) libraries

Lee, Y. C., Chen, I. C., Yu, C. M., Huang, Y. J., Hsu, H. J. & Yang, A. S., Jul 29 2011, In : Biochemical and Biophysical Research Communications. 411, 2, p. 348-353 6 p.

Research output: Contribution to journalArticle

2010

A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies

Tsai, K. C., Chen, Y. C., Hsiao, N. W., Wang, C. L., Lin, C. L., Lee, Y. C., Li, M. & Wang, B., Apr 1 2010, In : European Journal of Medicinal Chemistry. 45, 4, p. 1544-1551 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Engineering anti-vascular endothelial growth factor single chain disulfide-stabilized antibody variable fragments (sc-dsFv) with phage-displayed sc-dsFv libraries

Huang, Y. J., Chen, I. C., Yu, C. M., Lee, Y. C., Hsu, H. J., Ching, A. T. C., Chang, H. J. & Yang, A. S., Mar 12 2010, In : Journal of Biological Chemistry. 285, 11, p. 7880-7891 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Signal sequence as a determinant in expressing disulfide-stabilized single chain antibody variable fragments (sc-dsFv) against human VEGF

Chen, I. C., Yu, C. M., Lee, Y. C., Huang, Y. J., Hsu, H. J. & Yang, A. S., Jun 21 2010, In : Molecular BioSystems. 6, 7, p. 1307-1315 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2009

The first pharmacophore model for potent NF-κB inhibitors

Tsai, K-C., Teng, L-W., Shao, Y-M., Chen, Y-C., Lee, Y-C., Li, M-Y. & Hsiao, N-W., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 19, p. 5665-5669 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2007

A dominant antigenic epitope on SARS-CoV spike protein identified by an avian single-chain variable fragment (scFv)-expressing phage

Lee, Y. C., Leu, S. J. C., Hung, H. C., Wu, H. H., Huang, I. J., Hsieh, W. S., Chiu, W. T., Hsieh, M. S., Cheng, T. F. & Yang, Y. Y., May 15 2007, In : Veterinary Immunology and Immunopathology. 117, 1-2, p. 75-85 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Chicken single-chain variable fragments against the SARS-CoV spike protein

Lee, Y. C., Leu, S. J. C., Hu, C. J., Shih, N. Y., Huang, I. J., Wu, H. H., Hsieh, W. S., Chiang, B. L., Chiu, W. T. & Yang, Y. Y., Dec 2007, In : Journal of Virological Methods. 146, 1-2, p. 104-111 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2002

Contribution of heavy chain genes on the binding property of a recombinant human IgG rheumatoid factor

Lee, Y-C., Leu, S-J., Hsieh, M-S., Huang, I. J. & Yang, Y-Y., 2002, In : J. Biomedical and Laboratory Sciences. 14, p. 89-94 6 p.

Research output: Contribution to journalArticle