Tzu-Hua Wu

2019

Obsessive-compulsive symptoms in patients with schizophrenia: Relationships with olanzapine pharmacological parameters, psychopathology, and quality of life

Wu, T. H., Chiu, C. C., Chen, P. Y., Huang, M. C., Chen, C. H., Shen, W. W. & Lu, M. L., Jun 1 2019, In : Psychiatry Research. 276, p. 1-5 5 p.

Research output: Contribution to journal › Article

olanzapine

Psychopathology

Schizophrenia

Quality of Life

Pharmacology

The association between the sedative loads and clinical severity indicators in the first-onset major depressive disorder

Wang, Y. C., Lin, H. T., Lu, M. L., Huang, M. C., Chen, C. H., Wu, T. H., Wang, S., Mao, W. C., Kuo, P. H. & Chen, H. C., Jan 1 2019, In : Frontiers in Psychiatry. 10, MAR, 129.

Research output: Contribution to journal › Article

Open Access

Major Depressive Disorder

Hypnotics and Sedatives

Antidepressive Agents

Lorazepam

Anxiety Disorders

2018

7 Citations (Scopus)

Application of plasma levels of olanzapine and N-desmethyl-olanzapine to monitor metabolic parameters in patients with schizophrenia

Lu, M. L., Chen, C. H., Kuo, P. T., Lin, C. H. & Wu, T. H., Mar 2018, In : Schizophrenia Research. 193, p. 139-145

Research output: Contribution to journal › Article

olanzapine

Schizophrenia

Drug Monitoring

C-Peptide

Waist Circumference

1 Citation (Scopus)

Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin

Lu, C. P., Huang, C. Y., Wang, S. H., Chiu, C. H., Li, L. H., Hua, K. F. & Wu, T. H., Jun 25 2018, In : Chemico-Biological Interactions. 290, p. 12-18 7 p.

Research output: Contribution to journal › Article

Inflammasomes

Silymarin

Macrophages

Interleukin-1

Hyperglycemia

2017

19 Citations (Scopus)

Antroquinonol, a ubiquinone derivative from the mushroom antrodia camphorata, inhibits colon cancer stem cell-like properties: Insights into the molecular mechanism & inhibitory targets

Lin, H. C., Lin, M. H., Liao, J. H., Wu, T. H., Lee, T. H., Mi, F. L., Wu, C. H., Chen, K. C., Cheng, C. H. & Lin, C. W., 2017, In : Journal of Agricultural and Food Chemistry. 65, 1, p. 51-59 9 p.

Research output: Contribution to journal › Article

Antrodia

Taiwanofungus camphoratus

Ubiquinone

Neoplastic Stem Cells

ubiquinones

2 Citations (Scopus)

Deferasirox-Iron Complex Formation Ratio as an Indicator of Long-term Chelation Efficacy in β-Thalassemia Major

Lu, M. Y., Lin, T. H., Chiang, P. H., Kuo, P. H., Wang, N., Wu, W. H., Lin, K. H. & Wu, T. H., Jan 30 2017, (Accepted/In press) In : Therapeutic Drug Monitoring.

Research output: Contribution to journal › Article

beta-Thalassemia

Iron

Ferritins

alanylglycine

Serum

2016

6 Citations (Scopus)

Anticataractogenesis Mechanisms of Curcumin and a Comparison of Its Degradation Products: An in Vitro Study

Liao, J. H., Huang, Y. S., Lin, Y. C., Huang, F. Y., Wu, S. H. & Wu, T. H., Mar 16 2016, In : Journal of Agricultural and Food Chemistry. 64, 10, p. 2080-2086 7 p.

Research output: Contribution to journal › Article

Curcumin

curcumin

in vitro studies

Degradation

ferulic acid

9 Citations (Scopus)

Application of plasma levels of olanzapine and N-desmethyl-olanzapine to monitor clinical efficacy in patients with schizophrenia

Lu, M. L., Wu, Y. X., Chen, C. H., Kuo, P. T., Chen, Y. H., Lin, C. H. & Wu, T. H., Feb 1 2016, In : PLoS One. 11, 2, e0148539.

Research output: Contribution to journal › Article

olanzapine

Schizophrenia

Plasmas

monitoring

dosage

2015

2 Citations (Scopus)

Silymarin and protein kinase A inhibitor modulate glucose-mediated mouse sperm motility: An in vitro study

Chen, Y. C., Pan, L. C., Lai, C. W., Chien, Y. S. & Wu, T. H., Sep 1 2015, In : Reproductive biology. 15, 3, p. 172-177 6 p.

Research output: Contribution to journal › Article

Silymarin

silymarin

cAMP-dependent protein kinase

Sperm Motility

Protein Kinase Inhibitors

8 Citations (Scopus)

Simultaneous Determination of Plasma Deferasirox and Deferasirox-Iron Complex Using an HPLC-UV System and Pharmacokinetics of Deferasirox in Patients with β-Thalassemia Major: Once-daily Versus Twice-daily Administration

Lu, M. Y., Wang, N., Wu, W. H., Lai, C. W., Kuo, P. H., Chiang, P. H., Lin, K. H. & Wu, T. H., Aug 1 2015, In : Clinical Therapeutics. 37, 8, p. 1751-1760 10 p.

Research output: Contribution to journal › Article

beta-Thalassemia

Iron

Pharmacokinetics

High Pressure Liquid Chromatography

deferasirox

2 Citations (Scopus)

The Comparative Studies of Binding Activity of Curcumin and Didemethylated Curcumin with Selenite: Hydrogen Bonding vs Acid-Base Interactions

Liao, J. H., Wu, T. H., Chen, M. Y., Chen, W. T., Lu, S. Y., Wang, Y. H., Wang, S. P., Hsu, Y. M., Huang, Y. S., Huang, Z. Y., Lin, Y. C., Chang, C. M., Huang, F. Y. & Wu, S. H., Dec 4 2015, In : Scientific Reports. 5, 17614.

Research output: Contribution to journal › Article

Selenious Acid

Curcumin

Hydrogen Bonding

Acids

Crystallins

2014

9 Citations (Scopus)

Carnosine ameliorates lens protein turbidity formations by inhibiting calpain proteolysis and ultraviolet C-induced degradation

Liao, J. H., Lin, I. L., Huang, K. F., Kuo, P. T., Wu, S. H. & Wu, T. H., Jun 25 2014, In : Journal of Agricultural and Food Chemistry. 62, 25, p. 5932-5938 7 p.

Research output: Contribution to journal › Article

Carnosine

Proteolysis

carnosine

Crystallins

calpain

2013

45 Citations (Scopus)

Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome

Yang, S. M., Ka, S. M., Hua, K. F., Wu, T. H., Chuang, Y. P., Lin, Y. W., Yang, F. L., Wu, S. H., Yang, S. S., Lin, S. H., Chang, J. M. & Chen, A., 2013, In : Free Radical Biology and Medicine. 61, p. 285-297 13 p.

Research output: Contribution to journal › Article

Inflammasomes

T-cells

Immunoglobulin A

T-Lymphocytes

Kidney

12 Citations (Scopus)

Determination of Olanzapine and N-desmethyl-olanzapine in Plasma Using a Reversed-Phase HPLC Coupled with Coulochemical Detection: Correlation of Olanzapine or N-desmethyl-olanzapine Concentration with Metabolic Parameters

Lu, M. L., Lin, C. H., Chen, Y. C., Yang, H. C. & Wu, T. H., May 31 2013, In : PLoS One. 8, 5, e65719.

Research output: Contribution to journal › Article

olanzapine

reversed-phase high performance liquid chromatography

High Pressure Liquid Chromatography

Plasmas

homocysteine

12 Citations (Scopus)

Ethosomes in hair dye products as carriers of the major compounds of black tea extracts

Yeh, M. I., Huang, H. C., Liaw, J. H., Huang, M. C., Wu, T. H., Huang, K. F. & Hsu, F-L., Jul 2013, In : International Journal of Dermatology. 52, 7, p. 868-875 8 p.

Research output: Contribution to journal › Article

Hair Dyes

Tea

Hair

Surface-Active Agents

Adsorption

2012

2 Citations (Scopus)

Combined therapy with thioridazine decreases plasma levels of quetiapine in taiwanese schizophrenic patients

Chang, S. C., Lu, M. L., Wang, Y. C., Lin, F. W., Huang, S. H., Kuo, P. H., Ho, H. O. & Wu, T. H., Jun 2012, In : Therapeutic Drug Monitoring. 34, 3, p. 345-348 4 p.

Research output: Contribution to journal › Article

Thioridazine

Therapeutics

Schizophrenia

Quetiapine Fumarate

Pharmacokinetics

16 Citations (Scopus)

Evaluation of antioxidant and free radical scavenging capacities of polyphenolics from pods of caesalpinia pulcherrima

Hsu, F-L., Huang, W. J., Wu, T. H., Lee, M. H., Chen, L. C., Lu, H. J., Hou, W. C. & Lin, M. H., May 2012, In : International Journal of Molecular Sciences. 13, 5, p. 6073-6088 16 p.

Research output: Contribution to journal › Article

Caesalpinia

Scavenging

scavenging

antioxidants

Antioxidants

20 Citations (Scopus)

High glucose increases nitric oxide generation in lipopolysaccharide- activated macrophages by enhancing activity of protein kinase C-α/δ and NF-κB

Hua, K. F., Wang, S. H., Dong, W. C., Lin, C. Y., Ho, C. L. & Wu, T. H., Oct 2012, In : Inflammation Research. 61, 10, p. 1107-1116 10 p.

Research output: Contribution to journal › Article

NF-kappa B

Protein Kinase C

Lipopolysaccharides

Nitric Oxide

Macrophages

1 Citation (Scopus)

Medical device on pharmacists' work-related musculoskeletal complaints and burnouts

Chou, Y. C., Chen, C. L. & Wu, T. H., Nov 2012, In : Ergonomics. 55, 11, p. 1420-1428 9 p.

Research output: Contribution to journal › Article

burnout

pharmacist

Pharmacists

complaint

Needles

2011

2 Citations (Scopus)

Anti-UVC irradiation and metal chelation properties of 6-benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: An implications for anti-cataract agent

Liao, J. H., Wu, T. H., Hsu, F-L., Huang, Y. S., Chiang, P. H., Huang, Z. Y., Huang, C. H., Wu, S. H. & Lin, M. H., Oct 2011, In : International Journal of Molecular Sciences. 12, 10, p. 7059-7076 18 p.

Research output: Contribution to journal › Article

cataracts

Crystallins

chelation

Chelation

Cataract

18 Citations (Scopus)

Ditopic complexation of selenite anions or calcium cations by pirenoxine: An implication for anti-cataractogenesis

Liao, J. H., Chen, C. S., Hu, C. C., Chen, W. T., Wang, S. P., Lin, I. L., Huang, Y. H., Tsai, M. H., Wu, T. H., Huang, F. Y. & Wu, S. H., Jan 3 2011, In : Inorganic Chemistry. 50, 1, p. 365-377 13 p.

Research output: Contribution to journal › Article

Selenious Acid

Complexation

Anions

Cations

calcium

44 Citations (Scopus)

Evaluation of the potential hypoglycemic and beta-cell protective constituents isolated from corni fructus to tackle insulin-dependent diabetes mellitus

Lin, M. H., Liu, H. K., Huang, W. J., Huang, C. C., Wu, T. H. & Hsu, F-L., Jul 27 2011, In : Journal of Agricultural and Food Chemistry. 59, 14, p. 7743-7751 9 p.

Research output: Contribution to journal › Article

Cornus officinalis

Cornus

Phosphoenolpyruvate

insulin-dependent diabetes mellitus

Medical problems

13 Citations (Scopus)

Role of pirenoxine in the effects of catalin on in vitro ultravioletinduced lens protein turbidity and selenite-induced cataractogenesis in vivo

Hu, C. C., Liao, J. H., Hsu, K. Y., Lin, I. L., Tsai, M. H., Wu, W. H., Wei, T. T., Huang, Y. S., Chiu, S. J., Chen, H. Y., Wu, S. H. & Wu, T. H., 2011, In : Molecular Vision. 17, p. 1862-1870 9 p.

Research output: Contribution to journal › Article

Selenious Acid

Crystallins

Cataract

Lenses

Calpain

2010

Binding and cleavage of E. coli HUß by the E. coli Lon protease (Biophysical Journal (2010) 98, (129-137))

Liao, J. H., Lin, Y. C., Hsu, J., Lee, A. Y. L., Chen, T. A., Hsu, C. H., Chir, J. L., Hua, K. F., Wu, T. H., Hong, L. J., Yen, P. W., Chiou, A. & Wu, S. H., Mar 3 2010, In : Biophysical Journal. 98, 5, p. 932 1 p.

Research output: Contribution to journal › Article

Taiwan

Escherichia coli

Publications

E coli Lon protein

7 Citations (Scopus)

Binding and cleavage of E. coli HUβ by the E. coli Lon protease

Liao, J. H., Lin, Y. C., Hsu, J., Lee, A. Y. L., Chen, T. A., Hsu, C. H., Chir, J. L., Hua, K. F., Wu, T. H., Hong, L. J., Yen, P. W., Chiou, A. & Wu, S. H., Jan 6 2010, In : Biophysical Journal. 98, 1, p. 129-137 9 p.

Research output: Contribution to journal › Article

Protease La

Escherichia coli

Proteins

Adenosine Triphosphate

Rupture

13 Citations (Scopus)

Grape seed proanthocyanidin extract chelates iron and attenuates the toxic effects of 6-hydroxydopamine: Implications for Parkinson's disease

Wu, T. H., Liao, J. H., Hsu, F-L., Wu, H. R., Shen, C. K., Yuann, J. M. P. & Chen, S. T., Apr 2010, In : Journal of Food Biochemistry. 34, 2, p. 244-262 19 p.

Research output: Contribution to journal › Article

Grape Seed Extract

Iron Chelating Agents

grape seeds

Parkinson disease

Poisons

2009

13 Citations (Scopus)

Astaxanthin interacts with selenite and attenuates selenite-induced cataractogenesis

Liao, J. H., Chen, C. S., Maher, T. J., Liu, C. Y., Lin, M. H., Wu, T. H. & Wu, S. H., Mar 16 2009, In : Chemical Research in Toxicology. 22, 3, p. 518-525 8 p.

Research output: Contribution to journal › Article

Selenious Acid

Rats

Selenic Acid

astaxanthine

Calorimetry

2008

41 Citations (Scopus)

Metformin for metabolic dysregulation in schizophrenic patients treated with olanzapine

Chen, C. H., Chiu, C. C., Huang, M. C., Wu, T. H., Liu, H. C. & Lu, M. L., May 15 2008, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32, 4, p. 925-931 7 p.

Research output: Contribution to journal › Article

olanzapine

Metformin

Antipsychotic Agents

Therapeutics

Insulin

22 Citations (Scopus)

Pharmacokinetics of olanzapine in Chinese male schizophrenic patients with various smoking behaviors

Wu, T. H., Chiu, C. C., Shen, W. W., Lin, F. W., Wang, L. H., Chen, H. Y. & Lu, M. L., Dec 12 2008, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32, 8, p. 1889-1893 5 p.

Research output: Contribution to journal › Article

olanzapine

Pharmacokinetics

Smoking

Tobacco Products

Light

2007

17 Citations (Scopus)

Properties of astaxanthin/Ca²⁺ complex formation in the deceleration of Cis/trans isomerization

Chen, C. S., Wu, S. H., Wu, Y. Y., Fang, J. M. & Wu, T. H., Aug 2 2007, In : Organic Letters. 9, 16, p. 2985-2988 4 p.

Research output: Contribution to journal › Article

chelation

Deceleration

turbidity

deceleration

Isomerization

2006

5 Citations (Scopus)

A screening platform for compounds with potential immuno-regulatory activities using human cord blood mononuclear cells

Chen, C. J., Chia, C. T., Hsieh, J. F., Chien, C. M., Wu, T. H. & Chen, S. T., Dec 2006, In : Combinatorial Chemistry and High Throughput Screening. 9, 10, p. 777-784 8 p.

Research output: Contribution to journal › Article

Fetal Blood

Human Activities

Blood Cells

Screening

Blood

32 Citations (Scopus)

Astaxanthin protects against oxidative stress and calcium-induced porcine lens protein degradation

Wu, T. H., Liao, J. H., Hou, W. C., Huang, F. Y., Maher, T. J. & Hu, C. C., Mar 22 2006, In : Journal of Agricultural and Food Chemistry. 54, 6, p. 2418-2423 6 p.

Research output: Contribution to journal › Article

Crystallins

Oxidative stress

astaxanthin

protein degradation

Lens

11 Citations (Scopus)

The impact of an intensive antimicrobial control program in a Taiwanese medical center

Chang, M. T., Wu, T. H., Wang, C. Y., Jang, T. N. & Huang, C. Y., Aug 2006, In : Pharmacy World and Science. 28, 4, p. 257-264 8 p.

Research output: Contribution to journal › Article

Ciprofloxacin

Taiwan

Prescriptions

Inpatients

Serratia

2002

1 Citation (Scopus)

Antioxidative and free radical scavenging activities of phenolics from Scutellaria baicalensis

Lin, T. C., Nishikawa, K., Wu, T. H. & Ishimaru, K., Jun 2002, In : Chinese Pharmaceutical Journal. 54, 3, p. 193-198 6 p.

Research output: Contribution to journal › Article

Scutellaria baicalensis

Lamiaceae

Glycosides

Scavenging

Free radicals

2001

Growth rate and polyphenol production in transformed root cultures of Fragaria x ananassa in phytohormone-free BF liquid medium

Lin, T. C., Yamada, S., Wu, T. H. & Ishimaru, K., 2001, In : Chinese Pharmaceutical Journal. 53, 5, p. 225-232 8 p.

Research output: Contribution to journal › Article

Fragaria

Plant Growth Regulators

Polyphenols

Proanthocyanidins

Flavonoids

2000

37 Citations (Scopus)

The effect of steroid sulfatase inhibition on learning and spatial memory

Johnson, D. A., Wu, T. H., Li, P. K. & Maher, T. J., May 26 2000, In : Brain Research. 865, 2, p. 286-290 5 p.

Research output: Contribution to journal › Article

Steryl-Sulfatase

Scopolamine Hydrobromide

Learning

Amnesia

Tyramine

1998

Influence of different routes of administration on the cardiovascular effects of dihydrexidine (DHX) in rats

Wu, T. H., Locke, K. W., Loar, S. B. & Maher, T. J., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journal › Article

Rats

Intranasal Administration

Arterial Pressure

Corpus Striatum

Oxidopamine

1996

1 Citation (Scopus)

Effects of salicylic acid on basal and amphetamine-induced striatal dop amine release: A microdialysis study

Wu, T. H., Acwonh, I. N. & Mäher, T. J., 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journal › Article

amphetamine

Corpus Striatum

Salicylic Acid

Microdialysis

Amphetamine