Projects per year
Personal profile
Education
- 2002, Ph.D. National Taiwan University
- 1994, M.S. Taipei Medical University
Experience
- 2009-2013 Assistant Investigator, National Health Research Institutes
- 2007-2009 Assistant Investigator, National Taiwan University
- 2002-2007 Postdoctor, National Taiwan Universiy
- 1994-1998 Teaching Assistant, Chang-Gung University
Research Interests
- Drug Discovery
- Disease animal model
- Pharmacology
URL
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
- 14 Similar Profiles
Apoptosis
Medicine & Life Sciences
Neoplasms
Medicine & Life Sciences
Cells
Chemical Compounds
Histone Deacetylase Inhibitors
Medicine & Life Sciences
Smooth Muscle Myocytes
Medicine & Life Sciences
Antineoplastic Agents
Medicine & Life Sciences
Heterografts
Medicine & Life Sciences
Indazoles
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2013 2019
新穎性pan-HDAC 抑制劑抑制血管新生之藥物研發與藥理作用機轉(3/3)
8/1/16 → 7/31/17
Project: b - Ministry of Science and Technology
Preclinical evaluation of novel selective HDAC6 inhibitors for human cancers treatment
1/1/16 → 12/31/16
Project: c - Ministry of Health and Welfare
Research Output 1996 2018
- 2686 Citations
- 30 h-Index
- 120 Article
1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC
Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., Apr 25 2018, In : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.Research output: Contribution to journal › Article
Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy
Lin, S. Y., Yeh, T. K., Song, J. S., Hung, M. S., Cheng, M. F., Liao, F. Y., Li, A. S., Cheng, S. Y., Lin, L. M., Chiu, C. H., Wu, M. H., Lin, Y. J., Hsiao, W., Sun, M., Wang, Y. H., Huang, C. H., Tang, Y. C., Chang, H. H., Huang, Z. T., Chao, Y. S. & 5 others, Apr 1 2018, In : Bioorganic Chemistry. 77, p. 600-607 8 p.Research output: Contribution to journal › Article
Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumors
Neoplasms
T-cells
Pharmaceutical Preparations
A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo
Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.Research output: Contribution to journal › Article
Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation
1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma
Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., Nov 10 2017, In : European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.Research output: Contribution to journal › Article
Ubiquitin-Protein Ligases
Multiple Myeloma
Tumors
Lead compounds
Growth
4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo
Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P., Jul 7 2017, In : European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.Research output: Contribution to journal › Article
Heterografts
Tumors
Bearings (structural)
Histone Deacetylase Inhibitors
Acrylamide
Press / Media
WIPO PUBLISHES PATENT OF TAIPEI MEDICAL UNIVERSITY FOR "HEAT SHOCK PROTEIN 90 INHIBITORS" (CHINESE INVENTORS)
9/30/18
1 item of media coverage
Press/Media: Press / Media
Australia Patent: Yun Yen, Taipei Medical University File Application for 'Aminonapthoquinone compounds and pharmaceutical composition for blocking ubiquitination-proteasome system in diseases'
3/10/18
1 item of media coverage
Press/Media: Press / Media
Australia Patent: Taipei Medical University Files Application for 'Compounds and pharmaceutical composition associated with ubiquitination-proteasome system'
2/10/18
1 item of media coverage
Press/Media: Press / Media
WIPO PUBLISHES PATENT OF YUN YEN AND TAIPEI MEDICAL UNIVERSITY FOR "COMPOUNDS AND PHARMACEUTICAL COMPOSITION ASSOCIATED WITH UBIQUITINATION-PROTEASOME SYSTEM" (TAIWANESE, AMERICAN INVENTORS)
2/5/17
1 item of media coverage
Press/Media: Press / Media
WIPO PUBLISHES PATENT OF TAIPEI MEDICAL UNIVERSITY AND YUN YEN FOR "AMINONAPTHOQUINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITION FOR BLOCKING UBIQUITINATION-PROTEASOME SYSTEM IN DISEASES" (TAIWANESE, AMERICAN INVENTORS)
1/29/17
1 item of media coverage
Press/Media: Press / Media