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Research Output 1980 2020

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Review article
2020

Plasma fractionation in countries with limited infrastructure and low-/medium income: How to move forward?

Burnouf, T., Faber, J. C., Radosevic, M., Goubran, H. & Seghatchian, J., Jan 1 2020, (Accepted/In press) In : Transfusion and Apheresis Science. 102715.

Research output: Contribution to journalReview article

Blood Proteins
Safety
Virus Inactivation
Technology
Therapeutics

Vitamin B12 deficiency and metabolism-mediated thrombotic microangiopathy (MM-TMA)

Sabry, W., Elemary, M., Burnouf, T., Seghatchian, J. & Goubran, H., Jan 1 2020, (Accepted/In press) In : Transfusion and Apheresis Science. 102717.

Research output: Contribution to journalReview article

Thrombotic Microangiopathies
Vitamin B 12 Deficiency
Vitamin B 12
Reticulocytosis
Erythrocyte Indices
2019
12 Citations (Scopus)

Human platelet lysate current standards and future developments

Henschler, R., Gabriel, C., Schallmoser, K., Burnouf, T. & Koh, M. B. C., Jan 1 2019, In : Transfusion.

Research output: Contribution to journalReview article

Blood Platelets
Mesenchymal Stromal Cells
Cell- and Tissue-Based Therapy
Safety
Education
1 Citation (Scopus)

New monoclonal/bi-specific antibodies: Reshaping transfusion medicine beyond replacement

Goubran, H., Goubran, M., Seghatchian, J. & Burnouf, T., Apr 1 2019, In : Transfusion and Apheresis Science. 58, 2, p. 208-211 4 p.

Research output: Contribution to journalReview article

Transfusion Medicine
Antibodies
Bispecific Antibodies
Hereditary Angioedemas
Thrombotic Thrombocytopenic Purpura
3 Citations (Scopus)
Platelets
Blood Platelets
Inventions
Quality management
Pathogens
2 Citations (Scopus)

Viral safety of human platelet lysate for cell therapy and regenerative medicine: Moving forward, yes, but without forgetting the past

Burnouf, T., Barro, L., Nebie, O., Wu, Y. W., Goubran, H., Knutson, F. & Seghatchian, J., Dec 2019, In : Transfusion and Apheresis Science. 58, 6, 102674.

Research output: Contribution to journalReview article

Regenerative Medicine
Cell- and Tissue-Based Therapy
Blood Platelets
Safety
Inborn Genetic Diseases
2018

Multifaceted regenerative lives of ‘expired’ platelets

Burnouf, T. P. R., 2018, In : Vox Sanguinis. p. 323-330

Research output: Contribution to journalReview article

Blood Platelets
Regenerative Medicine
Cell- and Tissue-Based Therapy
Mesenchymal Stromal Cells
Intercellular Signaling Peptides and Proteins
11 Citations (Scopus)

Reflections on dry eye syndrome treatment: Therapeutic role of blood products

Drew, V. J., Tseng, C. L., Seghatchian, J. & Burnouf, T., Feb 1 2018, In : Frontiers in Medicine. 5, FEB, 33.

Research output: Contribution to journalReview article

Dry Eye Syndromes
Ophthalmic Solutions
Tears
Serum
Pathology
2017
12 Citations (Scopus)

Duration of red blood cell storage and inflammatory marker generation

Sut, C., Tariket, S., Chou, M. L., Garraud, O., Laradi, S., Hamzeh-Cognasse, H., Seghatchian, J., Burnouf, T. & Cognasse, F., Mar 1 2017, In : Blood Transfusion. 15, 2, p. 145-152 8 p.

Research output: Contribution to journalReview article

Erythrocyte Transfusion
Erythrocytes
Immunomodulation
Pathology
Therapeutics
3 Citations (Scopus)

Platelet transfusion in thrombocytopenic cancer patients: Sometimes justified but likely insidious

Burnouf, T., Elemary, M., Radosevic, J., Seghatchian, J. & Goubran, H., Jun 1 2017, In : Transfusion and Apheresis Science. 56, 3, p. 305-309 5 p.

Research output: Contribution to journalReview article

Platelet Transfusion
Neoplasms
Blood Platelets
Transfusion Medicine
Circulating Neoplastic Cells
2 Citations (Scopus)

Red blood cell transfusion and outcome in cancer

Iqbal, N., Haider, K., Sundaram, V., Radosevic, J., Burnouf, T., Seghatchian, J. & Goubran, H., Jun 1 2017, In : Transfusion and Apheresis Science. 56, 3, p. 287-290 4 p.

Research output: Contribution to journalReview article

Erythrocyte Transfusion
Blood Transfusion
Hemodilution
Blood Cell Count
Neoplasms
2 Citations (Scopus)

The Current Global Status and Production Trends of Plasma Fractionation

Kim, M-J. & Burnouf, T. P. R., 2017, In : Korean J Blood Transfus. p. 113-125

Research output: Contribution to journalReview article

Gross Domestic Product
Plasmapheresis
Intravenous Immunoglobulins
Contracts
Developed Countries
5 Citations (Scopus)

The microbiome and transfusion in cancer patients

Goubran, H., Seghatchian, J., Radosevic, J., Ragab, G. & Burnouf, T., Jun 1 2017, In : Transfusion and Apheresis Science. 56, 3, p. 330-335 6 p.

Research output: Contribution to journalReview article

Microbiota
Neoplasms
Mucositis
Micronutrients
Vulnerable Populations
28 Citations (Scopus)

Towards pathogen inactivation of red blood cells and whole blood targeting viral DNA/RNA: Design, technologies, and future prospects for developing countries

Drew, V. J., Barro, L., Seghatchian, J. & Burnouf, T., 2017, In : Blood Transfusion. 15, 6, p. 512-521 10 p.

Research output: Contribution to journalReview article

Viral DNA
Viral RNA
Developing Countries
Erythrocytes
Technology
17 Citations (Scopus)

Transfusion-related immunomodulation and cancer

Goubran, H., Sheridan, D., Radosevic, J., Burnouf, T. & Seghatchian, J., Jun 1 2017, In : Transfusion and Apheresis Science. 56, 3, p. 336-340 5 p.

Research output: Contribution to journalReview article

Immunomodulation
Neoplasms
Hemoglobins
Tissue Donors
Metabolomics
2016
2 Citations (Scopus)
Ophthalmic Solutions
Cytokines
Safety
Serum
Cell Engineering
Tissue Engineering
Cell- and Tissue-Based Therapy
Blood Platelets
Safety

Current status and new developments in the production of plasma derivatives

Burnouf, T. P. R., Jun 28 2016, In : Vox Sanguinis. 11, p. 18-25

Research output: Contribution to journalReview article

Technology
Blood Proteins
Ethanol
Virus Integration
Protein Deficiency
147 Citations (Scopus)

Human platelet lysate: Replacing fetal bovine serum as a gold standard for human cell propagation?

Burnouf, T., Strunk, D., Koh, M. B. C. & Schallmoser, K., 2016, In : Biomaterials. 76, p. 371-387 17 p.

Research output: Contribution to journalReview article

Platelets
Blood Platelets
Cells
Serum
Cell culture

Impact of Transfusion on Cancer Growth and Outcome

Goubran, H. A., Elemary, M., Radosevich, M., Seghatchian, J., El-Ekiaby, M. & Burnouf, T., 2016, In : Cancer growth and metastasis. 9, p. 1-8 8 p.

Research output: Contribution to journalReview article

Blood Component Transfusion
Growth
Neoplasms
Precision Medicine
Blood Cell Count
6 Citations (Scopus)
Dry Eye Syndromes
Ophthalmic Solutions
Safety
Serum
Research
15 Citations (Scopus)

Smart blood cell and microvesicle-based Trojan horse drug delivery: Merging expertise in blood transfusion and biomedical engineering in the field of nanomedicine

Wu, Y. W., Goubran, H., Seghatchian, J. & Burnouf, T., Apr 1 2016, In : Transfusion and Apheresis Science. 54, 2, p. 309-318 10 p.

Research output: Contribution to journalReview article

Nanomedicine
Biomedical Engineering
Blood Transfusion
Blood Cells
Pharmaceutical Preparations
2015
12 Citations (Scopus)

A Call for Incorporating Social Research in the Global Struggle against Snakebite

Gutiérrez, J. M., Burnouf, T., Harrison, R. A., Calvete, J. J., Brown, N., Jensen, S. D., Warrell, D. A. & Williams, D. J., Sep 17 2015, In : PLoS Neglected Tropical Diseases. 9, 9, e0003960.

Research output: Contribution to journalReview article

Snake Bites
Research
61 Citations (Scopus)

An overview of the role of microparticles/microvesicles in blood components: Are they clinically beneficial or harmful?

Burnouf, T., Chou, M. L., Goubran, H., Cognasse, F., Garraud, O. & Seghatchian, J., Oct 1 2015, In : Transfusion and Apheresis Science. 53, 2, p. 137-145 9 p.

Research output: Contribution to journalReview article

Blood Safety
Transfusion Medicine
Leukocytes
Coagulants
Blood Component Removal
10 Citations (Scopus)

Platelet-derived microparticles trigger THP-1 monocytic cell aggregation and release of pro-coagulant tissue factor-expressing microparticles in vitro

Lin, H. C., Chang, H. W., Hsiao, S. H., Chou, M. L., Seghatchian, J. & Burnouf, T., Oct 1 2015, In : Transfusion and Apheresis Science. 53, 2, p. 246-252 7 p.

Research output: Contribution to journalReview article

Coagulants
Cell Aggregation
Thromboplastin
Blood Platelets
Thrombin
35 Citations (Scopus)

Platelet microparticle: A sensitive physiological "fine tuning" balancing factor in health and disease

Goubran, H. A., Burnouf, T., Stakiw, J. & Seghatchian, J., Feb 1 2015, In : Transfusion and Apheresis Science. 52, 1, p. 12-18 7 p.

Research output: Contribution to journalReview article

Blood Platelets
Health
Transfusion Medicine
Disease Vectors
Neoplasms
32 Citations (Scopus)

Platelet microparticles and cancer: An intimate cross-talk

Goubran, H., Sabry, W., Kotb, R., Seghatchian, J. & Burnouf, T., Oct 1 2015, In : Transfusion and Apheresis Science. 53, 2, p. 168-172 5 p.

Research output: Contribution to journalReview article

Blood Platelets
Neoplasms
Intercellular Signaling Peptides and Proteins
Cell-Derived Microparticles
Immunologic Surveillance
43 Citations (Scopus)

The role of microparticles in inflammation and transfusion: A concise review

Cognasse, F., Hamzeh-Cognasse, H., Laradi, S., Chou, M. L., Seghatchian, J., Burnouf, T., Boulanger, C., Garraud, O. & Amabile, N., Oct 1 2015, In : Transfusion and Apheresis Science. 53, 2, p. 159-167 9 p.

Research output: Contribution to journalReview article

Inflammation
Cytoskeletal Proteins
Membrane Glycoproteins
Lipid Bilayers
Body Fluids
2014
17 Citations (Scopus)

Ebola virus convalescent blood products: Where we are now and where we may need to go

Burnouf, T. & Seghatchian, J., 2014, In : Transfusion and Apheresis Science. 51, 2, p. 120-125 6 p.

Research output: Contribution to journalReview article

Ebolavirus
Ebola Hemorrhagic Fever
Immunoglobulins
Passive Immunization
Pandemics
7 Citations (Scopus)
Plasma Volume
Industry
Blood Coagulation Factors
Intravenous Immunoglobulins
Recombinant Proteins
8 Citations (Scopus)

Multifaceted regenerative lives of expired platelets in the second decade of the 21st century

Burnouf, T., Goubran, H. A. & Seghatchian, J., 2014, In : Transfusion and Apheresis Science. 51, 2, p. 107-112 6 p.

Research output: Contribution to journalReview article

Blood Platelets
Hemostatics
Intercellular Signaling Peptides and Proteins
Transfusion Medicine
Regenerative Medicine
88 Citations (Scopus)

Platelet microparticles: Detection and assessment of their paradoxical functional roles in disease and regenerative medicine

Burnouf, T., Goubran, H. A., Chou, M. L., Devos, D. & Radosevic, M., 2014, In : Blood Reviews. 28, 4, p. 155-166 12 p.

Research output: Contribution to journalReview article

Regenerative Medicine
Blood Platelets
Regeneration
Thrombosis
Phosphatidylserines
2013
103 Citations (Scopus)

Blood-derived biomaterials and platelet growth factors in regenerative medicine

Burnouf, T., Goubran, H. A., Chen, T. M., Ou, K. L., El-Ekiaby, M. & Radosevic, M., Mar 2013, In : Blood Reviews. 27, 2, p. 77-89 13 p.

Research output: Contribution to journalReview article

Regenerative Medicine
Platelet-Derived Growth Factor
Biocompatible Materials
Blood Platelets
Fibrin Tissue Adhesive
77 Citations (Scopus)

The platelet-cancer loop

Goubran, H. A., Burnouf, T., Radosevic, M. & El-Ekiaby, M., Jul 2013, In : European Journal of Internal Medicine. 24, 5, p. 393-400 8 p.

Research output: Contribution to journalReview article

Blood Platelets
Neoplasms
Thrombosis
Neoplasm Metastasis
Thrombophlebitis
2011
28 Citations (Scopus)

Recombinant plasma proteins

Burnouf, T., Jan 2011, In : Vox Sanguinis. 100, 1, p. 68-83 16 p.

Research output: Contribution to journalReview article

Recombinant Proteins
Blood Proteins
Technology
Cell Culture Techniques
Genetically Modified Animals
2010
91 Citations (Scopus)

Intravenous immunoglobulin G: Trends in production methods, quality control and quality assurance

Radosevich, M. & Burnouf, T., Jan 2010, In : Vox Sanguinis. 98, 1, p. 12-28 17 p.

Research output: Contribution to journalReview article

Intravenous Immunoglobulins
Quality Control
Immunoglobulin G
Safety
Infectious Disease Transmission
2008
1 Citation (Scopus)

Actualités sur les médicaments dérivés du sang

Translated title of the contribution: Current status of fractionated plasma productsBurnouf, T., Jan 2008, In : Hematologie. 14, 1, p. 36-47 12 p.

Research output: Contribution to journalReview article

Creutzfeldt-Jakob Syndrome
Virus Inactivation
Donor Selection
Blood Coagulation Factors
Prions
2007
1 Citation (Scopus)

Biological and biochemical assays to ensure the quality and safety of plasma-derived products: Factor VIII concentrates

Radosevich, M. & Burnouf, T., May 2007, In : Current Pharmaceutical Analysis. 3, 2, p. 83-94 12 p.

Research output: Contribution to journalReview article

Factor VIII
Biological Assay
Quality Control
Quality control
Assays
6 Citations (Scopus)

Recommendations for the production, control and regulation of human plasma for fractionation

Burnouf, T., Padilla, A., Schärer, C., Snape, T., Strengers, P., Urbaniak, S. & Van Aken, W. G., 2007, In : World Health Organization technical report series. 941, p. 189-264 76 p.

Research output: Contribution to journalReview article

2005
7 Citations (Scopus)

PDA Technical Report No. 41: Virus filtration

Sofer, G., Brorson, K., Abujoub, A., Aranha, H., Burnouf, T., Carter, J., Jocham, U. E., Jornitz, M., Korneyeva, M., Krishnan, M., Marcus-Sekura, C., Martin, J., Morgan, M., Prashad, M., Robertson, G. A., Rubino, M., Shanks, M., Shepherd, A., Smith, T., Sundaram, S. & 4 others, Van Engelenburg, F., Willkommen, H., Wojciechowski, P. & Yoshinari, K. B., Mar 2005, In : PDA Journal of Pharmaceutical Science and Technology. 59, SUPPL. 2, p. 1-42 42 p.

Research output: Contribution to journalReview article

2004
1 Citation (Scopus)

Blood-derived, tissue engineering biomaterials

Burnouf, T., Dec 25 2004, In : Biomedical Engineering - Applications, Basis and Communications. 16, 6, p. 294-304 11 p.

Research output: Contribution to journalReview article

Biocompatible Materials
Tissue Engineering
Platelets
Tissue engineering
Biomaterials
2003
148 Citations (Scopus)

Nanofiltration of plasma-derived biopharmaceutical products

Burnouf, T. & Radosevich, M., Jan 2003, In : Haemophilia. 9, 1, p. 24-37 14 p.

Research output: Contribution to journalReview article

Viruses
Safety
Blood Coagulation Factors
Prions
Hepatitis B
2001
79 Citations (Scopus)

Affinity chromatography in the industrial purification of plasma proteins for therapeutic use

Burnouf, T. & Radosevich, M., Oct 30 2001, In : Journal of Biochemical and Biophysical Methods. 49, 1-3, p. 575-586 12 p.

Research output: Contribution to journalReview article

Affinity chromatography
Therapeutic Uses
Affinity Chromatography
Purification
Blood Proteins
2000
2 Citations (Scopus)

La prevention des risques infectieux des derives plasmatiques

Translated title of the contribution: Procedures for preventing infectious risks from plasma productsBurnouf, T. & Radosevich, M., 2000, In : Hematologie. 6, 4, p. 289-299 11 p.

Research output: Contribution to journalReview article

Virus Inactivation
Tissue Donors
HIV
Viral Antibodies
Pasteurization
157 Citations (Scopus)

Reducing the risk of infection from plasma products: Specific preventative strategies

Burnouf, T. & Radosevich, M., Jun 2000, In : Blood Reviews. 14, 2, p. 94-110 17 p.

Research output: Contribution to journalReview article

Infection
Hot Temperature
Nucleic Acid Amplification Techniques
HIV
Viral Antibodies
18 Citations (Scopus)

Virucidal heat-treatment of single plasma units: A potential approach for developing countries

Goubran, H. A., Burnouf, T. & Radosevich, M., 2000, In : Haemophilia. 6, 6, p. 597-604 8 p.

Research output: Contribution to journalReview article

Developing Countries
Hot Temperature
HIV
Viruses
Calcium Gluconate
1998
22 Citations (Scopus)

Application of bioaffinity technology in therapeutic extracorporeal plasmapheresis and large-scale fractionation of human plasma

Burnouf, T., Goubran, H. & Radosevich, M., Sep 11 1998, In : Journal of Chromatography B: Biomedical Applications. 715, 1, p. 65-80 16 p.

Research output: Contribution to journalReview article

Plasma (human)
Fractionation
Plasmas
Affinity chromatography
Coagulation
1997
280 Citations (Scopus)

Fibrin sealant: Scientific rationale, production methods, properties, and current clinical use

Radosevich, M., Goubran, H. A. & Burnouf, T., Apr 1997, In : Vox Sanguinis. 72, 3, p. 133-143 11 p.

Research output: Contribution to journalReview article

Fibrin Tissue Adhesive
Tissue Adhesives
Air
Hemorrhage
Safety
1995
79 Citations (Scopus)

Chromatography in plasma fractionation: benefits and future trends

Burnouf, T., Feb 3 1995, In : Journal of Chromatography B: Biomedical Sciences and Applications. 664, 1, p. 3-15 13 p.

Research output: Contribution to journalReview article

Fractionation
Chromatography
Plasmas
Purification
Blood Proteins
1993
27 Citations (Scopus)

Chromatographic removal of viruses from plasma derivatives.

Burnouf, T., 1993, In : Developments in Biological Standardization. 81, p. 199-209 11 p.

Research output: Contribution to journalReview article

Viruses
Validation Studies
Chromatography
Mammalian orthoreovirus 3
Sindbis Virus