Projects per year
Personal profile
Education
- 2008 Ph.D., Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University
- 2004 M.S., Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University
Experience
- Deputy Director, Department of Medical Research, Taipei Municipal Wanfang Hospital
- 2021.02- Associate Professor, Department of Urology, School of Medicine, College of Medicine, Taipei Medical University
- 2015.11-2021.01 Assistant Professor, Department of Urology, School of Medicine, College of Medicine, Taipei Medical University
- 2013.04- Assistant Researcher, Taipei Municipal Wanfang Hospital
- 2012.08-2013.03 Research Assistant, Division of Cardiology, Tao-Yuan General Hospital, Ministry of Health and Welfare
- 2008.08-2011.07 Postdoctoral Researcher, Graduate Institute of Toxicology, College of Medicine, National Taiwan University
Research Interests
- 醫學之生化及分子生物
- 藥理及毒理
Awards
- 2015 萬芳醫學中心論文獎(第二名)
Fingerprint
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Projects
- 5 Finished
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應用人源性腫瘤組織異種移植模型發展熱療作為膀胱原位癌患者的輔助治療策略
1/1/21 → 12/31/21
Project: B - Project of TMU › h - Higher Education Sprout Project
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闡明SPOCK1/PI3K/AKT訊息路徑在透明細胞腎細胞癌對舒尼替尼抗藥性的潛在機制
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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應用人源性腫瘤組織異種移植模型發展熱療作為膀胱原位癌患者的輔助治療策略
1/1/20 → 12/1/20
Project: B - Project of TMU › h - Higher Education Sprout Project
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Unraveling the Underlying Mechanism of Spock1 in Melatonin Suppression of Breast Cancer Cell Transendothelial Migration and Metastasis
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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Proteoglycan SPOCK1 as a Poor Prognostic Marker Promotes Malignant Progression of Clear Cell Renal Cell Carcinoma via Triggering the Snail/Slug-MMP-2 Axis-Mediated Epithelial-to-Mesenchymal Transition
Lin, Y-W., Wen, Y-C., Hsiao, C-H., Lai, F-R., Yang, S-F., Yang, Y-C., Ho, K-H., Hsieh, F-K., Hsiao, M., Lee, W-J. & Chien, M-H., 2023, In: Cells. 12, 3Research output: Contribution to journal › Article › peer-review
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Human Papillomavirus Oncoproteins Confer Sensitivity to Cisplatin by Interfering with Epidermal Growth Factor Receptor Nuclear Trafficking Related to More Favorable Clinical Survival Outcomes in Non-Small Cell Lung Cancer
Wang, J. L., Lee, W. J., Fang, C. L., Hsu, H. L., Chen, B. J. & Liu, H. E., Nov 2022, In: Cancers. 14, 21, 5333.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteoglycan Endocan: A multifaceted therapeutic target in Cancer
Pan, K. F., Yang, Y. C., Lee, W. J., Hua, K. T. & Chien, M. H., Jan 2022, In: Biochimica et Biophysica Acta - Reviews on Cancer. 1877, 1, 188672.Research output: Contribution to journal › Review article › peer-review
1 Citation (Scopus) -
Synergistic Tumor Inhibition via Energy Elimination by Repurposing Penfluridol and 2-Deoxy-D-Glucose in Lung Cancer
Lai, T. C., Lee, Y. L., Lee, W. J., Hung, W. Y., Cheng, G. Z., Chen, J. Q., Hsiao, M., Chien, M. H. & Chang, J. H., Jun 1 2022, In: Cancers. 14, 11, 2750.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Targeting DRD2 by the antipsychotic drug, penfluridol, retards growth of renal cell carcinoma via inducing stemness inhibition and autophagy-mediated apoptosis
Tung, M. C., Lin, Y. W., Lee, W. J., Wen, Y. C., Liu, Y. C., Chen, J. Q., Hsiao, M., Yang, Y. C. & Chien, M. H., Apr 2022, In: Cell Death and Disease. 13, 4, 400.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus)
Datasets
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Additional file 1: of Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis
Huang, H. (Contributor), Lin, Y. (Contributor), Wen, Y. (Contributor), Lee, W. (Contributor), Yang, Y. (Contributor), Chang, J. (Contributor), Chien, M. (Contributor) & Hsiao, M. (Creator), Figshare, 2019
DOI: 10.6084/m9.figshare.8252111.v1, https://doi.org/10.6084%2Fm9.figshare.8252111.v1
Dataset
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Additional file 1: Table S1. of The Gαh-PLCδ1 signaling axis drives metastatic progression in triple-negative breast cancer
Huang, S. (Contributor), Liu, P. (Contributor), Kuo, C. (Contributor), Chen, C. (Contributor), Lee, W. (Contributor), Tsai, Y. (Contributor) & Lin, Y. (Contributor), Unknown Publisher, Jun 2 2017
DOI: 10.6084/m9.figshare.c.3794620_d1.v1, https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_Table_S1_of_The_G_h-PLC_1_signaling_axis_drives_metastatic_progression_in_triple-negative_breast_cancer/5072119/1
Dataset
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Additional file 1: of Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses
Cheng, C. (Contributor), Chow, J. (Contributor), Lee, W. (Contributor), Chen, W. (Contributor), Yang, Y. (Contributor), Hung, W. (Contributor), Chang, J. (Contributor), Hsiao, M. (Creator), Chen, P. (Contributor) & Chien, M. (Contributor), Figshare, 2018
DOI: 10.6084/m9.figshare.6999656.v1, https://doi.org/10.6084%2Fm9.figshare.6999656.v1
Dataset
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Tricetin suppresses the migration/invasion of human glioblastoma multiforme cells by inhibiting matrix metalloproteinase-2 through modulation of the expression and transcriptional activity of specificity protein 1
Chao, R. (Contributor), Chow, J. (Contributor), Hsieh, Y. (Contributor), Chen, C. (Contributor), Lee, W. (Contributor), Hsieh, F. (Contributor), Yu, N. (Contributor), Chou, M. (Contributor), Cheng, C. (Contributor), Yang, S. (Contributor) & Chien, M. (Contributor), Figshare, 2015
DOI: 10.6084/m9.figshare.1568934.v1, https://figshare.com/articles/Tricetin_suppresses_the_migration_invasion_of_human_glioblastoma_multiforme_cells_by_inhibiting_matrix_metalloproteinase_2_through_modulation_of_the_expression_and_transcriptional_activity_of_specificity_protein_1/1568934/1
Dataset
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Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses
Wu, S. (Contributor), Wen, Y. (Contributor), Ku, C. (Creator), Yang, Y. (Contributor), Chow, J. (Contributor), Yang, S. (Contributor), Lee, W. (Contributor) & Chien, M. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.c.4650602.v1, https://springernature.figshare.com/collections/Penfluridol_triggers_cytoprotective_autophagy_and_cellular_apoptosis_through_ROS_induction_and_activation_of_the_PP2A-modulated_MAPK_pathway_in_acute_myeloid_leukemia_with_different_FLT3_statuses/4650602/1
Dataset