Wei-Jiunn Lee

Research output

Research output per year 2006 2021

• 1604 Citations
• 24 h-Index
• 59 Article
• 2 Comment/debate
• 1 Conference contribution

Research output per year

Research output per year

Search results

• 2021

  Direct interaction of β-catenin with nuclear ESM1 supports stemness of metastatic prostate cancer

  Pan, K. F., Lee, W. J., Chou, C. C., Yang, Y. C., Chang, Y. C., Chien, M. H., Hsiao, M. & Hua, K. T., Feb 15 2021, In: EMBO Journal. 40, 4, e105450.

  Research output: Contribution to journal › Article › peer-review

  • Endothelial cells
  • Catenins
  • Molecules
  • Prostatic Neoplasms
  • Endothelial Cells

• Histone methyltransferase g9a-promoted progression of hepatocellular carcinoma is targeted by liver-specific hsa-mir-122

  Yuan, L. T., Lee, W. J., Yang, Y. C., Chen, B. R., Yang, C. Y., Chen, M. W., Chen, J. Q., Hsiao, M., Chien, M. H. & Hua, K. T., May 2 2021, In: Cancers. 13, 10, 2376.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Histone Methyltransferases
  • Hepatocellular Carcinoma
  • Liver
  • Disease-Free Survival
  • MicroRNAs
• 2020

  Circulating proteoglycan endocan mediates EGFR-driven progression of non-small cell lung cancer

  Yang, Y-C., Pan, K-F., Lee, W-J., Chang, J-H., Tan, P., Gu, C-C., Chang, W-M., Yang, S-F., Hsiao, M., Hua, K-T. & Chien, M-H., Jun 19 2020, (E-pub ahead of print) In: Cancer Research.

  Research output: Contribution to journal › Article › peer-review

  • Proteoglycans
  • Non-Small Cell Lung Carcinoma
  • Protein-Tyrosine Kinases
  • Neoplasms
  • Mutation
  1 Citation (Scopus)

• DNA polymerase theta repression enhances the docetaxel responsiveness in metastatic castration-resistant prostate cancer

  Kuei, C. H., Lin, H. Y., Lin, M. H., Lee, H. H., Lin, C. H., Lee, W. J., Chen, Y. L., Lu, L. S., Zheng, J. Q., Hung, R. C., Chiu, H. W., Chen, K. C. & Lin, Y. F., Dec 1 2020, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1866, 12, p. 165954 165954.

  Research output: Contribution to journal › Article › peer-review

  • DNA polymerase theta
  • Docetaxel
  • Castration
  • Prostatic Neoplasms
  • Luciferases

• Dual targeting of the p38 MAPK‐HO‐1 axis and cIAP1/XIAP by demethoxycurcumin triggers caspase‐mediated apoptotic cell death in oral squamous cell carcinoma cells

  Chien, M. H., Yang, W. E., Yang, Y. C., Ku, C. C., Lee, W. J., Tsai, M. Y., Lin, C. W. & Yang, S. F., Mar 2020, In: Cancers. 12, 3, 703.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • demethoxycurcumin
  • Squamous Cell Carcinoma
  • Cell Death
  • Heme
  • Gefitinib
  6 Citations (Scopus)

• Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics

  Lin, C. H., Hsieh, M. J., Lee, H. L., Yang, S. F., Su, S. C., Lee, W. J. & Chou, Y. E., Jan 1 2020, In: Journal of Cancer. 11, 6, p. 1641-1647 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Colonic Neoplasms
  • Hepatocellular Carcinoma
  • Neoplasm Metastasis
  • Odds Ratio
  • Single Nucleotide Polymorphism
  2 Citations (Scopus)

• Melatonin-triggered post-transcriptional and post-translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma

  Wen, Y. C., Lin, Y. W., Chu, C. Y., Yang, Y. C., Yang, S. F., Liu, Y. F., Hsiao, M., Lee, W. J. & Chien, M. H., Sep 1 2020, In: Journal of Pineal Research. 69, 2, e12668.

  Research output: Contribution to journal › Article › peer-review

  • Melatonin
  • Post Translational Protein Processing
  • Renal Cell Carcinoma
  • Carcinogenesis
  • Neoplasm Metastasis
  7 Citations (Scopus)

• Stabilization of ADAM9 by N-α-acetyltransferase 10 protein contributes to promoting progression of androgen-independent prostate cancer

  Lin, Y. W., Wen, Y. C., Chu, C. Y., Tung, M. C., Yang, Y. C., Hua, K. T., Pan, K. F., Hsiao, M., Lee, W. J. & Chien, M. H., Jul 1 2020, In: Cell Death and Disease. 11, 7, 591.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Disintegrins
  • Acetyltransferases
  • Metalloproteases
  • Androgens
  • Prostatic Neoplasms
  3 Citations (Scopus)

• The curcumin analogue, ef-24, triggers p38 mapkmediated apoptotic cell death via inducing pp2amodulated erk deactivation in human acute myeloid leukemia cells

  Hsiao, P. C., Chang, J. H., Lee, W. J., Ku, C. C., Tsai, M. Y., Yang, S. F. & Chien, M. H., Aug 2020, In: Cancers. 12, 8, p. 1-17 17 p., 2163.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Curcumin
  • Myeloid Cells
  • Acute Myeloid Leukemia
  • demethoxycurcumin
  • Cell Death
  1 Citation (Scopus)
• 2019

  Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response

  Hung, W. Y., Chang, J. H., Cheng, Y., Cheng, G. Z., Huang, H. C., Hsiao, M., Chung, C. L., Lee, W. J. & Chien, M. H., Aug 1 2019, In: Cell Death and Disease. 10, 8, 538.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Penfluridol
  • Unfolded Protein Response
  • Autophagosomes
  • Lung Neoplasms
  • Adenosine Triphosphate
  1 Citation (Scopus)

• Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses

  Wu, S. Y., Wen, Y. C., Ku, C. C., Yang, Y. C., Chow, J. M., Yang, S. F., Lee, W. J. & Chien, M. H., Aug 31 2019, In: Journal of Biomedical Science. 26, 1, 63.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Penfluridol
  • fms-Like Tyrosine Kinase 3
  • Protein Phosphatase 2
  • Mitogen-Activated Protein Kinases
  • Autophagy
  4 Citations (Scopus)

• Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis

  Chien, M. H., Lin, Y. W., Wen, Y. C., Yang, Y. C., Hsiao, M., Chang, J. L., Huang, H. C. & Lee, W. J., Jun 10 2019, In: Journal of Experimental and Clinical Cancer Research. 38, 1, 246.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Kazal Motifs
  • Osteonectin
  • Apigenin
  • Gastropoda
  • Snails
  15 Citations (Scopus)
• 2018

  Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses

  Chang, J. H., Cheng, C. W., Yang, Y. C., Chen, W. S., Hung, W. Y., Chow, J. M., Chen, P. S., Hsiao, M., Lee, W. J. & Chien, M. H., Aug 22 2018, In: Journal of Experimental and Clinical Cancer Research. 37, 1, 199.

  Research output: Contribution to journal › Article › peer-review

  • Apigenin
  • Dipeptidyl Peptidase 4
  • Gastropoda
  • ErbB Receptors
  • Lung Neoplasms
  23 Citations (Scopus)

• Leukocyte Cell-Derived Chemotaxin 2 Retards Non-Small Cell Lung Cancer Progression Through Antagonizing MET and EGFR Activities

  Hung, W. Y., Chang, J. H., Cheng, Y., Chen, C. K., Chen, J. Q., Hua, K. T., Cheng, C. W., Hsiao, M., Chung, C. L., Lee, W. J. & Chien, M. H., Jan 1 2018, In: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 51, 1, p. 337-355 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemotactic Factors
  • ErbB Receptors
  • Non-Small Cell Lung Carcinoma
  • Leukocytes
  • Lewis Lung Carcinoma
  7 Citations (Scopus)

• Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress

  Yang, Y. C., Chien, M. H., Liu, H. Y., Chang, Y. C., Chen, C. K., Lee, W. J., Kuo, T. C., Hsiao, M., Hua, K. T. & Cheng, T. Y., May 1 2018, In: Cancer Letters. 421, p. 28-40 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Pyruvate Kinase
  • Neoplastic Stem Cells
  • Glucose
  • Physiological Stress
  • Population
  23 Citations (Scopus)

• N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas

  Chien, M. H., Lee, W. J., Yang, Y. C., Tan, P., Pan, K. F., Liu, Y. C., Tsai, H. C., Hsu, C. H., Wen, Y. C., Hsiao, M. & Hua, K. T., Oct 1 2018, In: Cancer Letters. 433, p. 86-98 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Acetyltransferases
  • Matrix Metalloproteinase 2
  • Osteosarcoma
  • Neoplasm Metastasis
  • Proteins
  13 Citations (Scopus)

• Stimulation of Fas/FasL-mediated apoptosis by luteolin through enhancement of histone H3 acetylation and c-Jun activation in HL-60 leukemia cells

  Wang, S. W., Chen, Y. R., Chow, J. M., Chien, M. H., Yang, S. F., Wen, Y. C., Lee, W. J. & Tseng, T. H., Jul 2018, In: Molecular Carcinogenesis. 57, 7, p. 866-877 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Luteolin
  • Fas Ligand Protein
  • HL-60 Cells
  • Acetylation
  • Histones
  10 Citations (Scopus)
• 2017

  3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma

  Hua, K. T., Liu, Y. F., Hsu, C. L., Cheng, T. Y., Yang, C. Y., Chang, J. S., Lee, W. J., Hsiao, M., Juan, H. F., Chien, M. H. & Yang, S. F., Dec 1 2017, In: Scientific Reports. 7, 1, 4466.

  Research output: Contribution to journal › Article › peer-review

  • Carbonic Anhydrase IX
  • Hepatocellular Carcinoma
  • Alleles
  • RNA Stability
  • Neoplasms
  32 Citations (Scopus)

• A Fas Ligand (FasL)-fused humanized antibody against tumor-Associated glycoprotein 72 selectively exhibits the cytotoxic effect against oral cancer cells with a low FasL/Fas ratio

  Chien, M. H., Chang, W. M., Lee, W. J., Chang, Y. C., Lai, T. C., Chan, D. V., Sharma, R., Lin, Y. F. & Hsiao, M., Jun 1 2017, In: Molecular Cancer Therapeutics. 16, 6, p. 1102-1113 12 p.

  Research output: Contribution to journal › Article › peer-review

  • tumor-associated antigen 72
  • Antibodies, Monoclonal, Humanized
  • Fas Ligand Protein
  • Mouth Neoplasms
  • Squamous Cell Carcinoma
  7 Citations (Scopus)

• Corrigendum to "Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells" [383 (2016) 282-294]

  Kuo, T. C., Chen, C. K., Hua, K. T., Yu, P., Lee, W. J., Chen, M. W., Jeng, Y. M., Chien, M. H., Kuo, K. T., Hsiao, M. & Kuo, M. L., May 1 2017, In: Cancer Letters. 393, p. 130-131 2 p.

  Research output: Contribution to journal › Article › peer-review

• Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21^WAF1/CIP1 expression

  Tseng, T. H., Chien, M. H., Lin, W. L., Wen, Y-C., Chow, J. M., Chen, C. K., Kuo, T. C. & Lee, W. J., Feb 1 2017, In: Environmental Toxicology. 32, 2, p. 434-444 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Acetylation
  • Cell proliferation
  • Apigenin
  • tumor
  • Tumors
  56 Citations (Scopus)

• KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer

  Chien, M. H., Lee, W. J., Yang, Y. C., Li, Y. L., Chen, B. R., Cheng, T. Y., Yang, P. W., Wang, M. Y., Jan, Y. H., Lin, Y. K., Lee, J. M., Hsiao, M., Chen, J. S. & Hua, K. T., Oct 1 2017, In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1860, 10, p. 1013-1024 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein Splicing
  • RNA Stability
  • Cells
  • Non-Small Cell Lung Carcinoma
  • Degradation
  14 Citations (Scopus)

• Quercetin simultaneously induces G₀/G₁-phase arrest and caspase-mediated crosstalk between apoptosis and autophagy in human leukemia HL-60 cells

  Chang, J. L., Chow, J. M., Chang, J. H., Wen, Y-C., Lin, Y. W., Yang, S. F., Lee, W. J. & Chien, M. H., Jul 2017, In: Environmental Toxicology. 32, 7, p. 1857-1868 12 p.

  Research output: Contribution to journal › Article › peer-review

  • apoptosis
  • leukemia
  • Cell Cycle Resting Phase
  • Quercetin
  • HL-60 Cells
  14 Citations (Scopus)

• Quercetin suppresses the metastatic ability of lung cancer through inhibiting Snail-dependent Akt activation and Snail-independent ADAM9 expression pathways

  Chang, J. H., Lai, S. L., Chen, W. S., Hung, W. Y., Chow, J. M., Hsiao, M., Lee, W. J. & Chien, M. H., Oct 1 2017, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 10, p. 1746-1758 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Quercetin
  • Lung Neoplasms
  • Non-Small Cell Lung Carcinoma
  • Neoplasm Metastasis
  • SERPIN-B5
  37 Citations (Scopus)

• Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer

  Kao, S. J., Lee, W. J., Chang, J. H., Chow, J. M., Chung, C. L., Hung, W. Y. & Chien, M. H., Apr 1 2017, In: Environmental Toxicology. 32, 4, p. 1426-1438

  Research output: Contribution to journal › Article › peer-review

  • dihydromyricetin
  • apoptosis
  • reactive oxygen species
  • JNK Mitogen-Activated Protein Kinases
  • Extracellular Signal-Regulated MAP Kinases
  34 Citations (Scopus)

• The Gαh-PLCδ1 signaling axis drives metastatic progression in triple-negative breast cancer

  Huang, S. P., Liu, P. Y., Kuo, C. J., Chen, C. L., Lee, W. J., Tsai, Y. H. & Lin, Y. F., Jun 2 2017, In: Journal of Hematology and Oncology. 10, 1, 114.

  Research output: Contribution to journal › Article › peer-review

  • Triple Negative Breast Neoplasms
  • Breast Neoplasms
  • Neoplasm Metastasis
  • transglutaminase 2
  • Lung
  5 Citations (Scopus)

• Tricetin induces apoptosis of human leukemic HL-60 cells through a reactive oxygen species-mediated c-jun N-terminal kinase activation pathway

  Chien, M. H., Chow, J. M., Lee, W. J., Chen, H. Y., Tan, P., Wen, Y. C., Lin, Y. W., Hsiao, P. C. & Yang, S. F., Aug 1 2017, In: International Journal of Molecular Sciences. 18, 8, 1667.

  Research output: Contribution to journal › Article › peer-review

  • tricetin
  • Cell death
  • apoptosis
  • HL-60 Cells
  • JNK Mitogen-Activated Protein Kinases
  12 Citations (Scopus)

• Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts

  Chien, M. H., Lee, T. H., Lee, W. J., Yeh, Y. H., Li, T. K., Wang, P. C., Chen, J. J., Chow, J. M., Lin, Y. W., Hsiao, M., Wang, S. W. & Hua, K. T., Mar 1 2017, In: Cancer Letters. 388, p. 249-261 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Trichodermin
  • JNK Mitogen-Activated Protein Kinases
  • Pancreatic Neoplasms
  • Heterografts
  • DNA Damage
  8 Citations (Scopus)
• 2016

  Akt activation correlates with snail expression and potentially determines the recurrence of prostate cancer in patients at stage T2 after a radical prostatectomy

  Chen, W. Y., Hua, K. T., Lee, W. J., Lin, Y. W., Liu, Y. N., Chen, C. L., Wen, Y-C. & Chien, M. H., Aug 1 2016, In: International Journal of Molecular Sciences. 17, 8, 1194.

  Research output: Contribution to journal › Article › peer-review

  • snails
  • Snails
  • Prostatectomy
  • cancer
  • Chemical activation
  2 Citations (Scopus)

• G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway

  Cha, S. T., Tan, C. T., Chang, C. C., Chu, C. Y., Lee, W. J., Lin, B. Z., Lin, M. T. & Kuo, M. L., Sep 1 2016, In: Nature Cell Biology. 18, 9, p. 993-1005 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Catenins
  • Colonic Neoplasms
  • Epigenomics
  • Colorectal Neoplasms
  • Neoplasms
  18 Citations (Scopus)

• Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells

  Kuo, T. C., Chen, C. K., Hua, K. T., Yu, P., Lee, W-J., Chen, M. W., Jeng, Y. M., Chien, M-H., Kuo, K., Hsiao, M. & Kuo, M. L., Dec 28 2016, In: Cancer Letters. 383, 2, p. 282-294 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutaminase
  • Hepatocellular Carcinoma
  • Neoplasm Metastasis
  • Snails
  • Glutamine
  33 Citations (Scopus)

• Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis

  Lin, C. W., Yang, W. E., Lee, W. J., Hua, K. T., Hsieh, F. K., Hsiao, M., Chen, C. C., Chow, J. M., Chen, M. K., Yang, S. F. & Chien, M. H., Jul 1 2016, In: Carcinogenesis. 37, 7, p. 712-722 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Carbonic Anhydrase IX
  • Lipocalin-2
  • Mouth Neoplasms
  • Squamous Cell Carcinoma
  • Neoplasm Metastasis
  41 Citations (Scopus)

• Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity

  Lin, Y. W., Lee, L. M., Lee, W. J., Chu, C. Y., Tan, P., Yang, Y. C., Chen, W. Y., Yang, S. F., Hsiao, M. & Chien, M. H., Apr 2016, In: Journal of Pineal Research. 60, 3, p. 277-290 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Melatonin
  • Renal Cell Carcinoma
  • Matrix Metalloproteinases
  • Transcriptional Activation
  • Neoplasm Metastasis
  102 Citations (Scopus)
• 2015

  By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer

  Wen, Y-C., Lee, W. J., Tan, P., Yang, S. F., Hsiao, M., Lee, L. M. & Chien, M. H., 2015, In: Oncotarget. 6, 25, p. 21120-21136 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • osthol
  • Snails
  • Epithelial-Mesenchymal Transition
  • Cadherins
  • Prostatic Neoplasms
  51 Citations (Scopus)

• GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis

  Chang, J. S., Su, C. Y., Yu, W. H., Lee, W. J., Liu, Y. P., Lai, T. C., Jan, Y. H., Yang, Y. F., Shen, C. N., Shew, J. Y., Lu, J., Yang, C. J., Huang, M. S., Lu, P. J., Lin, Y. F., Kuo, M. L., Hua, K. T. & Hsiao, M., 2015, In: Oncotarget. 6, 34, p. 36278-36291 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Non-Small Cell Lung Carcinoma
  • Lung Neoplasms
  • Neoplasm Metastasis
  • G-Protein-Coupled Receptor Kinases
  • Receptor-Interacting Protein Serine-Threonine Kinases
  31 Citations (Scopus)

• Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development

  Lin, F. Y., Lin, C. W., Yang, S. F., Lee, W. J., Lin, Y. W., Lee, L. M., Chang, J. L., Weng, W. C., Lin, C. H. & Chien, M. H., Mar 25 2015, In: PLoS One. 10, 3, e0121677.

  Research output: Contribution to journal › Article › peer-review

  • mouth neoplasms
  • Melatonin Receptors
  • Polymorphism
  • Mouth Neoplasms
  • melatonin
  13 Citations (Scopus)

• Keap1-Nrf2 interaction suppresses cell motility in lung adenocarcinomas by targeting the S100P protein

  Chien, M. H., Lee, W. J., Hsieh, F. K., Li, C. F., Cheng, T. Y., Wang, M. Y., Chen, J. S., Chow, J. M., Jan, Y. H., Hsiao, M., Hua, K. T. & Kuo, M. L., Oct 15 2015, In: Clinical Cancer Research. 21, 20, p. 4719-4732 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • Adenocarcinoma of Lung
  • Protein Transport
  • Cell Movement
  • Non-Small Cell Lung Carcinoma
  30 Citations (Scopus)

• Macrophage infiltration induces gastric cancer invasiveness by activating the β-catenin pathway

  Wu, M. H., Lee, W. J., Hua, K. T., Kuo, M. L. & Lin, M. T., Jul 30 2015, In: PLoS ONE. 10, 7, 134122.

  Research output: Contribution to journal › Article › peer-review

  • Macrophages
  • catenins
  • stomach neoplasms
  • Catenins
  • Infiltration
  24 Citations (Scopus)

• Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress

  Lee, W. J., Chien, M. H., Chow, J. M., Chang, J. L., Wen, Y-C., Lin, Y. W., Cheng, C. W., Lai, G. M., Hsiao, M. & Lee, L. M., May 27 2015, In: Scientific Reports. 5, 10420.

  Research output: Contribution to journal › Article › peer-review

  • Curcumin
  • Endoplasmic Reticulum Stress
  • Reactive Oxygen Species
  • Prostatic Neoplasms
  • Cell Death
  35 Citations (Scopus)

• Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft

  Lee, W-J., Hsiao, M., Chang, J. L., Yang, S. F., Tseng, T. H., Cheng, C-W., Chow, J-M., Lin, K. H., Lin, Y. W., Liu, C. C., Lee, L-M. & Chien, M-H., Jul 15 2015, In: Archives of Toxicology. 89, 7, p. 1103-1117 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Quercetin
  • HL-60 Cells
  • Extracellular Signal-Regulated MAP Kinases
  • Heterografts
  • Chemical activation
  54 Citations (Scopus)

• Tricetin suppresses the migration/invasion of human glioblastoma multiforme cells by inhibiting matrix metalloproteinase-2 through modulation of the expression and transcriptional activity of specificity protein 1

  Chao, R., Chow, J. M., Hsieh, Y. H., Chen, C. K., Lee, W. J., Hsieh, F. K., Yu, N. Y., Chou, M. C., Cheng, C. W., Yang, S. F. & Chien, M. H., Oct 3 2015, In: Expert Opinion on Therapeutic Targets. 19, 10, p. 1293-1306 14 p.

  Research output: Contribution to journal › Article › peer-review

  • tricetin
  • Matrix Metalloproteinase 2
  • Glioblastoma
  • Modulation
  • Matrix Metalloproteinases
  16 Citations (Scopus)

• Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

  Yang, S. F., Lee, W. J., Tan, P., Tang, C. H., Hsiao, M., Hsieh, F. K. & Chien, M. H., 2015, In: Oncotarget. 6, 5, p. 2736-2753 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Resveratrol
  • Matrix Metalloproteinase 2
  • Osteosarcoma
  • MicroRNAs
  • Up-Regulation
  80 Citations (Scopus)
• 2014

  Associations of VEGF-C genetic polymorphisms with urothelial cell carcinoma susceptibility differ between smokers and non-smokers in Taiwan

  Tung, M. C., Hsieh, M. J., Wang, S. S., Yang, S. F., Chen, S. S., Wang, S. W., Lee, L. M., Lee, W. J. & Chien, M. H., Mar 7 2014, In: PLoS One. 9, 3, e91147.

  Research output: Contribution to journal › Article › peer-review

  • vascular endothelial growth factor C
  • Vascular Endothelial Growth Factor C
  • Polymorphism
  • Genetic Polymorphisms
  • carcinoma
  14 Citations (Scopus)

• Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment

  Chen, C. K., Yang, C. Y., Hua, K. T., Ho, M. C., Johansson, G., Jeng, Y. M., Chen, C. N., Chen, M. W., Lee, W. J., Su, J. L., Lai, T. C., Chou, C. C., Ho, B. C., Chang, C. F., Lee, P. H., Chang, K. J., Hsiao, M., Lin, M. T. & Kuo, M. L., Mar 2014, In: Hepatology. 59, 3, p. 974-985 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Non-Receptor Type 1 Protein Tyrosine Phosphatase
  • Chemotactic Factors
  • Hepatocellular Carcinoma
  • Leukocytes
  • Blood Vessels
  33 Citations (Scopus)

• Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells

  Hsiao, P. C., Lee, W-J., Yang, S. F., Tan, P., Chen, H. Y., Lee, L-M., Chang, J. L., Lai, G-M., Chow, J-M. & Chien, M-H., Dec 1 2014, In: Tumor Biology. 35, 12, p. 11903-11911 9 p.

  Research output: Contribution to journal › Article › peer-review

  • nobiletin
  • Caspase 8
  • Myeloid Cells
  • Acute Myeloid Leukemia
  • Apoptosis
  27 Citations (Scopus)

• Pterostilbene simultaneously induced G0/G1-phase arrest and MAPK-mediated mitochondrial-derived apoptosis in human acute myeloid leukemia cell lines

  Hsiao, P. C., Chou, Y. E., Tan, P., Lee, W-J., Yang, S. F., Chow, J-M., Chen, H. Y., Lin, C-H., Lee, L-M. & Chien, M-H., Aug 21 2014, In: PLoS One. 9, 8, e105342.

  Research output: Contribution to journal › Article › peer-review

  • pterostilbene
  • myeloid leukemia
  • Cell Cycle Resting Phase
  • G1 Phase
  • Myeloid Cells
  41 Citations (Scopus)

• Snail as a potential marker for predicting the recurrence of prostate cancer in patients at stage T2 after radical prostatectomy

  Wen, Y-C., Chen, W. Y., Lee, W. J., Yang, S. F., Lee, L. M. & Chien, M. H., Apr 20 2014, In: Clinica Chimica Acta. 431, p. 169-173 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Snails
  • Microarrays
  • Tumors
  • Prostatectomy
  • Tissue
  9 Citations (Scopus)

• Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2

  Hua, K. T., Lee, W. J., Yang, S. F., Chen, C. K., Hsiao, M., Ku, C. C., Wei, L. H., Kuo, M. L. & Chien, M. H., Feb 2014, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 2, p. 387-397 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Vascular Endothelial Growth Factor C
  • Endothelin-1
  • Cyclooxygenase 2
  • Myeloid Cells
  • Acute Myeloid Leukemia
  18 Citations (Scopus)

• α-Solanine inhibits invasion of human prostate cancer cell by suppressing epithelial-mesenchymal transition and MMPs expression

  Shen, K. H., Liao, A. C. H., Hung, J. H., Lee, W. J., Hu, K. C., Lin, P. T., Liao, R. F. & Chen, P. S., 2014, In: Molecules. 19, 8, p. 11896-11914 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Solanine
  • Epithelial-Mesenchymal Transition
  • Cells
  • Matrix Metalloproteinases
  • cancer
  51 Citations (Scopus)
• 2013

  Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

  Kuo, T. C., Tan, C. T., Chang, Y. W., Hong, C. C., Lee, W. J., Chen, M. W., Jeng, Y. M., Chiou, J., Yu, P., Chen, P. S., Wang, M. Y., Hsiao, M., Su, J. L. & Kuo, M. L., Mar 1 2013, In: Journal of Clinical Investigation. 123, 3, p. 1082-1095 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Angiopoietin-like Proteins
  • Cell Movement
  • Lung Neoplasms
  • Neoplasms
  • Epithelial-Mesenchymal Transition
  60 Citations (Scopus)