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Sy-Jye Leu

Professor

 https://orcid.org/0000-0003-0334-4688
  • 1690 Citations
  • 21 h-Index
1989 …2020

Research output per year

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Research Output

  • 1690 Citations
  • 21 h-Index
  • 80 Article
  • 2 Comment/debate
  • 1 Book
  • 1 Erratum
2020

Er, Cr:YSGG laser performance improves biological response on titanium surfaces

Yao, W. L., Lin, J. C. Y., Salamanca, E., Pan, Y. H., Tsai, P. Y., Leu, S. J., Yang, K. C., Huang, H. M., Huang, H. Y. & Chang, W. J., Feb 1 2020, In : Materials. 13, 3, 756.

Research output: Contribution to journal › Article

Open Access

Expression, purification, and characterization of anti-Zika virus envelope protein: Polyclonal and chicken-derived single chain variable fragment antibodies

Mwale, P. F., Lee, C. H., Lin, L. T., Leu, S. J., Huang, Y. J., Chiang, L. C., Mao, Y. C. & Yang, Y. Y., Jan 13 2020, In : International Journal of Molecular Sciences. 21, 2, 492.

Research output: Contribution to journal › Article

Open Access
2 Citations (Scopus)
2019

Antigenic epitopes on the outer membrane protein A of Escherichia coli identified with single-chain variable fragment (scFv) antibodies

Mwale, P. F., Lee, C-H., Leu, S-J., Lee, Y-C., Wu, H-H., Lin, L-T., Lin, T. E., Huang, Y-J. & Yang, Y-Y., Apr 26 2019, In : Applied Microbiology and Biotechnology.

Research output: Contribution to journal › Article

Cardamonin Induces Cell Cycle Arrest, Apoptosis and Alters Apoptosis Associated Gene Expression in WEHI-3 Mouse Leukemia Cells

Liao, N-C., Shih, Y-L., Chou, J-S., Chen, K-W., Chen, Y-L., Lee, M-H., Peng, S-F., Leu, S-J. & Chung, J-G., Apr 25 2019, In : The American journal of Chinese medicine. p. 1-22 22 p.

Research output: Contribution to journal › Article

6 Citations (Scopus)

Cardamonin induces immune responses and enhances survival rate in WEHI-3 cell–generated mouse leukemia in vivo

Liao, N. C., Shih, Y. L., Ho, M. T., Lu, T. J., Lee, C. H., Peng, S. F., Leu, S. J. & Chung, J. G., Jan 1 2019, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journal › Article

Improvement in the biological properties of titanium surfaces with low-temperature plasma

Pan, Y. H., Yao, W. L., Lin, J. C. Y., Salamanca, E., Tsai, P. Y., Leu, S. J., Yang, K. C., Huang, H. M., Teng, N. C. & Chang, W. J., Sep 1 2019, In : Metals. 9, 9, 943.

Research output: Contribution to journal › Article

Open Access
2018

A comparison study of SiO2/nano metal oxide composite sphere for antibacterial application

Hou, Y. X., Abdullah, H., Kuo, D. H., Leu, S. J., Gultom, N. S. & Su, C. H., Jan 15 2018, In : Composites Part B: Engineering. 133, p. 166-176 11 p.

Research output: Contribution to journal › Article

16 Citations (Scopus)

Characterization of chicken-derived single chain antibody fragments against venom of Naja naja atra

Lee, C. H., Leu, S. J., Lee, Y. C., Liu, C. I., Lin, L. T., Mwale, P. F., Chiang, J. R., Tsai, B. Y., Chen, C. C., Hung, C. S. & Yang, Y. Y., Oct 1 2018, In : Toxins. 10, 10, 383.

Research output: Contribution to journal › Article

3 Citations (Scopus)

Overexpression of Notch ligand Delta-like-1 by dendritic cells enhances their immunoregulatory capacity and exerts antiallergic effects on Th2-mediated allergic asthma in mice

Lee, C. C., Lin, C. L., Leu, S. J. & Lee, Y. L., Feb 2018, In : Clinical Immunology. 187, p. 58-67 10 p.

Research output: Contribution to journal › Article

6 Citations (Scopus)
2017

Correction: Production and characterization of neutralizing antibodies against Bungarus multicinctus snake venom [Applied and Environmental Microbiology, 82, 23, (2016), (6973-6982)] DOI:10.1128/AEM.01876-16

Lee, C. H., Lee, Y. C., Leu, S. J., Lin, L. T., Chiang, J. R., Hsu, W. J. & Yangd, Y. Y., Nov 1 2017, In : Applied and Environmental Microbiology. 83, 22, e01949-17.

Research output: Contribution to journal › Comment/debate

Correction: Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 production (PLoS ONE (2013) 8:5 (e63613) DOI: 10.1371/journal.pone.0063613)

Huang, H. M., Hsiao, G., Fan, C. K., Lin, C. L., Leu, S. J., Chiang, B. L. & Lee, Y. L., Oct 1 2017, In : PLoS One. 12, 10, e0186529.

Research output: Contribution to journal › Erratum

Corrigendum to "Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice"

Yu, S. H., Chen, S. Y. T., Li, W. S., Dubey, N. K., Chen, W. H., Chuu, J. J., Leu, S. J. & Deng, W. P., Jan 1 2017, In : Journal of Diabetes Research. 2017, 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

Effects of Porphyromonas gingivalis on Titanium Surface by Different Clinical Treatment

Batsukh, N., Feng, S. W., Lee, W. F., Leu, S. J., Tsai, P. Y., Ho, K. N., Lin, C. T., Su, C. H. & Chang, W. J., Feb 1 2017, In : Journal of Medical and Biological Engineering. 37, 1, p. 35-44 10 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Metal oxide composite thin films made by magnetron sputtering for bactericidal application

Chuang, K. T., Abdullah, H., Leu, S. J., Cheng, K. B., Kuo, D. H., Chen, H. C., Chien, J. H. & Hu, W. T., Mar 15 2017, In : Journal of Photochemistry and Photobiology A: Chemistry. 337, p. 151-164 14 p.

Research output: Contribution to journal › Article

10 Citations (Scopus)

Single chain antibody fragment against venom from the snake Daboia russelii formosensis

Lee, C. H., Lee, Y. C., Lee, Y. L., Leu, S. J., Lin, L. T., Chen, C. C., Chiang, J. R., Fellow, P., Tsai, B. Y., Hung, C. S. & Yang, Y. Y., Nov 1 2017, In : Toxins. 9, 11, 347.

Research output: Contribution to journal › Article

8 Citations (Scopus)

Valproic Acid and Lithium Meditate Anti-Inflammatory Effects by Differentially Modulating Dendritic Cell Differentiation and Function

Leu, S. J., Yang, Y. Y., Liu, H. C., Cheng, C. Y., Wu, Y. C., Huang, M. C., Lee, Y. L., Chen, C. C., Shen, W. W. & Liu, K. J., May 1 2017, In : Journal of Cellular Physiology. 232, 5, p. 1176-1186 11 p.

Research output: Contribution to journal › Article

14 Citations (Scopus)
2016

Antibodies against venom of the snake Deinagkistrodon acutus

Lee, C. H., Lee, Y. C., Liang, M. H., Leu, S. J., Lin, L. T., Chiang, J. R. & Yang, Y. Y., 2016, In : Applied and Environmental Microbiology. 82, 1, p. 71-80 10 p.

Research output: Contribution to journal › Article

14 Citations (Scopus)

Cordyceps militaris treatment preserves renal function in type 2 diabetic nephropathy mice

Yu, S. H., Dubey, N. K., Li, W. S., Liu, M. C., Chiang, H. S., Leu, S. J., Shieh, Y. H., Tsai, F. C. & Deng, W. P., Nov 1 2016, In : PLoS One. 11, 11, e0166342.

Research output: Contribution to journal › Article

14 Citations (Scopus)

Production and characterization of neutralizing antibodies against Bungarus multicinctus snake venom

Lee, C. H., Lee, Y-C., Leu, S-J., Lin, L-T., Chiang, J. R., Hsu, W. J. & Yang, Y-Y., 2016, In : Applied and Environmental Microbiology. 82, 23, p. 6973-6982 10 p.

Research output: Contribution to journal › Article

12 Citations (Scopus)
2015

Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice

Lee, C. C., Wang, C. C., Huang, H. M., Lin, C. L., Leu, S. J. & Lee, Y. L., 2015, In : Evidence-based Complementary and Alternative Medicine. 2015, 678487.

Research output: Contribution to journal › Article

17 Citations (Scopus)

Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice

Yu, S. H., Chen, S. Y. T., Li, W. S., Dubey, N. K., Chen, W. H., Chuu, J. J., Leu, S. J. & Deng, W. P., 2015, In : Journal of Diabetes Research. 2015, 723190.

Research output: Contribution to journal › Article

12 Citations (Scopus)

Phage display - Mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom

Lee, Y-C., Hsiao, N-W., Tseng, T-S., Chen, W-C., Lin, H-H., Leu, S. J., Yang, E-W. & Tsai, K-C., Jan 1 2015, In : Molecular Pharmacology. 87, 2, p. 218-230 13 p., A8.

Research output: Contribution to journal › Article

12 Citations (Scopus)

Single chain antibody fragment with serine protease inhibitory property capable of neutralizing toxicity of Trimeresurus mucrosquamatus venom

Lee, Y. C., Chen, W. C., Liang, M. H., Lee, C. H., Tsai, K. C., Chiang, J. R., Chiang, L. C., Chen, C. C., Chang, C. Y., Lee, C. H., Leu, S. J. & Yang, Y. Y., May 1 2015, In : Biochemical and Biophysical Research Communications. 460, 2, p. 170-176 7 p.

Research output: Contribution to journal › Article

2 Citations (Scopus)
2013

Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population

Chen, C. C., Chen, C. C., Tu, J. D., Wu, Y. L. & Leu, S. J., Nov 2013, In : Clinical Biochemistry. 46, 16-17, p. 1664-1667 4 p.

Research output: Contribution to journal › Article

9 Citations (Scopus)

Isolation, characterization, and molecular modeling of a rheumatoid factor from a hepatitis C virus infected patient with sjögren's syndrome

Lee, Y. C., Tsai, K. C., Leu, S. J., Wang, T. J., Liu, C. Y. & Yang, Y. Y., 2013, In : Scientific World Journal. 2013, 516516.

Research output: Contribution to journal › Article

4 Citations (Scopus)

Notch Ligand Delta-Like 4-Pretreated Dendritic Cells Alleviate Allergic Airway Responses by Enhancing IL-10 Production

Huang, H. M., Hsiao, G., Fan, C. K., Lin, C. L., Leu, S. J., Chiang, B. L. & Lee, Y. L., May 16 2013, In : PLoS One. 8, 5, e63613.

Research output: Contribution to journal › Article

10 Citations (Scopus)

Virally inactivated human platelet concentrate lysate induces regulatory T cells and immunosuppressive effect in a murine asthma model

Lee, Y. L., Lee, L. W., Su, C. Y., Hsiao, G., Yang, Y. Y., Leu, S. J., Shieh, Y. H. & Burnouf, T., Sep 2013, In : Transfusion. 53, 9, p. 1918-1928 11 p.

Research output: Contribution to journal › Article

15 Citations (Scopus)
2012

Diverse effects of type II collagen on osteogenic and adipogenic differentiation of mesenchymal stem cells

Chiu, L. H., Tsai, T-S., Huang, H. M., Leu, S. J., Yang, C. B. & Tsai, Y-H., Jun 2012, In : Journal of Cellular Physiology. 227, 6, p. 2412-2420 9 p.

Research output: Contribution to journal › Article

18 Citations (Scopus)

Roles of Glycogen Synthase Kinase-3 in Alzheimer's Disease: From Pathology to Treatment Target

Liu, H. C., Leu, S. J. & Chuang, D. M., Jun 2012, In : Journal of Experimental and Clinical Medicine(Taiwan). 4, 3, p. 135-139 5 p.

Research output: Contribution to journal › Article

7 Citations (Scopus)
2011

Carbon tetrachloride-induced hepatotoxicity and its amelioration by Agaricus blazei Murrill extract in a mouse model

Chang, J. B., Wu, M. F., Yang, Y. Y., Leu, S. J., Chen, Y. L., Yu, C. S., Yu, C. C., Chang, S. J., Lu, H. F. & Chung, J. G., Nov 2011, In : In Vivo. 25, 6, p. 971-976 6 p.

Research output: Contribution to journal › Article

7 Citations (Scopus)

Differential Patterns of Serum Brain-Derived Neurotrophic Factor Levels in Alcoholic Patients With and Without Delirium Tremens During Acute Withdrawal

Huang, M. C., Chen, C. H., Liu, H. C., Chen, C. C., Ho, C. C. & Leu, S. J., Jan 2011, In : Alcoholism: Clinical and Experimental Research. 35, 1, p. 126-131 6 p.

Research output: Contribution to journal › Article

39 Citations (Scopus)

Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer

Charoenfuprasert, S., Yang, Y. Y., Lee, Y. C., Chao, K. C., Chu, P. Y., Lai, C. R., Hsu, K. F., Chang, K. C., Chen, Y. C., Chen, L. T., Chang, J. Y., Leu, S. J. & Shih, N. Y., Aug 18 2011, In : Oncogene. 30, 33, p. 3570-3584 15 p.

Research output: Contribution to journal › Article

21 Citations (Scopus)

Modulation of the development of human monocyte-derived dendritic cells by lithium chloride

Liu, K. J., Lee, Y. L., Yang, Y. Y., Shih, N. Y., Ho, C. C., Wu, Y. C., Huang, T. S., Huang, M. C., Liu, H. C., Shen, W. W. & Leu, S. J., Feb 2011, In : Journal of Cellular Physiology. 226, 2, p. 424-433 10 p.

Research output: Contribution to journal › Article

24 Citations (Scopus)

Selective activation of specific PKC isoforms dictating the fate of CD14+ monocytes towards differentiation or apoptosis

Lin, Y. F., Leu, S. J., Huang, H. M. & Tsai, Y. H., Jan 2011, In : Journal of Cellular Physiology. 226, 1, p. 122-131 10 p.

Research output: Contribution to journal › Article

8 Citations (Scopus)

The immuno-regulatory effects of Schisandra chinensis and its constituents on human monocytic leukemia cells

Lin, R. D., Mao, Y. W., Leu, S. J., Huang, C. Y. & Lee, M. H., Jun 2011, In : Molecules. 16, 6, p. 4836-4849 14 p.

Research output: Contribution to journal › Article

14 Citations (Scopus)
2010

Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced T helper type 2 responses in a mouse model of asthma

Liu, K. J., Leu, S. J., Su, C. H., Chiang, B. L., Chen, Y. L. & Lee, Y. L., Mar 2010, In : Immunology. 129, 3, p. 351-362 12 p.

Research output: Contribution to journal › Article

21 Citations (Scopus)

CC-chemokine ligand 18/pulmonary activation-regulated chemokine expression in the CNS with special reference to traumatic brain injuries and neoplastic disorders

Chang, C. Y., Lee, Y. H., Leu, S. J., Wang, C. Y., Wei, C. P., Hung, K. S., Pai, M. H., Tsai, M. D. & Wu, C. H., Feb 17 2010, In : Neuroscience. 165, 4, p. 1233-1243 11 p.

Research output: Contribution to journal › Article

16 Citations (Scopus)

Cytokine gene-modulated dendritic cells protect against allergic airway inflammation by inducing IL-10+ IFN-γ CD4+ T cells

Hsu, C. Y., Leu, S. J., Chiang, B. L., Liu, H. E., Su, H. C. & Lee, Y. L., Aug 2010, In : Gene Therapy. 17, 8, p. 1011-1021 11 p.

Research output: Contribution to journal › Article

14 Citations (Scopus)

Generation and characterization of anti-α-enolase single-chain antibodies in chicken

Leu, S. J., Lee, Y. C., Shih, N. Y., Huang, I. J., Liu, K. J., Lu, H. F., Huang, S. Y. & Yang, Y. Y., Oct 2010, In : Veterinary Immunology and Immunopathology. 137, 3-4, p. 251-260 10 p.

Research output: Contribution to journal › Article

9 Citations (Scopus)

Identification of a new peptide for fibrosarcoma tumor targeting and imaging in vivo

Wu, C. C., Lin, E. H., Lee, Y. C., Tai, C. J., Kuo, T. H., Wang, H. E., Luo, T. Y., Fu, Y. K., Chen, H. J., Sun, M. D., Wu, C. H., Wu, C. W., Leu, S. J. & Deng, W. P., 2010, In : Journal of Biomedicine and Biotechnology. 2010, 167045.

Research output: Contribution to journal › Article

3 Citations (Scopus)

Increased expression of enolase α in human breast cancer confers tamoxifen resistance in human breast cancer cells

Tu, S. H., Chang, C. C., Chen, C. S., Tam, K. W., Wang, Y. J., Lee, C. H., Lin, H. W., Cheng, T. C., Huang, C. S., Chu, J. S., Shih, N. Y., Chen, L. C., Leu, S. J., Ho, Y. S. & Wu, C. H., Jun 2010, In : Breast Cancer Research and Treatment. 121, 3, p. 539-553 15 p.

Research output: Contribution to journal › Article

66 Citations (Scopus)

MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover

Lung, J., Liu, K. J., Chang, J. Y., Leu, S. J. & Shih, N. Y., 2010, In : FEBS Journal. 277, 20, p. 4308-4321 14 p.

Research output: Contribution to journal › Article

18 Citations (Scopus)

Reduced expression of circadian clock genes in male alcoholic patients

Huang, M. C., Ho, C. W., Chen, C. H., Liu, S. C., Chen, C. C. & Leu, S. J., Nov 2010, In : Alcoholism: Clinical and Experimental Research. 34, 11, p. 1899-1904 6 p.

Research output: Contribution to journal › Article

47 Citations (Scopus)

Synergistic therapeutic effects of combined adenovirus-mediated interleukin-10 and interleukin-12 gene therapy on airway inflammation in asthmatic mice

Hsu, C. Y., Eugene Liu, H., Sheu, F. Y., Leu, S. J., Chiang, B. L., Hsiao, G. & Lee, Y. L., Jan 2010, In : Journal of Gene Medicine. 12, 1, p. 11-21 11 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)
2009

OmpA is the critical component for escherichia coli invasion-induced astrocyte activation

Wu, H. H., Yang, Y. Y., Hsieh, W. S., Lee, C. H., Leu, S. J. C. & Chen, M. R., Jun 2009, In : Journal of Neuropathology and Experimental Neurology. 68, 6, p. 677-690 14 p.

Research output: Contribution to journal › Article

15 Citations (Scopus)

Reduction of monocyte chemoattractant protein-1 and interleukin-8 levels by ticlopidine in TNF-α stimulated human umbilical vein endothelial cells

Hu, C. J., Lee, Y. L., Shih, N. Y., Yang, Y. Y., Charoenfuprasert, S., Dai, Y. S., Chang, S. M., Tsai, Y-H., Tseng, H., Liu, C. Y. & Leu, S. J., 2009, In : Journal of Biomedicine and Biotechnology. 2009, 917837.

Research output: Contribution to journal › Article

8 Citations (Scopus)

Taiwanese native plants inhibit matrix metalloproteinase-9 activity after ultraviolet B irradiation

Lee, Y. L., Lee, M. H., Chang, H. J., Huang, P. Y., Huang, I. J., Cheng, K. T. & Leu, S. J., Mar 2009, In : Molecules. 14, 3, p. 1062-1071 10 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)
2008

Alterations of serum brain-derived neurotrophic factor levels in early alcohol withdrawal

Huang, M. C., Chen, C. H., Chen, C. H., Liu, S. C., Ho, C. J., Shen, W. W. & Leu, S. J., May 2008, In : Alcohol and Alcoholism. 43, 3, p. 241-245 5 p.

Research output: Contribution to journal › Article

48 Citations (Scopus)

Defective functions of circulating CD4+CD25+ and CD4+CD25- T cells in patients with chronic ordinary urticaria

Chen, W. C., Chiang, B. L., Liu, H. E., Leu, S. J. & Lee, Y. L., Aug 2008, In : Journal of Dermatological Science. 51, 2, p. 121-130 10 p.

Research output: Contribution to journal › Article

19 Citations (Scopus)

Inflammatory mediators of cerebrospinal fluid from patients with spinal cord injury

Tsai, M. C., Wei, C. P., Lee, D. Y., Tseng, Y. T., Tsai, M. D., Shih, Y. L., Lee, Y-H., Chang, S. F. & Leu, S. J., Dec 2008, In : Surgical Neurology. 70, SUPPL. 1

Research output: Contribution to journal › Article

28 Citations (Scopus)