Projects per year
Personal profile
Education
- 2008 Ph.D., Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University
- 2004 M.S., Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University
Experience
- Deputy Director, Department of Medical Research, Taipei Municipal Wanfang Hospital
- 2021.02- Associate Professor, Department of Urology, School of Medicine, College of Medicine, Taipei Medical University
- 2015.11-2021.01 Assistant Professor, Department of Urology, School of Medicine, College of Medicine, Taipei Medical University
- 2013.04- Assistant Researcher, Taipei Municipal Wanfang Hospital
- 2012.08-2013.03 Research Assistant, Division of Cardiology, Tao-Yuan General Hospital, Ministry of Health and Welfare
- 2008.08-2011.07 Postdoctoral Researcher, Graduate Institute of Toxicology, College of Medicine, National Taiwan University
Research Interests
- 醫學之生化及分子生物
- 藥理及毒理
Awards
- 2015 萬芳醫學中心論文獎(第二名)
Fingerprint
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 5 Finished
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應用人源性腫瘤組織異種移植模型發展熱療作為膀胱原位癌患者的輔助治療策略
1/1/21 → 12/31/21
Project: B - Project of TMU › h - Higher Education Sprout Project
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闡明SPOCK1/PI3K/AKT訊息路徑在透明細胞腎細胞癌對舒尼替尼抗藥性的潛在機制
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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應用人源性腫瘤組織異種移植模型發展熱療作為膀胱原位癌患者的輔助治療策略
1/1/20 → 12/1/20
Project: B - Project of TMU › h - Higher Education Sprout Project
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Unraveling the Underlying Mechanism of Spock1 in Melatonin Suppression of Breast Cancer Cell Transendothelial Migration and Metastasis
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
Research output
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Proteoglycan Endocan: A multifaceted therapeutic target in Cancer
Pan, K. F., Yang, Y. C., Lee, W. J., Hua, K. T. & Chien, M. H., Jan 2022, In: Biochimica et Biophysica Acta - Reviews on Cancer. 1877, 1, 188672.Research output: Contribution to journal › Review article › peer-review
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Targeting DRD2 by the antipsychotic drug, penfluridol, retards growth of renal cell carcinoma via inducing stemness inhibition and autophagy-mediated apoptosis
Tung, M. C., Lin, Y. W., Lee, W. J., Wen, Y. C., Liu, Y. C., Chen, J. Q., Hsiao, M., Yang, Y. C. & Chien, M. H., Apr 2022, In: Cell Death and Disease. 13, 4, 400.Research output: Contribution to journal › Article › peer-review
Open Access -
Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-β/Akt pathway
Hung, W. Y., Lee, W. J., Cheng, G. Z., Tsai, C. H., Yang, Y. C., Lai, T. C., Chen, J. Q., Chung, C. L., Chang, J. H. & Chien, M. H., Oct 2021, In: Cellular Oncology. 44, 5, p. 1087-1103 17 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Direct interaction of β-catenin with nuclear ESM1 supports stemness of metastatic prostate cancer
Pan, K. F., Lee, W. J., Chou, C. C., Yang, Y. C., Chang, Y. C., Chien, M. H., Hsiao, M. & Hua, K. T., Feb 15 2021, In: EMBO Journal. 40, 4, e105450.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Enhanced paclitaxel efficacy to suppress triple-negative breast cancer progression using metronomic chemotherapy with a controlled release system of electrospun poly-d-l-lactide-co-glycolide (Plga) nanofibers
Hsu, M. Y., Hsieh, C. H., Huang, Y. T., Chu, S. Y., Chen, C. M., Lee, W. J. & Liu, S. J., Jul 1 2021, In: Cancers. 13, 13, 3350.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus)
Datasets
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Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis
Chien, M. (Contributor), Lin, Y. (Contributor), Wen, Y. (Contributor), Yang, Y. (Contributor), Hsiao, M. (Contributor), Chang, J. (Contributor), Huang, H. (Contributor) & Lee, W. (Contributor), Unknown Publisher, Jun 10 2019
DOI: 10.6084/m9.figshare.c.4535717.v1, https://doi.org/10.6084%2Fm9.figshare.c.4535717.v1
Dataset
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Tricetin suppresses the migration/invasion of human glioblastoma multiforme cells by inhibiting matrix metalloproteinase-2 through modulation of the expression and transcriptional activity of specificity protein 1
Chao, R. (Contributor), Chow, J. (Contributor), Hsieh, Y. (Contributor), Chen, C. (Contributor), Lee, W. (Contributor), Hsieh, F. (Contributor), Yu, N. (Contributor), Chou, M. (Contributor), Cheng, C. (Contributor), Yang, S. (Contributor) & Chien, M. (Contributor), Unknown Publisher, Jan 1 2015
DOI: 10.6084/m9.figshare.1568934.v2, https://tandf.figshare.com/articles/journal_contribution/Tricetin_suppresses_the_migration_invasion_of_human_glioblastoma_multiforme_cells_by_inhibiting_matrix_metalloproteinase_2_through_modulation_of_the_expression_and_transcriptional_activity_of_specificity_protein_1/1568934/2
Dataset
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Additional file 1: of Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses
Chang, J. (Contributor), Cheng, C. (Contributor), Yang, Y. (Contributor), Chen, W. (Contributor), Hung, W. (Contributor), Chow, J. (Contributor), Chen, P. (Contributor), Hsiao, M. (Contributor), Lee, W. (Contributor) & Chien, M. (Contributor), Unknown Publisher, Aug 22 2018
DOI: 10.6084/m9.figshare.6999656.v1, https://springernature.figshare.com/articles/Additional_file_1_of_Downregulating_CD26_DPPIV_by_apigenin_modulates_the_interplay_between_Akt_and_Snail_Slug_signaling_to_restrain_metastasis_of_lung_cancer_with_multiple_EGFR_statuses/6999656/1
Dataset
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Additional file 1: of Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis
Chien, M. (Contributor), Lin, Y. (Contributor), Wen, Y. (Contributor), Yang, Y. (Contributor), Hsiao, M. (Contributor), Chang, J. (Contributor), Huang, H. (Contributor) & Lee, W. (Contributor), Unknown Publisher, Jun 10 2019
DOI: 10.6084/m9.figshare.8252111.v1, https://springernature.figshare.com/articles/Additional_file_1_of_Targeting_the_SPOCK1-snail_slug_axis-mediated_epithelial-to-mesenchymal_transition_by_apigenin_contributes_to_repression_of_prostate_cancer_metastasis/8252111/1
Dataset
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Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses
Chang, J. (Contributor), Cheng, C. (Contributor), Yang, Y. (Contributor), Chen, W. (Contributor), Hung, W. (Contributor), Chow, J. (Contributor), Chen, P. (Contributor), Hsiao, M. (Contributor), Lee, W. (Contributor) & Chien, M. (Contributor), Unknown Publisher, Aug 22 2018
DOI: 10.6084/m9.figshare.c.4207865.v1, https://figshare.com/collections/Downregulating_CD26_DPPIV_by_apigenin_modulates_the_interplay_between_Akt_and_Snail_Slug_signaling_to_restrain_metastasis_of_lung_cancer_with_multiple_EGFR_statuses/4207865/1
Dataset