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Research Output 1996 2018

  • 600 Citations
  • 16 h-Index
  • 37 Article
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Article
2018
3 Citations (Scopus)
pharmacokinetics
Hepatitis B virus
Pharmacokinetics
rats
Toll-Like Receptor 2

Dose-dependent pharmacokinetics and tentative identification of urine metabolites from an isosteviol derivative with anti-hepatitis B activity in rats

Kachingwe, B. H., Wang, L-H., Uang, Y-S., Huang, T-J. & Lin, S-J., Sep 1 2018, In : Biomedical Chromatography. 32, 9, p. e4266 e4266.

Research output: Contribution to journalArticle

Pharmacokinetics
Metabolites
Hepatitis B
Rats
Urine
4 Citations (Scopus)

Inhibitory effect of Anoectochilus formosanus extract on hyperglycemia-related PD-L1 expression and cancer proliferation

Ho, Y., Chen, Y. F., Wang, L. H., Hsu, K. Y., Chin, Y. T., Yang, Y. C. S. H., Wang, S. H., Chen, Y. R., Shih, Y. J., Liu, L. F., Wang, K., Whang-Peng, J., Tang, H. Y., Lin, H. Y., Liu, H. L. & Lin, S. J., Aug 2 2018, In : Frontiers in Pharmacology. 9, AUG, 807.

Research output: Contribution to journalArticle

Obese Mice
Hyperglycemia
Blood Glucose
Metformin
Hypoglycemic Agents
5 Citations (Scopus)

Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin αvβ3 and IGF-1R

Ho, Y., SH Yang, Y. C., Chin, Y. T., Chou, S. Y., Chen, Y. R., Shih, Y. J., Whang-Peng, J., Changou, C. A., Liu, H. L., Lin, S. J., Tang, H. Y., Lin, H. Y. & Davis, P. J., Oct 1 2018, In : Food and Chemical Toxicology. 120, p. 346-355 10 p.

Research output: Contribution to journalArticle

resveratrol
integrins
Myoma
Cell proliferation
somatomedins
2016
5 Citations (Scopus)

Synthesis of C-4-Substituted Steviol Derivatives and Their Inhibitory Effects against Hepatitis B Virus

Lin, S-J., Su, T. C., Chu, C. N., Chang, Y. C., Yang, L. M., Kuo, Y. C. & Huang, T. J., Dec 23 2016, In : Journal of Natural Products. 79, 12, p. 3057-3064 8 p.

Research output: Contribution to journalArticle

Viruses
Hepatitis B virus
Derivatives
Mitogen-Activated Protein Kinases
DNA Replication
2015
13 Citations (Scopus)

Synthesis and anti-hepatitis B virus activity of C4 amide-substituted isosteviol derivatives

Huang, T. J., Yang, C. L., Kuo, Y. C., Chang, Y. C., Yang, L. M., Chou, B. H. & Lin, S. J., Feb 15 2015, In : Bioorganic and Medicinal Chemistry. 23, 4, p. 720-728 9 p.

Research output: Contribution to journalArticle

Viruses
Hepatitis B virus
Amides
Derivatives
DNA
2014
16 Citations (Scopus)

Synthesis and antiviral effects of isosteviol-derived analogues against the hepatitis B virus

Huang, T. J., Chou, B. H., Lin, C. W., Weng, J. H., Chou, C. H., Yang, L. M. & Lin, S. J., Mar 2014, In : Phytochemistry. 99, p. 107-114 8 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Viruses
Antiviral Agents
synthesis
promoter regions
2013

Biotransformation of dihydroisosteviol and the effects of transformed products on steroidogenic gene expressions

Chang, S. F., Yang, L. M., Huang, T. J., Chen, C. Y., Sheu, S. Y., Liu, P. C. & Lin, S. J., Nov 2013, In : Phytochemistry. 95, p. 268-276 9 p.

Research output: Contribution to journalArticle

Biotransformation
biotransformation
Gene expression
Steroidogenic Factor 1
Gene Expression
2012
6 Citations (Scopus)

Oxygenated compounds from the bioconversion of isostevic acid and their inhibition of TNF-α and COX-2 expressions in LPS-stimulated RAW 264.7 cells

Yang, L. M., Chang, S. F., Lin, W. K., Chou, B. H., Wang, L. H., Liu, P. C. & Lin, S. J., Mar 2012, In : Phytochemistry. 75, p. 90-98 9 p.

Research output: Contribution to journalArticle

Bioconversion
prostaglandin synthase
dexamethasone
biotransformation
metabolites
2011
12 Citations (Scopus)

Transformation of isosteviol lactam by Fungi and the suppressive effects of its transformed products on LPS-induced iNOS expression in macrophages

Chou, B. H., Yang, L. M., Chang, S. F., Hsu, F-L., Wang, L. H., Lin, W. K., Liu, P. C. & Lin, S. J., Jun 24 2011, In : Journal of Natural Products. 74, 6, p. 1379-1385 7 p.

Research output: Contribution to journalArticle

Lactams
Macrophages
Fungi
Aspergillus niger
Absidia
2010
1 Citation (Scopus)

Caffeic acid improves the bioavailability of L-dopa in rabbit plasma

Wang, L. H., Hsu, K. Y., Uang, Y. S., Hsu, F-L., Yang, L. M. & Lin, S. J., Jun 2010, In : Phytotherapy Research. 24, 6, p. 852-858 7 p.

Research output: Contribution to journalArticle

Levodopa
Biological Availability
Rabbits
ferulic acid
Area Under Curve
2009
17 Citations (Scopus)

Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor

Chou, B. H., Yang, L. M., Chang, S. F., Hsu, F. L., Lo, C. H., Lin, W. K., Wang, L. H., Liu, P. C. & Lin, S. J., Apr 2009, In : Phytochemistry. 70, 6, p. 759-764 6 p.

Research output: Contribution to journalArticle

Aspergillus niger
Diterpenes
Macrophages
Aspergillus
Transcription Factor AP-1
19 Citations (Scopus)

Microbial transformation of isosteviol oxime and the inhibitory effects on NF-κB and AP-1 activation in LPS-stimulated macrophages

Chang, S. F., Chou, B. H., Yang, L. M., Hsu, F. L., Lin, W. K., Ho, Y. & Lin, S. J., Sep 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 17, p. 6348-6353 6 p.

Research output: Contribution to journalArticle

Oximes
Macrophages
Transcription Factor AP-1
Chemical activation
Acids
2008
1 Citation (Scopus)

A dose-dependent pharmacokinetic study of levodopa by intramuscular administration in rabbits

Wang, L. H., Hsu, K. Y., Hsu, F-L. & Lin, S. J., Oct 2008, In : Journal of Food and Drug Analysis. 16, 5, p. 21-27 7 p.

Research output: Contribution to journalArticle

L-dopa
Levodopa
intramuscular injection
pharmacokinetics
Pharmacokinetics
19 Citations (Scopus)

Bioavailability effect of methylprednisolone by polymeric micelles

Chen, C. L., Chang, S. F., Lee, D., Yang, L. Y., Lee, Y-H., Hsu, C-Y., Lin, S. J. & Liaw, J., Jan 2008, In : Pharmaceutical Research. 25, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Methylprednisolone
Micelles
Biological Availability
Spinal Cord
Plasmas
31 Citations (Scopus)
response elements
Response Elements
Metabolites
glucocorticoids
androgens
12 Citations (Scopus)

Microbial transformation of isosteviol lactone and evaluation of the transformation products on androgen response element

Chou, B. H., Yang, L. M., Chang, S. F., Hsu, F-L., Lo, C. H., Liaw, J. H., Liu, P. C. & Lin, S. J., Apr 2008, In : Journal of Natural Products. 71, 4, p. 602-607 6 p.

Research output: Contribution to journalArticle

Aspergillus niger
response elements
Response Elements
Metabolites
androgens
24 Citations (Scopus)

Selective COX-2 inhibitors. Part 2: Synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides

Lin, S. J., Tsai, W. J., Chiou, W. F., Yang, T. H. & Yang, L. M., Mar 1 2008, In : Bioorganic and Medicinal Chemistry. 16, 5, p. 2697-2706 10 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2 Inhibitors
Celecoxib
Cyclooxygenase 2
Structure-Activity Relationship
Inhibitory Concentration 50
5 Citations (Scopus)
ferulic acid
caffeic acid
high performance liquid chromatography
rabbits
High Pressure Liquid Chromatography
2007
11 Citations (Scopus)

Biotransformation of gallic acid by Beauveria sulfurescens ATCC 7159

Hsu, F-L., Yang, L. M., Chang, S. F., Wang, L. H., Hsu, C-Y., Liu, P. C. & Lin, S. J., Mar 2007, In : Applied Microbiology and Biotechnology. 74, 3, p. 659-666 8 p.

Research output: Contribution to journalArticle

Beauveria
Gallic Acid
Biotransformation
Metabolites
Pyrans
16 Citations (Scopus)

Microbial metabolism of steviol and steviol-16α,17-epoxide

Yang, L. M., Hsu, F-L., Chang, S. F., Cheng, J. T., Hsu, J. Y., Hsu, C-Y., Liu, P. C. & Lin, S. J., Feb 2007, In : Phytochemistry. 68, 4, p. 562-570 9 p.

Research output: Contribution to journalArticle

steviol
Epoxy Compounds
epoxides
Metabolism
Acids
8 Citations (Scopus)

Novel ent-beyeran-19-oic acids from biotransformations of isosteviol metabolites by Mortierella isabellina

Lin, C. L., Lin, S. J., Huang, W. J., Ku, Y. L., Tsai, T. H. & Hsu, F-L., Dec 2007, In : Planta Medica. 73, 15, p. 1581-1587 7 p.

Research output: Contribution to journalArticle

Mortierella
Biotransformation
Metabolites
biotransformation
metabolites
2006
43 Citations (Scopus)

Selective COX-2 inhibitors. Part 1: Synthesis and biological evaluation of phenylazobenzenesulfonamides

Tsai, W. J., Shiao, Y. J., Lin, S. J., Chiou, W. F., Lin, L. C., Yang, T. H., Teng, C. M., Wu, T. S. & Yang, L. M., Sep 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 17, p. 4440-4443 4 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2 Inhibitors
Celecoxib
Cyclooxygenase 2
Assays
Enzyme Assays
16 Citations (Scopus)

Transformation of steviol-16α,17-epoxide by Streptomyces griseus and Cunninghamella bainieri

Chang, S. F., Yang, L. M., Hsu, F-L., Hsu, J. Y., Liaw, J. H. & Lin, S. J., Oct 2006, In : Journal of Natural Products. 69, 10, p. 1450-1455 6 p.

Research output: Contribution to journalArticle

Cunninghamella
steviol
Streptomyces griseus
Epoxy Compounds
Metabolites
2004
16 Citations (Scopus)

Antioxidant iridoid glucosides from Wendlandia formosana

Raju, B. L., Lin, S. J., Hou, W. C., Lai, Z. Y., Liu, P. C. & Hsu, F-L., Aug 2004, In : Natural Product Research. 18, 4, p. 357-364 8 p.

Research output: Contribution to journalArticle

Wendlandia
Iridoid Glucosides
iridoid glycosides
Esters
Antioxidants
22 Citations (Scopus)

Aβ Aggregation inhibitors. Part 1: Synthesis and biological activity of phenylazo benzenesulfonamides

Lin, S. J., Shiao, Y. J., Chi, C. W. & Yang, L. M., Mar 8 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 5, p. 1173-1176 4 p.

Research output: Contribution to journalArticle

Bioactivity
Amyloid
Agglomeration
Neurons
Rats
14 Citations (Scopus)

Hydroxylation and glucosidation of ent-16β-Hydroxybeyeran-19-oic acid by Bacillus megaterium and Aspergillus niger

Yang, L. M., Hsu, F-L., Cheng, J. T., Chang, C. H., Liu, P. C. & Lin, S. J., Apr 2004, In : Planta Medica. 70, 4, p. 359-363 5 p.

Research output: Contribution to journalArticle

Bacillus megaterium
Hydroxylation
Aspergillus niger
Aspergillus
hydroxylation
2003
57 Citations (Scopus)

Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica

Hou, C. C., Lin, S. J., Cheng, J. T. & Hsu, F-L., May 1 2003, In : Journal of Natural Products. 66, 5, p. 625-629 5 p.

Research output: Contribution to journalArticle

Lactuca indica
hypoglycemic agents
Lignans
luteolin
Quercetin
2002
20 Citations (Scopus)

Antitumor agents. Part 3: Synthesis and cytotoxicity of new trans-stilbene benzenesulfonamide derivatives

Yang, L. M., Lin, S. J., Hsu, F. L. & Yang, T. H., Apr 8 2002, In : Bioorganic and Medicinal Chemistry Letters. 12, 7, p. 1013-1015 3 p.

Research output: Contribution to journalArticle

Stilbenes
National Cancer Institute (U.S.)
Cytotoxicity
Tumor Cell Line
Antineoplastic Agents
56 Citations (Scopus)

Bacopaside III, bacopasaponin G, and bacopasides A, B, and C from Bacopa monniera

Hou, C. C., Lin, S. J., Cheng, J. T. & Hsu, F-L., Dec 1 2002, In : Journal of Natural Products. 65, 12, p. 1759-1763 5 p.

Research output: Contribution to journalArticle

Bacopa
Glycosides
glycosides
alcohols
Alcohols
28 Citations (Scopus)

Microbial transformations of isosteviol

Hsu, F-L., Hou, C. C., Yang, L. M., Cheng, J. T., Chi, T. C., Liu, P. C. & Lin, S. J., 2002, In : Journal of Natural Products. 65, 3, p. 273-277 5 p.

Research output: Contribution to journalArticle

Acids
acids
Metabolites
Cunninghamella
metabolites
2001
8 Citations (Scopus)

Phenolic compounds from Formosan Euphorbia tirucalli

Lin, S. J., Yeh, C. H., Yang, L. M., Liu, P. C. & Hsu, F. L., 2001, In : Journal of the Chinese Chemical Society. 48, 1, p. 105-108 4 p.

Research output: Contribution to journalArticle

Polyphenolic compounds
Nuclear magnetic resonance
Ellagic Acid
Acetone
1999
6 Citations (Scopus)

Abortifacient Effects of a Unique Class of Vasoactive Lipids from Pinus ponderosa Needles

Ford, S. P., Rosazza, J. P. N., Al-Mahmoud, M. S., Lin, S., Farley, D. B. & Short, R. E., Aug 1999, In : Journal of Animal Science. 77, 8, p. 2187-2193 7 p.

Research output: Contribution to journalArticle

Pinus ponderosa
Abortifacient Agents
abortifacients
Needles
Diet
10 Citations (Scopus)

Antitumor agents. 2. Synthesis and cytotoxic evaluation of 10- bromorutaecarpine

Yang, L. M., Lin, S. J., Lin, L. C. & Kuo, Y. H., Jun 1999, In : Chinese Pharmaceutical Journal. 51, 3, p. 219-225 7 p.

Research output: Contribution to journalArticle

Tumor Cell Line
Alkaloids
Antineoplastic Agents
Ovarian Neoplasms
Cells
1998
21 Citations (Scopus)

In vitro biotransformations of isocupressic acid by cow rumen preparations: Formation of agathic and dihydroagathic acids

Lin, S. J., Short, R. E., Ford, S. P., Grings, E. E. & Rosazza, J. P. N., Jan 1998, In : Journal of Natural Products. 61, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

isocupressic acid
Rumen
Biotransformation
Metabolites
biotransformation
19 Citations (Scopus)

Microbial transformations of Isocupressic acid

Lin, S. J. & Rosazza, J. P. N., Jul 1998, In : Journal of Natural Products. 61, 7, p. 922-926 5 p.

Research output: Contribution to journalArticle

isocupressic acid
Acids
acids
Metabolites
Mucor mucedo
1996
36 Citations (Scopus)

Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

Yang, L. M., Lin, S. J., Yang, T. H. & Lee, K. H., Apr 23 1996, In : Bioorganic and Medicinal Chemistry Letters. 6, 8, p. 941-944 4 p.

Research output: Contribution to journalArticle

Lignans
Transesterification
Structure-Activity Relationship
Lipase
Antiviral Agents