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Research Output 1989 2018

  • 1883 Citations
  • 23 h-Index
  • 79 Article
  • 1 Chapter
3 Citations (Scopus)

YC-1 induces lipid droplet formation in RAW 264.7 macrophages

Tsui, L., Chang, S. F., Huang, H. P., Fong, T. H. & Wang, I. J., Jan 15 2016, (Accepted/In press) In : Journal of Biomedical Science.

Research output: Contribution to journalArticle

Macrophages
Lipids
Foam Cells
Foams
Guanylate Cyclase
22 Citations (Scopus)

Type-specific human papillomavirus oncogene messenger RNA levels correlate with the severity of cervical neoplasia

Ho, C. M., Lee, B. H., Chang, S. F., Chien, T. Y., Huang, S. H., Yan, C. C. & Cheng, W. F., Aug 1 2010, In : International Journal of Cancer. 127, 3, p. 622-632 11 p.

Research output: Contribution to journalArticle

Oncogenes
Human papillomavirus 6
Messenger RNA
DNA
Real-Time Polymerase Chain Reaction
16 Citations (Scopus)

Transformation of steviol-16α,17-epoxide by Streptomyces griseus and Cunninghamella bainieri

Chang, S. F., Yang, L. M., Hsu, F-L., Hsu, J. Y., Liaw, J. H. & Lin, S. J., Oct 2006, In : Journal of Natural Products. 69, 10, p. 1450-1455 6 p.

Research output: Contribution to journalArticle

Cunninghamella
steviol
Streptomyces griseus
Epoxy Compounds
Metabolites
13 Citations (Scopus)

Transformation of isosteviol lactam by Fungi and the suppressive effects of its transformed products on LPS-induced iNOS expression in macrophages

Chou, B. H., Yang, L. M., Chang, S. F., Hsu, F-L., Wang, L. H., Lin, W. K., Liu, P. C. & Lin, S. J., Jun 24 2011, In : Journal of Natural Products. 74, 6, p. 1379-1385 7 p.

Research output: Contribution to journalArticle

Lactams
Macrophages
Fungi
Aspergillus niger
Absidia
2 Citations (Scopus)

The suppression effect of DNA sequences within the C4A region on the transcription activity of human CYP21

Chang, S. F. & Cheng, C. L., 1998, In : Endocrine Research. 24, 3-4, p. 625-630 6 p.

Research output: Contribution to journalArticle

Human Activities
Genes
Leydig Cell Tumor
Complement C4
Pseudogenes
1 Citation (Scopus)

The subtypes, distribution and location of human papillomavirus DNA in Genital warts and Genital Bowen's disease - a study using in situ DNA.DNA hybridization

Jee, S. H., Chen, Y., Chang, S. F., Ho, S. W., Wu, Y. C., Wen, W. N. & Lu, Y. C., 1989, In : Chinese Journal of Microbiology and Immunology. 22, 4, p. 267-277 11 p.

Research output: Contribution to journalArticle

Bowen's Disease
Human papillomavirus 6
Condylomata Acuminata
Human papillomavirus 11
Human papillomavirus 18
8 Citations (Scopus)
PC12 Cells
Opioid Receptors
Pheochromocytoma
Nerve Growth Factor
Naloxone
6 Citations (Scopus)

The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-γ1/PKC/ERK Signaling and Microglial Polarization

Mohanraj, M., Sekar, P., Liou, H-H., Chang, S-F. & Lin, W-W., Jun 6 2018, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Kinase
Microglia
Cord Factors
AMP-Activated Protein Kinases
trehalose 6,6'-dibehenate
6 Citations (Scopus)
delta Opioid Receptor
PC12 Cells
Pheochromocytoma
Nerve Growth Factor
Poisons
14 Citations (Scopus)
trichostatin A
Nitric Oxide Synthase Type II
Lipopolysaccharides
Macrophages
Carrier Proteins
49 Citations (Scopus)

The effect of type II collagen on MSC osteogenic differentiation and bone defect repair

Chiu, L. H., Lai, W. F. T., Chang, S. F., Wong, C. C., Fan, C. Y., Fang, C. L. & Tsai, Y-H., Mar 2014, In : Biomaterials. 35, 9, p. 2680-2691 12 p.

Research output: Contribution to journalArticle

Collagen Type II
Collagen
Bone
Repair
Bone and Bones
31 Citations (Scopus)

The common I172N mutation causes conformational change of cytochrome P450c21 revealed by systematic mutation, kinetic, and structural studies

Hsu, L. C., Hsu, N. C., Guzova, J. A., Guzov, V. M., Chang, S. F. & Chung, B. C., Feb 9 1996, In : Journal of Biological Chemistry. 271, 6, p. 3306-3310 5 p.

Research output: Contribution to journalArticle

Steroid 21-Hydroxylase
Mutation
Kinetics
Proteins
Substitution reactions
13 Citations (Scopus)

The -104G nucleotide of the human CYP21 gene is important for CYP21 transcription activity and protein interaction

Chin, K. K. & Chang, S. F., Apr 15 1998, In : Nucleic Acids Research. 26, 8, p. 1959-1964 6 p.

Research output: Contribution to journalArticle

Nucleotides
Pseudogenes
Genes
Proteins
Nuclear Proteins
3 Citations (Scopus)

SB203580 increases G-CSF production via a stem-loop destabilizing element in the 3' untranslated region in macrophages independently of its effect on p38 MAPK activity

Chang, S. F., Li, H. C., Huang, Y. P., Tasi, W. J., Chou, Y. Y. & Lu, S. C., Jan 16 2016, In : Journal of Biomedical Science. 23, 1

Research output: Contribution to journalArticle

Macrophages
3' Untranslated Regions
p38 Mitogen-Activated Protein Kinases
Granulocyte Colony-Stimulating Factor
Messenger RNA
17 Citations (Scopus)
Macrophages
Nitric Oxide Synthase Type II
Granulocyte Colony-Stimulating Factor
Sirolimus
Lipopolysaccharides
37 Citations (Scopus)

PTEN promoter methylation and LOH of 10q22-23 locus in PTEN expression of ovarian clear cell adenocarcinomas

Ho, C. M., Lin, M. C., Huang, S. H., Huang, C. J., Lai, H. C., Chien, T. Y. & Chang, S. F., Feb 2009, In : Gynecologic Oncology. 112, 2, p. 307-313 7 p.

Research output: Contribution to journalArticle

Clear Cell Adenocarcinoma
Loss of Heterozygosity
Phosphoric Monoester Hydrolases
Methylation
Tensins
19 Citations (Scopus)

Promoter Methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma

Ho, C. M., Huang, C. J., Huang, C. Y., Wu, Y. Y., Chang, S. F. & Cheng, W. F., Aug 8 2012, (Accepted/In press) In : Molecular Cancer. p. 53 1 p.

Research output: Contribution to journalArticle

Clear Cell Adenocarcinoma
Methylation
Genes
Multiplex Polymerase Chain Reaction
Paclitaxel
16 Citations (Scopus)

Promoter methylation of sFRP5 in patients with ovarian clear cell adenocarcinomaARTICLE

Ho, C. M., Lai, H. C., Huang, S. H., Chien, T. Y., Lin, M. C. & Chang, S. F., Apr 2010, In : European Journal of Clinical Investigation. 40, 4, p. 310-318 9 p.

Research output: Contribution to journalArticle

Clear Cell Adenocarcinoma
Methylation
Genes
Tumor Suppressor Protein p14ARF
Cells
18 Citations (Scopus)

Polymeric micelle gene delivery of bcl-xL via eye drop reduced corneal apoptosis following epithelial debridement

Tong, Y. C., Chang, S. F., Kao, W. W. Y., Liu, C. Y. & Liaw, J., Oct 2010, In : Journal of Controlled Release. 147, 1, p. 76-83 8 p.

Research output: Contribution to journalArticle

Ophthalmic Solutions
Micelles
Debridement
DNA Fragmentation
Apoptosis
6 Citations (Scopus)

Oxygenated compounds from the bioconversion of isostevic acid and their inhibition of TNF-α and COX-2 expressions in LPS-stimulated RAW 264.7 cells

Yang, L. M., Chang, S. F., Lin, W. K., Chou, B. H., Wang, L. H., Liu, P. C. & Lin, S. J., Mar 2012, In : Phytochemistry. 75, p. 90-98 9 p.

Research output: Contribution to journalArticle

Bioconversion
prostaglandin synthase
dexamethasone
biotransformation
metabolites
8 Citations (Scopus)

Oral gene therapy for hypoparathyroidism: A rat model

Chou, F. F., Huang, S. C., Chang, S. F., Liaw, J. & Hung, P. H., Nov 1 2009, In : Human Gene Therapy. 20, 11, p. 1344-1350 7 p.

Research output: Contribution to journalArticle

Hypoparathyroidism
Parathyroid Hormone
Genetic Therapy
Complementary DNA
Edetic Acid
15 Citations (Scopus)

Oral gene delivery with cyclo -(d -Trp-Tyr) peptide nanotubes

Hsieh, W. H., Chang, S. F., Chen, H. M., Chen, J. H. & Liaw, J., May 7 2012, In : Molecular Pharmaceutics. 9, 5, p. 1231-1249 19 p.

Research output: Contribution to journalArticle

tryptophyltyrosine
Peptide Nanotubes
DNA
Genes
Deoxyribonuclease I
31 Citations (Scopus)

Nonionic polymeric micelles for oral gene delivery in vivo

Chang, S. F., Chang, H. Y., Tong, Y. C., Chen, S. H., Hsaio, F. C., Lu, S. C. & Liaw, J., May 2004, In : Human Gene Therapy. 15, 5, p. 481-493 13 p.

Research output: Contribution to journalArticle

Micelles
DNA
Genes
Lac Operon
Duodenum
36 Citations (Scopus)

Neuronal activity enhances aryl hydrocarbon receptor-mediated gene expression and dioxin neurotoxicity in cortical neurons

Lin, C. H., Juan, S. H., Wang, C. Y., Sun, Y. Y., Chou, C. M., Chang, S. F., Hu, S. Y., Lee, W. S. & Lee, Y-H., Mar 2008, In : Journal of Neurochemistry. 104, 5, p. 1415-1429 15 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Dioxins
Gene expression
Neurons
Gene Expression
8 Citations (Scopus)

Nanopolymeric micelle effect on the transdermal permeability, the bioavailability and gene expression of plasmid

Tong, Y. C., Yu, T. Y., Chang, S. F. & Liaw, J., Jan 1 2012, In : Molecular Pharmaceutics. 9, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

Micelles
Biological Availability
Permeability
Plasmids
Gene Expression
70 Citations (Scopus)

Mutations adjacent to the dimple of the canine parvovirus capsid structure affect sialic acid binding

Barbis, D. P., Chang, S. F. & Parrish, C. R., 1992, In : Virology. 191, 1, p. 301-308 8 p.

Research output: Contribution to journalArticle

Canine Parvovirus
Capsid
N-Acetylneuraminic Acid
Erythrocytes
Virus Attachment
15 Citations (Scopus)
Steroid 21-Hydroxylase
Genes
Mutation
Congenital Adrenal Hyperplasia
Haplotypes
12 Citations (Scopus)
Introns
Exons
RNA Splice Sites
COS Cells
Mutation
156 Citations (Scopus)
Canine Parvovirus
Carnivore protoparvovirus 1
capsid
Capsid
Host Specificity
21 Citations (Scopus)

Microbial transformation of isosteviol oxime and the inhibitory effects on NF-κB and AP-1 activation in LPS-stimulated macrophages

Chang, S. F., Chou, B. H., Yang, L. M., Hsu, F. L., Lin, W. K., Ho, Y. & Lin, S. J., Sep 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 17, p. 6348-6353 6 p.

Research output: Contribution to journalArticle

Oximes
Macrophages
Transcription Factor AP-1
Chemical activation
Acids
13 Citations (Scopus)

Microbial transformation of isosteviol lactone and evaluation of the transformation products on androgen response element

Chou, B. H., Yang, L. M., Chang, S. F., Hsu, F-L., Lo, C. H., Liaw, J. H., Liu, P. C. & Lin, S. J., Apr 2008, In : Journal of Natural Products. 71, 4, p. 602-607 6 p.

Research output: Contribution to journalArticle

Aspergillus niger
response elements
Response Elements
Metabolites
androgens
31 Citations (Scopus)
response elements
Response Elements
Metabolites
glucocorticoids
androgens
16 Citations (Scopus)

Microbial metabolism of steviol and steviol-16α,17-epoxide

Yang, L. M., Hsu, F-L., Chang, S. F., Cheng, J. T., Hsu, J. Y., Hsu, C-Y., Liu, P. C. & Lin, S. J., Feb 2007, In : Phytochemistry. 68, 4, p. 562-570 9 p.

Research output: Contribution to journalArticle

steviol
Epoxy Compounds
epoxides
Metabolism
Acids
22 Citations (Scopus)

Malondialdehyde mediates oxidized LDL-induced coronary toxicity through the Akt-FGF2 pathway via DNA methylation

Yang, T. C., Chen, Y. J., Chang, S. F., Chen, C. H., Chang, P. Y. & Lu, S. C., Feb 3 2014, In : Journal of Biomedical Science. 21, 1, 11.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
DNA Methylation
Malondialdehyde
Toxicity
Endothelial cells
7 Citations (Scopus)

LPS-induced G-CSF expression in macrophages is mediated by ERK2, but not ERK1

Chang, S. F., Lin, S. S., Yang, H. C., Chou, Y. Y., Gao, J. I. & Lu, S. C., Jun 26 2015, In : PLoS One. 10, 6, e0129685.

Research output: Contribution to journalArticle

granulocyte colony-stimulating factor
Macrophages
Granulocyte Colony-Stimulating Factor
lipopolysaccharides
Lipopolysaccharides
35 Citations (Scopus)

Isolation and characterization of stromal progenitor cells from ascites of patients with epithelial ovarian adenocarcinoma

Ho, C. M., Chang, S-F., Hsiao, C. C., Chien, T. Y. & Shih, T-B., 2012, In : Journal of Biomedical Science. 19, 1, 23.

Research output: Contribution to journalArticle

Stromal Cells
Ascites
Adenocarcinoma
Stem Cells
Cells
94 Citations (Scopus)
Ophthalmic Solutions
Micelles
Genes
Gene Expression
DNA
2 Citations (Scopus)

In vitro and in vivo assessment of delivery of hydrophobic molecules and plasmid DNAs with PEO-PPO-PEO polymeric micelles on cornea

Hsiao, F., Huang, P. Y., Aoyagi, T., Chang, S. F. & Liaw, J., Apr 2018, In : Journal of Food and Drug Analysis. 26, 2, p. 869-878

Research output: Contribution to journalArticle

rhodamine B
Energy Transfer
Micelles
cornea
micelles
23 Citations (Scopus)

Integration of human papillomavirus correlates with high levels of viral oncogene transcripts in cervical carcinogenesis

Ho, C. M., Lee, B. H., Chang, S. F., Chien, T. Y., Huang, S. H., Yan, C. C. & Cheng, W. F., Nov 2011, In : Virus Research. 161, 2, p. 124-130 7 p.

Research output: Contribution to journalArticle

Human papillomavirus 16
Oncogenes
Uterine Cervical Neoplasms
Cell Biology
Real-Time Polymerase Chain Reaction
67 Citations (Scopus)

Integrated human papillomavirus types 52 and 58 are infrequently found in cervical cancer, and high viral loads predict risk of cervical cancer

Ho, C. M., Chien, T. Y., Huang, S. H., Lee, B. H. & Chang, S. F., Jul 2006, In : Gynecologic Oncology. 102, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

Viral Load
Uterine Cervical Neoplasms
DNA
Human papillomavirus 18
Cervical Intraepithelial Neoplasia
35 Citations (Scopus)
GAP-43 Protein
Janus Kinases
STAT3 Transcription Factor
Spinal Ganglia
Neurites
25 Citations (Scopus)

Inflammatory mediators of cerebrospinal fluid from patients with spinal cord injury

Tsai, M. C., Wei, C. P., Lee, D. Y., Tseng, Y. T., Tsai, M. D., Shih, Y. L., Lee, Y-H., Chang, S. F. & Leu, S. J., Dec 2008, In : Surgical Neurology. 70, SUPPL. 1

Research output: Contribution to journalArticle

Spinal Cord Injuries
Cerebrospinal Fluid
Therapeutics
Cytokines
Tissue Inhibitor of Metalloproteinase-1
Congenital Adrenal Hyperplasia
Genome
Genes
Mutation
Androgens
8 Citations (Scopus)

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method

Lee, H. H., Chang, S. F., Tseng, Y. T. & Lee, Y. J., Oct 1 2006, In : Analytical Biochemistry. 357, 1, p. 122-127 6 p.

Research output: Contribution to journalArticle

Polymerase chain reaction
Amplification
Epitopes
Genes
Polymerase Chain Reaction
27 Citations (Scopus)

Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix

Ho, C. M., Cheng, W. F., Chu, T. Y., Chen, C. A., Chuang, M. H., Chang, S. F. & Hsieh, C. Y., Nov 20 2006, In : British Journal of Cancer. 95, 10, p. 1384-1389 6 p.

Research output: Contribution to journalArticle

Cervix Uteri
Viral Load
Papillomavirus Infections
Human papillomavirus 16
DNA
70 Citations (Scopus)

Homocysteine inhibits arterial endothelial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation

Chang, P. Y., Lu, S. C., Lee, C. M., Chen, Y. J., Dugan, T. A., Huang, W. H., Chang, S. F., Liao, W. S. L., Chen, C. H. & Lee, Y. T., Apr 2008, In : Circulation Research. 102, 8, p. 933-941 9 p.

Research output: Contribution to journalArticle

Homocysteine
Fibroblast Growth Factor 2
DNA Methylation
GTP-Binding Proteins
Down-Regulation
4 Citations (Scopus)

Gene methylation of human ovarian carcinoma stromal progenitor cells promotes tumorigenesis

Ho, C. M., Shih, T-B., Hsiao, C. C., Huang, S. H., Chang, S-F. & Cheng, W. F., Nov 23 2015, In : Journal of Translational Medicine. 13, 1, 367.

Research output: Contribution to journalArticle

Methylation
Stromal Cells
Tumors
Carcinogenesis
Stem Cells
2 Citations (Scopus)

Gene expression and behavior analysis of PC12 cells grown on synthetic biodegradable fibrous membranes coated with natural biopolymers

Tsai, T. H., Tai, C. C., Wu, Y. H. S., Hung, S. H., Chang, S. F., Yang, C. P. & Tseng, H., 2014, In : Current Nanoscience. 10, 2, p. 235-242 8 p.

Research output: Contribution to journalArticle

Fibrous membranes
Biopolymers
PC12 Cells
Gene expression
Cells
3 Citations (Scopus)

Gene expression and behavior analysis of PC12 cells grown on biodegradable nano-fibrous membranes

Chang, S. F., Yang, C. P., Tai, C. C. & Tseng, H., Dec 2011, In : Current Nanoscience. 7, 6, p. 886-892 7 p.

Research output: Contribution to journalArticle

Fibrous membranes
PC12 Cells
Gene expression
Cells
Membranes
17 Citations (Scopus)

Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor

Chou, B. H., Yang, L. M., Chang, S. F., Hsu, F. L., Lo, C. H., Lin, W. K., Wang, L. H., Liu, P. C. & Lin, S. J., Apr 2009, In : Phytochemistry. 70, 6, p. 759-764 6 p.

Research output: Contribution to journalArticle

Aspergillus niger
Diterpenes
Macrophages
Aspergillus
Transcription Factor AP-1