Projects per year
Personal profile
Education
- 2009 PhD, Graduate Institute of Life Sciences, National Defence Medical Center
- 2002 Master, Department of Life Science, National Tsing-Hua University
Experience
- 2020- Assistant Professor, Ph.D. Program in Drug Discovery and Development Industry, Taipei Medical University
- 2020- Jointly Appointed Assistant Professor, Master Program in Clinical Pharmacogenomics & Pharmacoproteomics, Taipei Medical University
- 2017-2020 Jointly Appointed Assistant Professor, Ph.D Program in Biotechnology Research and Development, Taipei Medical University.
- 2016-2020 Assistant Professor, Master Program in Clinical Pharmacogenomics & Pharmacoproteomics, Taipei Medical University.
- 2011-2016 Postdoctoral Fellow, BRIC, University of Copenhagen.
- 2009-2011 Postdoctoral Fellow, Genomics Research Center, Academia Sinica.
Research Interests
- Drug discovery, Genomic instability, Chromatin replication
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Projects
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發展干擾染色質複製時期基因體穩定性之藥劑 (第二至四年)
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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Targeting replication stress in cancer therapy(II)
7/1/20 → 6/30/21
Project: B - Project of TMU › i - Other (Funded by TMU)
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Discovery of Agents Disturbing Genome Stability during Chromatin Replication
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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Targeting replication stress in cancer therapy (I)
7/1/19 → 6/30/20
Project: B - Project of TMU › i - Other (Funded by TMU)
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Tlk Function and Regulation in Chromatin Replication (2nd Years)
8/1/18 → 7/1/19
Project: A - Government Institution › b - Ministry of Science and Technology
Research output
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A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling
Chang, T. Y., Nepali, K., Chen, Y. Y., Yang, Y. C. S. H., Hsu, K. C., Yen, Y., Pan, S. L., Liou, J. P. & Lee, S. B., Jun 2021, In: Biomedicine and Pharmacotherapy. 138, 111485.Research output: Contribution to journal › Article › peer-review
Open Access -
CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition
Singh, A., Chang, T. Y., Kaur, N., Hsu, K. C., Yen, Y., Lin, T. E., Lai, M. J., Lee, S. B. & Liou, J. P., Apr 5 2021, In: European Journal of Medicinal Chemistry. 215, 113169.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors
Nepali, K., Chang, T. Y., Lai, M. J., Hsu, K. C., Yen, Y., Lin, T. E., Lee, S. B. & Liou, J. P., Jun 15 2020, In: European Journal of Medicinal Chemistry. 196, 112291.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Retraction notice to “Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases” [Eur. J. Med. Chem. 190 (2020) 112074] (European Journal of Medicinal Chemistry (2020) 190, (S0223523420300416), (10.1016/j.ejmech.2020.112074))
Lee, J. F., Chang, T. Y., Liu, Z. F., Lee, N. Z., Yeh, Y. H., Chen, Y. S., Chen, T. C., Chou, H. S., Li, T. K., Lee, S. B. & Lin, M. H., Aug 1 2020, In: European Journal of Medicinal Chemistry. 199, 112490.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Endocytosis-dependent lysosomal degradation of Src induced by protease-activated receptor 1
Tsai, C. C., Kuo, F. T., Lee, S. B., Chang, Y. T. & Fu, H. W., Mar 1 2019, In: FEBS Letters. 593, 5, p. 504-517 14 p.Research output: Contribution to journal › Article › peer-review