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Research Output 2003 2019

  • 1560 Citations
  • 21 h-Index
  • 76 Article
  • 2 Comment/debate
  • 1 Review article
2019
Open Access
temozolomide
Glioblastoma
Phenotype
Glioma
Stem Cells
1 Citation (Scopus)

Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling

Chen, J. H., T.H Wu, A., T.W Tzeng, D., Huang, C. C., Tzeng, Y. M. & Chao, T. Y., Jan 1 2019, In : Phytomedicine. 52, p. 70-78 9 p.

Research output: Contribution to journalArticle

Antrodia
Catenins
Carcinogenesis
Breast
Down-Regulation
1 Citation (Scopus)

Antrodia cinnamomea enhances chemo-sensitivity of 5-fu and suppresses colon tumorigenesis and cancer stemness via up-regulation of tumor suppressor miR-142-3p

Huang, Y. J., Yadav, V. K., Srivastava, P., Wu, A. T. H., Huynh, T. T., Wei, P. L., Huang, C. Y. F. & Huang, T. H., Aug 1 2019, In : Biomolecules. 9, 8, 306.

Research output: Contribution to journalArticle

Open Access
Antrodia
Fluorouracil
Colonic Neoplasms
Tumors
Carcinogenesis
1 Citation (Scopus)
Open Access
Astragalus
dendritic cells
lung neoplasms
Dendritic Cells
Polysaccharides
AMP-Activated Protein Kinases
Epithelial-Mesenchymal Transition
Hypoxia-Inducible Factor 1
Colonic Neoplasms
Colorectal Neoplasms
1 Citation (Scopus)

Collagen 1A1 (COL1A1) is a reliable biomarker and putative therapeutic target for hepatocellular carcinogenesis and metastasis

Ma, H. P., Chang, H. L., Bamodu, O. A., Yadav, V. K., Huang, T. Y., Wu, A. T. H., Yeh, C. T., Tsai, S. H. & Lee, W. H., Jun 1 2019, In : Cancers. 11, 6, 786.

Research output: Contribution to journalArticle

Open Access
Hepatocellular Carcinoma
Carcinogenesis
Collagen
Biomarkers
Neoplasm Metastasis
5 Citations (Scopus)
Robotics
Rectal Neoplasms
Laparoscopy
Meta-Analysis
Randomized Controlled Trials

Identification of withaferin a as a potential candidate for anti-cancer therapy in non-small cell lung cancer

Hsu, J. H. M., Chang, P. M. H., Cheng, T. S., Kuo, Y. L., Wu, A. T. H., Tran, T. H., Yang, Y. H., Chen, J. M., Tsai, Y. C., Chu, Y. S., Huang, T. H., Huang, C. Y. F. & Lai, J. M., Jul 1 2019, In : Cancers. 11, 7, 1003.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Neoplasms
Cisplatin
Therapeutics

In silico identification of thiostrepton as an inhibitor of cancer stem cell growth and an enhancer for chemotherapy in non-small-cell lung cancer

Huang, T-H., Wu, A. T. H., Cheng, T-S., Lin, K-T., Lai, C-J., Hsieh, H-W., Chang, P. M-H., Wu, C-W., Huang, C-Y. F. & Chen, K-Y., Oct 22 2019, In : Journal of Cellular and Molecular Medicine.

Research output: Contribution to journalArticle

Thiostrepton
Neoplastic Stem Cells
Non-Small Cell Lung Carcinoma
Computer Simulation
Drug Therapy
Anthracyclines
Radiotherapy
Breast Neoplasms
Drug Therapy
Adjuvant Radiotherapy

The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells

Tai, P. A., Liu, Y. L., Wen, Y. T., Lin, C. M., Huynh, T. T., Hsiao, M., Wu, A. T. H. & Wei, L., Jan 1 2019, In : Molecular Imaging. 18

Research output: Contribution to journalArticle

Open Access
Optical Devices
stem cells
Optical Imaging
Stem cells
Glioma
Open Access
Conformal Radiotherapy
Intensity-Modulated Radiotherapy
Chemoradiotherapy
Thorax
Radiotherapy
2018

Destruxin B suppresses drug-resistant colon tumorigenesis and stemness is associated with the upregulation of miR-214 and downregulation of mTOR/β-catenin pathway

Wu, S. Y., Huang, Y. J., Tzeng, Y. M., Huang, C. Y. F., Hsiao, M., Wu, A. T. H. & Huang, T. H., Oct 1 2018, In : Cancers. 10, 10, 353.

Research output: Contribution to journalArticle

Catenins
Sirolimus
Colonic Neoplasms
Colon
Carcinogenesis
3 Citations (Scopus)
Catenins
Neoplastic Stem Cells
Diterpenes
Liver Neoplasms
Wnt Signaling Pathway
1 Citation (Scopus)
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Radiotherapy
Thorax
Therapeutics
2 Citations (Scopus)

Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3- associated signaling pathways

Fann, L. Y., Chen, Y., Chu, D. C., Weng, S. J., Chu, H. C., Wu, A. T. H., Lee, J. F., Ali, A. A. A., Chen, T. C., Huang, H. S. & Ma, K. H., Jan 1 2018, In : Oncotarget. 9, 15, p. 11922-11937 16 p.

Research output: Contribution to journalArticle

Glioblastoma
Brain Neoplasms
Caspase 3
Ataxia Telangiectasia Mutated Proteins
Staining and Labeling
1 Citation (Scopus)
Intensity-Modulated Radiotherapy
Propensity Score
Adenocarcinoma
Cohort Studies
Drug Therapy
1 Citation (Scopus)

Predicting 90-day mortality in locoregionally advanced head and neck squamous cell carcinoma after curative surgery

Qin, L., Chen, T. M., Kao, Y. W., Lin, K. C., Yuan, K. S. P., Wu, A. T. H., Shia, B. C. & Wu, S. Y., Oct 22 2018, In : Cancers. 10, 10, 392.

Research output: Contribution to journalArticle

Mortality
Comorbidity
Survival Rate
Carcinoma, squamous cell of head and neck
Neck Dissection

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study

Qin, L., Kao, Y. W., Lin, Y. L., Peng, B. Y., Deng, W. P., Chen, T. M., Lin, K. C., Yuan, K. S. P., Wu, A. T. H., Shia, B. C. & Wu, S. Y., Jan 1 2018, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

Case-Control Studies
Confidence Intervals
Neoplasms
Sutton disease 2
Databases
3 Citations (Scopus)

Transcriptome analysis and prognosis of ALDH isoforms in human cancer

Chang, P. M. H., Chen, C. H., Yeh, C. C., Lu, H. J., Liu, T. T., Chen, M. H., Liu, C. Y., Wu, A. T. H., Yang, M. H., Tai, S. K., Mochly-Rosen, D. & Huang, C. Y. F., Feb 9 2018, In : Scientific Reports. 8, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Gene Expression Profiling
Protein Isoforms
Neoplasms
RNA Sequence Analysis
Atlases
2017
6 Citations (Scopus)

4-Acetylantroquinonol B suppresses autophagic flux and improves cisplatin sensitivity in highly aggressive epithelial cancer through the PI3K/Akt/mTOR/p70S6K signaling pathway

Liu, M., Bamodu, O. A., Huang, W. C., Zucha, M. A., Lin, Y. K., Wu, A. T. H., Huang, C. C., Lee, W. H., Yuan, C. C., Hsiao, M., Deng, L., Tzeng, Y. M. & Yeh, C. T., Mar 15 2017, In : Toxicology and Applied Pharmacology. p. 48-60

Research output: Contribution to journalArticle

70-kDa Ribosomal Protein S6 Kinases
Autophagy
Phosphatidylinositol 3-Kinases
Cisplatin
Fluxes
7 Citations (Scopus)

Antrodia cinnamomea sensitizes radio-/chemo-therapy of cancer stem-like cells by modulating microRNA expression

Su, Y. K., Shih, P. H., Lee, W. H., Bamodu, O. A., Wu, A. T. H., Huang, C. C., Tzeng, Y. M., Hsiao, M., Yeh, C. T. & Lin, C. M., Jul 31 2017, In : Journal of Ethnopharmacology. 207, p. 47-56 10 p.

Research output: Contribution to journalArticle

Antrodia
Neoplastic Stem Cells
MicroRNAs
Radio
Neoplasms
1 Citation (Scopus)

BICD1 expression, as a potential biomarker for prognosis and predicting response to therapy in patients with glioblastomas

Huang, S. P., Chang, Y. C., Low, Q. H., Wu, A. T. H., Chen, C. L., Lin, Y. F. & Hsiao, M., Jan 1 2017, In : Oncotarget. 8, 69, p. 113766-113791 26 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Biomarkers
Atlases
Glioma

Cyproheptadine use in hepatocellular carcinoma

Hsieh, M. C., Lee, W. H., Wu, A. T. H., Chow, J. M., Chang, C. L., Yuan, K. S. P. & Wu, S. Y., 2017, In : American Journal of Cancer Research. 7, 3, p. 584-602 19 p.

Research output: Contribution to journalArticle

Cyproheptadine
Hepatocellular Carcinoma
Palliative Care
Cause of Death
Therapeutics
19 Citations (Scopus)
Intensity-Modulated Radiotherapy
Chemoradiotherapy
Thorax
Mortality
Neoplasms
17 Citations (Scopus)
Esophagectomy
Chemoradiotherapy
Radiotherapy
Thorax
Confidence Intervals
Epidermal Growth Factor Receptor
Squamous Cell Carcinoma
Lung Neoplasms
Adenocarcinoma
Radiotherapy
16 Citations (Scopus)

Feedback regulation of ALDOA activates the HIF-1α/MMP9 axis to promote lung cancer progression

Chang, Y. C., Chan, Y. C., Chang, W. M., Lin, Y. F., Yang, C. J., Su, C. Y., Huang, M. S., Wu, A. T. H. & Hsiao, M., Sep 10 2017, In : Cancer Letters. 403, p. 28-36 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Fructose-Bisphosphate Aldolase
Lung Neoplasms
Neoplasm Metastasis
Therapeutics
11 Citations (Scopus)
Neoplastic Stem Cells
Antioxidants
Side-Population Cells
Pancreatic Neoplasms
Tumors
2 Citations (Scopus)

Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck Squamous Cell Carcinoma

Chi, L. H., Chang, W. M., Chang, Y. C., Chan, Y. C., Tai, C. C., Leung, K. W., Chen, C. L., Wu, A. T., Lai, T. C., Li, Y. C. & Hsiao, M., Dec 1 2017, In : Scientific Reports. 7, 1, 9031.

Research output: Contribution to journalArticle

Proteomics
Biomarkers
Neoplasm Metastasis
Carcinoma, squamous cell of head and neck
thymosin beta(4)
10 Citations (Scopus)

Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis

Chang, Y. C., Chi, L. H., Chang, W. M., Su, C. Y., Lin, Y. F., Chen, C. L., Chen, M. H., Chang, P. M. H., Wu, A. T. H. & Hsiao, M., Jan 7 2017, In : Journal of Hematology and Oncology. 10, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Neoplasm Metastasis
Glycolysis
Glucose
Carcinoma, squamous cell of head and neck

Granulysin expressed in a humanized mouse model induces apoptotic cell death and suppresses tumorigenicity

Hsiao, Y. W., Lai, T. C., Lin, Y. H., Su, C. Y., Lee, J. J., Liao, A. T., Lin, Y. F., Hsieh, S. C., Wu, A. T. H. & Hsiao, M., 2017, In : Oncotarget. 8, 48, p. 83495-83508 14 p.

Research output: Contribution to journalArticle

Cell Death
Immune System
Cytotoxic T-Lymphocytes
Natural Killer Cells
Blood Cells
6 Citations (Scopus)
Cholangiocarcinoma
Case-Control Studies
Diabetes Mellitus
Population
Cholecystectomy
23 Citations (Scopus)
Survival
Incidence
Recurrence
Comorbidity
Chemoradiotherapy
43 Citations (Scopus)

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Shih, J. W., Chiang, W. F., Wu, A. T. H., Wu, M. H., Wang, L. Y., Yu, Y. L., Hung, Y. W., Wang, W. C., Chu, C. Y., Hung, C. L., Changou, C. A., Yen, Y. & Kung, H. J., Jun 22 2017, In : Nature Communications. 8, 15874.

Research output: Contribution to journalArticle

Long Noncoding RNA
Mouth Neoplasms
progressions
hypoxia
cancer
17 Citations (Scopus)

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Huang, Y. J., Yang, C. K., Wei, P. L., Huynh, T. T., Whang-Peng, J., Meng, T. C., Hsiao, M., Tzeng, Y. M., Wu, A. T. & Yen, Y., Feb 28 2017, In : Journal of hematology & oncology. 10, 1, p. 60 1 p.

Research output: Contribution to journalArticle

Colon
Carcinogenesis
Colonic Neoplasms
Macrophages
Neoplasms
4 Citations (Scopus)
Neoplastic Stem Cells
trichostatin A
Colonic Neoplasms
Colon
Carcinogenesis
12 Citations (Scopus)
Chemoradiotherapy
Thorax
Confidence Intervals
Therapeutics
Esophageal Squamous Cell Carcinoma
2016
40 Citations (Scopus)

Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448

Bamodu, O. A., Huang, W. C., Lee, W. H., Wu, A., Wang, L. S., Hsiao, M., Yeh, C-T. & Chao, T. Y., Feb 25 2016, In : BMC Cancer. 16, 1, 160.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Down-Regulation
Breast Neoplasms
Long Noncoding RNA
Neoplasm Metastasis
7 Citations (Scopus)

Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells

Wu, S. Y., Yan, M. D., Wu, A. T. H., Yuan, K. S. P. & Liu, S. H., 2016, In : Journal of Cancer. 7, 15, p. 2408-2419 12 p.

Research output: Contribution to journalArticle

Disintegrins
Seaweed
Metalloproteases
MicroRNAs
Phosphoric Monoester Hydrolases
12 Citations (Scopus)

Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes

Su, Y-H., Huang, W. C., Huang, H. T., Huang, Y. J., Sue, Y-K., Huynh, T. T., Hsiao, M., Liu, T. Z., Wu, TH. A. & Lin, C-M., May 31 2016, In : Oncotarget. 7, 22, p. 33246-33256 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Tumor Microenvironment
Folic Acid
Phenotype
Neoplasms
6 Citations (Scopus)
Areca
Radiation Tolerance
Mastication
MicroRNAs
Squamous Cell Carcinoma
14 Citations (Scopus)

Preclinical investigation of ibrutinib, a Bruton's kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes

Wei, L., Su, Y. K., Lin, C. M., Chao, T. Y., Huang, S. P., Huynh, T. T., Jan, H. J., Whang-Peng, J., Chiou, J. F., Wu, A. T. H. & Hsiao, M., 2016, In : Oncotarget. 7, 43, p. 69961-69975 15 p.

Research output: Contribution to journalArticle

Glioma
Carcinogenesis
Stem Cells
Phenotype
Agammaglobulinaemia tyrosine kinase
4 Citations (Scopus)
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Colonic Neoplasms
Chronic Obstructive Pulmonary Disease
Cohort Studies
Population
2015
17 Citations (Scopus)

4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype

Chang, T. C., Yeh, C-T., Adebayo, B. O., Lin, Y-C., Deng, L., Rao, Y. K., Huang, C. C., Lee, W. H., Wu, A. T. H., Hsiao, M., Wu, C. H., Wang, L. S. & Tzeng, Y. M., Oct 15 2015, In : Toxicology and Applied Pharmacology. 288, 2, p. 258-268 11 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Carcinogenesis
oxaliplatin
Phenotype
Tumors
17 Citations (Scopus)

Bruton's tyrosine kinase (Btk) inhibitor ibrutinib suppresses stem-like traits in ovarian cancer

Zucha, M. A., Wu, A. T. H., Lee, W. H., Wang, L. S., Lin, W. W., Yuan, C. C. & Yeh, C-T., 2015, In : Oncotarget. 6, 15, p. 13255-13268 14 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Cisplatin
Neoplastic Stem Cells
Up-Regulation
Databases
53 Citations (Scopus)

Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data

Cheng, H. W., Liang, Y. H., Kuo, Y. L., Chuu, C. P., Lin, C. Y., Lee, M. H., Wu, A. T. H., Yeh, C-T., Chen, E. T., Whang-Peng, J., Su, C. L. & Huang, C. Y. F., May 1 2015, In : Cell Death and Disease. 6, 5, e1753.

Research output: Contribution to journalArticle

Thioridazine
Glioblastoma
Antipsychotic Agents
Stem Cells
Gene Expression
19 Citations (Scopus)

Ovatodiolide sensitizes aggressive breast cancer cells to doxorubicin, eliminates their cancer stem cell-like phenotype, and reduces doxorubicin-associated toxicity

Bamodu, O. A., Huang, W. C., Tzeng, D. T. W., Wu, A., Wang, L. S., Yeh, C-T. & Chao, T. Y., Aug 10 2015, In : Cancer Letters. 364, 2, p. 125-134 10 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Doxorubicin
Breast Neoplasms
Phenotype
Triple Negative Breast Neoplasms
9 Citations (Scopus)

Plasminogen activator inhibitor-2 plays a leading prognostic role among protease families in non-small cell lung cancer

Su, C. Y., Liu, Y. P., Yang, C. J., Lin, Y. F., Chiou, J., Chi, L. H., Lee, J. J., Wu, A. T. H., Lu, P. J., Huang, M. S. & Hsiao, M., Jul 31 2015, In : PLoS One. 10, 7, e0133411.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 2
gelatinase B
lung neoplasms
Matrix Metalloproteinases
Non-Small Cell Lung Carcinoma
30 Citations (Scopus)
Triple Negative Breast Neoplasms
Epithelial-Mesenchymal Transition
MicroRNAs
Breast Neoplasms
Neoplasm Metastasis