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Research Output

  • 1516 Citations
  • 23 h-Index
  • 86 Article
26 Citations (Scopus)

Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats

Lin, T. Y., Huang, W. J., Wu, C. C., Lu, C. W. & Wang, S. J., Feb 10 2014, In : PLoS One. 9, 2, e88644.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Acetylcholinesterase inhibitory activity and neuroprotection: In vitro, molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice

Liu, Y. H., Lee, C. J., Chen, L. C., Lee, T. L., Hsieh, Y. Y., Han, C. H., Yang, C. H., Huang, W. J. & Hou, W. C., Mar 2020, In : Food and Function. 11, 3, p. 2328-2338 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Activation of iodosobenzene by catalytic tetrabutylammonium iodide and its application in the oxidation of some isoquinoline alkaloids

Huang, W. J., Singh, O. V., Chen, C. H., Chiou, S. Y. & Lee, S. S., 2002, In : Helvetica Chimica Acta. 85, 4, p. 1069-1078 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

A facile method for the synthesis of glaucine and norglaucine from boldine

Huang, W. J., Chen, C. H., Singh, O. V., Lee, S. L. & Lee, S. S., 2002, In : Synthetic Communications. 32, 23, p. 3681-3686 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., May 15 2017, In : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., Apr 28 2014, In : Cancer Letters. 346, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Alterations in histone deacetylase 8 lead to cell migration and poor prognosis in breast cancer

Hsieh, C. L., Ma, H. P., Su, C-M., Chang, Y. J., Hung, W. Y., Ho, Y. S., Huang, W. J. & Lin, R. K., Apr 15 2016, In : Life Sciences. 151, p. 7-14 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer

Chiu, H. W., Yeh, Y. L., Ho, S. Y., Wu, Y. H., Wang, B. J., Huang, W. J., Ho, Y. S., Wang, Y. J., Chen, L. C. & Tu, S. H., Nov 1 2019, In : Cancers. 11, 11, 1703.

Research output: Contribution to journalArticle

Open Access

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Wu, Y. H., Hong, C. W., Wang, Y. C., Huang, W. J., Yeh, Y. L., Wang, B. J., Wang, Y. J. & Chiu, H. W., Aug 1 2017, In : Cancer Letters. 400, p. 79-88 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A novel hydroxamate-based compound WMJ-J-09 causes head and neck squamous cell carcinoma cell death via LKB1-AMPK-p38MAPK-p63-survivin cascade

Yen, C. S., Choy, C. S., Huang, W. J., Huang, S. W., Lai, P. Y., Yu, M. C., Shiue, C., Hsu, Y. F. & Hsu, M. J., Mar 1 2018, In : Frontiers in Pharmacology. 9, MAR, p. 1-17 17 p., 167.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A novel hydroxysuberamide derivative potentiates MG132-mediated anticancer activity against human hormone refractory prostate cancers - The role of histone deacetylase and endoplasmic reticulum stress

Chen, Y. C., Huang, W. J., Hsu, J. L., Yu, C. C., Wang, W. T. & Guh, J. H., Sep 2013, In : Prostate. 73, 12, p. 1270-1280 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
18 Citations (Scopus)

Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats

Huang, W. J., Niu, H. S., Lin, M. H., Cheng, J. T. & Hsu, F-L., Jun 25 2010, In : Journal of Natural Products. 73, 6, p. 1170-1172 3 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
3 Citations (Scopus)

Carbon monoxide induces cyclooxygenase-2 expression through MAPKs and PKG in phagocytes

Lin, L. C., Ho, F. M., Yen, S. J., Wu, P. Y., Hung, L. F., Huang, W. J. & Liang, Y. C., Dec 2010, In : International Immunopharmacology. 10, 12, p. 1520-1525 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Cerebellar α6-subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders

Chiou, L-C., Lee, H-J., Ernst, M., Huang, W-J., Chou, J-F., Chen, H-L., Mouri, A., Chen, L-C., Treven, M., Mamiya, T., Fan, P-C., Knutson, D. E., Witzigmann, C., Cook, J., Sieghart, W. & Nabeshima, T., 2018, In : British Journal of Pharmacology. 175, 12, p. 2414-2427 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan

Chen, C. Y., Chiu, F. Y., Lin, Y., Huang, W. J., Hsieh, P. S. & Hsu, F-L., Jan 22 2015, In : International Journal of Molecular Sciences. 16, 2, p. 2497-2516 20 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis

Chen, C. N., Hsiao, C. J., Lee, S. S., Guh, J. H., Chiang, P. C., Huang, C. C. & Huang, W. J., Jan 1 2012, In : Natural Product Research. 26, 2, p. 116-124 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Clerodendrum inerme leaf extract alleviates animal behaviors, hyperlocomotion, and prepulse inhibition disruptions, mimicking tourette syndrome and schizophrenia

Chen, H. L., Lee, H. J., Huang, W. J., Chou, J. F., Fan, P. C., Du, J. C., Ku, Y. L. & Chiou, L. C., 2012, In : Evidence-based Complementary and Alternative Medicine. 2012, 284301.

Research output: Contribution to journalArticle

14 Citations (Scopus)
21 Citations (Scopus)

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., Jul 3 2018, In : Frontiers in Pharmacology. 9, JUL, 708.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., Jan 1 2018, In : European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

DUSP1 expression induced by HDAC1 inhibition mediates gefitinib sensitivity in non-small cell lung cancers

Lin, Y. C., Lin, Y. C., Shih, J. Y., Huang, W. J., Chao, S. W., Chang, Y. L. & Chen, C. C., Jan 15 2015, In : Clinical Cancer Research. 21, 2, p. 428-438 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities

Lin, Y. S., Chen, S-H., Huang, W. J., Chen, C. H., Chien, M. Y., Lin, S. Y. & Hou, W. C., Jun 15 2012, In : Food Chemistry. 132, 4, p. 2074-2080 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
27 Citations (Scopus)
20 Citations (Scopus)

Evaluation of the antihyperuricemic activity of phytochemicals from Davallia formosana by enzyme assay and hyperuricemic mice model

Chen, C. Y., Huang, C. C., Tsai, K. C., Huang, W. J., Huang, W. C., Hsu, Y. C. & Hsu, F-L., 2014, In : Evidence-based Complementary and Alternative Medicine. 2014, 873607.

Research output: Contribution to journalArticle

9 Citations (Scopus)
48 Citations (Scopus)

Ginsenosides Rg1 and Rb1 enhance glutamate release through activation of protein kinase A in rat cerebrocortical nerve terminals (synaptosomes)

Chang, Y., Huang, W. J., Tien, L. T. & Wang, S. J., Jan 6 2008, In : European Journal of Pharmacology. 578, 1, p. 28-36 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Growth stimulating effect on queen bee larvae of histone deacetylase inhibitors

Huang, C. Y., Chi, L. L., Huang, W. J., Chen, Y. W., Chen, W. J., Kuo, Y. C., Yuan, C. M. & Chen, C. N., Jun 20 2012, In : Journal of Agricultural and Food Chemistry. 60, 24, p. 6139-6149 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation

Qi, J., Singh, S., Hua, W. K., Cai, Q., Chao, S. W., Li, L., Liu, H., Ho, Y., McDonald, T., Lin, A., Marcucci, G., Bhatia, R., Huang, W. J., Chang, C. I. & Kuo, Y. H., Nov 5 2015, In : Cell Stem Cell. 17, 5, p. 597-610 14 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

HDAC8 inhibitor WK2-16 therapeutically targets lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation

Lin, F. L., Yen, J. L., Kuo, Y. C., Kang, J. J., Cheng, Y. W., Huang, W. J. & Hsiao, G., Jan 2 2019, In : International Journal of Molecular Sciences. 20, 2, p. 410 410.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Hispidulin, a constituent of Clerodendrum inerme that remitted motor tics, alleviated methamphetamine-induced hyperlocomotion without motor impairment in mice

Huang, W. J., Lee, H. J., Chen, H. L., Fan, P. C., Ku, Y. L. & Chiou, L. C., May 26 2015, In : Journal of Ethnopharmacology. 166, p. 18-22 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Hispidulin alleviated methamphetamine-induced hyperlocomotion by acting at α6 subunit-containing GABAA receptors in the cerebellum

Liao, Y. H., Lee, H. J., Huang, W. J., Fan, P. C. & Chiou, L. C., Sep 1 2016, In : Psychopharmacology. 233, 17, p. 3187-3199 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Identification of trans, trans-2,4-Decadienal metabolites in mouse and human cells using liquid chromatography-mass spectrometry

Pan, K. L., Huang, W. J., Hsu, M. H., Lee, H. L., Liu, H. J., Cheng, C. W., Tsai, M. H., Shen, M. Y. & Lin, P., Oct 20 2014, In : Chemical Research in Toxicology. 27, 10, p. 1707-1719 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Improved enamine-type addition of dehydroaporphine using microwave irradiation

Huang, W. J., Huang, C. C., Hsin, L. W., Tsai, Y. M., Lin, C. T., Lin, J. H. & Lee, S. S., Jun 9 2010, In : Tetrahedron Letters. 51, 23, p. 3062-3064 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies

Mahindroo, N., Wang, C. C., Liao, C. C., Huang, C. F., Lu, I. L., Lien, T. W., Peng, Y. H., Huang, W. J., Lin, Y. T., Hsu, M. C., Lin, C. H., Tsai, C. H., Hsu, J. T. A., Chen, X., Lyu, P. C., Chao, Y. S., Wu, S. Y. & Hsieh, H. P., Feb 9 2006, In : Journal of Medicinal Chemistry. 49, 3, p. 1212-1216 5 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor

Chiu, C. F., Chin, H. K., Huang, W. J., Bai, L. Y., Huang, H. Y. & Weng, J. R., Dec 4 2019, In : Biomolecules. 9, 12

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer

Wei, T. T., Lin, Y. C., Lin, P. H., Shih, J. Y., Chou, C. W., Huang, W. J., Yang, Y. C., Hsiao, P. W. & Chen, C. C., 2015, In : Oncotarget. 6, 14, p. 12481-12492 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Inhibition of HDAC3- and HDAC6-promoted survivin expression plays an important role in SAHA-induced autophagy and viability reduction in breast cancer cells

Lee, J. Y. C., Kuo, C. W., Tsai, S. L., Cheng, S. M., Chen, S. H., Chan, H. H., Lin, C. H., Lin, K. Y., Li, C. F., Kanwar, J. R., Leung, E. Y., Cheung, C. C. H., Huang, W. J., Wang, Y. C. & Cheung, C. H. A., Mar 31 2016, In : Frontiers in Pharmacology. 7, MAR, 81.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Intractable chronic motor tics dramatically respond to clerodendrum inerme (L) gaertn

Fan, P. C., Huang, W. J. & Chiou, L. C., 2009, In : Journal of Child Neurology. 24, 7, p. 887-890 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Involvement of the cGMP pathway in the osthole-facilitated glutamate release in rat hippocampal nerve endings

Lin, T. Y., Lu, C. W., Huang, W. J. & Wang, S. J., Mar 2012, In : Synapse. 66, 3, p. 232-239 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Liposome encapsulation reduces cantharidin toxicity

Chang, C. C., Liu, D. Z., Lin, S. Y., Liang, H. J., Hou, W. C., Huang, W. J., Chang, C. H., Ho, F. M. & Liang, Y. C., Sep 2008, In : Food and Chemical Toxicology. 46, 9, p. 3116-3121 6 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Litebamine, a phenanthrene alkaloid from the wood of Litsea cubeba, inhibits rat smooth muscle cell adhesion and migration on collagen

Huang, C. H., Huang, W. J., Wang, S. J., Wu, P. H. & Wu, W. B., Oct 31 2008, In : European Journal of Pharmacology. 596, 1-3, p. 25-31 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Low-luminance blue light-enhanced phototoxicity in A2E-Laden RPE cell cultures and rats

Lin, C. H., Wu, M. R., Huang, W. J., Chow, D. S. L., Hsiao, G. & Cheng, Y. W., Apr 11 2019, In : International Journal of Molecular Sciences. 20, 7, 1799.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Manganese(III) acetate mediated oxidation of aporphines: a convenient and useful synthesis of oxoaporphines

Singh, O. V., Huang, W. J., Chen, C. H. & Lee, S. S., Nov 12 2007, In : Tetrahedron Letters. 48, 46, p. 8166-8169 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Marchantin A, a cyclic bis(bibenzyl ether), isolated from the liverwort Marchantia emarginata subsp. tosana induces apoptosis in human MCF-7 breast cancer cells

Huang, W. J., Wu, C. L., Lin, C. W., Chi, L. L., Chen, P. Y., Chiu, C. J., Huang, C. Y. & Chen, C. N., May 1 2010, In : Cancer Letters. 291, 1, p. 108-119 12 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Methoxychalcone induces cell-cycle arrest and apoptosis in human hormone-resistant prostate cancer cells through PI 3-kinase-independent inhibition of mTOR pathways

Sun, Y. W., Huang, W. J., Hsiao, C. J., Chen, Y. C., Lu, P. H. & Guh, J. H., Sep 1 2010, In : Prostate. 70, 12, p. 1295-1306 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Methylglyoxal-induced Fibronectin gene expression through Ras-mediated NADPH oxidase activation in renal mesangial cells

Ho, C., Lee, P. H., Huang, W. J., Hsu, Y. C., Lin, C. L. & Wang, J. Y., Aug 2007, In : Nephrology. 12, 4, p. 348-356 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)