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Research Output

  • 1516 Citations
  • 23 h-Index
  • 86 Article
2002

Activation of iodosobenzene by catalytic tetrabutylammonium iodide and its application in the oxidation of some isoquinoline alkaloids

Huang, W. J., Singh, O. V., Chen, C. H., Chiou, S. Y. & Lee, S. S., 2002, In : Helvetica Chimica Acta. 85, 4, p. 1069-1078 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

A facile method for the synthesis of glaucine and norglaucine from boldine

Huang, W. J., Chen, C. H., Singh, O. V., Lee, S. L. & Lee, S. S., 2002, In : Synthetic Communications. 32, 23, p. 3681-3686 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2003

Preparation of 6-phenyl- and 8-phenyl tetrahydroisoquinolines from boldine

Huang, W. J., Chen, C. H. & Lee, S. S., Jul 1 2003, In : Heterocycles. 60, 7, p. 1573-1588 16 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2004

Synthesis of (±)-Glaucine and (±)-Neospirodienone via an One-Pot Bischler-Napieralski Reaction and Oxidative Coupling by a Hypervalent Iodine Reagent

Huang, W. J., Singh, O. V., Chen, C. H. & Lee, S. S., 2004, In : Helvetica Chimica Acta. 87, 1, p. 167-174 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2005

Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities

Mahindroo, N., Huang, C. F., Peng, Y. H., Wang, C. C., Liao, C. C., Lien, T. W., Chittimalla, S. K., Huang, W. J., Chai, C. H., Prakash, E., Chen, C. P., Hsu, T. A., Peng, C. H., Lu, I. L., Lee, L. H., Chang, Y. W., Chen, W. C., Chou, Y. C., Chen, C. T., Goparaju, C. M. V. & 7 others, Chen, Y. S., Lan, S. J., Yu, M. C., Chen, X., Chao, Y. S., Wu, S. Y. & Hsieh, H. P., Dec 29 2005, In : Journal of Medicinal Chemistry. 48, 26, p. 8194-8208 15 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs

Lee, S. L., Huang, W. J., Lin, W. W., Lee, S. S. & Chen, C. H., Nov 15 2005, In : Bioorganic and Medicinal Chemistry. 13, 22, p. 6175-6181 7 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
2006

Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies

Mahindroo, N., Wang, C. C., Liao, C. C., Huang, C. F., Lu, I. L., Lien, T. W., Peng, Y. H., Huang, W. J., Lin, Y. T., Hsu, M. C., Lin, C. H., Tsai, C. H., Hsu, J. T. A., Chen, X., Lyu, P. C., Chao, Y. S., Wu, S. Y. & Hsieh, H. P., Feb 9 2006, In : Journal of Medicinal Chemistry. 49, 3, p. 1212-1216 5 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
2007
26 Citations (Scopus)

Manganese(III) acetate mediated oxidation of aporphines: a convenient and useful synthesis of oxoaporphines

Singh, O. V., Huang, W. J., Chen, C. H. & Lee, S. S., Nov 12 2007, In : Tetrahedron Letters. 48, 46, p. 8166-8169 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Methylglyoxal-induced Fibronectin gene expression through Ras-mediated NADPH oxidase activation in renal mesangial cells

Ho, C., Lee, P. H., Huang, W. J., Hsu, Y. C., Lin, C. L. & Wang, J. Y., Aug 2007, In : Nephrology. 12, 4, p. 348-356 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Novel ent-beyeran-19-oic acids from biotransformations of isosteviol metabolites by Mortierella isabellina

Lin, C. L., Lin, S. J., Huang, W. J., Ku, Y. L., Tsai, T. H. & Hsu, F-L., Dec 2007, In : Planta Medica. 73, 15, p. 1581-1587 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Propolin G, a prenylflavanone, isolated from Taiwanese propolis, induces caspase-dependent apoptosis in brain cancer cells

Huang, W. J., Huang, C. H., Wu, C. L., Lin, J. K., Chen, Y. W., Lin, C. L., Chuang, S. E., Huang, C. Y. & Chen, C. N., Sep 5 2007, In : Journal of Agricultural and Food Chemistry. 55, 18, p. 7366-7376 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Ras activation modulates methylglyoxal-induced mesangial cell apoptosis through superoxide production

Huang, W. J., Tung, C. W., Ho, C., Yang, J. T., Chen, M. L., Chang, P. J., Lee, P. H., Lin, C. L. & Wang, J. Y., Sep 2007, In : Renal Failure. 29, 7, p. 911-921 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2008

Ginsenosides Rg1 and Rb1 enhance glutamate release through activation of protein kinase A in rat cerebrocortical nerve terminals (synaptosomes)

Chang, Y., Huang, W. J., Tien, L. T. & Wang, S. J., Jan 6 2008, In : European Journal of Pharmacology. 578, 1, p. 28-36 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Liposome encapsulation reduces cantharidin toxicity

Chang, C. C., Liu, D. Z., Lin, S. Y., Liang, H. J., Hou, W. C., Huang, W. J., Chang, C. H., Ho, F. M. & Liang, Y. C., Sep 2008, In : Food and Chemical Toxicology. 46, 9, p. 3116-3121 6 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Litebamine, a phenanthrene alkaloid from the wood of Litsea cubeba, inhibits rat smooth muscle cell adhesion and migration on collagen

Huang, C. H., Huang, W. J., Wang, S. J., Wu, P. H. & Wu, W. B., Oct 31 2008, In : European Journal of Pharmacology. 596, 1-3, p. 25-31 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Osthole and imperatorin, the active constituents of Cnidium monnieri (L.) Cusson, facilitate glutamate release from rat hippocampal nerve terminals

Wang, S. J., Lin, T. Y., Lu, C. W. & Huang, W. J., Dec 2008, In : Neurochemistry International. 53, 6-8, p. 416-423 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Simvastatin reverses high glucose-induced apoptosis of mesangial cells via modulation of Wnt signaling pathway

Lin, C. L., Cheng, H., Tung, C. W., Huang, W. J., Chang, P. J., Yang, J. T. & Wang, J. Y., Jan 2008, In : American Journal of Nephrology. 28, 2, p. 290-297 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2009

Intractable chronic motor tics dramatically respond to clerodendrum inerme (L) gaertn

Fan, P. C., Huang, W. J. & Chiou, L. C., 2009, In : Journal of Child Neurology. 24, 7, p. 887-890 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2010

Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats

Huang, W. J., Niu, H. S., Lin, M. H., Cheng, J. T. & Hsu, F-L., Jun 25 2010, In : Journal of Natural Products. 73, 6, p. 1170-1172 3 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Carbon monoxide induces cyclooxygenase-2 expression through MAPKs and PKG in phagocytes

Lin, L. C., Ho, F. M., Yen, S. J., Wu, P. Y., Hung, L. F., Huang, W. J. & Liang, Y. C., Dec 2010, In : International Immunopharmacology. 10, 12, p. 1520-1525 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Improved enamine-type addition of dehydroaporphine using microwave irradiation

Huang, W. J., Huang, C. C., Hsin, L. W., Tsai, Y. M., Lin, C. T., Lin, J. H. & Lee, S. S., Jun 9 2010, In : Tetrahedron Letters. 51, 23, p. 3062-3064 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Marchantin A, a cyclic bis(bibenzyl ether), isolated from the liverwort Marchantia emarginata subsp. tosana induces apoptosis in human MCF-7 breast cancer cells

Huang, W. J., Wu, C. L., Lin, C. W., Chi, L. L., Chen, P. Y., Chiu, C. J., Huang, C. Y. & Chen, C. N., May 1 2010, In : Cancer Letters. 291, 1, p. 108-119 12 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Methoxychalcone induces cell-cycle arrest and apoptosis in human hormone-resistant prostate cancer cells through PI 3-kinase-independent inhibition of mTOR pathways

Sun, Y. W., Huang, W. J., Hsiao, C. J., Chen, Y. C., Lu, P. H. & Guh, J. H., Sep 1 2010, In : Prostate. 70, 12, p. 1295-1306 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings

Lin, T. Y., Lu, C. W., Huang, W. J. & Wang, S. J., May 2010, In : Synapse. 64, 5, p. 390-396 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Synthesis of n-hydroxycinnamides capped with a naturally occurring moiety as inhibitors of histone deacetylase

Huang, W. J., Chen, C. C., Chao, S. W., Lee, S. S., Hsu, F-L., Lu, Y. L., Hung, M. F. & Chang, C. I., Apr 6 2010, In : ChemMedChem. 5, 4, p. 598-607 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2011
48 Citations (Scopus)

NBM-HD-3, a novel histone deacetylase inhibitor with anticancer activity through modulation of PTEN and AKT in brain cancer cells

Huang, W. J., Lin, C. W., Lee, C. Y., Chi, L. L., Chao, Y. C., Wang, H. N., Chiou, B. L., Chen, T. J., Huang, C. Y. & Chen, C. N., Jun 14 2011, In : Journal of Ethnopharmacology. 136, 1, p. 156-167 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Semicarbazide-sensitive amine oxidase inhibitory activity of galacturonic acid hydroxamate

Liu, Y. H., Huang, W. J., Lu, Y. L., Lee, C. C., Tsai, Y. F., Wu, W. C. & Hou, W. C., Jan 2011, In : Botanical Studies. 52, 1, p. 35-40 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors

Huang, W. J., Chen, C. C., Chao, S. W., Yu, C. C., Yang, C. Y., Guh, J. H., Lin, Y. C., Kuo, C. I., Yang, P. & Chang, C. I., Sep 2011, In : European Journal of Medicinal Chemistry. 46, 9, p. 4042-4049 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Synthesis and evaluation of antibacterial activities of 5,7-dihydroxycoumarin derivatives

Chin, Y. P., Huang, W. J., Hsu, F-L., Lin, M. H. & Lin, Y. L., Jun 2011, In : Archiv der Pharmazie. 344, 6, p. 386-393 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
6 Citations (Scopus)
2012

Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis

Chen, C. N., Hsiao, C. J., Lee, S. S., Guh, J. H., Chiang, P. C., Huang, C. C. & Huang, W. J., Jan 1 2012, In : Natural Product Research. 26, 2, p. 116-124 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Clerodendrum inerme leaf extract alleviates animal behaviors, hyperlocomotion, and prepulse inhibition disruptions, mimicking tourette syndrome and schizophrenia

Chen, H. L., Lee, H. J., Huang, W. J., Chou, J. F., Fan, P. C., Du, J. C., Ku, Y. L. & Chiou, L. C., 2012, In : Evidence-based Complementary and Alternative Medicine. 2012, 284301.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities

Lin, Y. S., Chen, S-H., Huang, W. J., Chen, C. H., Chien, M. Y., Lin, S. Y. & Hou, W. C., Jun 15 2012, In : Food Chemistry. 132, 4, p. 2074-2080 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
20 Citations (Scopus)

Growth stimulating effect on queen bee larvae of histone deacetylase inhibitors

Huang, C. Y., Chi, L. L., Huang, W. J., Chen, Y. W., Chen, W. J., Kuo, Y. C., Yuan, C. M. & Chen, C. N., Jun 20 2012, In : Journal of Agricultural and Food Chemistry. 60, 24, p. 6139-6149 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Involvement of the cGMP pathway in the osthole-facilitated glutamate release in rat hippocampal nerve endings

Lin, T. Y., Lu, C. W., Huang, W. J. & Wang, S. J., Mar 2012, In : Synapse. 66, 3, p. 232-239 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

NBM-HD-1: A novel histone deacetylase inhibitor with anticancer activity

Huang, W. J., Liang, Y. C., Chuang, S. E., Chi, L. L., Lee, C. Y., Lin, C. W., Chen, A. L., Huang, J. S., Chiu, C. J., Lee, C. F., Huang, C. Y. & Chen, C. N., 2012, In : Evidence-based Complementary and Alternative Medicine. 2012, 781417.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors

Huang, W. J., Wang, Y. C., Chao, S. W., Yang, C. Y., Chen, L. C., Lin, M. H., Hou, W. C., Chen, M. Y., Lee, T. L., Yang, P. & Chang, C. I., Oct 2012, In : ChemMedChem. 7, 10, p. 1815-1824 10 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2013

A novel hydroxysuberamide derivative potentiates MG132-mediated anticancer activity against human hormone refractory prostate cancers - The role of histone deacetylase and endoplasmic reticulum stress

Chen, Y. C., Huang, W. J., Hsu, J. L., Yu, C. C., Wang, W. T. & Guh, J. H., Sep 2013, In : Prostate. 73, 12, p. 1270-1280 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
3 Citations (Scopus)

NBM-T-L-BMX-OS01, semisynthesized from osthole, is a novel inhibitor of histone deacetylase and enhances learning and memory in rats

Yang, Y. C., Chen, C. N., Wu, C. I., Huang, W. J., Kuo, T. Y., Kuan, M. C., Tsai, T. H., Huang, J. S. & Huang, C. Y., 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 514908.

Research output: Contribution to journalArticle

8 Citations (Scopus)
11 Citations (Scopus)

Semisynthesis and myocardial activity of thaliporphine N-homologues

Chiou, C. M., Lin, C. T., Huang, W. J., Chang, Y. M., Ho, Y. J., Su, M. J. & Lee, S. S., Mar 22 2013, In : Journal of Natural Products. 76, 3, p. 405-412 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo

Chiu, H. W., Yeh, Y. L., Wang, Y. C., Huang, W. J., Chen, Y. A., Chiou, Y. S., Ho, S. Y., Lin, P. & Wang, Y. J., Oct 10 2013, In : PLoS One. 8, 10, e76340.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2014

Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats

Lin, T. Y., Huang, W. J., Wu, C. C., Lu, C. W. & Wang, S. J., Feb 10 2014, In : PLoS One. 9, 2, e88644.

Research output: Contribution to journalArticle

31 Citations (Scopus)

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., Apr 28 2014, In : Cancer Letters. 346, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
18 Citations (Scopus)
27 Citations (Scopus)