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Research Output 1996 2019

  • 5466 Citations
  • 40 h-Index
  • 99 Article
2019
Curcumin
Endothelin-1
Fibroblasts
Thrombin
Phosphotransferases
2018
Vascular Endothelial Growth Factor A
Thromboembolism
Genetic Polymorphisms
Vasoconstriction
Cardiac Myocytes
2 Citations (Scopus)

Hypoxia stimulates the epithelial-to-mesenchymal transition in lung cancer cells through accumulation of nuclear β-catenin

Liu, K. H., Tsai, Y. T., Chin, S. Y., Lee, W. R., Chen, Y. C. & Shen, S. C., Nov 1 2018, In : Anticancer Research. 38, 11, p. 6299-6308 10 p.

Research output: Contribution to journalArticle

Catenins
Epithelial-Mesenchymal Transition
Lung Neoplasms
Hypoxia-Inducible Factor 1
Snails
1 Citation (Scopus)
Tubulin Modulators
G2 Phase Cell Cycle Checkpoints
Colorectal Neoplasms
Apoptosis
Growth
Monophenol Monooxygenase
Acetylcysteine
Melanoma
Reactive Oxygen Species
Phosphotransferases
2017
16 Citations (Scopus)

Evodiamine Prevents Glioma Growth, Induces Glioblastoma Cell Apoptosis and Cell Cycle Arrest through JNK Activation

Wu, W. S., Chien, C. C., Liu, K. H., Chen, Y. C. & Chiu, W. T., 2017, In : American Journal of Chinese Medicine. 45, 4, p. 879-899 21 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Cycle Checkpoints
Glioma
Phosphotransferases
Apoptosis
3 Citations (Scopus)

Hispolon Suppresses LPS- or LTA-Induced iNOS/NO Production and Apoptosis in BV-2 Microglial Cells

Wu, M. S., Chien, C. C., Cheng, K. T., Subbaraju, G. V. & Chen, Y. C., 2017, (Accepted/In press) In : American Journal of Chinese Medicine. p. 1-18 18 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Nitric Oxide Synthase
Lipopolysaccharides
Nitric Oxide
Apoptosis
2016
29 Citations (Scopus)

Evodiamine from Evodia rutaecarpa induces apoptosis via activation of JNK and PERK in human ovarian cancer cells

Chen, T. C., Chien, C. C., Wu, M. S. & Chen, Y. C., Jan 15 2016, In : Phytomedicine. 23, 1, p. 68-78 11 p.

Research output: Contribution to journalArticle

Evodia
Ovarian Neoplasms
Apoptosis
Mitochondrial Membrane Potential
evodiamine
10 Citations (Scopus)

miR-19a, -19b, and -26b Mediate CTGF Expression and Pulmonary Fibroblast Differentiation

Chen, Y. C., Chen, B. C., Yu, C. C., Lin, S. H. & Lin, C-H., Oct 1 2016, In : Journal of Cellular Physiology. 231, 10, p. 2236-2248 13 p.

Research output: Contribution to journalArticle

Connective Tissue Growth Factor
Fibroblasts
MicroRNAs
Lung
Endothelin-1
7 Citations (Scopus)

Nilotinib reduced the viability of human ovarian cancer cells via mitochondria-dependent apoptosis, independent of JNK activation

Chen, T. C., Yu, M. C., Chien, C. C., Wu, M. S., Lee, Y. C. & Chen, Y. C., Mar 1 2016, In : Toxicology in Vitro. 31, p. 1-11 11 p.

Research output: Contribution to journalArticle

Mitochondria
Ovarian Neoplasms
Phosphotransferases
Chemical activation
Cells
9 Citations (Scopus)
Phosphorylation
protein phosphorylation
kidney cells
Renal Cell Carcinoma
Endoplasmic Reticulum
2015
33 Citations (Scopus)
Antrodia
Taiwanofungus camphoratus
gelatinase B
Epithelial-Mesenchymal Transition
Transcription Factor AP-1

Congenital anomaly of single dominant right coronary artery with hypoplastic left coronary artery

Chuang, C. Y., Chen, Y. C., Cheng, H. S. & Hsieh, M. H., Nov 1 2015, In : Acta Cardiologica Sinica. 31, 6, p. 557-559 3 p.

Research output: Contribution to journalArticle

Coronary Vessels
Coronary Angiography
Arteries
Tomography
Coronary Circulation
7 Citations (Scopus)

Early decline in serum phospho-CSE1L levels in vemurafenib/sunitinib-treated melanoma and sorafenib/lapatinib-treated colorectal tumor xenografts

Lee, W. R., Shen, S. C., Shih, Y. H., Chou, C. L., Tseng, J. T. P., Chin, S. Y., Liu, K. H., Chen, Y. C. & Jiang, M. C., Jun 13 2015, In : Journal of Translational Medicine. 13, 1, 191.

Research output: Contribution to journalArticle

Heterografts
Tumors
Colorectal Neoplasms
Melanoma
Phosphorylation
2014
41 Citations (Scopus)

Activation of JNK contributes to evodiamine-induced apoptosis and G 2/M arrest in human colorectal carcinoma cells: A structure-activity study of evodiamine

Chien, C. C., Wu, M. S., Shen, S. C., Ko, C. H., Chen, C. H., Yang, L. L. & Chen, Y. C., Jun 24 2014, In : PLoS One. 9, 6, e99729.

Research output: Contribution to journalArticle

HT29 Cells
colorectal neoplasms
Colorectal Neoplasms
phosphotransferases (kinases)
Phosphotransferases
4 Citations (Scopus)
Ventricular Fibrillation
Electrocardiography
Lead
13 Citations (Scopus)

Hispolon inhibition of inflammatory apoptosis through reduction of iNOS/NO production via HO-1 induction in macrophages

Yang, L. Y., Shen, S. C., Cheng, K. T., Subbaraju, G. V., Chien, C. C. & Chen, Y. C., Oct 28 2014, In : Journal of Ethnopharmacology. 156, p. 61-72 12 p.

Research output: Contribution to journalArticle

Macrophages
Transcription Factor AP-1
Proteins
Acetylcysteine
Anti-Inflammatory Agents
18 Citations (Scopus)
Acetylcysteine
Colonic Neoplasms
Apoptosis
Caspase 3
Caspase Inhibitors
40 Citations (Scopus)

Phosphorylation of paxillin confers cisplatin resistance in non-small cell lung cancer via activating ERK-mediated Bcl-2 expression

Wu, D. W., Wu, T. C., Wu, J. Y., Cheng, Y. W., Chen, Y. C., Lee, M. C., Chen, C. Y. & Lee, H., Aug 28 2014, In : Oncogene. 33, 35, p. 4385-4395 11 p.

Research output: Contribution to journalArticle

Paxillin
Non-Small Cell Lung Carcinoma
Cisplatin
Phosphorylation
Neoplasms
21 Citations (Scopus)

Reactive oxygen species-dependent nitric oxide production in reciprocal interactions of glioma and microglial cells

Shen, S. C., Wu, M. S., Lin, H. Y., Yang, L. Y., Chen, Y. H. & Chen, Y. C., 2014, In : Journal of Cellular Physiology. 229, 12, p. 2015-2026 12 p.

Research output: Contribution to journalArticle

Conditioned Culture Medium
Glioma
Reactive Oxygen Species
Nitric Oxide
Chemokine CCL2
34 Citations (Scopus)
HSP90 Heat-Shock Proteins
Heme Oxygenase-1
Carbon Monoxide
Byproducts
Cells
2013
Ehlers-Danlos Syndrome
Coronary Angiography
Compartment Syndromes
Endovascular Procedures
Radial Artery
2 Citations (Scopus)
HL-60 Cells
Tetradecanoylphorbol Acetate
Arachidonic Acid
Reactive Oxygen Species
Leukemia
12 Citations (Scopus)
Colonic Neoplasms
Apoptosis
Caspase 3
Caspase 9
monorden
41 Citations (Scopus)
Propionibacterium acnes
Macrophage Activation
Macrophages
Transcription Factor AP-1
Nitric Oxide Synthase Type II
9 Citations (Scopus)

Screening of flavonoids for effective osteoclastogenesis suppression

Wu, Y. W., Chen, S. C., Lai, W-F., Chen, Y. C. & Tsai, Y-H., Feb 1 2013, In : Analytical Biochemistry. 433, 1, p. 48-55 8 p.

Research output: Contribution to journalArticle

Osteoclasts
Acid Phosphatase
Flavonoids
Osteogenesis
Screening
5 Citations (Scopus)

Wunderlich syndrome

Chen, Y. C. & Lin, Y. C., Feb 2013, In : QJM. 106, 2, p. 187-188 2 p., hcr266.

Research output: Contribution to journalArticle

Fecal Impaction
Angiomyolipoma
X Ray Computed Tomography
Creatine
Kidney Neoplasms
2012
9 Citations (Scopus)

Nitric oxide inhibits androgen receptor-mediated collagen production in human gingival fibroblasts

Lin, S. J., Lu, H. K., Lee, H. W., Chen, Y. C., Li, C. L. & Wang, L-F., Dec 2012, In : Journal of Periodontal Research. 47, 6, p. 701-710 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
Nifedipine
Interleukin-1
Gingival Overgrowth
Nitric Oxide
8 Citations (Scopus)
Heme Oxygenase-1
Peptidoglycan
Nitric Oxide Synthase Type II
Prostaglandins
Lipopolysaccharides
22 Citations (Scopus)
Ubiquitination
Quercetin
Arsenic
Keratinocytes
Reactive Oxygen Species
15 Citations (Scopus)

The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells

Chien, C. C., Ko, C. H., Shen, S. C., Yang, L. Y. & Chen, Y. C., Aug 2012, In : Journal of Cellular Physiology. 227, 8, p. 3128-3137 10 p.

Research output: Contribution to journalArticle

Gossypol
Cyclooxygenase 2
Dinoprostone
Colorectal Neoplasms
Cells
2011
22 Citations (Scopus)

Direct and indirect effects of ceramic far infrared radiation on the hydrogen peroxide-scavenging capacity and on murine macrophages under oxidative stress

Leung, T-K., Lin, Y. S., Lee, C-M., Chen, Y. C., Shang, H. F., Hsiao, S. Y., Chang, H. T. & Chao, J. S., 2011, In : Journal of Medical and Biological Engineering. 31, 5, p. 345-351 7 p.

Research output: Contribution to journalArticle

Infrared Rays
Oxidative stress
Macrophages
Scavenging
Ceramics
13 Citations (Scopus)

Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells

Chang, S. P., Shen, S. C., Lee, W. R., Yang, L-L. & Chen, Y. C., Jun 2011, In : Journal of Dermatological Science. 62, 3, p. 183-191 9 p.

Research output: Contribution to journalArticle

Melanoma
Reactive Oxygen Species
Apoptosis
Acetylcysteine
Enzyme activity
18 Citations (Scopus)

Inhibition of HSP90-dependent telomerase activity in amyloid β-induced apoptosis of cerebral endothelial cells

Chiu, W-T., Shen, S-C., Yang, L-Y., Chow, J-M., Wu, C. Y. & Chen, Y-C., Aug 2011, In : Journal of Cellular Physiology. 226, 8, p. 2041-2051 11 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Telomerase
Endothelial cells
Amyloid
Endothelial Cells
16 Citations (Scopus)

Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells

Wu, J., Chien, C. C., Yang, L. Y., Huang, G. C., Cheng, M. C., Lin, C. T., Shen, S. C. & Chen, Y. C., Aug 15 2011, In : Chemico-Biological Interactions. 193, 1, p. 3-11 9 p.

Research output: Contribution to journalArticle

Vitamin K 3
Phosphorylation
Epoxy Compounds
Glioma
Caspase 3
2010
74 Citations (Scopus)
Extracellular Signal-Regulated MAP Kinases
Tetradecanoylphorbol Acetate
Glioblastoma
Matrix Metalloproteinases
Protein Kinase C
67 Citations (Scopus)
Extracellular Signal-Regulated MAP Kinases
Tetradecanoylphorbol Acetate
Cyclooxygenase 2
Glioblastoma
Dinoprostone
23 Citations (Scopus)

Reciprocal activation of macrophages and breast carcinoma cells by nitric oxide and colony-stimulating factor-1

Liny, C. W., Shen, S-C., Ko, C. H., Lin, H. Y. & Chen, Y-C., Dec 2010, In : Carcinogenesis. 31, 12, p. 2039-2048 10 p.

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor
Macrophage Activation
Nitric Oxide Synthase Type II
Nitric Oxide
Macrophages
2009
9 Citations (Scopus)

Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis

Chien, C. C., Shen, S. C., Yang, L. Y., Wu, C. Y., Liau, J. S. & Chen, Y. C., Feb 2009, In : Journal of Cellular Physiology. 218, 2, p. 405-415 11 p.

Research output: Contribution to journalArticle

Telomerase
Platelet-Derived Growth Factor
Cyclooxygenase 2
Chemical activation
Fibroblast Growth Factor 2
1 Citation (Scopus)

Biochemical alteration in cerebrospinal fluid precedes behavioral deficits in Parkinsonian rats induced by 6-hydroxydopamine

Lin, J-W., Shih, C-M., Chen, Y-C., Lin, C-M., Tsai, J-T., Chiang, Y-H., Shih, R., Chiu, P. L., Hung, K-S., Yeh, Y. S., Wei, L., Chiu, W-T. & Yang, L-Y., Dec 2009, In : Surgical Neurology. 72, SUPPL. 2, p. S55-S65

Research output: Contribution to journalArticle

Oxidopamine
Dopaminergic Neurons
Cerebrospinal Fluid
Hypokinesia
Animal Behavior
11 Citations (Scopus)
JNK Mitogen-Activated Protein Kinases
Enzyme activity
Lipopolysaccharides
Nitric Oxide
Chemical activation
36 Citations (Scopus)

Hyaluronic acid inhibits the glial scar formation after brain damage with tissue loss in rats

Lin, C. M., Lin, J. W., Chen, Y. C., Shen, H. H., Wei, L., Yeh, Y. S., Chiang, Y. H., Shih, R., Chiu, P. L., Hung, K. S., Yang, L. Y. & Chiu, W. T., Dec 2009, In : Surgical Neurology. 72, SUPPL. 2, p. S50-S54

Research output: Contribution to journalArticle

Gliosis
Hyaluronic Acid
Neuroglia
Cicatrix
Brain
24 Citations (Scopus)

Immunomodulatory effects of far-infrared ray irradiation via increasing calmodulin and nitric oxide production in raw 264.7 macrophages

Leung, T-K., Lin, Y. S., Chen, Y. C., Shang, H. F., Lee, Y. H., Su, C. H., Liao, H. C. & Chang, T. M., Oct 2009, In : Biomedical Engineering - Applications, Basis and Communications. 21, 5, p. 317-323 7 p.

Research output: Contribution to journalArticle

Calmodulin
Infrared Rays
Macrophages
Nitric oxide
Nitric Oxide
70 Citations (Scopus)

The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells

Wang, A. M., Ku, H. H., Liang, Y. C., Chen, Y. C., Hwu, Y. M. & Tsai, T-S., Mar 1 2009, In : Journal of Cellular Biochemistry. 106, 4, p. 682-692 11 p.

Research output: Contribution to journalArticle

Niclosamide
K562 Cells
Signal Transduction
Notch Receptors
Luciferases
16 Citations (Scopus)
Peptidoglycan
Ubiquitination
Lipopolysaccharides
Nitric Oxide
Heme Oxygenase-1
2008
22 Citations (Scopus)

Cytotoxic effects of metal protoporphyrins in glioblastoma cells: Roles of albumin, reactive oxygen species, and heme oxygenase-1

Chow, J-M., Huang, G. C., Lin, H. Y., Shen, S-C., Yang, L-Y. & Chen, Y-C., Mar 15 2008, In : Toxicology Letters. 177, 2, p. 97-107 11 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Protoporphyrins
Glioblastoma
Albumins
Reactive Oxygen Species
27 Citations (Scopus)

Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells

Chow, J-M., Huang, G. C., Shen, S-C., Wu, C. Y., Lin, C-W. & Chen, Y-C., Apr 1 2008, In : Journal of Cellular Biochemistry. 103, 5, p. 1394-1404 11 p.

Research output: Contribution to journalArticle

Hydroxyl Radical
Leukemia
HL-60 Cells
Flavonoids
Apoptosis
87 Citations (Scopus)
Heme Oxygenase-1
Matrix Metalloproteinase 9
Tetradecanoylphorbol Acetate
Breast Neoplasms
MCF-7 Cells
151 Citations (Scopus)
Proto-Oncogene Proteins c-jun
Quercetin
Extracellular Signal-Regulated MAP Kinases
Matrix Metalloproteinase 9
Transcription Factor AP-1
26 Citations (Scopus)
Arsenicals
Telomerase
Reactive Oxygen Species
Chemical activation
Apoptosis