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Research Output

  • 1430 Citations
  • 22 h-Index
  • 73 Article
  • 2 Patent
  • 1 Comment/debate
2019

Gene-Embedded Nanostructural Biotic-Abiotic Optoelectrode Arrays Applied for Synchronous Brain Optogenetics and Neural Signal Recording

Huang, W. C., Chi, H. S., Lee, Y. C., Lo, Y. C., Liu, T. C., Chiang, M. Y., Chen, H. Y., Li, S. J., Chen, Y. Y. & Chen, S. Y., Mar 27 2019, In : ACS Applied Materials and Interfaces. 11, 12, p. 11270-11282 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Incidence of hydrocephalus in traumatic brain injury: A nationwide population-based cohort study

Chen, K. H., Lee, C. P., Yang, Y. H., Yang, Y. H., Chen, C. M., Lu, M. L., Lee, Y. C. & Chen, V. C. H., Oct 1 2019, In : Medicine. 98, 42, p. e17568

Research output: Contribution to journalArticle

Open Access

Ketamine ameliorates severe traumatic event-induced antidepressant-resistant depression in a rat model through ERK activation

Lee, C. W., Chen, Y. J., Wu, H. F., Chung, Y. J., Lee, Y. C., Li, C. T. & Lin, H. C., Jul 13 2019, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 93, p. 102-113 12 p.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46

Liu, Y-N., Niu, S., Chen, W-Y., Zhang, Q., Tao, Y., Chen, W-H., Jiang, K-C., Chen, X., Shi, H., Liu, A., Li, J., Li, Y., Lee, Y-C., Zhang, X. & Huang, J., Apr 8 2019, In : Clinical cancer research : an official journal of the American Association for Cancer Research.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Morphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations

Huang, N. K., Lin, C. C., Lin, Y. L., Huang, C. L., Chiou, C. T., Lee, Y. C., Lee, S. Y., Huang, H. T. & Yang, Y. C., Jun 1 2019, In : Phytomedicine. 59, 152756.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex

Kuo, C. J., Huang, C. C., Chou, S. Y., Lo, Y. C., Kao, T. J., Huang, N. K., Lin, C., Lin, H. C., Lin, H. C. & Lee, Y. C., Feb 15 2019, In : Phytomedicine. 54, p. 132-139 8 p.

Research output: Contribution to journalArticle

Promyelocytic leukemia zinc finger is involved in the formation of deep layer cortical neurons

Lin, H. C., Ching, Y. H., Huang, C. C., Pao, P. C., Lee, Y. H., Chang, W. C., Kao, T. J. & Lee, Y. C., Apr 26 2019, In : Journal of Biomedical Science. 26, 1, 30.

Research output: Contribution to journalArticle

Open Access
2018
7 Citations (Scopus)

Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts

Hsu, C. K., Lin, H. H., Harn, H. I., Ogawa, R., Wang, Y. K., Ho, Y. T., Chen, W. R., Lee, Y. C., Lee, J. Y. Y., Shieh, S. J., Cheng, C. M., McGrath, J. A. & Tang, M. J., Jan 1 2018, In : Journal of Investigative Dermatology. 138, 1, p. 208-218 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
1 Citation (Scopus)

Highly sensitive/selective 3D nanostructured immunoparticle-based interface on a multichannel sensor array for detecting amyloid-beta in Alzheimer's disease

Liu, T. C., Lee, Y. C., Ko, C. Y., Liu, R. S., Ke, C. C., Lo, Y. C., Hong, P. S., Chu, C. Y., Chang, C. W., Wu, P. W., Chen, Y. Y. & Chen, S. Y., Jan 1 2018, In : Theranostics. 8, 15, p. 4210-4225 16 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Hypoxia-Preconditioned Human Umbilical Vein Endothelial Cells Protect Against Neurovascular Damage After Hypoxic Ischemia in Neonatal Brain

Lee, Y. C., Chang, Y. C., Wu, C. C. & Huang, C. C., Feb 19 2018, (Accepted/In press) In : Molecular Neurobiology. p. 1-15 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway

Yang, J. M., Huang, H. M., Cheng, J. J., Huang, C. L., Lee, Y. C., Chiou, C. T., Huang, H. T., Huang, N. K. & Yang, Y. C., Dec 1 2018, In : Toxicology. 410, p. 65-72 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Nck2 is essential for limb trajectory selection by spinal motor axons

Chang, C. J., Chang, M. Y., Lee, Y. C., Chen, K. Y., Hsu, T. I., Wu, Y. H., Chuang, J. Y. & Kao, T. J., Sep 1 2018, In : Developmental Dynamics. 247, 9, p. 1043-1056 14 p.

Research output: Contribution to journalArticle

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress

Wu, C. C., Lee, P. T., Kao, T. J., Chou, S. Y., Su, R. Y., Lee, Y. C., Yeh, S. H., Liou, J. P., Hsu, T. I., Su, T. P., Chuang, C. K., Chang, W. C. & Chuang, J. Y., Oct 1 2018, In : Redox Biology. 19, p. 74-80 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

Lee, Y-C., Huang, W-C., Lin, J-H., Kao, T-J., Lin, H-C., Lee, K-H., Lin, H-C., Shen, C-K. J., Chang, W-C. & Huang, C-C., Nov 8 2018, In : Journal of Biomedical Science. 25, 1, p. 76 1 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Blockade of dengue virus infection and viral cytotoxicity in neuronal cells in vitro and in vivo by targeting endocytic pathways

Ho, M. R., Tsai, T. T., Chen, C. L., Jhan, M. K., Tsai, C. C., Lee, Y. C., Chen, C. H. & Lin, C. F., Dec 1 2017, In : Scientific Reports. 7, 1, 7023.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Dengue virus infection increases microglial cell migration

Jhan, M. K., Tsai, T. T., Chen, C. L., Tsai, C. C., Cheng, Y. L., Lee, Y. C., Ko, C. Y., Lin, Y. S., Chang, C. P., Lin, L. T. & Lin, C. F., Jan 1 2017, In : Scientific Reports. 7, 1, 91.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells

Huang, T. C., Lee, P. T., Wu, M. H., Huang, C. C., Ko, C. Y., Lee, Y. C., Lin, D. Y., Cheng, Y. W. & Lee, K. H., Aug 1 2017, In : PLoS One. 12, 8, e0181034.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions

Tsou, J. H., Yang, Y. C., Pao, P. C., Lin, H. C., Huang, N. K., Lin, S. T., Hsu, K. S., Yeh, C. M., Lee, K. H., Kuo, C. J., Yang, D. M., Lin, J. H., Chang, W. C. & Lee, Y. C., 2017, In : Molecular Neurobiology. p. 1-15 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus

Wu, H. F., Chen, Y. J., Wu, S. Z., Lee, C. W., Chen, I. T., Lee, Y. C., Huang, C. C., Hsing, C. H., Tang, C. W. & Lin, H. C., 2017, In : Neural Plasticity. 2017, 3467805.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury

Chuang, J-Y., Kao, T-J., Lin, S. H., Wu, A. C., Lee, P. T., Su, T. P., Yeh, S. H., Lee, Y-C., Wu, C-C. & Chang, W-C., Apr 1 2017, In : Redox Biology. 11, p. 135-143 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
4 Citations (Scopus)
2016
6 Citations (Scopus)

Involvement of L-type Ca2+ Channel and Toll-Like Receptor-4 in Nickel-Induced Interleukin-8 Gene Expression

Lin, C. H., Chung, C. A., Wong, J. H., Chen, B. K., Chiu, S. J., Klahan, S., Lee, Y. C. & Chang, W-C., Jan 1 2016, In : Environmental Toxicology. 31, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Microglia retard dengue virus-induced acute viral encephalitis

Tsai, T. T., Chen, C. L., Lin, Y. S., Chang, C. P., Tsai, C. C., Cheng, Y. L., Huang, C. C., Ho, C. J., Lee, Y. C., Lin, L. T., Jhan, M. K. & Lin, C. F., Jun 9 2016, In : Scientific Reports. 6, 27670.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability

Huang, C. L., Chao, C. C., Lee, Y. C., Lu, M. K., Cheng, J. J., Yang, Y. C., Wang, V. C., Chang, W. C. & Huang, N. K., 2016, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

16 Citations (Scopus)

RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription

Yang, C. P., Kuo, Y. L., Lee, Y. C., Lee, K. H., Chiang, C. W., Wang, J. M., Hsu, C. C., Chang, W. C. & Lin, D. Y., Sep 16 2016, In : Biochemical and Biophysical Research Communications. 478, 2, p. 873-880 8 p.

Research output: Contribution to journalArticle

Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS

Chang, C-F., Lee, Y-C., Lee, K-H., Lin, C. H., Chen, C-L., Shen, C. K. J. & Huang, C-C., Oct 21 2016, In : Journal of Biomedical Science. 23, 1, 72.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury

Su, T. C., Lin, S. H., Lee, P. T., Yeh, S. H., Hsieh, T. H., Chou, S. Y., Su, T. P., Hung, J. J., Chang, W. C., Lee, Y. C. & Chuang, J. Y., Jun 1 2016, In : Neuropharmacology. 105, p. 1-9 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2015

BAI1-Associated Protein 2-Like 1 (BAIAP2L1) Is a potential biomarker in ovarian cancer

Chao, A., Tsai, C. L., Jung, S. M., Chuang, W. C., Kao, C., Hsu, A., Chen, S. H., Lin, C. Y., Lee, Y. C., Lee, Y. S., Wang, T. H., Wang, H. S. & Lai, C. H., Jul 29 2015, In : PLoS One. 10, 7, e0133081.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2 Citations (Scopus)

Deficits in cerebellar granule cell development and social interactions in CD47 knockout mice

Hsieh, C. P., Chang, W. T., Lee, Y. C. & Huang, A. M., May 1 2015, In : Developmental Neurobiology. 75, 5, p. 463-484 22 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Erratum: Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58) (Journal of Biomedical Science (2015) 22:60 )

Yang, C. P., Chiang, C. W., Chen, C. H., Lee, Y. C., Wu, M. H., Tsou, Y. H., Yang, Y. S., Chang, W. C. & Lin, D. Y., Jul 24 2015, In : Journal of Biomedical Science. 22, 1, 60.

Research output: Contribution to journalArticle

Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58)

Yang, C. P., Chiang, C. W., Chen, C. H., Lee, Y. C., Wu, M. H., Tsou, Y. H., Yang, Y. S., Chang, W. C. & Lin, D. Y., May 16 2015, In : Journal of Biomedical Science. 22, 1, 33.

Research output: Contribution to journalArticle

6 Citations (Scopus)
10 Citations (Scopus)

Pb2+ induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human gastric carcinoma cells

Lin, Y. C., Wei, P. L., Tsai, Y. T., Wong, J. H., Chang, C. M., Wang, J. Y., Hou, M. F., Lee, Y. C., Chuang, H. Y. & Chang, W. C., Mar 1 2015, In : Environmental Toxicology. 30, 3, p. 315-322 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex

Wu, H. F., Yen, H. J., Huang, C. C., Lee, Y. C., Wu, S. Z., Lee, T. S. & Lin, H. C., Oct 22 2015, (Accepted/In press) In : Journal of Biomedical Science.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer

Su, Y-H., Tang, W. C., Cheng, Y. W., Sia, P., Huang, C. C., Lee, Y. C., Jiang, H. Y., Wu, M. H., Lai, I. L., Lee, J. W. & Lee, K. H., Oct 1 2015, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 10, p. 2261-2272 12 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2014

Increase of Zinc Finger Protein 179 in Response to CCAAT/Enhancer Binding Protein Delta Conferring an Antiapoptotic Effect in Astrocytes of Alzheimer’s Disease

Wang, S. M., Lee, Y. C., Ko, C. Y., Lai, M. D., Lin, D. Y., Pao, P. C., Chi, J. Y., Hsiao, Y. W., Liu, T. L. & Wang, J. M., 2014, In : Molecular Neurobiology. 51, 1, p. 370-382 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
12 Citations (Scopus)

The A2A adenosine receptor is a dual coding gene: A novel mechanism of gene usage and signal transduction

Lee, C. F., Lai, H. L., Lee, Y. C., Chien, C. L. & Chern, Y., Jan 17 2014, In : Journal of Biological Chemistry. 289, 3, p. 1257-1270 14 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2013

Analysis of the interaction between Zinc finger protein 179 (Znf179) and promyelocytic leukemia zinc finger (Plzf)

Lin, D. Y., Huang, C. C., Hsieh, Y. T., Lin, H. C., Pao, P. C., Tsou, J. H., Lai, C. Y., Hung, L. Y., Wang, J. M., Chang, W. C. & Lee, Y. C., Dec 20 2013, In : Journal of Biomedical Science. 20, 1, 98.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2012

58-kDa microspherule protein (MSP58) is novel brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway

Hsu, C. C., Lee, Y. C., Yeh, S. H., Chen, C. H., Wu, C. C., Wang, T. Y., Chen, Y. N., Hung, L. Y., Liu, Y. W., Chen, H. K., Hsiao, Y. T., Wang, W. S., Tsou, J. H., Tsou, Y. H., Wu, M. H., Chang, W. C. & Lin, D. Y., Jun 29 2012, In : Journal of Biological Chemistry. 287, 27, p. 22533-22548 16 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells

Ko, C. Y., Chang, L. H., Lee, Y. C., Sterneck, E., Cheng, C. P., Chen, S. H., Huang, A. M., Tseng, J. T. & Wang, J. M., Feb 2012, In : Neurobiology of Aging. 33, 2

Research output: Contribution to journalArticle

36 Citations (Scopus)

MicroRNA-494 reduces ATF3 expression and promotes AKI

Lan, Y. F., Chen, H. H., Lai, P. F., Cheng, C. F., Huang, Y. T., Lee, Y. C., Chen, T-W. & Lin, H., 2012, In : Journal of the American Society of Nephrology. 23, 12, p. 2012-2023 12 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Minocycline prevents paraquat-induced cell death through attenuating endoplasmic reticulum stress and mitochondrial dysfunction

Huang, C. L., Lee, Y. C., Yang, Y. C., Kuo, T. Y. & Huang, N. K., Mar 25 2012, In : Toxicology Letters. 209, 3, p. 203-210 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

When cytokinin, a plant hormone, meets the adenosine A2A receptor: A novel neuroprotectant and lead for treating neurodegenerative disorders?

Lee, Y. C., Yang, Y. C., Huang, C. L., Kuo, T. Y., Lin, J. H., Yang, D. M. & Huang, N. K., Jun 18 2012, In : PLoS One. 7, 6, e38865.

Research output: Contribution to journalArticle

9 Citations (Scopus)