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Research Output

  • 641 Citations
  • 16 h-Index
  • 42 Article
  • 3 Comment/debate
2020
Open Access
Open Access
2019

Embelin as a Novel Inhibitor of PKC in the Prevention of Platelet Activation and Thrombus Formation

Li, J. Y., Chen, R. J., Huang, L. T., Lee, T. Y., Lu, W. J. & Lin, K. H., Oct 18 2019, In : Journal of Clinical Medicine. 8, 10

Research output: Contribution to journalArticle

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

Lu, W-J., Lin, K-H., Tseng, M-F., Yuan, K-C., Huang, H-C., Sheu, J-R. & Chen, R-J., Mar 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1723-1734 12 p.

Research output: Contribution to journalArticle

Suppression of human platelet activation via integrin αiibβ3 outside-in independent signal and reduction of the mortality in pulmonary thrombosis by auraptene

Hsia, C. W., Tsai, C. L., Sheu, J. R., Lu, W. J., Hsia, C. H., Velusamy, M., Jayakumar, T. & Li, J. Y., Nov 2 2019, In : International Journal of Molecular Sciences. 20, 22, 5585.

Research output: Contribution to journalArticle

Open Access

VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC

Lu, W. J., Li, J. Y., Chen, R. J., Huang, L. T., Lee, T. Y. & Lin, K. H., Dec 1 2019, In : Scientific Reports. 9, 1, 18852.

Research output: Contribution to journalArticle

Open Access
2018

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., Nov 14 2018, In : Journal of Clinical Medicine. 7, 11

Research output: Contribution to journalArticle

Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest

Lu, W. J., Wu, G. J., Chen, R. J., Chang, C. C., Lien, L. M., Chiu, C. C., Tseng, M. F., Huang, L. T. & Lin, K. H., Aug 1 2018, In : Food and Function. 9, 8, p. 4500-4507 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
3 Citations (Scopus)
2017

A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies

Hsia, C. H., Velusamy, M., Sheu, J. R., Khamrang, T., Jayakumar, T., Lu, W. J., Lin, K. H. & Chang, C. C., Dec 1 2017, In : Scientific Reports. 7, 1, 9556.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Development of benzimidazole derivatives as novel anti-platelet drugs

Yao, W. C., Yuan, L. T., Yang, W. B., Hsia, C. H., Huang, L. T., Lee, T. Y., Sheu, J. R., Lu, W-J., Jayakumar, T. & Chen, R. J., Jan 1 2017, In : Current Pharmaceutical Biotechnology. 18, 7, p. 594-605 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access

Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies

Lee, T. Y., Chang, C. C., Lu, W-J., Yen, T. L., Lin, K. H., Geraldine, P., Li, J. Y. & Sheu, J-R., Jan 5 2017, In : Scientific Reports. 7, 40002.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Licochalcone a prevents platelet activation and thrombus formation through the inhibition of PLCγ2-PKC, Akt, and MAPK pathways

Lien, L. M., Lin, K. H., Huang, L. T., Tseng, M. F., Chiu, H. C., Chen, R. J. & Lu, W. J., Jul 12 2017, In : International Journal of Molecular Sciences. 18, 7, 1500.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Nobiletin, a citrus flavonoid, activates Vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms

Jayakumar, T., Lin, K. C., Lu, W-J., Lin, C. Y., Pitchairaj, G., Li, J. Y. & Sheu, J-R., Jan 1 2017, In : International Journal of Molecular Medicine. 39, 1, p. 174-182 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Structure-activity relationship of three synthesized benzimidazole-based oligosaccharides in human platelet activation

Chang, Y., Hsu, W. H., Yang, W. B., Jayakumar, T., Lee, T. Y., Sheu, J. R., Lu, W. J. & Li, J. Y., Nov 1 2017, In : International Journal of Molecular Medicine. 40, 5, p. 1520-1528 9 p.

Research output: Contribution to journalArticle

2016
32 Citations (Scopus)

Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways

Lien, L. M., Wang, M. J., Chen, R. J., Chiu, H. C., Wu, J. L., Shen, M. Y., Chou, D. S., Sheu, J. R., Lin, K. H. & Lu, W-J., Feb 1 2016, In : Phytotherapy Research. 30, 2, p. 214-221 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism

Yen, T. L., Wu, M. P., Chung, C. L., Yang, W. B., Jayakumar, T., Geraldine, P., Chou, C. M., Chang, C. Y., Lu, W-J. & Sheu, J. R., Feb 17 2016, In : Journal of Biomedical Science. 23, 1, 26.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Prevention of arterial thrombosis by nobiletin: In vitro and in vivo studies

Lu, W-J., Lin, K. C., Liu, C. P., Lin, C. Y., Wu, H. C., Chou, D. S., Geraldine, P., Huang, S. Y., Hsieh, C. Y. & Sheu, J. R., Feb 1 2016, In : Journal of Nutritional Biochemistry. 28, p. 1-8 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2015

Astaxanthin, a carotenoid, stimulates immune responses by enhancing IFN-γ and Il-2 secretion in primary cultured lymphocytes in Vitro and ex Vivo

Lin, K. H., Lin, K. C., Lu, W-J., Thomas, P. A., Jayakumar, T. & Sheu, J. R., Dec 29 2015, In : International Journal of Molecular Sciences. 17, 1, 44.

Research output: Contribution to journalArticle

23 Citations (Scopus)
3 Citations (Scopus)

Inhibitory mechanisms of cme-1, a novel polysaccharide from the mycelia of cordyceps sinensis, in platelet activation

Chang, Y., Hsu, W. H., Lu, W. J., Jayakumar, T., Liao, J. C., Lin, M. J., Wang, S. H., Geraldine, P., Lin, K. H. & Sheu, J. R., 2015, In : Current Pharmaceutical Biotechnology. 16, 5, p. 451-461 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

N-3 Polyunsaturated fatty acids ameliorate cognitive age-related impairments and depressive behaviour in unchallenged aged prediabetic rats

Guo, Y. R., Hsu, Y. H., Liang, A., Lu, W. J., Wu, C. H., Lee, H. C. & Huang, S. Y., Dec 1 2015, In : Journal of Functional Foods. 19, p. 522-536 15 p., 1300.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Xanthohumol from Humulus lupulus L. induces glioma cell autophagy via inhibiting Akt/mTOR/S6K pathway

Lu, W-J., Chang, C. C., Lien, L. M., Yen, T. L., Chiu, H. C., Huang, S. Y., Sheu, J. R. & Lin, K. H., Oct 1 2015, In : Journal of Functional Foods. 18, p. 538-549 12 p., 1255.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2014

Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC γ 2 -PKC and MAPK pathways

Yen, T. L., Lu, W-J., Lien, L. M., Thomas, P. A., Lee, T. Y., Chiu, H. C., Sheu, J. R. & Lin, K. H., 2014, In : BioMed Research International. 2014, 728019.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade

Chen, Y. Y., Hsieh, C. Y., Jayakumar, T., Lin, K. H., Chou, D. S., Lu, W-J., Hsu, M. J. & Sheu, J. R., Jul 10 2014, In : Scientific Reports. 4, 5651.

Research output: Contribution to journalArticle

23 Citations (Scopus)
13 Citations (Scopus)

Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: The pivotal role of protein kinase C

Lu, W-J., Lin, S. C., Lan, C. C., Lee, T. Y., Hsia, C. H., Huang, Y. K., Lee, H. C. & Sheu, J. R., 2014, In : Scientific World Journal. 2014, 745802.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation by activating adenylate cyclase/cyclic AMP

Lu, W-J., Chang, N. C., Jayakumar, T., Liao, J. C., Lin, M. J., Wang, S. H., Chou, D. S., Thomas, P. A. & Sheu, J. R., Dec 1 2014, In : Thrombosis Research. 134, 6, p. 1301-1310 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Hinokitiol is a novel glycoprotein VI antagonist on human platelets

Lu, W-J., Wu, M. P., Lin, K. H., Lin, Y. C., Chou, H. C. & Sheu, J. R., Dec 1 2014, In : Platelets. 25, 8, p. 595-602 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Multidrug resistance protein 4 (MRP4/ABCC4) regulates thrombus formation in vitro and in vivo

Lien, L. M., Chen, Z. C., Chung, C. L., Yen, T. L., Chiu, H. C., Chou, D. S., Huang, S. Y., Sheu, J. R., Lu, W-J. & Lin, K. H., Aug 15 2014, In : European Journal of Pharmacology. 737, p. 159-167 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Role of a Janus kinase 2-dependent signaling pathway in platelet activation

Lu, W-J., Lin, K. C., Huang, S. Y., Thomas, P. A., Wu, Y. H., Wu, H. C., Lin, K. H. & Sheu, J. R., 2014, In : Thrombosis Research. 133, 6, p. 1088-1096 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2013

A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: Ex vivo and in vivo studies

Jayakumar, T., Chen, W. F., Lu, W-J., Chou, D. S., Hsiao, G., Hsu, C-Y., Sheu, J. R. & Hsieh, C. Y., Jun 2013, In : Journal of Nutritional Biochemistry. 24, 6, p. 1086-1095 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

A novel bioactivity of andrographolide from Andrographis paniculata on cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis

Yen, T. L., Hsu, W. H., Huang, S. K. H., Lu, W-J., Chang, C. C., Lien, L. M., Hsiao, G., Sheu, J. R. & Lin, K. H., Sep 2013, In : Pharmaceutical Biology. 51, 9, p. 1150-1157 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets

Chang, Y., Huang, S. K. H., Lu, W. J., Chung, C. L., Chen, W. L., Lu, S. H., Lin, K. H. & Sheu, J. R., Jan 25 2013, In : Journal of Biomedical Science. p. 4 1 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo

Lin, K. H., Kuo, J. R., Lu, W-J., Chung, C. L., Chou, D. S., Huang, S. Y., Lee, H. C. & Sheu, J. R., May 15 2013, In : Biochemical Pharmacology. 85, 10, p. 1478-1485 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Mechanisms of andrographolide-induced platelet apoptosis in human platelets: Regulatory roles of the extrinsic apoptotic pathway

Lien, L-M., Su, C. C., Hsu, W. H., Lu, W-J., Chung, C-L., Yen, T. L., Chiu, H. C., Sheu, J-R. & Lin, K. H., 2013, In : Phytotherapy Research. 27, 11, p. 1671-1677 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2012
56 Citations (Scopus)
47 Citations (Scopus)
20 Citations (Scopus)
2011
59 Citations (Scopus)

A novel role of sesamol in inhibiting NF-B-mediated signaling in platelet activation

Chang, C. C., Lu, W-J., Ong, E. T., Chiang, C-W., Lin, S-C., Huang, S. Y. & Sheu, J. R., 2011, In : Journal of Biomedical Science. 18, 1, 93.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2010

Potent antiplatelet activity of sesamol in an in vitro and in vivo model: Pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase

Chang, C. C., Lu, W-J., Chiang, C-W., Jayakumar, T., Ong, E. T., Hsiao, G., Fong, T. H., Chou, D. S. & Sheu, J. R., Dec 2010, In : Journal of Nutritional Biochemistry. 21, 12, p. 1214-1221 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2009

Comparison of the relative activities of inducing platelet apoptosis stimulated by various platelet-activating agents

Lin, K. H., Chang, H-C., Lu, W-J., Jayakumar, T., Chou, H-C., Fong, T-H., Hsiao, G. & Sheu, J-R., 2009, In : Platelets. 20, 8, p. 575-581 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)