Sung-Bau Lee

Personal profile

Education

2009 PhD, Graduate Institute of Life Sciences, National Defence Medical Center
2002 Master, Department of Life Science, National Tsing-Hua University

Experience

2020- Assistant Professor, Ph.D. Program in Drug Discovery and Development Industry, Taipei Medical University
2020- Jointly Appointed Assistant Professor, Master Program in Clinical Pharmacogenomics & Pharmacoproteomics, Taipei Medical University
2016-2020 Assistant Professor, Master Program in Clinical Pharmacogenomics & Pharmacoproteomics, Taipei Medical University.
2017-2020 Jointly Appointed Assistant Professor, Ph.D Program in Biotechnology Research and Development, Taipei Medical University.
2011-2016 Postdoctoral Fellow, BRIC, University of Copenhagen.
2009-2011 Postdoctoral Fellow, Genomics Research Center, Academia Sinica.

Research Interests

Drug discovery, Genomic instability, Chromatin replication

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Projects

2 Active
4 Finished

發展干擾染色質複製時期基因體穩定性之藥劑 (第二至四年)

Lee, S.

8/1/20 → 7/1/21

Project: A - Government Institution › b - Ministry of Science and Technology

Targeting replication stress in cancer therapy(II)

Lee, S.

7/1/20 → 6/30/21

Project: B - Project of TMU › i - Other (Funded by TMU)

Discovery of Agents Disturbing Genome Stability during Chromatin Replication

Lee, S.

8/1/19 → 7/31/20

Project: A - Government Institution › b - Ministry of Science and Technology

Targeting replication stress in cancer therapy (I)

Lee, S.

7/1/19 → 6/30/20

Project: B - Project of TMU › i - Other (Funded by TMU)

Tlk Function and Regulation in Chromatin Replication (2nd Years)

Lee, S.

8/1/18 → 7/1/19

Project: A - Government Institution › b - Ministry of Science and Technology

Research Output

515 Citations
7 h-Index
10 Article
1 Comment/debate
1 Short survey

Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors

Nepali, K., Chang, T. Y., Lai, M. J., Hsu, K. C., Yen, Y., Lin, T. E., Lee, S. B. & Liou, J. P., Jun 15 2020, In : European Journal of Medicinal Chemistry. 196, 112291.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Retraction notice to “Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases” [Eur. J. Med. Chem. 190 (2020) 112074] (European Journal of Medicinal Chemistry (2020) 190, (S0223523420300416), (10.1016/j.ejmech.2020.112074))

Lee, J. F., Chang, T. Y., Liu, Z. F., Lee, N. Z., Yeh, Y. H., Chen, Y. S., Chen, T. C., Chou, H. S., Li, T. K., Lee, S. B. & Lin, M. H., Aug 1 2020, In : European Journal of Medicinal Chemistry. 199, 112490.

Research output: Contribution to journal › Comment/debate

Open Access

Endocytosis-dependent lysosomal degradation of Src induced by protease-activated receptor 1

Tsai, C. C., Kuo, F. T., Lee, S. B., Chang, Y. T. & Fu, H. W., Mar 1 2019, In : FEBS Letters. 593, 5, p. 504-517 14 p.

Research output: Contribution to journal › Article

Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors

Lee, S. B., Segura-Bayona, S., Villamor-Payà, M., Saredi, G., Todd, M. A. M., Attolini, C. S. O., Chang, T. Y., Stracker, T. H. & Groth, A., Aug 8 2018, In : Science advances. 4, 8, eaat4985.

Research output: Contribution to journal › Article

11 Citations (Scopus)

BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation

Feng, Y., Vlassis, A., Roques, C., Lalonde, M. E., González-Aguilera, C., Lambert, J. P., Lee, S. B., Zhao, X., Alabert, C., Johansen, J. V., Paquet, E., Yang, X. J., Gingras, A. C., Côté, J. & Groth, A., Jan 1 2016, In : EMBO Journal. 35, 2, p. 176-192 17 p.

Research output: Contribution to journal › Article

44 Citations (Scopus)