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Personal profile

Education

  • 1993-1997 Ph.D., Institute of Biochemistry, College of Sciences, National Taiwan University
  • 1991-1993 M.S., Institute of Biochemistry, College of Sciences, National Taiwan University
  • 1985-1989 B.S., Department of Chemistry, National Taiwan Normal University

Experience

  • 2017.08- Professor, International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University
  • 2017.08- Professor, International Ph.D. Program for Cell Therapy and Regeneration Medicine, Taipei Medical University
  • 2016- Member of Director Board, TaiGen Biotechnology (Presenter for National Development Fund, Executive Yuan, Taiwan 行政院國家發展基金會)
  • 2016- Director, Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2016- Director, TMU GTP Laboratory, Taipei Medical University, Taipei, Taiwan
  • 2016- Distinguished Professor, Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2015- Committee Member of Regeneration Medicine and Cell Therapy Development Board, Ministry of Health and Welfare (MOWH衛生福利部再生醫學及細胞治療發展諮議會委員)
  • 2019.08-2022.07 Executive Director, TMU Center for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan
  • 2018.06-2022.07 Director, Core Laboratory of Good Tissue Practice, Office of Research & Development, Taipei Medical University
  • 2019.01-2021.12 Dean, Research and Development, Taipei Medical University
  • 2016.09-2018.12 Director, International Ph.D. Program for Cell Therapy and Regeneration Medicine, Taipei Medical University
  • 2015.04-2019.07 Director, International Ph.D. Program for Cell Therapy and Regeneration Medicine, Taipei Medical University
  • 2014.08-2018.12 Professor Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2014.02- The Ph.D. Program for Translational Medicine, Taipei Medical University
  • 2014.02-2014.07 Director, Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2014- Member of Director Board, Taiwan Society for Stem Cell Research (TSSCR), Taiwan
  • 2014- Member of Director Board, Taiwan Association for Cell Therapy (TACT)
  • 2014- Committee member of JIRB, Taipei Medical University (TMU-JIRB), Taiwan
  • 2014- Committee member of Regeneration Medicine Board, Food and Drug Administration, Taiwan (TFDA 再生醫學諮議小組委員會)
  • 2013.04-2014.07 Professor, Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2011-2013 Secretary General, Taiwan Society for Stem Cell Research (TSSCR), Taiwan
  • 2007.08- Assistant Professor, Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
  • 2007.02-2013.03 Associate Professor, Department of Biochemistry and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2009- Visiting Scholarship, the Stem Cell Core, NTU Research Center for Medical Excellence, National Taiwan University, Taipei, Taiwan
  • 2002-2006 Assistant Professor, Department of Biochemistry and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2003-2004 Visiting Scholarship, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan
  • 2002.02-2007.01 Assistant Professor, Department of Biochemistry and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2001-2002 Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
  • 1998-2001 Postdoctoral Fellow, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
  • 1997.08-1998.07 Postdoctoral Fellow, Institute of Biomedical Sciences, College of Life Sciences, National Taiwan University
  • 1990.01-1991.06 Teaching Assistant, Department of Chemistry, National Taiwan Normal University

Awards

2017

  • 2017 Project Review Board, Food and Health Bureau (FHB) of The Government of the HKSAR, Hong Kong
  • 2017 The Best Paper Award, “IGF-1R Promotes Symmetric Self-Renewal and Migration of Alkaline Phosphatase-Positive Germ Stem Cells”, 2017 International Conference of Development Biology, Stem Cells and Regenerative Medicine-From Basic Research to Applications (2017 DBSRM), Taipei, Taiwan
  • 2017 The Best Paper Award, “IL-6 Upregulates the OCT4 Expression through STAT3-Dependent DNMT3b-OCT4-DNMT1 Axis in HBV-related Hepatocellular Carcinoma”, 2017 International Conference of Development Biology, Stem Cells and Regenerative Medicine-From Basic Research to Applications (2017 DBSRM), Taipei, Taiwan

2016

  • 2016 臺北醫學大學特聘教授
  • 2016 Distinguished Professor, Taipei Medical University, Taipei, Taiwan       
  • 2016 台灣癌症醫學會 董大成博士癌症基礎醫學研究傑出獎
  • 2016 The Outstanding Basic Research Award for Cancer Medicine of Dr. Da-Cheng Tung, The Chinese Oncology Society (COS).
  • 2016 The Prize Poster Award, “Niche ECM Laminin Mediates the Expressions of Pluripotent Transcription Factor Oct4 through IGF-IR- HIF-2α- CD49f Circuit Loop in Mouse Germline Stem Cells” 2016 Taiwan Society for Stem Cell Research (2016 TSSCR), Taipei, Taiwan
  • 2016 科技部105年度補助大專校院獎勵特殊優秀人才獎勵
  • 2016 臺灣女科技人群像介紹

2015

  • 2015臺北醫學大學國際頂尖論文獎  2015 The International Top Journal Research Award of Taipei Medical University
  • 2015   臺北醫學大學研究論文獎­—優良獎  2015 The Excellent Prize Research Award of Taipei Medical University
  • 2015   科技部104年度補助大專校院獎勵特殊優秀人才獎勵
  • 2015   The Prize Oral Award, “Insulin-like Growth Factor I Stimulates Cell Migration Through SDF-1/CXCR4 Regulation in Mouse Germline Stem Cells”, 2015 Taiwan Society For Stem Cell Research (2015 TSSCR), Taipei, Taiwan
  • 2015   The Prize Poster Award, “Insulin-like Growth Factor I Stimulates the Expressions of HIF-2α and Oct-4 Requiring α6 Integrin in Mouse Germline Stem Cells”, 2014 Taiwan Society For Stem Cell Research (2015 TSSCR), Taipei, Taiwan

2014  

  • 2014 The Prize Poster Award, “Insulin-like Growth Factor I Stimulates the Expressions of HIF-2α and Oct-4 Requiring α6 Integrin in Mouse Germline Stem Cells”, 2014 Taiwan Society For Stem Cell Research (2014 TSSCR), Taipei, Taiwan
  • 2014 科技部103年度補助大專校院獎勵特殊優秀人才獎勵

2013   

  • 2013 臺北醫學大學師鐸獎  2013 Faculty Award of Taipei Medical University in Excellence of Teaching, Administration, and Research.
  • 2013    The First Prize Oral Award, “IGF-1R-HIF-2 Signal Loop Supports the Proliferation and Oct-4 Maintenance of Alkaline Phosphatase Positive Mouse Germline Stem Cells Under Hypoxia. 2013 TSRM, Annual Meeting of Taiwan Society for Reproductive Medicine
  • 2013    The Prize Poster Award, “Interleukin-6 Regulates Stemness Expression and Early Recurrence of HBV-related Hepatocellular Carcinoma via IGF-IR Activation” & “Role of IGF-1R Signaling in Oct-4 Maintenance of Alkaline Phosphatase Positive Germline Stem Cells”. 2013 The 27th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.
  • 2013    The Excellent Research Paper Award,” Interleukin-6 Regulates Stemness Expression and Early Recurrence of HBV-related Hepatocellular Carcinoma via IGF-IR Activation “. 2013 Teachers and Students Joint Academic Research Symposium,Taipei Medical University, Taipei, Taiwan
  • 2013    The Prize Poster Award, “ IGF-IR-HIF-2 Signaling Loop Supports the Cell Proliferation and Oct4 Maintenance of Alkaline Phosphatase Positive Mouse Germline Stem Cell. 2013 Taiwan Society for Stem Cell Research (2013 TSSCR), Taipei, Taiwan.
  • 2013    The Prize Poster Award, “ HBx Stimulates the Expression of Stemness-related Properties through SENP1in HBV-related Hepatocellular Carcinomas. 2013 Taiwan Society for Stem Cell Research (2013 TSSCR), Taipei, Taiwan.
  • 2013    2013 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2012   

  • 2012 The Prize Poster Award, “ IL-6 stimulates stemness properties and early recurrence of HCC through IGF-IR activation. 2012 Taiwan Society for Stem Cell Research (2012 TSSCR), Taipei, Taiwan.
  • 2012    2012 The Second Prize Award of Excellent Research, Taipei Medical University, Taipei, Taiwan
  • 2012    The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2011       

  • 2011 The Second Prize Oral Award, “ SENP1 Regulates OCT4 Under Hypoxia: Effect of Sumoylation on Protein Stability and Drug Susceptibility of Human Pluripotent Germ Cell Tumors” 2011 International Symposium on Recent Advances in Pluripotent Stem Cells &  7th Annual Meeting of Taiwan Society for Stem Cell Research (2011 TSSCR).
  • 2011   The First Prize Oral Award, “Inflammation enhances the transformation of epithelial-like endometrium stem cells and initiates endometriosis”. 2011 Taiwan Society for Reproductive Medicine, Taipei, Taiwan (2011 TSRM)
  • 2011    The First Prize Award of Excellent Research, “Role of IL-6-IGF-1R Signaling in Early Recurrence and OCT4/NANOG Expression of HBV-related HCCs”. Taipei Medical University, Taipei, Taiwan
  • 2011    The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2010  

  • 2010 臺北醫學大學第一屆校級優良教師
  • 2010   2010 Prize Poster Award, “Crosstalking of Hypoxia and IGF-1 Signaling in Transformation of Mouse Germline Stem Cells”. The 18th Conference of The Chinese Society of Cell and Molecular Biology, Kaoshung, Taiwan
  • 2010 The First Prize Poster Award, “Role of inflammation in transformation of epithelial-like endometrium stem cells and it’s implication on endometriosis”. 2010 Taiwan Society for Reproductive Medicine, Taipei, Taiwan (2010 TSRM)
  • 2010 The First Prize Award of Excellent Research, “Role of Inflammation in Transformation of Epithelial-like Endometrium Stem Cells and its Implication on Endometriosis”, Taipei Medical University, Taipei, Taiwan
  • 2010 The Second Prize Award of Excellent Research, “IGF-1 is Required for Maintenance of Pluripotency of Mouse Spermatogonial Stem Cells”, Taipei Medical University, Taipei, Taiwan
  • 2010 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2009

  • 2009 Prize Award, The 7th Conference of the Pacific Rim Society for Fertility and Sterility (PRSFS 2009) – “ Hypoxia Stress Enhances the IGF-1 Signaling in Pluripotent Mouse Germline Stem Cells” , Taipei, Taiwan (2009 PRSFS)
  • 2009 Prize Award, The 7th Conference of the Pacific Rim Society for Fertility and Sterility (PRSFS 2009)- “Role of IGF-1/IGF-1R Signaling in Mouse Germline Stem Cells’ Pluripotency and Tumorigenesis”, Taipei, Taiwan  (2009 PRSFS)
  • 2009 Prize Poster Award, “Insulin-like Growth Factor 1 is Required for Pluripotency of Mouse Spermatogonial Stem Cells”. The 17th Conference of The Chinese Society of Cell and Molecular Biology, Kaoshung, Taiwan
  • 2009 The First Prize Award of Excellent Research,“Cross-talking of Hypoxia and IGF-1 Signaling in Pluripotent Spermatogonial Stem Cells“, Taipei Medical University, Taipei, Taiwan
  • 2009 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2008

  • 2008 Travel Award of theInternational Society for Stem Cell Research 6th Annual Meeting, Philadephia, USA
  • 2008 Prize Poster Award, The 17th Conference of Cell and Molecular Biology- “IGF-1 is Required for Maintenance of Pluripotency in Mouse Germ Line Stem Cells”. Kaoshing, Taiwan
  • 2008 The First Prize Award of Excellent Research, “IGF-1 is Required for Maintenance of Pluripotency of Mouse Spermatogonial Stem Cells”, Taipei Medical University, Taipei, Taiwan
  • 2008 The Second Prize Award of Excellent Research, Taipei Medical University, Taipei, Taiwan
  • 2008 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2007

  • 2007 The First Prize Award of Excellent Research, “Functional Characterization of a Novel Human Guanylyl Cyclase in Sperm“, Taipei Medical University, Taipei, Taiwan
  • 2007 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2006

  • 2006 The Second Prize Award of Excellent Research, “Functional Characterization of an Orphan Receptor, Gguanylyl Cyclase G, in Mouse Sperm”, Taipei Medical University, Taipei, Taiwan
  • 2006 Travel Award of theInternational Society for Stem Cell Research 4th Annual Meeting, Toronto, Canada
  • 2006 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2005   

  • 2005 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2004   

  • 2004 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2004 Visiting Scholarship, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan

2003

  • 2003 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2003 Visiting Scholarship, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan

2002

  • 2002 Visiting Scholarship, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan

2001

  • 2001 Postdoctoral Fellowship Award, Academia Sinica, Taipei, Taiwan

2000

  • 2000 The Prize Award of The 8th K.T.Li General Scientific Composition of K.T.Li Foundation for the Development of Science and Technology, Taipei, Taiwan
  • 2000 Postdoctoral Fellowship Award, Academia Sinica, Taipei, Taiwan

1999

  • 1999 The Prize Award of The 7th K.T.Li General Scientific Composition of K.T.Li Foundation for the Development of Science and Technology, Taipei, Taiwan
  • Postdoctoral Fellowship Award, Academia Sinica, Taipei, Taiwan 

1998

  • 1998 Postdoctoral Fellowship Award, Academia Sinica, Taipei, Taiwan

Research Interests

  • Stem cells and cancer stem cytology, Stem cell therapy, cytology, biochemistry, molecular biology

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