Projects per year
Personal profile
Education
- 2009 PhD, Graduate Institute of Life Sciences, National Defence Medical Center
- 2002 Master, Department of Life Science, National Tsing-Hua University
Experience
- 2021- Associate Professor, Ph.D. Program in Drug Discovery and Development Industry, Taipei Medical University
- 2020- Assistant Professor, Ph.D. Program in Drug Discovery and Development Industry, Taipei Medical University
- 2020- Jointly Appointed Assistant Professor, Master Program in Clinical Pharmacogenomics & Pharmacoproteomics, Taipei Medical University
- 2017-2020 Jointly Appointed Assistant Professor, Ph.D Program in Biotechnology Research and Development, Taipei Medical University.
- 2016-2020 Assistant Professor, Master Program in Clinical Pharmacogenomics & Pharmacoproteomics, Taipei Medical University.
- 2011-2016 Postdoctoral Fellow, BRIC, University of Copenhagen.
- 2009-2011 Postdoctoral Fellow, Genomics Research Center, Academia Sinica.
Research Interests
- Drug discovery, Genomic instability, Chromatin replication
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Pharmacological Investigation of Hdac8 Inhibitor in Perturbation of Chromatin Replication and Evaluation of Its Cancer Therapeutic Potential in Combination with Checkpoint Kinase Inhibitors
8/1/22 → 7/31/23
Project: A - Government Institution › b - Ministry of Science and Technology
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發展干擾染色質複製時期基因體穩定性之藥劑 (第二至四年)
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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Targeting replication stress in cancer therapy(II)
7/1/20 → 6/30/21
Project: B - Project of TMU › i - Other (Funded by TMU)
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Discovery of Agents Disturbing Genome Stability during Chromatin Replication
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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Targeting replication stress in cancer therapy (I)
7/1/19 → 6/30/20
Project: B - Project of TMU › i - Other (Funded by TMU)
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Accommodation of ring C expanded deoxyvasicinone in the HDAC inhibitory pharmacophore culminates into a tractable anti-lung cancer agent and pH-responsive nanocarrier
Sharma, R., Chatterjee, E., Mathew, J., Sharma, S., Rao, N. V., Pan, C. H., Lee, S. B., Dhingra, A., Grewal, A. S., Liou, J. P., Guru, S. K. & Nepali, K., Oct 5 2022, In: European Journal of Medicinal Chemistry. 240, 114602.Research output: Contribution to journal › Article › peer-review
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Design, synthesis and biological evaluation of bisindole derivatives as anticancer agents against Tousled-like kinases
Lee, S. B., Chang, T. Y., Lee, N. Z., Yu, Z. Y., Liu, C. Y. & Lee, H. Y., Jan 5 2022, In: European Journal of Medicinal Chemistry. 227, 113904.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling
Chang, T. Y., Nepali, K., Chen, Y. Y., Yang, Y. C. S. H., Hsu, K. C., Yen, Y., Pan, S. L., Liou, J. P. & Lee, S. B., Jun 2021, In: Biomedicine and Pharmacotherapy. 138, 111485.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition
Singh, A., Chang, T. Y., Kaur, N., Hsu, K. C., Yen, Y., Lin, T. E., Lai, M. J., Lee, S. B. & Liou, J. P., Apr 5 2021, In: European Journal of Medicinal Chemistry. 215, 113169.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
The Anti-Proliferative Activity of Secondary Metabolite from the Marine Streptomyces sp. against Prostate Cancer Cells
Lin, H. Y., Lin, Y. S., Shih, S. P., Lee, S. B., El-Shazly, M., Chang, K. M., Yang, Y. C. S. H., Lee, Y. L. & Lu, M. C., Dec 2021, In: Life. 11, 12, 1414.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus)