Research Output per year
Research Output
2020
Circulating proteoglycan endocan mediates EGFR-driven progression of non-small cell lung cancer
Yang, Y-C., Pan, K-F., Lee, W-J., Chang, J-H., Tan, P., Gu, C-C., Chang, W-M., Yang, S-F., Hsiao, M., Hua, K-T. & Chien, M-H., Jun 19 2020, In : Cancer Research.Research output: Contribution to journal › Article
Dual targeting of the p38 MAPK‐HO‐1 axis and cIAP1/XIAP by demethoxycurcumin triggers caspase‐mediated apoptotic cell death in oral squamous cell carcinoma cells
Chien, M. H., Yang, W. E., Yang, Y. C., Ku, C. C., Lee, W. J., Tsai, M. Y., Lin, C. W. & Yang, S. F., Mar 2020, In : Cancers. 12, 3, 703.Research output: Contribution to journal › Article
Open Access
Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics
Lin, C. H., Hsieh, M. J., Lee, H. L., Yang, S. F., Su, S. C., Lee, W. J. & Chou, Y. E., Jan 1 2020, In : Journal of Cancer. 11, 6, p. 1641-1647 7 p.Research output: Contribution to journal › Article
Open Access
1
Citation
(Scopus)
2019
Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response
Hung, W. Y., Chang, J. H., Cheng, Y., Cheng, G. Z., Huang, H. C., Hsiao, M., Chung, C. L., Lee, W. J. & Chien, M. H., Aug 1 2019, In : Cell Death and Disease. 10, 8, 538.Research output: Contribution to journal › Article
Open Access
1
Citation
(Scopus)
Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses
Wu, S. Y., Wen, Y. C., Ku, C. C., Yang, Y. C., Chow, J. M., Yang, S. F., Lee, W. J. & Chien, M. H., Aug 31 2019, In : Journal of Biomedical Science. 26, 1, 63.Research output: Contribution to journal › Article
Open Access
2
Citations
(Scopus)
Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis
Chien, M. H., Lin, Y. W., Wen, Y. C., Yang, Y. C., Hsiao, M., Chang, J. L., Huang, H. C. & Lee, W. J., Jun 10 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 246.Research output: Contribution to journal › Article
Open Access
7
Citations
(Scopus)
2018
Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses
Chang, J. H., Cheng, C. W., Yang, Y. C., Chen, W. S., Hung, W. Y., Chow, J. M., Chen, P. S., Hsiao, M., Lee, W. J. & Chien, M. H., Aug 22 2018, In : Journal of Experimental and Clinical Cancer Research. 37, 1, 199.Research output: Contribution to journal › Article
16
Citations
(Scopus)
Leukocyte Cell-Derived Chemotaxin 2 Retards Non-Small Cell Lung Cancer Progression Through Antagonizing MET and EGFR Activities
Hung, W. Y., Chang, J. H., Cheng, Y., Chen, C. K., Chen, J. Q., Hua, K. T., Cheng, C. W., Hsiao, M., Chung, C. L., Lee, W. J. & Chien, M. H., Jan 1 2018, In : Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 51, 1, p. 337-355 19 p.Research output: Contribution to journal › Article
4
Citations
(Scopus)
Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress
Yang, Y. C., Chien, M. H., Liu, H. Y., Chang, Y. C., Chen, C. K., Lee, W. J., Kuo, T. C., Hsiao, M., Hua, K. T. & Cheng, T. Y., May 1 2018, In : Cancer Letters. 421, p. 28-40 13 p.Research output: Contribution to journal › Article
12
Citations
(Scopus)
N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas
Chien, M. H., Lee, W. J., Yang, Y. C., Tan, P., Pan, K. F., Liu, Y. C., Tsai, H. C., Hsu, C. H., Wen, Y. C., Hsiao, M. & Hua, K. T., Oct 1 2018, In : Cancer Letters. 433, p. 86-98 13 p.Research output: Contribution to journal › Article
8
Citations
(Scopus)
Stimulation of Fas/FasL-mediated apoptosis by luteolin through enhancement of histone H3 acetylation and c-Jun activation in HL-60 leukemia cells
Wang, S. W., Chen, Y. R., Chow, J. M., Chien, M. H., Yang, S. F., Wen, Y. C., Lee, W. J. & Tseng, T. H., Jan 1 2018, (Accepted/In press) In : Molecular Carcinogenesis.Research output: Contribution to journal › Article
5
Citations
(Scopus)
2017
3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma
Hua, K. T., Liu, Y. F., Hsu, C. L., Cheng, T. Y., Yang, C. Y., Chang, J. S., Lee, W. J., Hsiao, M., Juan, H. F., Chien, M. H. & Yang, S. F., Dec 1 2017, In : Scientific Reports. 7, 1, 4466.Research output: Contribution to journal › Article
27
Citations
(Scopus)
A Fas Ligand (FasL)-fused humanized antibody against tumor-Associated glycoprotein 72 selectively exhibits the cytotoxic effect against oral cancer cells with a low FasL/Fas ratio
Chien, M. H., Chang, W. M., Lee, W. J., Chang, Y. C., Lai, T. C., Chan, D. V., Sharma, R., Lin, Y. F. & Hsiao, M., Jun 1 2017, In : Molecular Cancer Therapeutics. 16, 6, p. 1102-1113 12 p.Research output: Contribution to journal › Article
5
Citations
(Scopus)
Corrigendum to "Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells" [383 (2016) 282-294]
Kuo, T. C., Chen, C. K., Hua, K. T., Yu, P., Lee, W. J., Chen, M. W., Jeng, Y. M., Chien, M. H., Kuo, K. T., Hsiao, M. & Kuo, M. L., 2017, (Accepted/In press) In : Cancer Letters.Research output: Contribution to journal › Article
KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer
Chien, M. H., Lee, W. J., Yang, Y. C., Li, Y. L., Chen, B. R., Cheng, T. Y., Yang, P. W., Wang, M. Y., Jan, Y. H., Lin, Y. K., Lee, J. M., Hsiao, M., Chen, J. S. & Hua, K. T., Oct 1 2017, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1860, 10, p. 1013-1024 12 p.Research output: Contribution to journal › Article
11
Citations
(Scopus)
Quercetin simultaneously induces G0/G1-phase arrest and caspase-mediated crosstalk between apoptosis and autophagy in human leukemia HL-60 cells
Chang, J. L., Chow, J. M., Chang, J. H., Wen, Y-C., Lin, Y. W., Yang, S. F., Lee, W. J. & Chien, M. H., 2017, (Accepted/In press) In : Environmental Toxicology.Research output: Contribution to journal › Article
10
Citations
(Scopus)
Quercetin suppresses the metastatic ability of lung cancer through inhibiting Snail-dependent Akt activation and Snail-independent ADAM9 expression pathways
Chang, J. H., Lai, S. L., Chen, W. S., Hung, W. Y., Chow, J. M., Hsiao, M., Lee, W. J. & Chien, M. H., Oct 1 2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 10, p. 1746-1758 13 p.Research output: Contribution to journal › Article
25
Citations
(Scopus)
Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer
Kao, S. J., Lee, W. J., Chang, J. H., Chow, J. M., Chung, C. L., Hung, W. Y. & Chien, M. H., Apr 1 2017, In : Environmental Toxicology. 32, 4, p. 1426-1438Research output: Contribution to journal › Article
25
Citations
(Scopus)
The Gαh-PLCδ1 signaling axis drives metastatic progression in triple-negative breast cancer
Huang, S. P., Liu, P. Y., Kuo, C. J., Chen, C. L., Lee, W. J., Tsai, Y. H. & Lin, Y. F., Jun 2 2017, In : Journal of Hematology and Oncology. 10, 1, 114.Research output: Contribution to journal › Article
4
Citations
(Scopus)
Tricetin induces apoptosis of human leukemic HL-60 cells through a reactive oxygen species-mediated c-jun N-terminal kinase activation pathway
Chien, M. H., Chow, J. M., Lee, W. J., Chen, H. Y., Tan, P., Wen, Y. C., Lin, Y. W., Hsiao, P. C. & Yang, S. F., Aug 1 2017, In : International Journal of Molecular Sciences. 18, 8, 1667.Research output: Contribution to journal › Article
9
Citations
(Scopus)
Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts
Chien, M. H., Lee, T. H., Lee, W. J., Yeh, Y. H., Li, T. K., Wang, P. C., Chen, J. J., Chow, J. M., Lin, Y. W., Hsiao, M., Wang, S. W. & Hua, K. T., Mar 1 2017, In : Cancer Letters. 388, p. 249-261 13 p.Research output: Contribution to journal › Article
6
Citations
(Scopus)
2016
Akt activation correlates with snail expression and potentially determines the recurrence of prostate cancer in patients at stage T2 after a radical prostatectomy
Chen, W. Y., Hua, K. T., Lee, W. J., Lin, Y. W., Liu, Y. N., Chen, C. L., Wen, Y-C. & Chien, M. H., Aug 1 2016, In : International Journal of Molecular Sciences. 17, 8, 1194.Research output: Contribution to journal › Article
1
Citation
(Scopus)
G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway
Cha, S. T., Tan, C. T., Chang, C. C., Chu, C. Y., Lee, W. J., Lin, B. Z., Lin, M. T. & Kuo, M. L., Sep 1 2016, In : Nature Cell Biology. 18, 9, p. 993-1005 13 p.Research output: Contribution to journal › Article
14
Citations
(Scopus)
Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells
Kuo, T. C., Chen, C. K., Hua, K. T., Yu, P., Lee, W-J., Chen, M. W., Jeng, Y. M., Chien, M-H., Kuo, K., Hsiao, M. & Kuo, M. L., Dec 28 2016, In : Cancer Letters. 383, 2, p. 282-294 13 p.Research output: Contribution to journal › Article
23
Citations
(Scopus)
Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1 expression
Tseng, T. H., Chien, M. H., Lin, W. L., Wen, Y-C., Chow, J. M., Chen, C. K., Kuo, T. C. & Lee, W. J., 2016, (Accepted/In press) In : Environmental Toxicology.Research output: Contribution to journal › Article
46
Citations
(Scopus)
Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis
Lin, C. W., Yang, W. E., Lee, W. J., Hua, K. T., Hsieh, F. K., Hsiao, M., Chen, C. C., Chow, J. M., Chen, M. K., Yang, S. F. & Chien, M. H., Jul 1 2016, In : Carcinogenesis. 37, 7, p. 712-722 11 p.Research output: Contribution to journal › Article
35
Citations
(Scopus)
Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity
Lin, Y. W., Lee, L. M., Lee, W. J., Chu, C. Y., Tan, P., Yang, Y. C., Chen, W. Y., Yang, S. F., Hsiao, M. & Chien, M. H., Apr 1 2016, In : Journal of Pineal Research. 60, 3, p. 277-290 14 p.Research output: Contribution to journal › Article
86
Citations
(Scopus)
2015
By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer
Wen, Y-C., Lee, W. J., Tan, P., Yang, S. F., Hsiao, M., Lee, L. M. & Chien, M. H., 2015, In : Oncotarget. 6, 25, p. 21120-21136 17 p.Research output: Contribution to journal › Article
46
Citations
(Scopus)
GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis
Chang, J. S., Su, C. Y., Yu, W. H., Lee, W. J., Liu, Y. P., Lai, T. C., Jan, Y. H., Yang, Y. F., Shen, C. N., Shew, J. Y., Lu, J., Yang, C. J., Huang, M. S., Lu, P. J., Lin, Y. F., Kuo, M. L., Hua, K. T. & Hsiao, M., 2015, In : Oncotarget. 6, 34, p. 36278-36291 14 p.Research output: Contribution to journal › Article
26
Citations
(Scopus)
Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development
Lin, F. Y., Lin, C. W., Yang, S. F., Lee, W. J., Lin, Y. W., Lee, L. M., Chang, J. L., Weng, W. C., Lin, C. H. & Chien, M. H., Mar 25 2015, In : PLoS One. 10, 3, e0121677.Research output: Contribution to journal › Article
13
Citations
(Scopus)
Keap1-Nrf2 interaction suppresses cell motility in lung adenocarcinomas by targeting the S100P protein
Chien, M. H., Lee, W. J., Hsieh, F. K., Li, C. F., Cheng, T. Y., Wang, M. Y., Chen, J. S., Chow, J. M., Jan, Y. H., Hsiao, M., Hua, K. T. & Kuo, M. L., Oct 15 2015, In : Clinical Cancer Research. 21, 20, p. 4719-4732 14 p.Research output: Contribution to journal › Article
24
Citations
(Scopus)
Macrophage infiltration induces gastric cancer invasiveness by activating the β-catenin pathway
Wu, M. H., Lee, W. J., Hua, K. T., Kuo, M. L. & Lin, M. T., Jul 30 2015, In : PLoS One. 10, 7, 134122.Research output: Contribution to journal › Article
21
Citations
(Scopus)
Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress
Lee, W. J., Chien, M. H., Chow, J. M., Chang, J. L., Wen, Y-C., Lin, Y. W., Cheng, C. W., Lai, G. M., Hsiao, M. & Lee, L. M., May 27 2015, In : Scientific Reports. 5, 10420.Research output: Contribution to journal › Article
32
Citations
(Scopus)
Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft
Lee, W-J., Hsiao, M., Chang, J. L., Yang, S. F., Tseng, T. H., Cheng, C-W., Chow, J-M., Lin, K. H., Lin, Y. W., Liu, C. C., Lee, L-M. & Chien, M-H., Jul 15 2015, In : Archives of Toxicology. 89, 7, p. 1103-1117 15 p.Research output: Contribution to journal › Article
47
Citations
(Scopus)
Tricetin suppresses the migration/invasion of human glioblastoma multiforme cells by inhibiting matrix metalloproteinase-2 through modulation of the expression and transcriptional activity of specificity protein 1
Chao, R., Chow, J. M., Hsieh, Y. H., Chen, C. K., Lee, W. J., Hsieh, F. K., Yu, N. Y., Chou, M. C., Cheng, C. W., Yang, S. F. & Chien, M. H., Oct 3 2015, In : Expert Opinion on Therapeutic Targets. 19, 10, p. 1293-1306 14 p.Research output: Contribution to journal › Article
14
Citations
(Scopus)
Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas
Yang, S. F., Lee, W. J., Tan, P., Tang, C. H., Hsiao, M., Hsieh, F. K. & Chien, M. H., 2015, In : Oncotarget. 6, 5, p. 2736-2753 18 p.Research output: Contribution to journal › Article
74
Citations
(Scopus)
2014
Associations of VEGF-C genetic polymorphisms with urothelial cell carcinoma susceptibility differ between smokers and non-smokers in Taiwan
Tung, M. C., Hsieh, M. J., Wang, S. S., Yang, S. F., Chen, S. S., Wang, S. W., Lee, L. M., Lee, W. J. & Chien, M. H., Mar 7 2014, In : PLoS One. 9, 3, e91147.Research output: Contribution to journal › Article
13
Citations
(Scopus)
Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment
Chen, C. K., Yang, C. Y., Hua, K. T., Ho, M. C., Johansson, G., Jeng, Y. M., Chen, C. N., Chen, M. W., Lee, W. J., Su, J. L., Lai, T. C., Chou, C. C., Ho, B. C., Chang, C. F., Lee, P. H., Chang, K. J., Hsiao, M., Lin, M. T. & Kuo, M. L., Mar 2014, In : Hepatology. 59, 3, p. 974-985 12 p.Research output: Contribution to journal › Article
29
Citations
(Scopus)
Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells
Hsiao, P. C., Lee, W-J., Yang, S. F., Tan, P., Chen, H. Y., Lee, L-M., Chang, J. L., Lai, G-M., Chow, J-M. & Chien, M-H., Dec 1 2014, In : Tumor Biology. 35, 12, p. 11903-11911 9 p.Research output: Contribution to journal › Article
24
Citations
(Scopus)
Pterostilbene simultaneously induced G0/G1-phase arrest and MAPK-mediated mitochondrial-derived apoptosis in human acute myeloid leukemia cell lines
Hsiao, P. C., Chou, Y. E., Tan, P., Lee, W-J., Yang, S. F., Chow, J-M., Chen, H. Y., Lin, C-H., Lee, L-M. & Chien, M-H., Aug 21 2014, In : PLoS One. 9, 8, e105342.Research output: Contribution to journal › Article
35
Citations
(Scopus)
Snail as a potential marker for predicting the recurrence of prostate cancer in patients at stage T2 after radical prostatectomy
Wen, Y-C., Chen, W. Y., Lee, W. J., Yang, S. F., Lee, L. M. & Chien, M. H., Apr 20 2014, In : Clinica Chimica Acta. 431, p. 169-173 5 p.Research output: Contribution to journal › Article
8
Citations
(Scopus)
Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2
Hua, K. T., Lee, W. J., Yang, S. F., Chen, C. K., Hsiao, M., Ku, C. C., Wei, L. H., Kuo, M. L. & Chien, M. H., Feb 2014, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 2, p. 387-397 11 p.Research output: Contribution to journal › Article
16
Citations
(Scopus)
α-Solanine inhibits invasion of human prostate cancer cell by suppressing epithelial-mesenchymal transition and MMPs expression
Shen, K. H., Liao, A. C. H., Hung, J. H., Lee, W. J., Hu, K. C., Lin, P. T., Liao, R. F. & Chen, P. S., 2014, In : Molecules. 19, 8, p. 11896-11914 19 p.Research output: Contribution to journal › Article
41
Citations
(Scopus)
2013
Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility
Kuo, T. C., Tan, C. T., Chang, Y. W., Hong, C. C., Lee, W. J., Chen, M. W., Jeng, Y. M., Chiou, J., Yu, P., Chen, P. S., Wang, M. Y., Hsiao, M., Su, J. L. & Kuo, M. L., Mar 1 2013, In : Journal of Clinical Investigation. 123, 3, p. 1082-1095 14 p.Research output: Contribution to journal › Article
54
Citations
(Scopus)
Combined Effects of ICAM-1 Single-Nucleotide Polymorphisms and Environmental Carcinogens on Oral Cancer Susceptibility and Clinicopathologic Development
Lin, C. W., Chuang, C. Y., Tang, C. H., Chang, J. L., Lee, L-M., Lee, W-J., Chow, J-M., Yang, S. F. & Chien, M-H., Sep 12 2013, In : PLoS One. 8, 9, e72940.Research output: Contribution to journal › Article
24
Citations
(Scopus)
2012
Estimating the Delivery Efficiency of Drug-Loaded Microbubbles in Cancer Cells with Ultrasound and Bioluminescence Imaging
Liao, A. H., Li, Y. K., Lee, W. J., Wu, M. F., Liu, H. L. & Kuo, M. L., Nov 2012, In : Ultrasound in Medicine and Biology. 38, 11, p. 1938-1948 11 p.Research output: Contribution to journal › Article
15
Citations
(Scopus)
2011
N-α-Acetyltransferase 10 Protein Suppresses Cancer Cell Metastasis by Binding PIX Proteins and Inhibiting Cdc42/Rac1 Activity
Hua, K. T., Tan, C. T., Johansson, G., Lee, J. M., Yang, P. W., Lu, H. Y., Chen, C. K., Su, J. L., Chen, P. B., Wu, Y. L., Chi, C. C., Kao, H. J., Shih, H. J., Chen, M. W., Chien, M. H., Chen, P. S., Lee, W. J., Cheng, T. Y., Rosenberger, G., Chai, C. Y. & 6 others, , Feb 15 2011, In : Cancer Cell. 19, 2, p. 218-231 14 p.Research output: Contribution to journal › Article
64
Citations
(Scopus)
Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells
Lee, W. J., Chen, Y. R. & Tseng, T. H., Feb 2011, In : Oncology Reports. 25, 2, p. 583-591 9 p.Research output: Contribution to journal › Article
86
Citations
(Scopus)
2009
In vitro enhancement effect of humic acid on the progression of lung cancer cells
Lee, W. J., Lu, F. J., Wang, S. F., Chen, Y. R. & Tseng, T. H., Oct 30 2009, In : Chemico-Biological Interactions. 181, 3, p. 463-471 9 p.Research output: Contribution to journal › Article
11
Citations
(Scopus)
2008
Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells
Lee, W. J., Chen, W. K., Wang, C. J., Lin, W. L. & Tseng, T. H., Jan 15 2008, In : Toxicology and Applied Pharmacology. 226, 2, p. 178-191 14 p.Research output: Contribution to journal › Article
132
Citations
(Scopus)