Projects per year
Personal profile
Education
- 2002 Ph. D., School of Pharmacy, National Taiwan University, Taipei, Organic Synthesis and Medicinal Chemistry
- 1995 M. S., School of Pharmacy, National Taiwan University, Taipei, Organic Synthesis and Medicinal Chemistry
- 1992 B. S., School of Pharmacy, Taipei Medical University
Experience
- 2019.11- Professor , Department of Pharmaceutical Sciences, Taipei Medical University
- 2019.08- Director, Department of Pharmaceutical Sciences, Taipei Medical University
- 2017.08- Professor, Graduate Institute of Pharmacognosy, Taipei Medical Universit
- 2013.08- Ph.D. Program in Clinical Drug Development of Herbal Medicine, Taipei Medical University
- 2011.08-2017.07 Associate Professor, Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan.
- 2007.08-2011.07 Assistant Professor, Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan.
- 2004.08-2007.07 Assistant Professor, Department of Nursing, Chang Gung University of Science and Technology, Chiayi campus, Taiwan.
- 2003.09-2004.07 Postdoctoral Fellow, Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan.
- 2002.08-2003.08 Postdoctoral Fellow, Drug Research Center, National Taiwan University, Taipei, Taiwan
Research Interests
- Total synthesis and chemical modification of naturalproduct
- Development of natural product scaffold
- Structure-based drug design
- Microwave-assisted organic synthesis
Fingerprint
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Projects
- 16 Finished
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開發蛋白質雙硫鍵異構酶抑制劑作為抗多形性神經膠質母細胞瘤藥物
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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新穎小分子抗多發性骨髓瘤藥物機轉研究
7/1/20 → 2/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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Discovery of Multitarget Agents That Target Alzheimer'S Disease
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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Exploiting Acridine Scaffold to Develop Novel Anticancer Agents Based on a Dual Target Strategy
8/1/18 → 7/1/19
Project: A - Government Institution › b - Ministry of Science and Technology
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Exploiting Acridine Scaffold to Develop Novel Anticancer Agents Based on a Dual Target Strategy
8/1/17 → 7/31/18
Project: A - Government Institution › b - Ministry of Science and Technology
Research output
- 1715 Citations
- 25 h-Index
- 92 Article
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Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach
Chao, M. W., Lin, T. E., HuangFu, W. C., Chang, C. D., Tu, H. J., Chen, L. C., Yen, S. C., Sung, T. Y., Huang, W. J., Yang, C. R., Pan, S. L. & Hsu, K. C., Dec 2021, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 98-108 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia
Yen, S. C., Chen, L. C., Huang, H. L., Ngo, S. T., Wu, Y. W., Lin, T. E., Sung, T. Y., Lien, S. T., Tseng, H. J., Pan, S. L., Huang, W. J. & Hsu, K. C., Jan 22 2021, In: Journal of Natural Products. 84, 1, p. 1-10 10 p.Research output: Contribution to journal › Article › peer-review
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Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors
Hsu, K-C., Chu, J-C., Tseng, H-J., Liu, C-I., Wang, H-C., Lin, T. E., Lee, H-S., Hsin, L-W., Wang, A. H-J., Lin, C-H. & Huang, W-J., Jul 5 2021, In: European Journal of Medicinal Chemistry. 219, 113419.Research output: Contribution to journal › Article › peer-review
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Synthesis of yakuchinone b-inspired inhibitors against islet amyloid polypeptide aggregation
Liu, H. K., Huang, W. J., Hsu, J. Y., Sathyan, A. R., Hsu, K. C., Chen, L. C., Yen, C. C., Tseng, H. J. & Wu, K. C., Apr 2021, In: Journal of Natural Products. 84, 4, p. 1096-1103 8 p.Research output: Contribution to journal › Article › peer-review
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Acetylcholinesterase inhibitory activity and neuroprotection: In vitro, molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice
Liu, Y. H., Lee, C. J., Chen, L. C., Lee, T. L., Hsieh, Y. Y., Han, C. H., Yang, C. H., Huang, W. J. & Hou, W. C., Mar 2020, In: Food and Function. 11, 3, p. 2328-2338 11 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus)
Datasets
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Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model
Chiu, H. (Contributor), Yeh, Y. (Contributor), Wang, Y. (Contributor), Huang, W. (Contributor), Ho, S. (Contributor), Lin, P. (Contributor) & Wang, Y. (Contributor), Unknown Publisher, Jun 10 2016
DOI: 10.6084/m9.figshare.c.3697276.v1, https://figshare.com/collections/Combination_of_the_novel_histone_deacetylase_inhibitor_YCW1_and_radiation_induces_autophagic_cell_death_through_the_downregulation_of_BNIP3_in_triple-negative_breast_cancer_cells_in_vitro_and_in_an_orthotopic_mouse_model/3697276/1
Dataset
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Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach
Chao, M. (Contributor), Lin, T. E. (Contributor), HuangFu, W. (Contributor), Chang, C. (Contributor), Tu, H. (Contributor), Chen, L. (Contributor), Yen, S. (Contributor), Sung, T. (Contributor), Huang, W. (Contributor), Yang, C. (Contributor), Pan, S. (Contributor) & Hsu, K. (Contributor), Unknown Publisher, Jan 1 2020
DOI: 10.6084/m9.figshare.13213424.v1, https://tandf.figshare.com/articles/dataset/Identification_of_a_dual_TAOK1_and_MAP4K5_inhibitor_using_a_structure-based_virtual_screening_approach/13213424/1
Dataset
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Additional file 1: of Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model
Chiu, H. (Contributor), Yeh, Y. (Contributor), Wang, Y. (Contributor), Huang, W. (Contributor), Ho, S. (Contributor), Lin, P. (Contributor) & Wang, Y. (Contributor), Unknown Publisher, Jun 10 2016
DOI: 10.6084/m9.figshare.c.3697276_d1.v1, https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_of_Combination_of_the_novel_histone_deacetylase_inhibitor_YCW1_and_radiation_induces_autophagic_cell_death_through_the_downregulation_of_BNIP3_in_triple-negative_breast_cancer_cells_in_vitro_and_in_an_orthotopic_mouse_model/4672645/1
Dataset