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Research Output 2006 2020

  • 597 Citations
  • 14 h-Index
  • 37 Article
  • 3 Book
  • 1 Comment/debate
  • 1 Patent
2020
1 Citation (Scopus)

Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation

Lin, P. H., Tung, Y. T., Chen, H. Y., Chiang, Y. F., Hong, H. C., Huang, K. C., Hsu, S. P., Huang, T. C. & Hsia, S. M., Jan 1 2020, In : Journal of Pineal Research. 68, 1, e12620.

Research output: Contribution to journalArticle

Leiomyoma
Melatonin
Cell Death
Cell Proliferation
Myometrium
2019
4 Citations (Scopus)

Natural Antioxidant Resveratrol Suppresses Uterine Fibroid Cell Growth and Extracellular Matrix Formation In Vitro and In Vivo

Chen, H-Y., Lin, P-H., Shih, Y-H., Wang, K-L., Hong, Y-H., Shieh, T-M., Huang, T-C. & Hsia, S-M., Apr 12 2019, In : Antioxidants. 8, 4

Research output: Contribution to journalArticle

Leiomyoma
Cell growth
Extracellular Matrix
Antioxidants
Growth

The expression profile and prognostic significance of metallothionein genes in colorectal cancer

Hung, K. C., Huang, T. C., Cheng, C. H., Cheng, Y. W., Lin, D. Y., Fan, J. J. & Lee, K. H., Aug 2 2019, In : International Journal of Molecular Sciences. 20, 16, 3849.

Research output: Contribution to journalArticle

Open Access
Metallothionein
genes
Colorectal Neoplasms
Genes
cancer
Open Access
Tissue Inhibitor of Metalloproteinase-3
Colorectal Neoplasms
Neoplasm Metastasis
Growth
Neoplasms
2018
3 Citations (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.

Research output: Contribution to journalArticle

Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation
4 Citations (Scopus)

Fucoidan Inhibits the Proliferation of Leiomyoma Cells and Decreases Extracellular Matrix-Associated Protein Expression

Chen, H. Y., Huang, T. C., Lin, L. C., Shieh, T. M., Wu, C. H., Wang, K. L., Hong, Y. H. & Hsia, S. M., Oct 1 2018, In : Cellular Physiology and Biochemistry. 49, 5, p. 1970-1986 17 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
Leiomyoma
Cell Proliferation
Heterografts
Neoplasms
6 Citations (Scopus)

Manzamine a exerts anticancer activity against human colorectal cancer cells

Lin, L. C., Kuo, T. T., Chang, H. Y., Liu, W. S., Hsia, S. M. & Huang, T. C., Jul 29 2018, In : Marine Drugs. 16, 8, 252.

Research output: Contribution to journalArticle

Human Activities
Colorectal Neoplasms
Porifera
HCT116 Cells
Carbolines
9 Citations (Scopus)

Protective Effect of Melatonin against Oxidative Stress-Induced Apoptosis and Enhanced Autophagy in Human Retinal Pigment Epithelium Cells

Chang, C. C., Huang, T. Y., Chen, H. Y., Huang, T. C., Lin, L. C., Chang, Y. J. & Hsia, S. M., Jan 1 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 9015765.

Research output: Contribution to journalArticle

Oxidative stress
Retinal Pigments
Retinal Pigment Epithelium
Autophagy
Melatonin
4 Citations (Scopus)

Roles of Fc domain and exudation in L2 antibody-mediated protection against human papillomavirus

Wang, J. W., Wu, W. H., Huang, T. C., Wong, M., Kwak, K., Ozato, K., Hung, C. F. & Roden, R. B. S., Aug 1 2018, In : Journal of Virology. 92, 15, e00572-18.

Research output: Contribution to journalArticle

Papillomaviridae
exudation
Immunoglobulin G
neutralization
antibodies
2017
6 Citations (Scopus)

Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells

Huang, T. C., Lee, P. T., Wu, M. H., Huang, C. C., Ko, C. Y., Lee, Y. C., Lin, D. Y., Cheng, Y. W. & Lee, K. H., Aug 1 2017, In : PLoS One. 12, 8, e0181034.

Research output: Contribution to journalArticle

RNA Isoforms
colorectal neoplasms
Colorectal Neoplasms
Catenins
Cells

Effects of Adlay Hull and Testa Ethanolic Extracts on the Growth of Uterine Leiomyoma Cells

Hsia, S-M., Lin, K-H., Chiang, W., Wu, C-H., Shieh, T-M., Huang, T-C., Chen, H-Y. & Lin, L-C., 2017, In : 調適醫學. 9, 2, p. 85-96 12 p.

Research output: Contribution to journalArticle

Leiomyoma
Growth
Quercetin
G2 Phase
Health
15 Citations (Scopus)

Isoliquiritigenin induces autophagy and inhibits ovarian cancer cell growth

Chen, H. Y., Huang, T. C., Shieh, T. M., Wu, C. H., Lin, L. C. & Hsia, S. M., Oct 1 2017, In : International Journal of Molecular Sciences. 18, 10, 2025.

Research output: Contribution to journalArticle

Autophagy
Cell growth
Ovarian Neoplasms
cancer
Fluorescence
12 Citations (Scopus)

Overexpression of miR-194 Reverses HMGA2-driven Signatures in Colorectal Cancer

Chang, H. Y., Ye, S. P., Pan, S. L., Kuo, T. T., Liu, B. C., Chen, Y. L. & Huang, T. C., 2017, In : Theranostics. 7, 16, p. 3889-3900 12 p.

Research output: Contribution to journalArticle

AT-Hook Motifs
Colorectal Neoplasms
Neoplasms
Epithelial-Mesenchymal Transition
MicroRNAs
10 Citations (Scopus)

Spontaneous and vaccine-induced clearance of Mus musculus papillomavirus 1 infection

Jiang, R. T., Wang, J. W., Peng, S., Huang, T. C., Wang, C., Cannella, F., Chang, Y. N., Viscidi, R. P., Best, S. R. A., Hung, C. F. & Roden, R. B. S., Aug 1 2017, In : Journal of Virology. 91, 15, e00699-17.

Research output: Contribution to journalArticle

Papillomavirus Infections
Papillomaviridae
Mus musculus
papilloma
Papilloma
9 Citations (Scopus)
Glycyrrhiza
licorice
doxorubicin
autophagy
Autophagy
2016
decitabine
Azacitidine
Drug Discovery
Genomics
Medicine
29 Citations (Scopus)

Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice

Wu, C-H., Chen, H. Y., Wang, C-W., Shieh, T. M., Huang, T-C., Lin, L. C., Wang, K. L. & Hsia, S-M., 2016, In : Oncotarget. 7, 45, p. 73432-73447 16 p.

Research output: Contribution to journalArticle

Autophagy
Endometrial Neoplasms
Apoptosis
Growth
Neoplasms
8 Citations (Scopus)

Resveratrol inhibits proliferation of myometrial and leiomyoma cells and decreases extracellular matrix-associated protein expression

Wu, C. H., Shieh, T. M., Wei, L. H., Cheng, T. F., Chen, H. Y., Huang, T. C., Wang, K. L. & Hsia, S. M., May 1 2016, In : Journal of Functional Foods. 23, p. 241-252 12 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
resveratrol
Leiomyoma
extracellular matrix
smooth muscle
19 Citations (Scopus)

Signature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol

Sun, G., Cheng, Y. W., Lai, L., Huang, T. C., Wang, J., Wu, X., Wang, Y., Huang, Y., Wang, J., Zhang, K., Hu, S., Yang, J. R. & Yen, Y., 2016, In : Oncotarget. 7, 4, p. 3857-3872 16 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
High-Throughput Nucleotide Sequencing
MicroRNAs
Colorectal Neoplasms
Rectal Neoplasms
5 Citations (Scopus)

Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: Identification of functional disparities between azacytidine and decitabine

Hsieh, Y. Y., Huang, T. C., Lo, H. L., Jhan, J. Y., Chen, S. T. & Yang, P. M., May 10 2016, In : Oncotarget. 7, 19, p. 27363-27378 16 p.

Research output: Contribution to journalArticle

decitabine
Azacitidine
Drug Discovery
Genomics
Polypharmacology
2015
4 Citations (Scopus)

Quantitative proteomics reveals middle infrared radiation-interfered networks in breast cancer cells

Chang, H. Y., Li, M. H., Huang, T. C., Hsu, C. L., Tsai, S. R., Lee, S. C., Huang, H. C. & Juan, H. F., Feb 6 2015, In : Journal of Proteome Research. 14, 2, p. 1250-1262 13 p.

Research output: Contribution to journalArticle

Proteomics
Cells
Radiation
Breast Neoplasms
Infrared radiation
2 Citations (Scopus)

Quercetin, a main flavonoid in onion, inhibits the PGF-induced uterine contraction in vitro and in vivo

Wu, C. H., Shieh, T. M., Wang, K. L., Huang, T. C. & Hsia, S. M., Dec 1 2015, In : Journal of Functional Foods. 19, p. 495-504 10 p., 1300.

Research output: Contribution to journalArticle

uterine contraction
Uterine Contraction
Dinoprost
Onions
Quercetin
2014
14 Citations (Scopus)

Combination therapy targeting ectopic ATP synthase and 26S proteasome induces ER stress in breast cancer cells

Chang, H. Y., Huang, T. C., Chen, N. N., Huang, H. C. & Juan, H. F., Jan 1 2014, In : Cell Death and Disease. 5, 11, e1540.

Research output: Contribution to journalArticle

Adenosine Triphosphate
Breast Neoplasms
Proteasome Inhibitors
Cyclin D3
Therapeutics
41 Citations (Scopus)

Radiation induces senescence and a bystander effect through metabolic alterations.

Liao, E. C., Hsu, Y. T., Chuah, Q. Y., Lee, Y. J., Hu, J. Y., Huang, T. C., Yang, P. M. & Chiu, S. J., 2014, In : Cell Death and Disease. 5

Research output: Contribution to journalArticle

Bystander Effect
Radiation
Glycolysis
Lactic Acid
Anaphase
26 Citations (Scopus)

The mechanisms by which pardaxin, a natural cationic antimicrobial peptide, targets the endoplasmic reticulum and induces c-FOS

Ting, C. H., Huang, H. N., Huang, T. C., Wu, C. J. & Chen, J. Y., Apr 2014, In : Biomaterials. 35, 11, p. 3627-3640 14 p.

Research output: Contribution to journalArticle

Antimicrobial Cationic Peptides
Cell death
Endoplasmic Reticulum
Peptides
Transcription factors
2013

Flow Cytometric Detection of Mitochondrial Membrane Potential

Chang, H-Y., Huang, H-C., Huang, T-C., Yang, P-C., Wang, Y-C. & Juan, H-F., Jan 1 2013

Research output: Book/ReportBook

Flow Cytometric Detection of Reactive Oxygen Species

Chang, H-Y., Huang, H-C., Huang, T-C., Yang, P-C., Wang, Y-C. & Juan, H-F., Jan 1 2013

Research output: Book/ReportBook

18 Citations (Scopus)
HeLa Cells
Proteomics
Reactive Oxygen Species
Carcinoma
Apoptosis
13 Citations (Scopus)

Proteomic and functional analysis of zebrafish after administration of antimicrobial peptide epinecidin-1

Huang, T. C. & Chen, J. Y., Feb 2013, In : Fish and Shellfish Immunology. 34, 2, p. 593-598 6 p.

Research output: Contribution to journalArticle

Functional analysis
proteomics
antimicrobial peptides
Danio rerio
peptide
2012
39 Citations (Scopus)

Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response

Chang, H. Y., Huang, H. C., Huang, T. C., Yang, P. C., Wang, Y. C. & Juan, H. F., Sep 15 2012, In : Cancer Research. 72, 18, p. 4696-4706 11 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Adenosine Triphosphate
Cell Membrane
Growth
Reactive Oxygen Species

Erratum: Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR (FEBS Letters (2011) 585 (3582-3586))

Huang, T. C., Chang, H. Y., Chen, C. Y., Wu, P. Y., Lee, H., Liao, Y. F., Hsu, W. M., Huang, H. C. & Juan, H. F., Jan 2 2012, In : FEBS Letters. 586, 1, p. 107 1 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Neuroblastoma
Cell Differentiation
Apoptosis
43 Citations (Scopus)
Epinephelus coioides
Vibrio vulnificus
grouper
Escherichia coli Proteins
Danio rerio
26 Citations (Scopus)

Pardaxin, a fish antimicrobial peptide, exhibits antitumor activity toward murine fibrosarcoma in Vitro and in Vivo

Wu, S. P., Huang, T. C., Lin, C. C., Hui, C. F., Lin, C. H. & Chen, J. Y., Aug 2012, In : Marine Drugs. 10, 8, p. 1852-1872 21 p.

Research output: Contribution to journalArticle

Fibrosarcoma
Fishes
Peptides
Apoptosis
Caspase 7
27 Citations (Scopus)

Piscidin-1, an antimicrobial peptide from fish (Hybrid Striped Bass Morone saxatilis x M. chrysops), induces apoptotic and necrotic activity in HT1080 cells

Lin, H. J., Huang, T. C., Muthusamy, S., Lee, J. F., Duann, Y. F. & Lin, C. H., May 2012, In : Zoological Science. 29, 5, p. 327-332 6 p.

Research output: Contribution to journalArticle

Morone chrysops x Morone saxatilis
Morone saxatilis
antimicrobial peptides
dosage
fish

耐受醇類之大腸桿菌及其製備方法

H, M., Chang, H-Y., Huang, H-C., Huang, T-C., Liao, J-C. & Juan, H-F., 2012

Research output: Patent

2011
49 Citations (Scopus)

Pardaxin, an antimicrobial peptide, triggers caspase-dependent and ROS-mediated apoptosis in HT-1080 cells

Huang, T. C., Lee, J. F. & Chen, J. Y., Oct 2011, In : Marine Drugs. 9, 10, p. 1995-2009 15 p.

Research output: Contribution to journalArticle

Caspases
Reactive Oxygen Species
Apoptosis
Peptides
Caspase 7
49 Citations (Scopus)

Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

Huang, T. C., Chang, H. Y., Chen, C. Y., Wu, P. Y., Lee, H., Liao, Y. F., Hsu, W. M., Huang, H. C. & Juan, H. F., Nov 16 2011, In : FEBS Letters. 585, 22, p. 3582-3586 5 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Cell Cycle Checkpoints
Neuroblastoma
Cell Differentiation
Cells
7 Citations (Scopus)

The effect of narrow bandwidth infrared radiation on the growth of Escherichia coli

Tsai, S. R., Huang, T. C., Liang, C. M., Chang, H. Y., Chang, Y. T., Huang, H. C., Juan, H. F. & Lee, S. C., Oct 17 2011, In : Applied Physics Letters. 99, 16, 163704.

Research output: Contribution to journalArticle

infrared radiation
Escherichia
bandwidth
wavelengths
transporter
2008
69 Citations (Scopus)

Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin b

Huang, T. C., Chang, H. Y., Hsu, C. H., Kuo, W. H., Chang, K. J. & Juan, H. F., Apr 2008, In : Journal of Proteome Research. 7, 4, p. 1433-1444 12 p.

Research output: Contribution to journalArticle

Aurovertins
Adenosine Triphosphate
Cells
Breast Neoplasms
Tumors
2007
10 Citations (Scopus)

An apoptosis-related gene network induced by novel compound-cRGD in human breast cancer cells

Huang, T. C., Huang, H. C., Chang, C. C., Chang, H. Y., Ou, C. H., Hsu, C. H., Chen, S. T. & Juan, H. F., Jul 24 2007, In : FEBS Letters. 581, 18, p. 3517-3522 6 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Genes
Cells
Cell death
Apoptosis
2006
16 Citations (Scopus)

Proteomics analysis of a novel compound: Cyclic RGD in breast carcinoma cell line MCF-7

Juan, H. F., Wang, I. H., Huang, T. C., Li, J. J., Chen, S. T. & Huang, H. C., May 2006, In : Proteomics. 6, 10, p. 2991-3000 10 p.

Research output: Contribution to journalArticle

Proteomics
MCF-7 Cells
Cells
Breast Neoplasms
Cell Line