• 2872 Citations
  • 29 h-Index
1984 …2020

Research output per year

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Research Output

  • 2872 Citations
  • 29 h-Index
  • 150 Article
  • 5 Letter
  • 5 Review article
  • 1 Chapter
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Article
2020

A single-center study of treatment outcomes of pediatric basal ganglia germinoma in Taiwan

Kang, Y. M., Lin, S. C., Lee, Y. Y., Chang, F. C., Liang, M. L., Chen, H. H., Wong, T. T. & Chen, Y. W., Jan 1 2020, (Accepted/In press) In : Child's Nervous System.

Research output: Contribution to journalArticle

Effect of early radiotherapy initiation and high-dose chemotherapy on the prognosis of pediatric atypical teratoid rhabdoid tumors in different age groups

Yang, W. C., Yen, H. J., Liang, M. L., Chen, H. H., Lee, Y. Y., Chang, F. C., Lin, S. C., Wong, T. T., Hu, Y. W. & Chen, Y. W., Jan 1 2020, (Accepted/In press) In : Journal of Neuro-Oncology.

Research output: Contribution to journalArticle

Molecular-clinical correlation in pediatric medulloblastoma: A cohort series study of 52 cases in Taiwan

Wu, K. S., Ho, D. M. T., Jou, S. T., Yu, A. L., Tran, H. M., Liang, M. L., Chen, H. H., Lee, Y. Y., Chen, Y. W., Lin, S. C., Chang, F. C., Tsai, M. L., Liu, Y. L., Lee, H. L., Hsieh, K. L. C., Huang, W. C., Sung, S. Y., Chang, C. C., Changou, C. A., Liang, K. H. & 7 others, Hsieh, T. H., Liu, Y. R., Chao, M. E., Chen, W., Chu, S. S., Cho, E. C. & Wong, T. T., Mar 2020, In : Cancers. 12, 3, 653.

Research output: Contribution to journalArticle

Open Access

Upregulation of protein synthesis and proteasome degradation confers sensitivity to proteasome inhibitor bortezomib in myc-atypical teratoid/rhabdoid tumors

Tran, H. M., Wu, K. S., Sung, S. Y., Changou, C. A., Hsieh, T. H., Liu, Y. R., Liu, Y. L., Tsai, M. L., Lee, H. L., Hsieh, K. L. C., Huang, W. C., Liang, M. L., Chen, H. H., Lee, Y. Y., Lin, S. C., Ho, D. M. T., Chang, F. C., Chao, M. E., Chen, W., Chu, S. S. & 4 others, Yu, A. L., Yen, Y., Chang, C. C. & Wong, T. T., Mar 22 2020, In : Cancers. 12, 3, 752.

Research output: Contribution to journalArticle

Open Access
2019

Role of early and aggressive post-operative radiation therapy in improving outcome for pediatric central nervous system atypical teratoid/rhabdoid tumor

Yang, W. C., Yen, H. J., Liang, M. L., Chen, H. H., Lee, Y. Y., Wong, T-T., Hu, Y. W. & Chen, Y. W., Jun 1 2019, In : Child's Nervous System. 35, 6, p. 1013-1020 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

Global DNA methylation analysis reveals miR-214-3p contributes to cisplatin resistance in pediatric intracranial nongerminomatous malignant germ cell tumors

Hsieh, T. H., Liu, Y. R., Chang, T. Y., Liang, M. L., Chen, H. H., Wang, H. W., Yen, Y. & Wong, T-T., Mar 27 2018, In : Neuro-Oncology. 20, 4, p. 519-530 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Irradiation-Induced Secondary Tumors following Pediatric Central Nervous System Tumors: Experiences of a Single Institute in Taiwan (1975-2013)

Lee, C. Y., Chen, Y. W., Lee, Y. Y., Chang, F. C., Chen, H. H., Lin, S. C., Ho, D. M. T., Huang, M. C., Yen, S. H., Wong, T-T. & Liang, M. L., Aug 1 2018, In : International Journal of Radiation Oncology Biology Physics. 101, 5, p. 1243-1252 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Seizure characteristics are related to tumor pathology in children with brain tumors

Tsai, M. L., Chen, C. L., Hsieh, K. L. C., Miser, J. S., Chang, H., Liu, Y. L. & Wong, T-T., Nov 1 2018, In : Epilepsy Research. 147, p. 15-21 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Significance of cyclin D1 overexpression in progression and radio-resistance of pediatric ependymomas

Liang, M. L., Hsieh, T. H., Liu, Y. R., Chen, Y. W., Lee, Y. Y., Chang, F. C., Lin, S. C., Huang, M. C., Ho, D. M. T., Wong, T-T., Yen, Y. & Yang, M. H., Jan 1 2018, In : Oncotarget. 9, 2, p. 2527-2542 16 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Extrarenal rhabdoid tumor presented with an immobile arm in a one-year-old boy

Chung, C. T., Liu, Y. L., Cheng, C. J., Hsieh, K. L. C., Tsai, M. L. & Wong, T. T., 2017, (Accepted/In press) In : Brain and Development.

Research output: Contribution to journalArticle

Large cell/anaplastic medulloblastoma is associated with poor prognosis—a retrospective analysis at a single institute

Huang, P. I., Lin, S. C., Lee, Y. Y., Ho, D. M. T., Guo, W. Y., Chang, K. P., Chang, F. C., Liang, M. L., Chen, H. H., Liu, Y. M., Yen, S. H., Wong, T-T. & Chen, Y. W., Aug 1 2017, In : Child's Nervous System. 33, 8, p. 1285-1294 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

MRI features of pediatric intracranial germ cell tumor subtypes

Wu, C. C., Guo, W. Y., Chang, F. C., Luo, C. B., Lee, H. J., Chen, Y. W., Lee, Y. Y. & Wong, T-T., Aug 1 2017, In : Journal of Neuro-Oncology. 134, 1, p. 221-230 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Transcranial pulsed ultrasound facilitates brain uptake of laronidase in enzyme replacement therapy for Mucopolysaccharidosis type i disease

Hsu, Y. H., Liu, R. S., Lin, W. L., Yuh, Y. S., Lin, S. P. & Wong, T-T., Jun 8 2017, In : Orphanet Journal of Rare Diseases. 12, 1, 109.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

Epileptic seizure in primary intracranial sarcoma: a case report and literature review

Chen, Y. P., Lee, H. F. & Wong, T-T., Sep 1 2016, In : Child's Nervous System. 32, 9, p. 1709-1714 6 p.

Research output: Contribution to journalArticle

Incidence and long-term outcome of postradiotherapy moyamoya syndrome in pediatric patients with primary brain tumors: a single institute experience in Taiwan

Wu, Y. H., Chang, F. C., Liang, M. L., Chen, H. H., Wong, T-T., Yen, S. H. & Chen, Y. W., Aug 1 2016, In : Cancer Medicine. 5, 8, p. 2155-2160 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Radiotherapy-related intracranial aneurysm: case presentation of a 17-year male and a meta-analysis based on individual patient data

Wu, Y. H., Lin, S. S., Chen, H. H., Chang, F. C., Liang, M. L., Wong, T-T., Yen, S. H. & Chen, Y. W., Sep 1 2016, In : Child's Nervous System. 32, 9, p. 1641-1652 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

Can mixed pure hepatocellular carcinoma and germinoma arise together in the brain?

Chen, L. J., Lai, I. C., Wong, T-T., Lin, S. C., Ho, D. M. T., Chang, K. P., Guo, W. Y., Yen, S. H., Chen, M. T. & Chen, Y. W., Sep 1 2015, In : Journal of the Chinese Medical Association. 78, 9, p. 562-566 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Integrated genomics has identified a new AT/RT-like yet INI1-positive brain tumor subtype among primary pediatric embryonal tumors

Ho, D. M. T., Shih, C. C., Liang, M. L., Tsai, C. Y., Hsieh, T. H., Tsai, C. H., Lin, S. C., Chang, T. Y., Chao, M. E., Wang, H. W. & Wong, T-T., Jun 25 2015, In : BMC Medical Genomics. 8, 1, 32.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Treatment results and prognostic factors for intracranial nongerminomatous germ cell tumors: single institute experience

Lai, I. C., Wong, T-T., Shiau, C. Y., Hu, Y. W., Ho, D. M. T., Chang, K. P., Guo, W. Y., Chang, F. C., Liang, M. L., Lee, Y. Y., Chen, H. H., Yen, S. H. & Chen, Y. W., May 1 2015, In : Child's Nervous System. 31, 5, p. 683-691 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2014

Clinical manifestation and neurosurgical intervention of encephalocraniocutaneous lipomatosis - A case report and review of the literature

Chiang, C. C., Lin, S. C., Wu, H. M., Wang, J. C., Yang, T. F., Chen, H. H., Ho, D. M. & Wong, T-T., Jan 1 2014, In : Child's Nervous System. 30, 1, p. 13-17 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Cognitive and epilepsy outcomes after epilepsy surgery caused by focal cortical dysplasia in children: early intervention maybe better

Chen, H. H., Chen, C., Hung, S. C., Liang, S. Y., Lin, S. C., Hsu, T. R., Yeh, T. C., Yu, H. Y., Lin, C. F., Hsu, S. P. C., Liang, M. L., Yang, T. F., Chu, L. S., Lin, Y. Y., Chang, K. P., Kwan, S. Y., Ho, D. M., Wong, T-T. & Shih, Y. H., Jan 1 2014, In : Child's Nervous System. 30, 11, p. 1885-1895 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Comparison of resilience in adolescent survivors of brain tumors and healthy adolescents

Chen, C. M., Chen, Y. C. & Wong, T-T., Jan 1 2014, In : Cancer Nursing. 37, 5, p. 373-381 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Downregulation of SUN2, a novel tumor suppressor, mediates miR-221/222-induced malignancy in central nervous system embryonal tumors

Hsieh, T. H., Chien, C. L., Lee, Y. H., Lin, C. I., Hsieh, J. Y., Chao, M. E., Liu, D. J., Chu, S. S., Chen, W., Lin, S. C., Ho, D. M. T., Liu, R. S., Lin, C. H., Wong, T-T. & Wang, H. W., Jan 1 2014, In : Carcinogenesis. 35, 10, p. 2164-2174 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

DriverDB: An exome sequencing database for cancer driver gene identification

Cheng, W. C., Chung, I. F., Chen, C. Y., Sun, H. J., Fen, J. J., Tang, W. C., Chang, T. Y., Wong, T-T. & Wang, H. W., Jan 1 2014, In : Nucleic Acids Research. 42, D1

Research output: Contribution to journalArticle

45 Citations (Scopus)

New grading of moyamoya disease using color-coded parametric quantitative digital subtraction angiography

Hung, S. C., Liang, M. L., Lin, C. F., Lin, C. J., Guo, W. Y., Chang, F. C., Wong, T-T. & Chang, C. Y., Jan 1 2014, In : Journal of the Chinese Medical Association. 77, 8, p. 437-442 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2013

Clinical analysis of catastrophic epilepsy in infancy and early childhood: Results of the Far-East Asia Catastrophic Epilepsy (FACE) study group

Oguni, H., Otsuki, T., Kobayashi, K., Inoue, Y., Watanabe, E., Sugai, K., Takahashi, A., Hirose, S., Kameyama, S., Yamamoto, H., Hamano, S., Baba, K., Baba, H., Hong, S. C., Kim, H. D., Kang, H. C., Luan, G. & Wong, T-T., Sep 1 2013, In : Brain and Development. 35, 8, p. 786-792 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Efficacy of therapeutic play for pediatric brain tumor patients during external beam radiotherapy

Tsai, Y. L., Tsai, S. C., Yen, S. H., Huang, K. L., Mu, P. F., Liou, H. C., Wong, T-T., Lai, I. C., Liu, P., Lou, H. L., Chiang, I. T. & Chen, Y. W., Jul 1 2013, In : Child's Nervous System. 29, 7, p. 1123-1129 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Health-related quality of life in children and adolescents with spinal dysraphism: Results from a Taiwanese sample

Wang, J. C., Lai, C. J., Wong, T-T., Liang, M. L., Chen, H. H., Chan, R. C. & Yang, T. F., Sep 1 2013, In : Child's Nervous System. 29, 9, p. 1671-1679 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Neuropsychological functions and quality of life in survived patients with intracranial germ cell tumors after treatment

Liang, S. Y., Yang, T. F., Chen, Y. W., Liang, M. L., Chen, H. H., Chang, K. P., Shan, I. K., Chen, Y. S. & Wong, T-T., Dec 1 2013, In : Neuro-Oncology. 15, 11, p. 1543-1551 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Preoperative embolization of hypervascular pediatric brain tumors: Evaluation of technical safety and outcome

Wang, H. H., Luo, C. B., Guo, W. Y., Wu, H. M., Lirng, J. F., Wong, T-T., Lu, Y. H. & Chang, F. C., Nov 1 2013, In : Child's Nervous System. 29, 11, p. 2043-2049 7 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Rhabdoid glioblastoma: A recently recognized subtype of glioblastoma

Chen, S. C., Lin, D. S. C., Lee, C. C., Hung, S. C., Chen, Y. W., Hsu, S. P. C., Lin, C. F., Wong, T-T., Chen, M. H. & Chen, H. H., Aug 1 2013, In : Acta Neurochirurgica. 155, 8, p. 1443-1448 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Spinal subdural hematoma following posterior fossa surgery

Liao, C. H., Chang, F. C., Hsu, S. P. C., Hung, Y. C., Chen, H. H., Liang, M. L., Wong, T-T. & Shih, Y. H., Jan 1 2013, In : Formosan Journal of Surgery. 46, 2, p. 52-55 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Systematic Review and Meta-Analysis of Nonpharmacological Interventions for Fatigue in Children and Adolescents With Cancer

Chang, C. W., Mu, P. F., Jou, S. T., Wong, T-T. & Chen, Y. C., Nov 1 2013, In : Worldviews on Evidence-Based Nursing. 10, 4, p. 208-217 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Unusual giant intraspinal teratoma in an infant

Lu, Y. H., Wang, H. H., Lirng, J. F., Guo, W. Y., Wong, T-T., Teng, M. M. H., Chang, F. C. & Chang, C. Y., Jul 1 2013, In : Journal of the Chinese Medical Association. 76, 7, p. 411-414 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

YM500: A small RNA sequencing (smRNA-seq) database for microRNA research

Cheng, W. C., Chung, I. F., Huang, T. S., Chang, S. T., Sun, H. J., Tsai, C. F., Liang, M. L., Wong, T-T. & Wang, H. W., Jan 1 2013, In : Nucleic Acids Research. 41, D1

Research output: Contribution to journalArticle

42 Citations (Scopus)
2012

Bilateral sciatic neuropathy as a complication of craniotomy performed in the sitting position: Localization of nerve injury by using magnetic resonance imaging

Wang, J. C., Wong, T-T., Chen, H. H., Chang, P. Y. & Yang, T. F., Jan 1 2012, In : Child's Nervous System. 28, 1, p. 159-163 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Body image of children and adolescents with cancer: A metasynthesis on qualitative research findings

Lee, M. Y., Mu, P. F., Tsay, S. F., Chou, S. S., Chen, Y. C. & Wong, T-T., Sep 1 2012, In : Nursing and Health Sciences. 14, 3, p. 381-390 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Boron neutron capture therapy for glioblastoma multiforme: Enhanced drug delivery and antitumor effect following blood-brain barrier disruption induced by focused ultrasound

Yang, F. Y., Chen, Y. W., Chou, F. I., Yen, S. H., Lin, Y. L. & Wong, T-T., Oct 1 2012, In : Future Oncology. 8, 10, p. 1361-1369 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Change in treatment strategy for intracranial germinoma: Long-term follow-up experience at a single institute

Chen, Y. W., Huang, P. I., Ho, D. M. T., Hu, Y. W., Chang, K. P., Chiou, S. H., Guo, W. Y., Chang, F. C., Liang, M. L., Lee, Y. Y., Chen, H. H., Hsu, T. R., Lin, S. C., Wong, T-T. & Yen, S. H., May 15 2012, In : Cancer. 118, 10, p. 2752-2762 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Evaluation of the increase in permeability of the blood-brain barrier during tumor progression after pulsed focused ultrasound

Yang, F. Y., Wang, H. E., Lin, G. L., Lin, H. H. & Wong, T-T., Dec 5 2012, In : International Journal of Nanomedicine. 7, p. 723-730 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Focused ultrasound and interleukin-4 receptor-targeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor effect in glioblastoma multiforme

Yang, F. Y., Wong, T-T., Teng, M. C., Liu, R. S., Lu, M., Liang, H. F. & Wei, M. C., Jun 28 2012, In : Journal of Controlled Release. 160, 3, p. 652-658 7 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Gamma Knife radiosurgery as a treatment modality for low-grade pediatric brainstem gliomas: Report of two cases

Liao, C. H., Pan, D. H. C., Yang, H. C., Wu, H. M., Ho, D. M. T., Wong, T-T. & Shih, Y. H., Jan 1 2012, In : Child's Nervous System. 28, 1, p. 175-178 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Intact INI1 gene region with paradoxical loss of protein expression in AT/RT: Implications for a possible novel mechanism associated with absence of INI1 protein immunoreactivity

Tsai, C. Y., Wong, T-T., Lee, Y. H., Chao, M. E., Lin, S. C., Liu, D. J., Liang, M. L., Wang, H. W. & Ming-Tak Ho, D., Jan 1 2012, In : American Journal of Surgical Pathology. 36, 1, p. 128-133 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Langerhans' cell histiocytosis in the pediatric spine: Therapeutic dynamic change of spinal deformity

Hung, Y. C., Chang, F. C., Chen, Y. W., Liang, M. L., Chen, H. H., Hsu, S. P. C., Yang, H. C. & Wong, T-T., Aug 1 2012, In : Child's Nervous System. 28, 8, p. 1243-1250 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Pharmacokinetic Analysis of 111In-Labeled Liposomal Doxorubicin in Murine Glioblastoma after Blood-Brain Barrier Disruption by Focused Ultrasound

Yang, F. Y., Wang, H. E., Liu, R. S., Teng, M. C., Li, J. J., Lu, M., Wei, M. C. & Wong, T-T., Sep 18 2012, In : PLoS One. 7, 9, e45468.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Salvage treatment for recurrent intracranial germinoma after reduced-volume radiotherapy: A single-institution experience and review of the literature

Hu, Y. W., Huang, P. I., Wong, T-T., Ho, D. M. T., Chang, K. P., Guo, W. Y., Chang, F. C., Shiau, C. Y., Liang, M. L., Lee, Y. Y., Chen, H. H., Yen, S. H. & Chen, Y. W., Nov 1 2012, In : International Journal of Radiation Oncology Biology Physics. 84, 3, p. 639-647 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Treating glioblastoma multiforme with selective high-dose liposomal doxorubicin chemotherapy induced by repeated focused ultrasound

Yang, F. Y., Teng, M. C., Lu, M., Liang, H. F., Lee, Y. R., Yen, C. C., Liang, M. L. & Wong, T-T., Dec 5 2012, In : International Journal of Nanomedicine. 7, p. 965-974 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Treatment strategies for initially disseminated intracranial germinomas: Experiences at a single institute

Chen, Y. W., Huang, P. I., Hu, Y. W., Ho, D. M. T., Chang, K. P., Guo, W. Y., Chang, F. C., Lee, Y. Y., Shiau, C. Y., Wong, T-T. & Yen, S. H., Apr 1 2012, In : Child's Nervous System. 28, 4, p. 557-563 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2011

Brain, the last fortress of sarcoma: Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma

Chou, Y. S., Liu, C. Y., Chen, W. M., Chen, T. H., Chen, P. C. H., Wu, H. T. H., Shiau, C. Y., Wu, Y. C., Liu, C. L., Chao, T. C., Tzeng, C. H., Wong, T-T. & Yen, C. C., Dec 1 2011, In : Journal of Surgical Oncology. 104, 7, p. 765-770 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Gamma knife radiosurgery for central neurocytoma: Retrospective analysis of fourteen cases with a median follow-up period of sixty-five months

Chen, M. C., Pan, D. H. C., Chung, W. Y., Liu, K. D., Yen, Y. S., Chen, M. T., Wong, T-T., Shih, Y. H., Wu, H. M., Guo, W. Y., Shiau, C. Y., Wang, L. W. & Lin, C. W., Jun 1 2011, In : Stereotactic and Functional Neurosurgery. 89, 3, p. 185-193 9 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)