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Wei-Jiunn Lee

Assistant Professor

 https://orcid.org/0000-0002-4003-9503
  • 1170 Citations
  • 20 h-Index
20062020
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Research Output 2006 2019

  • 1170 Citations
  • 20 h-Index
  • 50 Article
  • 1 Conference contribution
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Article
2019
1 Citation (Scopus)

Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response

Hung, W. Y., Chang, J. H., Cheng, Y., Cheng, G. Z., Huang, H. C., Hsiao, M., Chung, C. L., Lee, W. J. & Chien, M. H., Aug 1 2019, In : Cell Death and Disease. 10, 8, 538.

Research output: Contribution to journal › Article

Open Access
Penfluridol
Unfolded Protein Response
Lung Neoplasms
Cell Death
Adenosine Triphosphate
1 Citation (Scopus)

Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses

Wu, S. Y., Wen, Y. C., Ku, C. C., Yang, Y. C., Chow, J. M., Yang, S. F., Lee, W. J. & Chien, M. H., Aug 31 2019, In : Journal of Biomedical Science. 26, 1, 63.

Research output: Contribution to journal › Article

Open Access
Penfluridol
fms-Like Tyrosine Kinase 3
Protein Phosphatase 2
Autophagy
Mitogen-Activated Protein Kinases
1 Citation (Scopus)

Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis

Chien, M. H., Lin, Y. W., Wen, Y. C., Yang, Y. C., Hsiao, M., Chang, J. L., Huang, H. C. & Lee, W. J., Jun 10 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 246.

Research output: Contribution to journal › Article

Open Access
Osteonectin
Apigenin
Gastropoda
Epithelial-Mesenchymal Transition
Snails
2018
10 Citations (Scopus)

Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses

Chang, J. H., Cheng, C. W., Yang, Y. C., Chen, W. S., Hung, W. Y., Chow, J. M., Chen, P. S., Hsiao, M., Lee, W. J. & Chien, M. H., Aug 22 2018, In : Journal of Experimental and Clinical Cancer Research. 37, 1, 199.

Research output: Contribution to journal › Article

Dipeptidyl Peptidase 4
Apigenin
Gastropoda
Epidermal Growth Factor Receptor
Lung Neoplasms
2 Citations (Scopus)

Leukocyte Cell-Derived Chemotaxin 2 Retards Non-Small Cell Lung Cancer Progression Through Antagonizing MET and EGFR Activities

Hung, W. Y., Chang, J. H., Cheng, Y., Chen, C. K., Chen, J. Q., Hua, K. T., Cheng, C. W., Hsiao, M., Chung, C. L., Lee, W. J. & Chien, M. H., Jan 1 2018, In : Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 51, 1, p. 337-355 19 p.

Research output: Contribution to journal › Article

Chemotactic Factors
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Leukocytes
Lewis Lung Carcinoma
8 Citations (Scopus)

Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress

Yang, Y. C., Chien, M. H., Liu, H. Y., Chang, Y. C., Chen, C. K., Lee, W. J., Kuo, T. C., Hsiao, M., Hua, K. T. & Cheng, T. Y., May 1 2018, In : Cancer Letters. 421, p. 28-40 13 p.

Research output: Contribution to journal › Article

AMP-Activated Protein Kinases
Pyruvate Kinase
Neoplastic Stem Cells
Glucose
Physiological Stress
2 Citations (Scopus)

N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas

Chien, M. H., Lee, W. J., Yang, Y. C., Tan, P., Pan, K. F., Liu, Y. C., Tsai, H. C., Hsu, C. H., Wen, Y. C., Hsiao, M. & Hua, K. T., Oct 1 2018, In : Cancer Letters. 433, p. 86-98 13 p.

Research output: Contribution to journal › Article

Acetyltransferases
Matrix Metalloproteinase 2
Osteosarcoma
Neoplasm Metastasis
Proteins
2 Citations (Scopus)

Stimulation of Fas/FasL-mediated apoptosis by luteolin through enhancement of histone H3 acetylation and c-Jun activation in HL-60 leukemia cells

Wang, S. W., Chen, Y. R., Chow, J. M., Chien, M. H., Yang, S. F., Wen, Y. C., Lee, W. J. & Tseng, T. H., Jan 1 2018, (Accepted/In press) In : Molecular Carcinogenesis.

Research output: Contribution to journal › Article

Luteolin
Fas Ligand Protein
HL-60 Cells
Acetylation
Histones
2017
22 Citations (Scopus)

3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma

Hua, K. T., Liu, Y. F., Hsu, C. L., Cheng, T. Y., Yang, C. Y., Chang, J. S., Lee, W. J., Hsiao, M., Juan, H. F., Chien, M. H. & Yang, S. F., Dec 1 2017, In : Scientific Reports. 7, 1, 4466.

Research output: Contribution to journal › Article

Hepatocellular Carcinoma
Alleles
Carbonic Anhydrase IX
Neoplasms
RNA Stability
4 Citations (Scopus)

A Fas Ligand (FasL)-fused humanized antibody against tumor-Associated glycoprotein 72 selectively exhibits the cytotoxic effect against oral cancer cells with a low FasL/Fas ratio

Chien, M. H., Chang, W. M., Lee, W. J., Chang, Y. C., Lai, T. C., Chan, D. V., Sharma, R., Lin, Y. F. & Hsiao, M., Jun 1 2017, In : Molecular Cancer Therapeutics. 16, 6, p. 1102-1113 12 p.

Research output: Contribution to journal › Article

Antibodies, Monoclonal, Humanized
Fas Ligand Protein
Mouth Neoplasms
Squamous Cell Carcinoma
Neoplasms

Corrigendum to "Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells" [383 (2016) 282-294]

Kuo, T. C., Chen, C. K., Hua, K. T., Yu, P., Lee, W. J., Chen, M. W., Jeng, Y. M., Chien, M. H., Kuo, K. T., Hsiao, M. & Kuo, M. L., 2017, (Accepted/In press) In : Cancer Letters.

Research output: Contribution to journal › Article

7 Citations (Scopus)

KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer

Chien, M. H., Lee, W. J., Yang, Y. C., Li, Y. L., Chen, B. R., Cheng, T. Y., Yang, P. W., Wang, M. Y., Jan, Y. H., Lin, Y. K., Lee, J. M., Hsiao, M., Chen, J. S. & Hua, K. T., Oct 1 2017, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1860, 10, p. 1013-1024 12 p.

Research output: Contribution to journal › Article

Protein Splicing
RNA Stability
Non-Small Cell Lung Carcinoma
Cells
Neoplasm Metastasis
9 Citations (Scopus)

Quercetin simultaneously induces G0/G1-phase arrest and caspase-mediated crosstalk between apoptosis and autophagy in human leukemia HL-60 cells

Chang, J. L., Chow, J. M., Chang, J. H., Wen, Y-C., Lin, Y. W., Yang, S. F., Lee, W. J. & Chien, M. H., 2017, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journal › Article

Cell Cycle Resting Phase
HL-60 Cells
Quercetin
Autophagy
apoptosis
13 Citations (Scopus)

Quercetin suppresses the metastatic ability of lung cancer through inhibiting Snail-dependent Akt activation and Snail-independent ADAM9 expression pathways

Chang, J. H., Lai, S. L., Chen, W. S., Hung, W. Y., Chow, J. M., Hsiao, M., Lee, W. J. & Chien, M. H., Oct 1 2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 10, p. 1746-1758 13 p.

Research output: Contribution to journal › Article

Quercetin
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Disintegrins
22 Citations (Scopus)

Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer

Kao, S. J., Lee, W. J., Chang, J. H., Chow, J. M., Chung, C. L., Hung, W. Y. & Chien, M. H., Apr 1 2017, In : Environmental Toxicology. 32, 4, p. 1426-1438

Research output: Contribution to journal › Article

JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
apoptosis
Non-Small Cell Lung Carcinoma
cancer
2 Citations (Scopus)

The Gαh-PLCδ1 signaling axis drives metastatic progression in triple-negative breast cancer

Huang, S. P., Liu, P. Y., Kuo, C. J., Chen, C. L., Lee, W. J., Tsai, Y. H. & Lin, Y. F., Jun 2 2017, In : Journal of Hematology and Oncology. 10, 1, 114.

Research output: Contribution to journal › Article

Triple Negative Breast Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Lung
Proteins
6 Citations (Scopus)

Tricetin induces apoptosis of human leukemic HL-60 cells through a reactive oxygen species-mediated c-jun N-terminal kinase activation pathway

Chien, M. H., Chow, J. M., Lee, W. J., Chen, H. Y., Tan, P., Wen, Y. C., Lin, Y. W., Hsiao, P. C. & Yang, S. F., Aug 1 2017, In : International Journal of Molecular Sciences. 18, 8, 1667.

Research output: Contribution to journal › Article

JNK Mitogen-Activated Protein Kinases
HL-60 Cells
apoptosis
Cell death
Reactive Oxygen Species
5 Citations (Scopus)

Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts

Chien, M. H., Lee, T. H., Lee, W. J., Yeh, Y. H., Li, T. K., Wang, P. C., Chen, J. J., Chow, J. M., Lin, Y. W., Hsiao, M., Wang, S. W. & Hua, K. T., Mar 1 2017, In : Cancer Letters. 388, p. 249-261 13 p.

Research output: Contribution to journal › Article

Trichodermin
JNK Mitogen-Activated Protein Kinases
Pancreatic Neoplasms
Heterografts
DNA Damage
2016
1 Citation (Scopus)

Akt activation correlates with snail expression and potentially determines the recurrence of prostate cancer in patients at stage T2 after a radical prostatectomy

Chen, W. Y., Hua, K. T., Lee, W. J., Lin, Y. W., Liu, Y. N., Chen, C. L., Wen, Y-C. & Chien, M. H., Aug 1 2016, In : International Journal of Molecular Sciences. 17, 8, 1194.

Research output: Contribution to journal › Article

snails
Snails
Prostatectomy
Prostatic Neoplasms
Hazards
12 Citations (Scopus)

G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway

Cha, S. T., Tan, C. T., Chang, C. C., Chu, C. Y., Lee, W. J., Lin, B. Z., Lin, M. T. & Kuo, M. L., Sep 1 2016, In : Nature Cell Biology. 18, 9, p. 993-1005 13 p.

Research output: Contribution to journal › Article

Catenins
Colonic Neoplasms
Epigenomics
Colorectal Neoplasms
Neoplasms
14 Citations (Scopus)

Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells

Kuo, T. C., Chen, C. K., Hua, K. T., Yu, P., Lee, W-J., Chen, M. W., Jeng, Y. M., Chien, M-H., Kuo, K., Hsiao, M. & Kuo, M. L., Dec 28 2016, In : Cancer Letters. 383, 2, p. 282-294 13 p.

Research output: Contribution to journal › Article

Glutaminase
Hepatocellular Carcinoma
Neoplasm Metastasis
Snails
Neoplasms
36 Citations (Scopus)

Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1 expression

Tseng, T. H., Chien, M. H., Lin, W. L., Wen, Y-C., Chow, J. M., Chen, C. K., Kuo, T. C. & Lee, W. J., 2016, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journal › Article

Apigenin
Acetylation
Cell proliferation
tumor
Histones
28 Citations (Scopus)

Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis

Lin, C. W., Yang, W. E., Lee, W. J., Hua, K. T., Hsieh, F. K., Hsiao, M., Chen, C. C., Chow, J. M., Chen, M. K., Yang, S. F. & Chien, M. H., Jul 1 2016, In : Carcinogenesis. 37, 7, p. 712-722 11 p.

Research output: Contribution to journal › Article

Mouth Neoplasms
Squamous Cell Carcinoma
Neoplasm Metastasis
Cell Movement
MicroRNAs
72 Citations (Scopus)

Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity

Lin, Y. W., Lee, L. M., Lee, W. J., Chu, C. Y., Tan, P., Yang, Y. C., Chen, W. Y., Yang, S. F., Hsiao, M. & Chien, M. H., Apr 1 2016, In : Journal of Pineal Research. 60, 3, p. 277-290 14 p.

Research output: Contribution to journal › Article

Melatonin
Matrix Metalloproteinases
Renal Cell Carcinoma
Transcriptional Activation
Neoplasm Metastasis
2015
36 Citations (Scopus)

By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer

Wen, Y-C., Lee, W. J., Tan, P., Yang, S. F., Hsiao, M., Lee, L. M. & Chien, M. H., 2015, In : Oncotarget. 6, 25, p. 21120-21136 17 p.

Research output: Contribution to journal › Article

Epithelial-Mesenchymal Transition
Snails
Cadherins
Prostatic Neoplasms
Androgens
23 Citations (Scopus)

GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis

Chang, J. S., Su, C. Y., Yu, W. H., Lee, W. J., Liu, Y. P., Lai, T. C., Jan, Y. H., Yang, Y. F., Shen, C. N., Shew, J. Y., Lu, J., Yang, C. J., Huang, M. S., Lu, P. J., Lin, Y. F., Kuo, M. L., Hua, K. T. & Hsiao, M., 2015, In : Oncotarget. 6, 34, p. 36278-36291 14 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Neoplasm Metastasis
G-Protein-Coupled Receptor Kinases
Receptor-Interacting Protein Serine-Threonine Kinases
11 Citations (Scopus)

Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development

Lin, F. Y., Lin, C. W., Yang, S. F., Lee, W. J., Lin, Y. W., Lee, L. M., Chang, J. L., Weng, W. C., Lin, C. H. & Chien, M. H., Mar 25 2015, In : PLoS One. 10, 3, e0121677.

Research output: Contribution to journal › Article

Melatonin Receptors
Mouth Neoplasms
melatonin
Polymorphism
genetic polymorphism
19 Citations (Scopus)

Keap1-Nrf2 interaction suppresses cell motility in lung adenocarcinomas by targeting the S100P protein

Chien, M. H., Lee, W. J., Hsieh, F. K., Li, C. F., Cheng, T. Y., Wang, M. Y., Chen, J. S., Chow, J. M., Jan, Y. H., Hsiao, M., Hua, K. T. & Kuo, M. L., Oct 15 2015, In : Clinical Cancer Research. 21, 20, p. 4719-4732 14 p.

Research output: Contribution to journal › Article

Protein Transport
Cell Movement
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Kelch-Like ECH-Associated Protein 1
17 Citations (Scopus)

Macrophage infiltration induces gastric cancer invasiveness by activating the β-catenin pathway

Wu, M. H., Lee, W. J., Hua, K. T., Kuo, M. L. & Lin, M. T., Jul 30 2015, In : PLoS One. 10, 7, 134122.

Research output: Contribution to journal › Article

Catenins
stomach neoplasms
Macrophages
Infiltration
Stomach Neoplasms
32 Citations (Scopus)

Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress

Lee, W. J., Chien, M. H., Chow, J. M., Chang, J. L., Wen, Y-C., Lin, Y. W., Cheng, C. W., Lai, G. M., Hsiao, M. & Lee, L. M., May 27 2015, In : Scientific Reports. 5, 10420.

Research output: Contribution to journal › Article

Endoplasmic Reticulum Stress
Curcumin
Reactive Oxygen Species
Prostatic Neoplasms
Cell Death
40 Citations (Scopus)

Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft

Lee, W-J., Hsiao, M., Chang, J. L., Yang, S. F., Tseng, T. H., Cheng, C-W., Chow, J-M., Lin, K. H., Lin, Y. W., Liu, C. C., Lee, L-M. & Chien, M-H., Jul 15 2015, In : Archives of Toxicology. 89, 7, p. 1103-1117 15 p.

Research output: Contribution to journal › Article

HL-60 Cells
Quercetin
Extracellular Signal-Regulated MAP Kinases
Heterografts
Reactive Oxygen Species
12 Citations (Scopus)

Tricetin suppresses the migration/invasion of human glioblastoma multiforme cells by inhibiting matrix metalloproteinase-2 through modulation of the expression and transcriptional activity of specificity protein 1

Chao, R., Chow, J. M., Hsieh, Y. H., Chen, C. K., Lee, W. J., Hsieh, F. K., Yu, N. Y., Chou, M. C., Cheng, C. W., Yang, S. F. & Chien, M. H., Oct 3 2015, In : Expert Opinion on Therapeutic Targets. 19, 10, p. 1293-1306 14 p.

Research output: Contribution to journal › Article

Matrix Metalloproteinase 2
Glioblastoma
Modulation
Matrix Metalloproteinases
Proteins
68 Citations (Scopus)

Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

Yang, S. F., Lee, W. J., Tan, P., Tang, C. H., Hsiao, M., Hsieh, F. K. & Chien, M. H., 2015, In : Oncotarget. 6, 5, p. 2736-2753 18 p.

Research output: Contribution to journal › Article

Matrix Metalloproteinase 2
Osteosarcoma
MicroRNAs
Up-Regulation
DNA
2014
13 Citations (Scopus)

Associations of VEGF-C genetic polymorphisms with urothelial cell carcinoma susceptibility differ between smokers and non-smokers in Taiwan

Tung, M. C., Hsieh, M. J., Wang, S. S., Yang, S. F., Chen, S. S., Wang, S. W., Lee, L. M., Lee, W. J. & Chien, M. H., Mar 7 2014, In : PLoS One. 9, 3, e91147.

Research output: Contribution to journal › Article

vascular endothelial growth factor C
Vascular Endothelial Growth Factor C
Genetic Polymorphisms
Polymorphism
Taiwan
26 Citations (Scopus)

Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment

Chen, C. K., Yang, C. Y., Hua, K. T., Ho, M. C., Johansson, G., Jeng, Y. M., Chen, C. N., Chen, M. W., Lee, W. J., Su, J. L., Lai, T. C., Chou, C. C., Ho, B. C., Chang, C. F., Lee, P. H., Chang, K. J., Hsiao, M., Lin, M. T. & Kuo, M. L., Mar 2014, In : Hepatology. 59, 3, p. 974-985 12 p.

Research output: Contribution to journal › Article

Non-Receptor Type 1 Protein Tyrosine Phosphatase
Chemotactic Factors
Blood Vessels
Hepatocellular Carcinoma
Leukocytes
21 Citations (Scopus)

Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells

Hsiao, P. C., Lee, W-J., Yang, S. F., Tan, P., Chen, H. Y., Lee, L-M., Chang, J. L., Lai, G-M., Chow, J-M. & Chien, M-H., Dec 1 2014, In : Tumor Biology. 35, 12, p. 11903-11911 9 p.

Research output: Contribution to journal › Article

Caspase 9
Caspase 8
Myeloid Cells
Acute Myeloid Leukemia
Apoptosis
31 Citations (Scopus)

Pterostilbene simultaneously induced G0/G1-phase arrest and MAPK-mediated mitochondrial-derived apoptosis in human acute myeloid leukemia cell lines

Hsiao, P. C., Chou, Y. E., Tan, P., Lee, W-J., Yang, S. F., Chow, J-M., Chen, H. Y., Lin, C-H., Lee, L-M. & Chien, M-H., Aug 21 2014, In : PLoS One. 9, 8, e105342.

Research output: Contribution to journal › Article

myeloid leukemia
Cell Cycle Resting Phase
G1 Phase
Myeloid Cells
Acute Myeloid Leukemia
8 Citations (Scopus)

Snail as a potential marker for predicting the recurrence of prostate cancer in patients at stage T2 after radical prostatectomy

Wen, Y-C., Chen, W. Y., Lee, W. J., Yang, S. F., Lee, L. M. & Chien, M. H., Apr 20 2014, In : Clinica Chimica Acta. 431, p. 169-173 5 p.

Research output: Contribution to journal › Article

Snails
Microarrays
Prostatectomy
Tumors
Prostatic Neoplasms
15 Citations (Scopus)

Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2

Hua, K. T., Lee, W. J., Yang, S. F., Chen, C. K., Hsiao, M., Ku, C. C., Wei, L. H., Kuo, M. L. & Chien, M. H., Feb 2014, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 2, p. 387-397 11 p.

Research output: Contribution to journal › Article

Vascular Endothelial Growth Factor C
Endothelin-1
Myeloid Cells
Cyclooxygenase 2
Acute Myeloid Leukemia
38 Citations (Scopus)

α-Solanine inhibits invasion of human prostate cancer cell by suppressing epithelial-mesenchymal transition and MMPs expression

Shen, K. H., Liao, A. C. H., Hung, J. H., Lee, W. J., Hu, K. C., Lin, P. T., Liao, R. F. & Chen, P. S., 2014, In : Molecules. 19, 8, p. 11896-11914 19 p.

Research output: Contribution to journal › Article

Solanine
Epithelial-Mesenchymal Transition
Matrix Metalloproteinases
Prostatic Neoplasms
cancer
2013
48 Citations (Scopus)

Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

Kuo, T. C., Tan, C. T., Chang, Y. W., Hong, C. C., Lee, W. J., Chen, M. W., Jeng, Y. M., Chiou, J., Yu, P., Chen, P. S., Wang, M. Y., Hsiao, M., Su, J. L. & Kuo, M. L., Mar 1 2013, In : Journal of Clinical Investigation. 123, 3, p. 1082-1095 14 p.

Research output: Contribution to journal › Article

Angiopoietins
Cell Movement
Neoplasms
Proteins
Lung Neoplasms
24 Citations (Scopus)

Combined Effects of ICAM-1 Single-Nucleotide Polymorphisms and Environmental Carcinogens on Oral Cancer Susceptibility and Clinicopathologic Development

Lin, C. W., Chuang, C. Y., Tang, C. H., Chang, J. L., Lee, L-M., Lee, W-J., Chow, J-M., Yang, S. F. & Chien, M-H., Sep 12 2013, In : PLoS One. 8, 9, e72940.

Research output: Contribution to journal › Article

Environmental Carcinogens
Mouth Neoplasms
carcinogens
Intercellular Adhesion Molecule-1
Polymorphism
2012
15 Citations (Scopus)

Estimating the Delivery Efficiency of Drug-Loaded Microbubbles in Cancer Cells with Ultrasound and Bioluminescence Imaging

Liao, A. H., Li, Y. K., Lee, W. J., Wu, M. F., Liu, H. L. & Kuo, M. L., Nov 2012, In : Ultrasound in Medicine and Biology. 38, 11, p. 1938-1948 11 p.

Research output: Contribution to journal › Article

bioluminescence
Microbubbles
albumins
destruction
Ultrasonography
2011
62 Citations (Scopus)

N-α-Acetyltransferase 10 Protein Suppresses Cancer Cell Metastasis by Binding PIX Proteins and Inhibiting Cdc42/Rac1 Activity

Hua, K. T., Tan, C. T., Johansson, G., Lee, J. M., Yang, P. W., Lu, H. Y., Chen, C. K., Su, J. L., Chen, P. B., Wu, Y. L., Chi, C. C., Kao, H. J., Shih, H. J., Chen, M. W., Chien, M. H., Chen, P. S., Lee, W. J., Cheng, T. Y., Rosenberger, G., Chai, C. Y. & 6 others, Yang, C. J., Huang, M. S., Lai, T. C., Chou, T. Y., Hsiao, M. & Kuo, M. L., Feb 15 2011, In : Cancer Cell. 19, 2, p. 218-231 14 p.

Research output: Contribution to journal › Article

Acetyltransferases
Carrier Proteins
Neoplasm Metastasis
Paxillin
Neoplasms
76 Citations (Scopus)

Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells

Lee, W. J., Chen, Y. R. & Tseng, T. H., Feb 2011, In : Oncology Reports. 25, 2, p. 583-591 9 p.

Research output: Contribution to journal › Article

Fas Ligand Protein
HL-60 Cells
Quercetin
Acetylation
Histones
2009
11 Citations (Scopus)

In vitro enhancement effect of humic acid on the progression of lung cancer cells

Lee, W. J., Lu, F. J., Wang, S. F., Chen, Y. R. & Tseng, T. H., Oct 30 2009, In : Chemico-Biological Interactions. 181, 3, p. 463-471 9 p.

Research output: Contribution to journal › Article

Humic Substances
Lung Neoplasms
Cells
Phosphotransferases
Extracellular Signal-Regulated MAP Kinases
2008
127 Citations (Scopus)

Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells

Lee, W. J., Chen, W. K., Wang, C. J., Lin, W. L. & Tseng, T. H., Jan 15 2008, In : Toxicology and Applied Pharmacology. 226, 2, p. 178-191 14 p.

Research output: Contribution to journal › Article

Apigenin
Hepatocyte Growth Factor
Phosphatidylinositol 3-Kinases
Integrins
Cells
5 Citations (Scopus)

Studies on mercuric sulfide, a component of cinnabar, a Chinese herbal medicine, on celluar functions in mouse lung and fibroblasts

Yen, C. C., Huang, C. F., Lee, W. J., Hsu, M. J., Liu, S. H. & Lin-Shiau, S. Y., Jan 2008, In : Toxicological and Environmental Chemistry. 90, 1, p. 181-201 21 p.

Research output: Contribution to journal › Article

cinnabar
Mercuric Chloride
Herbal Medicine
Fibroblasts
Lipids
2006
97 Citations (Scopus)

Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways

Lee, W. J., Wu, L. F., Chen, W. K., Wang, C. J. & Tseng, T. H., Mar 25 2006, In : Chemico-Biological Interactions. 160, 2, p. 123-133 11 p.

Research output: Contribution to journal › Article

Luteolin
Hepatocyte Growth Factor
Hep G2 Cells
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-met
15 Citations (Scopus)

Promoting neoplastic transformation of humic acid in mouse epidermal JB6 Cl41 cells

Lu, F. J., Tseng, T. H., Lee, W. J., Yen, C. C., Yin, Y. F., Liao, C. W. & Liu, K. M., Sep 25 2006, In : Chemico-Biological Interactions. 162, 3, p. 249-258 10 p.

Research output: Contribution to journal › Article

Clone cells
Humic Substances
Clone Cells
Assays
Reactive Oxygen Species