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Research Output 2009 2019

  • 538 Citations
  • 15 h-Index
  • 39 Article
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Article
2019

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

Lu, W-J., Lin, K-H., Tseng, M-F., Yuan, K-C., Huang, H-C., Sheu, J-R. & Chen, R-J., Mar 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1723-1734 12 p.

Research output: Contribution to journalArticle

Hemorrhagic Shock
Liver
Wounds and Injuries
Resuscitation
Therapeutics
2018

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., Nov 14 2018, In : Journal of Clinical Medicine. 7, 11

Research output: Contribution to journalArticle

Phospholipase D
Blood Platelets
Platelet Activation
Platelet Aggregation
Thrombosis
2 Citations (Scopus)

Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest

Lu, W. J., Wu, G. J., Chen, R. J., Chang, C. C., Lien, L. M., Chiu, C. C., Tseng, M. F., Huang, L. T. & Lin, K. H., Aug 1 2018, In : Food and Function. 9, 8, p. 4500-4507 8 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Glioma
cell growth
licorice
neoplasms
1 Citation (Scopus)
norcantharidin
Integrins
Fibrinogen
Blood Platelets
Clot Retraction
2017
3 Citations (Scopus)

A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies

Hsia, C. H., Velusamy, M., Sheu, J. R., Khamrang, T., Jayakumar, T., Lu, W. J., Lin, K. H. & Chang, C. C., Dec 1 2017, In : Scientific Reports. 7, 1, 9556.

Research output: Contribution to journalArticle

Organometallic Compounds
Ruthenium
Fluorescein-5-isothiocyanate
Platelet Aggregation
Blood Platelets

Development of benzimidazole derivatives as novel anti-platelet drugs

Yao, W. C., Yuan, L. T., Yang, W. B., Hsia, C. H., Huang, L. T., Lee, T. Y., Sheu, J. R., Lu, W-J., Jayakumar, T. & Chen, R. J., Jan 1 2017, In : Current Pharmaceutical Biotechnology. 18, 7, p. 594-605 12 p.

Research output: Contribution to journalArticle

Thrombin
Blood Platelets
Platelet Aggregation
Pharmaceutical Preparations
Epinephrine
6 Citations (Scopus)

Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies

Lee, T. Y., Chang, C. C., Lu, W-J., Yen, T. L., Lin, K. H., Geraldine, P., Li, J. Y. & Sheu, J-R., Jan 5 2017, In : Scientific Reports. 7, 40002.

Research output: Contribution to journalArticle

Collagen Receptors
Glycoproteins
Blood Platelets
Collagen
Platelet Activation
7 Citations (Scopus)

Licochalcone a prevents platelet activation and thrombus formation through the inhibition of PLCγ2-PKC, Akt, and MAPK pathways

Lien, L. M., Lin, K. H., Huang, L. T., Tseng, M. F., Chiu, H. C., Chen, R. J. & Lu, W. J., Jul 12 2017, In : International Journal of Molecular Sciences. 18, 7, 1500.

Research output: Contribution to journalArticle

Platelet Activation
Platelets
platelets
Thrombosis
Chemical activation
4 Citations (Scopus)

Nobiletin, a citrus flavonoid, activates Vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms

Jayakumar, T., Lin, K. C., Lu, W-J., Lin, C. Y., Pitchairaj, G., Li, J. Y. & Sheu, J-R., Jan 1 2017, In : International Journal of Molecular Medicine. 39, 1, p. 174-182 9 p.

Research output: Contribution to journalArticle

Citrus
Flavonoids
Blood Platelets
Nucleotides
Phosphorylation

Structure-activity relationship of three synthesized benzimidazole-based oligosaccharides in human platelet activation

Chang, Y., Hsu, W. H., Yang, W. B., Jayakumar, T., Lee, T. Y., Sheu, J. R., Lu, W. J. & Li, J. Y., Nov 1 2017, In : International Journal of Molecular Medicine. 40, 5, p. 1520-1528 9 p.

Research output: Contribution to journalArticle

Platelet Activation
Structure-Activity Relationship
Oligosaccharides
Collagen
p38 Mitogen-Activated Protein Kinases
2016
21 Citations (Scopus)
Heme Oxygenase-1
Cytoprotection
Endothelial cells
p38 Mitogen-Activated Protein Kinases
Rats
20 Citations (Scopus)

Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways

Lien, L. M., Wang, M. J., Chen, R. J., Chiu, H. C., Wu, J. L., Shen, M. Y., Chou, D. S., Sheu, J. R., Lin, K. H. & Lu, W-J., Feb 1 2016, In : Phytotherapy Research. 30, 2, p. 214-221 8 p.

Research output: Contribution to journalArticle

flavone
Glioma
Cell Movement
Cell Cycle
Growth
3 Citations (Scopus)

Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism

Yen, T. L., Wu, M. P., Chung, C. L., Yang, W. B., Jayakumar, T., Geraldine, P., Chou, C. M., Chang, C. Y., Lu, W-J. & Sheu, J. R., Feb 17 2016, In : Journal of Biomedical Science. 23, 1, 26.

Research output: Contribution to journalArticle

Thromboembolism
Platelets
Oligosaccharides
Platelet Aggregation
Collagen
15 Citations (Scopus)

Prevention of arterial thrombosis by nobiletin: In vitro and in vivo studies

Lu, W-J., Lin, K. C., Liu, C. P., Lin, C. Y., Wu, H. C., Chou, D. S., Geraldine, P., Huang, S. Y., Hsieh, C. Y. & Sheu, J. R., Feb 1 2016, In : Journal of Nutritional Biochemistry. 28, p. 1-8 8 p.

Research output: Contribution to journalArticle

Platelets
Thrombosis
Platelet Aggregation
Platelet Activation
Blood Platelets
2015
15 Citations (Scopus)

Astaxanthin, a carotenoid, stimulates immune responses by enhancing IFN-γ and Il-2 secretion in primary cultured lymphocytes in Vitro and ex Vivo

Lin, K. H., Lin, K. C., Lu, W-J., Thomas, P. A., Jayakumar, T. & Sheu, J. R., Dec 29 2015, In : International Journal of Molecular Sciences. 17, 1, 44.

Research output: Contribution to journalArticle

carotenoids
secretions
Lymphocytes
lymphocytes
Carotenoids
3 Citations (Scopus)
Concanavalin A
Cell Cycle Checkpoints
Lymphocytes
T-Lymphocytes
Cell Cycle Resting Phase
11 Citations (Scopus)

Inhibitory mechanisms of cme-1, a novel polysaccharide from the mycelia of cordyceps sinensis, in platelet activation

Chang, Y., Hsu, W. H., Lu, W. J., Jayakumar, T., Liao, J. C., Lin, M. J., Wang, S. H., Geraldine, P., Lin, K. H. & Sheu, J. R., 2015, In : Current Pharmaceutical Biotechnology. 16, 5, p. 451-461 11 p.

Research output: Contribution to journalArticle

Cordyceps
Mycelium
Platelet Activation
Polysaccharides
Platelet Aggregation
3 Citations (Scopus)

N-3 Polyunsaturated fatty acids ameliorate cognitive age-related impairments and depressive behaviour in unchallenged aged prediabetic rats

Guo, Y. R., Hsu, Y. H., Liang, A., Lu, W. J., Wu, C. H., Lee, H. C. & Huang, S. Y., Dec 1 2015, In : Journal of Functional Foods. 19, p. 522-536 15 p., 1300.

Research output: Contribution to journalArticle

Omega-3 Fatty Acids
omega-3 fatty acids
polyunsaturated fatty acids
rats
Oils
5 Citations (Scopus)

Xanthohumol from Humulus lupulus L. induces glioma cell autophagy via inhibiting Akt/mTOR/S6K pathway

Lu, W-J., Chang, C. C., Lien, L. M., Yen, T. L., Chiu, H. C., Huang, S. Y., Sheu, J. R. & Lin, K. H., Oct 1 2015, In : Journal of Functional Foods. 18, p. 538-549 12 p., 1255.

Research output: Contribution to journalArticle

Humulus lupulus
Humulus
autophagy
Autophagy
Glioma
2014
6 Citations (Scopus)

Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC γ 2 -PKC and MAPK pathways

Yen, T. L., Lu, W-J., Lien, L. M., Thomas, P. A., Lee, T. Y., Chiu, H. C., Sheu, J. R. & Lin, K. H., 2014, In : BioMed Research International. 2014, 728019.

Research output: Contribution to journalArticle

Iridoid Glycosides
Platelet Activation
Type C Phospholipases
Platelets
Mitogen-Activated Protein Kinases
21 Citations (Scopus)

Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade

Chen, Y. Y., Hsieh, C. Y., Jayakumar, T., Lin, K. H., Chou, D. S., Lu, W-J., Hsu, M. J. & Sheu, J. R., Jul 10 2014, In : Scientific Reports. 4, 5651.

Research output: Contribution to journalArticle

Non-Receptor Type 6 Protein Tyrosine Phosphatase
Protein Phosphatase 2
p38 Mitogen-Activated Protein Kinases
Vascular Smooth Muscle
Smooth Muscle Myocytes
11 Citations (Scopus)
Aminobutyrates
gamma-Aminobutyric Acid
Glycoproteins
Collagen
Blood Platelets
4 Citations (Scopus)

Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: The pivotal role of protein kinase C

Lu, W-J., Lin, S. C., Lan, C. C., Lee, T. Y., Hsia, C. H., Huang, Y. K., Lee, H. C. & Sheu, J. R., 2014, In : Scientific World Journal. 2014, 745802.

Research output: Contribution to journalArticle

Antrodia
Platelet Activation
Platelets
Protein Kinase C
Thrombosis
12 Citations (Scopus)

Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation by activating adenylate cyclase/cyclic AMP

Lu, W-J., Chang, N. C., Jayakumar, T., Liao, J. C., Lin, M. J., Wang, S. H., Chou, D. S., Thomas, P. A. & Sheu, J. R., Dec 1 2014, In : Thrombosis Research. 134, 6, p. 1301-1310 10 p.

Research output: Contribution to journalArticle

Cordyceps
Mycelium
Platelet Activation
Adenylyl Cyclases
Cyclic AMP
7 Citations (Scopus)

Hinokitiol is a novel glycoprotein VI antagonist on human platelets

Lu, W-J., Wu, M. P., Lin, K. H., Lin, Y. C., Chou, H. C. & Sheu, J. R., Dec 1 2014, In : Platelets. 25, 8, p. 595-602 8 p.

Research output: Contribution to journalArticle

Glycoproteins
Blood Platelets
Platelet Activation
Platelet Aggregation
Integrins
14 Citations (Scopus)

Multidrug resistance protein 4 (MRP4/ABCC4) regulates thrombus formation in vitro and in vivo

Lien, L. M., Chen, Z. C., Chung, C. L., Yen, T. L., Chiu, H. C., Chou, D. S., Huang, S. Y., Sheu, J. R., Lu, W-J. & Lin, K. H., Aug 15 2014, In : European Journal of Pharmacology. 737, p. 159-167 9 p.

Research output: Contribution to journalArticle

P-Glycoproteins
Thrombosis
Cyclic Nucleotides
Platelet Activation
Collagen
21 Citations (Scopus)

Role of a Janus kinase 2-dependent signaling pathway in platelet activation

Lu, W-J., Lin, K. C., Huang, S. Y., Thomas, P. A., Wu, Y. H., Wu, H. C., Lin, K. H. & Sheu, J. R., 2014, In : Thrombosis Research. 133, 6, p. 1088-1096 9 p.

Research output: Contribution to journalArticle

Janus Kinase 2
Platelet Activation
Collagen
Janus Kinases
Protein Kinase C
2013
23 Citations (Scopus)

A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: Ex vivo and in vivo studies

Jayakumar, T., Chen, W. F., Lu, W-J., Chou, D. S., Hsiao, G., Hsu, C-Y., Sheu, J. R. & Hsieh, C. Y., Jun 2013, In : Journal of Nutritional Biochemistry. 24, 6, p. 1086-1095 10 p.

Research output: Contribution to journalArticle

Platelet Activation
Platelets
Adenylyl Cyclases
Chemical activation
Phosphorylation
10 Citations (Scopus)

A novel bioactivity of andrographolide from Andrographis paniculata on cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis

Yen, T. L., Hsu, W. H., Huang, S. K. H., Lu, W-J., Chang, C. C., Lien, L. M., Hsiao, G., Sheu, J. R. & Lin, K. H., Sep 2013, In : Pharmaceutical Biology. 51, 9, p. 1150-1157 8 p.

Research output: Contribution to journalArticle

Andrographis
Brain Ischemia
Brain Injuries
Reperfusion
Endothelial Cells
8 Citations (Scopus)

Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets

Chang, Y., Huang, S. K. H., Lu, W. J., Chung, C. L., Chen, W. L., Lu, S. H., Lin, K. H. & Sheu, J. R., Jan 25 2013, In : Journal of Biomedical Science. p. 4 1 p.

Research output: Contribution to journalArticle

Caesalpinia
Collagen Receptors
Platelets
Blood Platelets
Platelet Aggregation
26 Citations (Scopus)

Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo

Lin, K. H., Kuo, J. R., Lu, W-J., Chung, C. L., Chou, D. S., Huang, S. Y., Lee, H. C. & Sheu, J. R., May 15 2013, In : Biochemical Pharmacology. 85, 10, p. 1478-1485 8 p.

Research output: Contribution to journalArticle

Platelet Activation
Platelets
Thrombosis
Chemical activation
Platelet Aggregation
23 Citations (Scopus)

Mechanisms of andrographolide-induced platelet apoptosis in human platelets: Regulatory roles of the extrinsic apoptotic pathway

Lien, L-M., Su, C. C., Hsu, W. H., Lu, W-J., Chung, C-L., Yen, T. L., Chiu, H. C., Sheu, J-R. & Lin, K. H., 2013, In : Phytotherapy Research. 27, 11, p. 1671-1677 7 p.

Research output: Contribution to journalArticle

Blood Platelets
Apoptosis
Caspase 8
Platelet Activation
Andrographis
2012
48 Citations (Scopus)
Humulus lupulus
Humulus
neuroprotective effect
hops
Neuroprotective Agents
41 Citations (Scopus)
p38 Mitogen-Activated Protein Kinases
Phosphorylation
Platelets
Hydroxyl Radical
Blood Platelets
20 Citations (Scopus)
Humulus
Platelet Activation
Flavonoids
Blood Platelets
Platelet Aggregation
2011
52 Citations (Scopus)
NF-kappa B
Nitric Oxide Synthase Type III
Cyclic GMP
Platelet Activation
p38 Mitogen-Activated Protein Kinases
27 Citations (Scopus)

A novel role of sesamol in inhibiting NF-B-mediated signaling in platelet activation

Chang, C. C., Lu, W-J., Ong, E. T., Chiang, C-W., Lin, S-C., Huang, S. Y. & Sheu, J. R., 2011, In : Journal of Biomedical Science. 18, 1, 93.

Research output: Contribution to journalArticle

Platelet Activation
Platelets
Chemical activation
Platelet Aggregation
Phosphorylation
2010
24 Citations (Scopus)

Potent antiplatelet activity of sesamol in an in vitro and in vivo model: Pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase

Chang, C. C., Lu, W-J., Chiang, C-W., Jayakumar, T., Ong, E. T., Hsiao, G., Fong, T. H., Chou, D. S. & Sheu, J. R., Dec 2010, In : Journal of Nutritional Biochemistry. 21, 12, p. 1214-1221 8 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Cyclic AMP
Platelets
Phosphorylation
Nitric Oxide Synthase Type III
2009
21 Citations (Scopus)

Comparison of the relative activities of inducing platelet apoptosis stimulated by various platelet-activating agents

Lin, K. H., Chang, H-C., Lu, W-J., Jayakumar, T., Chou, H-C., Fong, T-H., Hsiao, G. & Sheu, J-R., 2009, In : Platelets. 20, 8, p. 575-581 7 p.

Research output: Contribution to journalArticle

Blood Platelets
Apoptosis
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Calcimycin
Platelet Activation