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Sung-Bau Lee

Assistant Professor

 https://orcid.org/0000-0002-8628-8687
  • 483 Citations
  • 7 h-Index
20092021

Research output per year

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Personal profile

Education

  • 2009 PhD, Graduate Institute of Life Sciences, National Defence Medical Center
  • 2002 Master, Department of Life Science, National Tsing-Hua University

Experience

  • 2020- Assistant Professor, Ph.D. Program in Drug Discovery and Development Industry, Taipei Medical University
  • 2020- Jointly Appointed Assistant Professor, Master Program in Clinical Pharmacogenomics & Pharmacoproteomics, Taipei Medical University
  • 2016-2020 Assistant Professor, Master Program in Clinical Pharmacogenomics & Pharmacoproteomics, Taipei Medical University.
  • 2017-2020 Jointly Appointed Assistant Professor, Ph.D Program in Biotechnology Research and Development, Taipei Medical University.
  • 2011-2016 Postdoctoral Fellow, BRIC, University of Copenhagen.
  • 2009-2011 Postdoctoral Fellow, Genomics Research Center, Academia Sinica.

Research Interests

  • Drug discovery, Genomic instability, Chromatin replication

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Projects

Discovery of Agents Disturbing Genome Stability during Chromatin Replication

Lee, S.

8/1/19 → 7/31/20

Project: A - Government Institution › b - Ministry of Science and Technology

Targeting replication stress in cancer therapy (I)

Lee, S.

7/1/19 → 6/30/20

Project: B - Project of TMU › i - Other (Funded by TMU)

Targeting replication stress in cancer therapy(II)

Lee, S.

7/1/20 → 6/30/21

Project: B - Project of TMU › i - Other (Funded by TMU)

Tlk Function and Regulation in Chromatin Replication (2nd Years)

Lee, S.

8/1/18 → 7/1/19

Project: A - Government Institution › b - Ministry of Science and Technology

Tlk Function and Regulation in Chromatin Replication

Lee, S.

8/1/17 → 7/31/18

Project: A - Government Institution › b - Ministry of Science and Technology

Research Output

  • 483 Citations
  • 7 h-Index
  • 10 Article
  • 1 Short survey

Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors

Nepali, K., Chang, T. Y., Lai, M. J., Hsu, K. C., Yen, Y., Lin, T. E., Lee, S. B. & Liou, J. P., Jun 15 2020, In : European Journal of Medicinal Chemistry. 196, 112291.

Research output: Contribution to journal › Article

    • Endocytosis-dependent lysosomal degradation of Src induced by protease-activated receptor 1

    Tsai, C. C., Kuo, F. T., Lee, S. B., Chang, Y. T. & Fu, H. W., Mar 1 2019, In : FEBS Letters. 593, 5, p. 504-517 14 p.

    Research output: Contribution to journal › Article

    • Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors

    Lee, S. B., Segura-Bayona, S., Villamor-Payà, M., Saredi, G., Todd, M. A. M., Attolini, C. S. O., Chang, T. Y., Stracker, T. H. & Groth, A., Aug 8 2018, In : Science advances. 4, 8, eaat4985.

    Research output: Contribution to journal › Article

    • 7 Citations (Scopus)

    BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation

    Feng, Y., Vlassis, A., Roques, C., Lalonde, M. E., González-Aguilera, C., Lambert, J. P., Lee, S. B., Zhao, X., Alabert, C., Johansen, J. V., Paquet, E., Yang, X. J., Gingras, A. C., Côté, J. & Groth, A., Jan 1 2016, In : EMBO Journal. 35, 2, p. 176-192 17 p.

    Research output: Contribution to journal › Article

    • 40 Citations (Scopus)

    Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components

    Alabert, C., Bukowski-Wills, J-C., Lee, S-B., Kustatscher, G., Nakamura, K., de Lima Alves, F., Menard, P., Mejlvang, J., Rappsilber, J. & Groth, A., Feb 23 2014, In : Nature Cell Biology. 16, 3, p. 281-93 13 p.

    Research output: Contribution to journal › Article

    • 161 Citations (Scopus)