• 1380 Citations
  • 23 h-Index
20062020

Research output per year

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Research Output

  • 1380 Citations
  • 23 h-Index
  • 54 Article
  • 2 Comment/debate
  • 1 Conference contribution
Article

3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma

Hua, K. T., Liu, Y. F., Hsu, C. L., Cheng, T. Y., Yang, C. Y., Chang, J. S., Lee, W. J., Hsiao, M., Juan, H. F., Chien, M. H. & Yang, S. F., Dec 1 2017, In : Scientific Reports. 7, 1, 4466.

Research output: Contribution to journalArticle

28 Citations (Scopus)
5 Citations (Scopus)

Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

Kuo, T. C., Tan, C. T., Chang, Y. W., Hong, C. C., Lee, W. J., Chen, M. W., Jeng, Y. M., Chiou, J., Yu, P., Chen, P. S., Wang, M. Y., Hsiao, M., Su, J. L. & Kuo, M. L., Mar 1 2013, In : Journal of Clinical Investigation. 123, 3, p. 1082-1095 14 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells

Lee, W. J., Chen, W. K., Wang, C. J., Lin, W. L. & Tseng, T. H., Jan 15 2008, In : Toxicology and Applied Pharmacology. 226, 2, p. 178-191 14 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)

Associations of VEGF-C genetic polymorphisms with urothelial cell carcinoma susceptibility differ between smokers and non-smokers in Taiwan

Tung, M. C., Hsieh, M. J., Wang, S. S., Yang, S. F., Chen, S. S., Wang, S. W., Lee, L. M., Lee, W. J. & Chien, M. H., Mar 7 2014, In : PLoS One. 9, 3, e91147.

Research output: Contribution to journalArticle

13 Citations (Scopus)
Open Access
1 Citation (Scopus)

By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer

Wen, Y-C., Lee, W. J., Tan, P., Yang, S. F., Hsiao, M., Lee, L. M. & Chien, M. H., 2015, In : Oncotarget. 6, 25, p. 21120-21136 17 p.

Research output: Contribution to journalArticle

Open Access
46 Citations (Scopus)

Circulating proteoglycan endocan mediates EGFR-driven progression of non-small cell lung cancer

Yang, Y-C., Pan, K-F., Lee, W-J., Chang, J-H., Tan, P., Gu, C-C., Chang, W-M., Yang, S-F., Hsiao, M., Hua, K-T. & Chien, M-H., Jun 19 2020, In : Cancer Research.

Research output: Contribution to journalArticle

Combined Effects of ICAM-1 Single-Nucleotide Polymorphisms and Environmental Carcinogens on Oral Cancer Susceptibility and Clinicopathologic Development

Lin, C. W., Chuang, C. Y., Tang, C. H., Chang, J. L., Lee, L-M., Lee, W-J., Chow, J-M., Yang, S. F. & Chien, M-H., Sep 12 2013, In : PLoS One. 8, 9, e72940.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Corrigendum to "Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells" [383 (2016) 282-294]

Kuo, T. C., Chen, C. K., Hua, K. T., Yu, P., Lee, W. J., Chen, M. W., Jeng, Y. M., Chien, M. H., Kuo, K. T., Hsiao, M. & Kuo, M. L., 2017, (Accepted/In press) In : Cancer Letters.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Dual targeting of the p38 MAPK‐HO‐1 axis and cIAP1/XIAP by demethoxycurcumin triggers caspase‐mediated apoptotic cell death in oral squamous cell carcinoma cells

Chien, M. H., Yang, W. E., Yang, Y. C., Ku, C. C., Lee, W. J., Tsai, M. Y., Lin, C. W. & Yang, S. F., Mar 2020, In : Cancers. 12, 3, 703.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics

Lin, C. H., Hsieh, M. J., Lee, H. L., Yang, S. F., Su, S. C., Lee, W. J. & Chou, Y. E., Jan 1 2020, In : Journal of Cancer. 11, 6, p. 1641-1647 7 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Estimating the Delivery Efficiency of Drug-Loaded Microbubbles in Cancer Cells with Ultrasound and Bioluminescence Imaging

Liao, A. H., Li, Y. K., Lee, W. J., Wu, M. F., Liu, H. L. & Kuo, M. L., Nov 2012, In : Ultrasound in Medicine and Biology. 38, 11, p. 1938-1948 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway

Cha, S. T., Tan, C. T., Chang, C. C., Chu, C. Y., Lee, W. J., Lin, B. Z., Lin, M. T. & Kuo, M. L., Sep 1 2016, In : Nature Cell Biology. 18, 9, p. 993-1005 13 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis

Chang, J. S., Su, C. Y., Yu, W. H., Lee, W. J., Liu, Y. P., Lai, T. C., Jan, Y. H., Yang, Y. F., Shen, C. N., Shew, J. Y., Lu, J., Yang, C. J., Huang, M. S., Lu, P. J., Lin, Y. F., Kuo, M. L., Hua, K. T. & Hsiao, M., 2015, In : Oncotarget. 6, 34, p. 36278-36291 14 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells

Kuo, T. C., Chen, C. K., Hua, K. T., Yu, P., Lee, W-J., Chen, M. W., Jeng, Y. M., Chien, M-H., Kuo, K., Hsiao, M. & Kuo, M. L., Dec 28 2016, In : Cancer Letters. 383, 2, p. 282-294 13 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
47 Citations (Scopus)

Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways

Lee, W. J., Wu, L. F., Chen, W. K., Wang, C. J. & Tseng, T. H., Mar 25 2006, In : Chemico-Biological Interactions. 160, 2, p. 123-133 11 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development

Lin, F. Y., Lin, C. W., Yang, S. F., Lee, W. J., Lin, Y. W., Lee, L. M., Chang, J. L., Weng, W. C., Lin, C. H. & Chien, M. H., Mar 25 2015, In : PLoS One. 10, 3, e0121677.

Research output: Contribution to journalArticle

13 Citations (Scopus)

In vitro enhancement effect of humic acid on the progression of lung cancer cells

Lee, W. J., Lu, F. J., Wang, S. F., Chen, Y. R. & Tseng, T. H., Oct 30 2009, In : Chemico-Biological Interactions. 181, 3, p. 463-471 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Keap1-Nrf2 interaction suppresses cell motility in lung adenocarcinomas by targeting the S100P protein

Chien, M. H., Lee, W. J., Hsieh, F. K., Li, C. F., Cheng, T. Y., Wang, M. Y., Chen, J. S., Chow, J. M., Jan, Y. H., Hsiao, M., Hua, K. T. & Kuo, M. L., Oct 15 2015, In : Clinical Cancer Research. 21, 20, p. 4719-4732 14 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer

Chien, M. H., Lee, W. J., Yang, Y. C., Li, Y. L., Chen, B. R., Cheng, T. Y., Yang, P. W., Wang, M. Y., Jan, Y. H., Lin, Y. K., Lee, J. M., Hsiao, M., Chen, J. S. & Hua, K. T., Oct 1 2017, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1860, 10, p. 1013-1024 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment

Chen, C. K., Yang, C. Y., Hua, K. T., Ho, M. C., Johansson, G., Jeng, Y. M., Chen, C. N., Chen, M. W., Lee, W. J., Su, J. L., Lai, T. C., Chou, C. C., Ho, B. C., Chang, C. F., Lee, P. H., Chang, K. J., Hsiao, M., Lin, M. T. & Kuo, M. L., Mar 2014, In : Hepatology. 59, 3, p. 974-985 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
4 Citations (Scopus)

Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis

Lin, C. W., Yang, W. E., Lee, W. J., Hua, K. T., Hsieh, F. K., Hsiao, M., Chen, C. C., Chow, J. M., Chen, M. K., Yang, S. F. & Chien, M. H., Jul 1 2016, In : Carcinogenesis. 37, 7, p. 712-722 11 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Macrophage infiltration induces gastric cancer invasiveness by activating the β-catenin pathway

Wu, M. H., Lee, W. J., Hua, K. T., Kuo, M. L. & Lin, M. T., Jul 30 2015, In : PLoS One. 10, 7, 134122.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity

Lin, Y. W., Lee, L. M., Lee, W. J., Chu, C. Y., Tan, P., Yang, Y. C., Chen, W. Y., Yang, S. F., Hsiao, M. & Chien, M. H., Apr 1 2016, In : Journal of Pineal Research. 60, 3, p. 277-290 14 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells

Hsiao, P. C., Lee, W-J., Yang, S. F., Tan, P., Chen, H. Y., Lee, L-M., Chang, J. L., Lai, G-M., Chow, J-M. & Chien, M-H., Dec 1 2014, In : Tumor Biology. 35, 12, p. 11903-11911 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
32 Citations (Scopus)

Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress

Yang, Y. C., Chien, M. H., Liu, H. Y., Chang, Y. C., Chen, C. K., Lee, W. J., Kuo, T. C., Hsiao, M., Hua, K. T. & Cheng, T. Y., May 1 2018, In : Cancer Letters. 421, p. 28-40 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas

Chien, M. H., Lee, W. J., Yang, Y. C., Tan, P., Pan, K. F., Liu, Y. C., Tsai, H. C., Hsu, C. H., Wen, Y. C., Hsiao, M. & Hua, K. T., Oct 1 2018, In : Cancer Letters. 433, p. 86-98 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

N-α-Acetyltransferase 10 Protein Suppresses Cancer Cell Metastasis by Binding PIX Proteins and Inhibiting Cdc42/Rac1 Activity

Hua, K. T., Tan, C. T., Johansson, G., Lee, J. M., Yang, P. W., Lu, H. Y., Chen, C. K., Su, J. L., Chen, P. B., Wu, Y. L., Chi, C. C., Kao, H. J., Shih, H. J., Chen, M. W., Chien, M. H., Chen, P. S., Lee, W. J., Cheng, T. Y., Rosenberger, G., Chai, C. Y. & 6 others, Yang, C. J., Huang, M. S., Lai, T. C., Chou, T. Y., Hsiao, M. & Kuo, M. L., Feb 15 2011, In : Cancer Cell. 19, 2, p. 218-231 14 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
Open Access
2 Citations (Scopus)

Promoting neoplastic transformation of humic acid in mouse epidermal JB6 Cl41 cells

Lu, F. J., Tseng, T. H., Lee, W. J., Yen, C. C., Yin, Y. F., Liao, C. W. & Liu, K. M., Sep 25 2006, In : Chemico-Biological Interactions. 162, 3, p. 249-258 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Pterostilbene simultaneously induced G0/G1-phase arrest and MAPK-mediated mitochondrial-derived apoptosis in human acute myeloid leukemia cell lines

Hsiao, P. C., Chou, Y. E., Tan, P., Lee, W-J., Yang, S. F., Chow, J-M., Chen, H. Y., Lin, C-H., Lee, L-M. & Chien, M-H., Aug 21 2014, In : PLoS One. 9, 8, e105342.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells

Lee, W. J., Chen, Y. R. & Tseng, T. H., Feb 2011, In : Oncology Reports. 25, 2, p. 583-591 9 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft

Lee, W-J., Hsiao, M., Chang, J. L., Yang, S. F., Tseng, T. H., Cheng, C-W., Chow, J-M., Lin, K. H., Lin, Y. W., Liu, C. C., Lee, L-M. & Chien, M-H., Jul 15 2015, In : Archives of Toxicology. 89, 7, p. 1103-1117 15 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
12 Citations (Scopus)
27 Citations (Scopus)
8 Citations (Scopus)

Stimulation of Fas/FasL-mediated apoptosis by luteolin through enhancement of histone H3 acetylation and c-Jun activation in HL-60 leukemia cells

Wang, S. W., Chen, Y. R., Chow, J. M., Chien, M. H., Yang, S. F., Wen, Y. C., Lee, W. J. & Tseng, T. H., Jan 1 2018, (Accepted/In press) In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Studies on mercuric sulfide, a component of cinnabar, a Chinese herbal medicine, on celluar functions in mouse lung and fibroblasts

Yen, C. C., Huang, C. F., Lee, W. J., Hsu, M. J., Liu, S. H. & Lin-Shiau, S. Y., Jan 2008, In : Toxicological and Environmental Chemistry. 90, 1, p. 181-201 21 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
25 Citations (Scopus)
Open Access
8 Citations (Scopus)

The Gαh-PLCδ1 signaling axis drives metastatic progression in triple-negative breast cancer

Huang, S. P., Liu, P. Y., Kuo, C. J., Chen, C. L., Lee, W. J., Tsai, Y. H. & Lin, Y. F., Jun 2 2017, In : Journal of Hematology and Oncology. 10, 1, 114.

Research output: Contribution to journalArticle

4 Citations (Scopus)
10 Citations (Scopus)
14 Citations (Scopus)