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Research Output 1991 2019

  • 2330 Citations
  • 28 h-Index
  • 111 Article
  • 2 Meeting Abstract
  • 1 Letter
  • 1 Review article
2011
34 Citations (Scopus)

Osthole enhances glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cells

Lee, W. H., Lin, R-J., Lin, S. Y., Chen, Y. C., Lin, H. M. & Liang, Y. C., Dec 28 2011, In : Journal of Agricultural and Food Chemistry. 59, 24, p. 12874-12881 8 p.

Research output: Contribution to journalArticle

AMP-activated protein kinase
AMP-Activated Protein Kinases
myocytes
Muscle Cells
Muscle
9 Citations (Scopus)
Nicotinic Receptors
Nicotine
Breast Neoplasms
Neoplasm Metastasis
Cell Movement
2010
16 Citations (Scopus)

Neuroprotective activity of vitis thunbergii var. taiwaniana extracts in vitro and in vivo

Wang, C. K., Chen, L. G., Wen, C. L., Hou, W. C., Hung, L. F., Yen, S. J., Shen, Y. J., Lin, S. Y. & Liang, Y. C., Feb 1 2010, In : Journal of Medicinal Food. 13, 1, p. 170-178 9 p.

Research output: Contribution to journalArticle

Vitis
Hydrogen Peroxide
Ethanol
Kainic Acid
Nitric Oxide
2009
15 Citations (Scopus)

15-Deoxy-Δ12,14-prostaglandin J2 inhibits fibrogenic response in human hepatoma cells

Suk, F. M., Chen, C. H., Lin, S. Y., Cheng, C. J., Yen, S. J., Hung, L. F., Liu, D. Z. & Liang, Y. C., May 22 2009, In : Toxicology Letters. 187, 1, p. 22-27 6 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Peroxisome Proliferator-Activated Receptors
Connective Tissue Growth Factor
Hepatocellular Carcinoma
Phosphorylation
14 Citations (Scopus)

Feeding trial of instant food containing lyophilised yam powder in hypertensive subjects

Liu, D. Z., Liang, H. J., Han, C. H., Lin, S. Y., Chen, C. T., Fan, M. & Hou, W. C., Jan 15 2009, In : Journal of the Science of Food and Agriculture. 89, 1, p. 138-143 6 p.

Research output: Contribution to journalArticle

instant foods
Dioscorea
yams
Powders
placebos
75 Citations (Scopus)

In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter

Wu, C. H., Ho, Y. S., Tsai, C. Y., Wang, Y. J., Tseng, H., Wei, P. L., Lee, C. H., Liu, R. S. & Lin, S. Y., May 1 2009, In : International Journal of Cancer. 124, 9, p. 2210-2219 10 p.

Research output: Contribution to journalArticle

Phloretin
Facilitative Glucose Transport Proteins
Liver Neoplasms
Apoptosis
Hep G2 Cells
20 Citations (Scopus)

Sustained release of 5-FU from Poloxamer gels interpenetrated by crosslinking chitosan network

Chung, T. W., Lin, S. Y., Liu, D. Z., Tyan, Y. C. & Yang, J. S., Dec 1 2009, In : International Journal of Pharmaceutics. 382, 1-2, p. 39-44 6 p.

Research output: Contribution to journalArticle

Poloxamer
Chitosan
Fluorouracil
Gels
Glutaral
58 Citations (Scopus)
Nicotinic Receptors
Carcinogens
Colonic Neoplasms
Tobacco
Cell Movement
2008
86 Citations (Scopus)
Phyllanthus urinaria
Phyllanthus
Amine Oxidase (Copper-Containing)
antihypertensive effect
amines
21 Citations (Scopus)

Antioxidant and nitric oxide production inhibitory activities of galacturonyl hydroxamic acid

Liu, Y. H., Lin, S. Y., Lee, C. C. & Hou, W. C., Jul 1 2008, In : Food Chemistry. 109, 1, p. 159-166 8 p.

Research output: Contribution to journalArticle

hydroxamic acids
Hydroxamic Acids
galacturonic acid
nitric oxide
Nitric Oxide
5 Citations (Scopus)

Effects of fungal-derived high molecular weight chitosan on 5-fluorouracil-induced adverse reactions

Uen, Y. H., Wang, Y. J., Hsu, T. M., Chen, M. H., Chan, H. Y., Ho, Y. S. & Lin, S. Y., Sep 2008, In : Journal of Bioactive and Compatible Polymers. 23, 5, p. 458-472 15 p.

Research output: Contribution to journalArticle

Chitosan
Fluorouracil
Molecular Weight
Molecular weight
Bearings (structural)
hydroxamic acids
Hydroxamic Acids
nitric oxide
Nitric Oxide
Antioxidants
19 Citations (Scopus)

Evaluation of multi-target and single-target liposomal drugs for the treatment of gastric cancer

Chen, C. H., Liu, D. Z., Fang, H. W., Liang, H. J., Yang, T. S. & Lin, S. Y., 2008, In : Bioscience, Biotechnology and Biochemistry. 72, 6, p. 1586-1594 9 p.

Research output: Contribution to journalArticle

stomach neoplasms
Liposomes
octreotide
drug therapy
Stomach Neoplasms
39 Citations (Scopus)

Liposome encapsulation reduces cantharidin toxicity

Chang, C. C., Liu, D. Z., Lin, S. Y., Liang, H. J., Hou, W. C., Huang, W. J., Chang, C. H., Ho, F. M. & Liang, Y. C., Sep 2008, In : Food and Chemical Toxicology. 46, 9, p. 3116-3121 6 p.

Research output: Contribution to journalArticle

Cantharidin
cantharidin
encapsulation
Encapsulation
Liposomes
19 Citations (Scopus)
Osmotic Pressure
Drug Delivery Systems
Tablets
Rupture
Membranes
9 Citations (Scopus)

Taiwanofungus camphoratus activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats

Suk, F. M., Lin, S. Y., Chen, C. H., Yen, S. J., Su, C. H., Liu, D. Z., Hou, W. C., Hung, L. F., Lin, P. J. & Liang, Y. C., 2008, In : Bioscience, Biotechnology and Biochemistry. 72, 7, p. 1704-1713 10 p.

Research output: Contribution to journalArticle

Taiwanofungus camphoratus
Peroxisome Proliferator-Activated Receptors
PPAR gamma
Rats
fruiting bodies
2007
46 Citations (Scopus)
Taiwanofungus camphoratus
antihypertensive effect
Inbred SHR Rats
Antihypertensive Agents
Methanol
23 Citations (Scopus)

Chitosan prevents the development of AOM-induced aberrant crypt foci in mice and suppressed the proliferation of AGS cells by inhibiting DNA synthesis

Lin, S. Y., Chan, H. Y., Shen, F. H., Chen, M. H., Wang, Y. J. & Yu, C. K., Apr 15 2007, In : Journal of Cellular Biochemistry. 100, 6, p. 1573-1580 8 p.

Research output: Contribution to journalArticle

Aberrant Crypt Foci
Chitosan
Cell Proliferation
Molecular Weight
Molecular weight
71 Citations (Scopus)

Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action

Liu, D. Z., Liang, H. J., Chen, C. H., Su, C. H., Li, Z-H., Huang, C. T., Hou, W. C., Lin, S. Y., Zhong, W-B., Lin, P. J., Hung, L. F. & Liang, Y. C., Aug 15 2007, In : Journal of Ethnopharmacology. 113, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

Microglia
Fermentation
Methanol
Anti-Inflammatory Agents
Neurodegenerative Diseases
5 Citations (Scopus)
Taiwanofungus camphoratus
Amine Oxidase (Copper-Containing)
Scavenging
amines
biphenyl
38 Citations (Scopus)

Involvement of Ras/Raf-1/ERK actions in the magnolol-induced upregulation of p21 and cell-cycle arrest in colon cancer cells

Hsu, Y. F., Lee, T. S., Lin, S. Y., Hsu, S. P., Juan, S. H., Hsu, Y. N., Zhong, W. B. & Lee, W. S., Apr 2007, In : Molecular Carcinogenesis. 46, 4, p. 275-283 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Cell Cycle Checkpoints
Colonic Neoplasms
Up-Regulation
Extracellular Signal-Regulated MAP Kinases
22 Citations (Scopus)

NF-κB pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL-60 cells

Uen, Y. H., Liu, D. Z., Weng, M. S., Ho, Y. S. & Lin, S. Y., Aug 1 2007, In : Journal of Cellular Biochemistry. 101, 5, p. 1165-1175 11 p.

Research output: Contribution to journalArticle

Griseofulvin
HL-60 Cells
Apoptosis
Tosylphenylalanyl Chloromethyl Ketone
G2 Phase Cell Cycle Checkpoints
27 Citations (Scopus)
Dextromethorphan
Plasma (human)
Metabolites
Dextrorphan
High Pressure Liquid Chromatography
12 Citations (Scopus)

Switch activation of PI-PLC downstream signals in activated macrophages with wortmannin

Liu, D. Z., Liang, H. J., Chen, C. H., Lin, S. Y., Zhong, W-B., Ho, F. M., Hou, W. C., Lo, J. L., Ho, Y. S., Lin, P. J., Hung, L. F. & Liang, Y. C., Jun 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 6, p. 869-879 11 p.

Research output: Contribution to journalArticle

Phosphoinositide Phospholipase C
Phosphatidylinositol 3-Kinase
Macrophages
Plasmids
Phosphatidylinositol 4,5-Diphosphate
2006
18 Citations (Scopus)
bcl-Associated Death Protein
Loratadine
M Phase Cell Cycle Checkpoints
G2 Phase
Phosphorylation
33 Citations (Scopus)
Dioscorea alata
Dioscorea
yams
Blood pressure
Inbred SHR Rats
20 Citations (Scopus)

Influence of iron on the severity of hepatic fibrosis in patients with chronic hepatitis C

Lin, T. J., Liao, L. Y., Lin, S. Y., Lin, C. L. & Chang, T. A., Aug 14 2006, In : World Journal of Gastroenterology. 12, 30, p. 4897-4901 5 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Fibrosis
Iron
Liver
Serum
8 Citations (Scopus)

Involvement of proapoptotic Bcl-2 family members in terbinafine-induced mitochondrial dysfunction and apoptosis in HL60 cells

Yang, K-C., Wu, C-C., Wu, C-H., Chen, J. H., Chu, C. H., Chen, C-H., Chou, Y. H., Wang, Y. J., Lee, W-S., Tseng, H., Lin, S-Y., Lee, C-H. & Ho, Y-S., Feb 2006, In : Food and Chemical Toxicology. 44, 2, p. 214-226 13 p.

Research output: Contribution to journalArticle

terbinafine
HL-60 Cells
apoptosis
Apoptosis
Mitochondria
30 Citations (Scopus)

Pro-oxidant and cytotoxic activities of atractylenolide I in human promyeloleukemic HL-60 cells

Wang, C. C., Lin, S. Y., Cheng, H. C. & Hou, W. C., Aug 2006, In : Food and Chemical Toxicology. 44, 8, p. 1308-1315 8 p.

Research output: Contribution to journalArticle

HL-60 Cells
oxidants
Reactive Oxygen Species
Cytotoxicity
superoxide dismutase
2005
20 Citations (Scopus)

Antioxidant activities of mucilages from different Taiwanese yam cultivars

Lin, S. Y., Liu, H. Y., Lu, Y. L. & Hou, W. C., Jul 2005, In : Botanical Bulletin of Academia Sinica. 46, 3, p. 183-188 6 p.

Research output: Contribution to journalArticle

mucilages
yams
antioxidant activity
cultivars
hydroxyl radicals
74 Citations (Scopus)

Balthazar computed tomography severity index is superior to Ranson criteria and APACHE II scoring system in predicting acute pancreatitis outcome

Leung, T-K., Lee, C-M., Lin, S. Y., Chen, H. C., Wang, H. J., Shen, L. K. & Chen, Y. Y., Oct 14 2005, In : World Journal of Gastroenterology. 11, 38, p. 6049-6052 4 p.

Research output: Contribution to journalArticle

APACHE
Pancreatitis
Tomography
Spiral Computed Tomography
Hospitalization
27 Citations (Scopus)

Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: Roles of cyclic AMP and p38 mitogen-activated protein kinase

Liang, Y. C., Wu, C. H., Chu, J. S., Wang, C. K., Hung, L. F., Wang, Y. J., Ho, Y. S., Chang, J. G. & Lin, S. Y., May 7 2005, In : World Journal of Gastroenterology. 11, 17, p. 2557-2563 7 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Coenzyme A
Ligases
Cyclic AMP
Hepatocellular Carcinoma
24 Citations (Scopus)

Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells

Yang, K-C., Uen, Y. H., Suk, F. M., Liang, Y. C., Wang, Y. J., Ho, Y. S., Li, I. H. & Lin, S. Y., May 28 2005, In : World Journal of Gastroenterology. 11, 20, p. 3040-3045 6 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Carcinogenesis
Apoptosis Inducing Factor
Apoptosis
Caspase 8
30 Citations (Scopus)
Econazole
G1 Phase Cell Cycle Checkpoints
caspase-8
Caspase 8
colorectal neoplasms
68 Citations (Scopus)
Succinic Acid
Surface-Active Agents
Polysorbates
Pharmaceutical Preparations
Proteins
22 Citations (Scopus)

The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1

Chou, Y. H., Ho, F. M., Liu, D. Z., Lin, S. Y., Tsai, L-H., Chen, C. H., Ho, Y. S., Hung, L. F. & Liang, Y. C., Mar 2005, In : International Journal of Biochemistry and Cell Biology. 37, 3, p. 604-615 12 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Shock
Hot Temperature
Gene expression
Gene Expression
88 Citations (Scopus)

Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFκB activation and cyclin D1 up-regulation

Ho, Y. S., Chen, C. H., Wang, Y. J., Pestell, R. G., Albanese, C., Chen, R. J., Chang, M. C., Jeng, J. H., Lin, S. Y., Liang, Y. C., Tseng, H., Lee, W. S., Lin, J. K., Chu, J. S., Chen, L. C., Lee, C. H., Tso, W. L., Lai, Y. C. & Wu, C. H., Jun 1 2005, In : Toxicology and Applied Pharmacology. 205, 2, p. 133-148 16 p.

Research output: Contribution to journalArticle

Tobacco
Cyclin D1
Cell proliferation
Carcinogens
Up-Regulation
2004
14 Citations (Scopus)

Anti-proliferation effect of 5,5-diphenyl-2-thiohydantoin (DPTH) in human vascular endothelial cells

Shih, C. R., Wu, J., Liu, Y., Liang, Y. C., Lin, S. Y., Sheu, M. T. & Lee, W. S., Jan 1 2004, In : Biochemical Pharmacology. 67, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Endothelial cells
Human Umbilical Vein Endothelial Cells
Endothelial Cells
Phosphotransferases
Thymidine
55 Citations (Scopus)

Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers.

Chen, S. T., Lin, S. Y., Yeh, K. T., Kuo, S. J., Chan, W. L., Chu, Y. P. & Chang, J. G., Oct 2004, In : International Journal of Molecular Medicine. 14, 4, p. 577-582 6 p.

Research output: Contribution to journalArticle

Caveolin 1
Epigenomics
Breast Neoplasms
Methylation
Genes
32 Citations (Scopus)

Promoter CpG methylation caveolin-1 in sporadic colorectal cancer

Lin, S. Y., Yeh, K. T., Chen, W. T. L., Chen, H. C., Chen, S. T. & Chang, J. G., May 2004, In : Anticancer Research. 24, 3 A, p. 1645-1650 6 p.

Research output: Contribution to journalArticle

Caveolin 1
Methylation
Colorectal Neoplasms
Genes
Gene Silencing
39 Citations (Scopus)

Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features

Lin, S. Y., Yeh, K. T., Chen, W. T. L., Chen, H. C., Chen, S. T., Chiou, H. Y. & Chang, J. G., Feb 2004, In : Oncology Reports. 11, 2, p. 341-348 8 p.

Research output: Contribution to journalArticle

Tumor Suppressor Genes
Methylation
Colorectal Neoplasms
Glycogen Synthase Kinase 3
Cadherins
27 Citations (Scopus)

Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-Δ 12,14-prostaglandin J2-induced heme oxygenase-1 expression

Liu, J-D., Tsai, S. H., Lin, S. Y., Ho, Y. S., Hung, L. F., Pan, S., Ho, F. M., Lin, C. M. & Liang, Y. C., Mar 26 2004, In : Life Sciences. 74, 19, p. 2451-2463 13 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Reducing Agents
Sulfhydryl Compounds
Antioxidants
Dithiothreitol
2003
14 Citations (Scopus)

Inflammatory Pseudotumor Resulting from Foreign Body in Abdominal Cavity Detected by FDG PET

Hsu, C-H., Lee, C-M. & Lin, S-Y., Oct 2003, In : Clinical Nuclear Medicine. 28, 10, p. 842-844 3 p.

Research output: Contribution to journalArticle

Plasma Cell Granuloma
Abdominal Cavity
Foreign Bodies
Abdomen
Body Image
53 Citations (Scopus)

In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest

Lee, W. S., Chen, R. J., Wang, Y. J., Tseng, H., Jeng, J. H., Lin, S. Y., Liang, Y. C., Chen, C. H., Lin, C. H., Lin, J. K., Ho, P. Y., Chu, J. S., Ho, W. L., Chen, L. C. & Ho, Y. S., Aug 10 2003, In : International Journal of Cancer. 106, 1, p. 125-137 13 p.

Research output: Contribution to journalArticle

terbinafine
Cell Cycle Checkpoints
Cell Line
Neoplasms
In Vitro Techniques
30 Citations (Scopus)
JNK Mitogen-Activated Protein Kinases
Stomach
Epithelial Cells
Phosphotransferases
Apoptosis
44 Citations (Scopus)

Molecular mechanisms of G0/G1 cell-cycle arrest and apoptosis induced by terfenadine in human cancer cells

Liu, J. D., Wang, Y. J., Chen, C. H., Yu, C. F., Chen, L. C., Lin, J. K., Liang, Y. C., Lin, S. Y. & Ho, Y. S., May 1 2003, In : Molecular Carcinogenesis. 37, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

Terfenadine
G1 Phase Cell Cycle Checkpoints
Apoptosis
Neoplasms
Oligodeoxyribonucleotides
2002
21 Citations (Scopus)

Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest

Wu, C. H., Jeng, J. H., Wang, Y. J., Tseng, C. J., Liang, Y. C., Chen, C. H., Lee, H. M., Lin, J. K., Lin, C-H., Lin, S. Y., Li, C. P. & Ho, Y. S., Apr 1 2002, In : Toxicology and Applied Pharmacology. 180, 1, p. 22-35 14 p.

Research output: Contribution to journalArticle

G1 Phase Cell Cycle Checkpoints
Miconazole
Heterografts
Nude Mice
Colon
36 Citations (Scopus)
JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
Tetradecanoylphorbol Acetate
Colonic Neoplasms
Up-Regulation
22 Citations (Scopus)

Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity

Wang, Y. J., Yu, C. F., Chen, L. C., Chen, C. H., Lin, J. K., Liang, Y. C., Lin, C. H., Lin, S. Y., Chen, C. F. & Ho, Y. S., 2002, In : Journal of Cellular Biochemistry. 87, 2, p. 147-159 13 p.

Research output: Contribution to journalArticle

Terfenadine
Cytochrome P-450 CYP3A
Ketoconazole
Hep G2 Cells
Apoptosis

Recent Advances in Cancer Therapy Research

Lin, S-Y., Dec 2002, In : New Taipei Journal of Medicine. 4, 4, p. 205-209 5 p.

Research output: Contribution to journalArticle