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Personal profile

Education

  • 2002 Ph. D., School of Pharmacy, National Taiwan University, Taipei, Organic Synthesis and Medicinal Chemistry
  • 1995 M. S., School of Pharmacy, National Taiwan University, Taipei, Organic Synthesis and Medicinal Chemistry
  • 1992 B. S., School of Pharmacy, Taipei Medical University

Experience

  • 2019.11- Professor , Department of Pharmaceutical Sciences, Taipei Medical University
  • 2017.08- Professor, Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan.
  • 2016-2019 Director, Department of Pharmaceutical Sciences, Taipei Medical University
  • 2011.08-2017.07 Associate Professor, Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan.
  • 2007.08-2011.07 Assistant Professor, Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan.
  • 2004.08-2007.07 Assistant Professor, Department of Nursing, Chang Gung University of Science and Technology, Chiayi campus, Taiwan.
  • 2003.09-2004.07 Postdoctoral Fellow, Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan.
  • 2002.08-2003.08 Postdoctoral Fellow, Drug Research Center, National Taiwan University, Taipei, Taiwan

Research Interests

  • Total synthesis and chemical modification of naturalproduct
  • Development of natural product scaffold
  • Structure-based drug design
  • Microwave-assisted organic synthesis

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Projects

Discovery of Multitarget Agents That Target Alzheimer'S Disease

Huang, W.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

以acridine為scaffold透過雙標靶策略發展新穎抗癌藥物(3/3)

Huang, W.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

以小分子化合物開發新穎且具選擇性塗藥用於血管支架(先期補助)

Huang, W.

8/1/177/31/18

Project: A - Government Institutionf - Other (Funded by Government)

以acridine為scaffold透過雙標靶策略發展新穎抗癌藥物(2/3)

Huang, W.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

Exploiting Acridine Scaffold to Develop Novel Anticancer Agents Based on a Dual Target Strategy

Huang, W.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

Research Output

  • 1463 Citations
  • 22 h-Index
  • 86 Article

Acetylcholinesterase inhibitory activity and neuroprotection: In vitro, molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice

Liu, Y. H., Lee, C. J., Chen, L. C., Lee, T. L., Hsieh, Y. Y., Han, C. H., Yang, C. H., Huang, W. J. & Hou, W. C., Mar 2020, In : Food and Function. 11, 3, p. 2328-2338 11 p.

Research output: Contribution to journalArticle

  • Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease

    Tseng, H. J., Lin, M. H., Shiao, Y. J., Yang, Y. C., Chu, J. C., Chen, C. Y., Chen, Y. Y., Lin, T. E., Su, C. J., Pan, S. L., Chen, L. C., Wang, C. Y., Hsu, K. C. & Huang, W. J., Apr 15 2020, In : European Journal of Medicinal Chemistry. 192, p. 112193 112193.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer

    Chiu, H. W., Yeh, Y. L., Ho, S. Y., Wu, Y. H., Wang, B. J., Huang, W. J., Ho, Y. S., Wang, Y. J., Chen, L. C. & Tu, S. H., Nov 1 2019, In : Cancers. 11, 11, 1703.

    Research output: Contribution to journalArticle

    Open Access
  • HDAC8 inhibitor WK2-16 therapeutically targets lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation

    Lin, F. L., Yen, J. L., Kuo, Y. C., Kang, J. J., Cheng, Y. W., Huang, W. J. & Hsiao, G., Jan 2 2019, In : International Journal of Molecular Sciences. 20, 2, p. 410 410.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor

    Chiu, C. F., Chin, H. K., Huang, W. J., Bai, L. Y., Huang, H. Y. & Weng, J. R., Dec 4 2019, In : Biomolecules. 9, 12

    Research output: Contribution to journalArticle

    Open Access
  • 1 Citation (Scopus)