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Research Output

  • 1317 Citations
  • 16 h-Index
  • 26 Article
2019

Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy

Lin, R. K., Choong, C. Y., Hsu, W. H., Tai, C. J. & Tai, C. J., Jun 2019, In : African Health Sciences. 19, 2, p. 2156-2163 8 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Hypermethylation of CCND2 in Lung and Breast Cancer Is a Potential Biomarker and Drug Target

Hung, C. S., Wang, S. C., Yen, Y. T., Lee, T. H., Wen, W. C. & Lin, R. K., Oct 10 2018, In : International Journal of Molecular Sciences. 19, 10

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

Bioactive constituents from the termite nest-derived medicinal fungus Xylaria nigripes

Chang, J. C., Hsiao, G., Lin, R. K., Kuo, Y. H., Ju, Y. M. & Lee, T. H., Jan 27 2017, In : Journal of Natural Products. 80, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Hypermethylation of BEND5 contributes to cell proliferation and is a prognostic marker of colorectal cancer

Lin, R. K., Hung, W. Y., Huang, Y. F., Chang, Y. J., Lin, C. H., Chen, W. Y., Chiu, S. F., Chang, S. C. & Tsai, S. F., Jan 1 2017, In : Oncotarget. 8, 69, p. 113431-113443 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

Alterations in histone deacetylase 8 lead to cell migration and poor prognosis in breast cancer

Hsieh, C. L., Ma, H. P., Su, C-M., Chang, Y. J., Hung, W. Y., Ho, Y. S., Huang, W. J. & Lin, R. K., Apr 15 2016, In : Life Sciences. 151, p. 7-14 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Angiogenesis Inhibitors and Anti-Inflammatory Agents from Phoma sp. NTOU4195

Lee, M. S., Wang, S. W., Wang, G. J., Pang, K. L., Lee, C. K., Kuo, Y. H., Cha, H. J., Lin, R. K. & Lee, T. H., Dec 23 2016, In : Journal of Natural Products. 79, 12, p. 2983-2990 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Synthesis and biological evaluation of lovastatin-derived aliphatic hydroxamates that induce reactive oxygen species

Lin, R. K., Lin, Y. F., Hsu, M. J., Hsieh, C. L., Wang, C. Y., Huang, C. C. & Huang, W. J., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5528-5533 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Terpenoids from the fermented broths of coprinellus radians

Lee, M. S., Hsiao, C. J., Ju, Y. M., Kuo, Y. H., Lin, R. K. & Lee, T. H., 2016, In : Natural Product Communications. 11, 9, p. 1229-1230 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Thrombomodulin influences the survival of patients with non-metastatic colorectal cancer through epithelial-to-mesenchymal transition (EMT)

Chang, Y. J., Cheng, Y. W., Lin, R. K., Huang, C. C., Chen, W. T. L., Ke, T. W. & Wei, P. L., Aug 1 2016, In : PLoS One. 11, 8, e0160550.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2015

FCGR2A promoter methylation and risks for intravenous immunoglobulin treatment responses in kawasaki disease

Kuo, H. C., Hsu, Y. W., Wu, M. S., Woon, P. Y., Wong, H. S. C., Tsai, L. J., Lin, R. K., Klahan, S., Hsieh, K. S. & Chang, W. C., 2015, In : Mediators of Inflammation. 2015, 564625.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2014

Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential

Wang, S. C., Li, Z-H., Hsu, C. H., Chang, Y. J., Chang, M. S., Wang, Y. C., Ho, Y. S., Wen, W. C. & Lin, R. K., Jun 18 2014, In : Journal of Agricultural and Food Chemistry. 62, 24, p. 5625-5635 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer

Yang, Y. C., Tang, Y. A., Shieh, J. M., Lin, R. K., Hsu, H. S. & Wang, Y. C., 2014, In : Journal of Thoracic Oncology. 9, 9, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer

Lin, R. K. & Wang, Y. C., Aug 19 2014, In : Cell and Bioscience. 4, 1, 46.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2012

MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer

Tang, Y. A., Lin, R. K., Tsai, Y. T., Hsu, H. S., Yang, Y. C., Chen, C. Y. & Wang, Y. C., Aug 15 2012, In : Clinical Cancer Research. 18, 16, p. 4325-4333 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

TET1 Suppresses Cancer Invasion by Activating the Tissue Inhibitors of Metalloproteinases

Hsu, C-H., Peng, K-L., Kang, M-L., Chen, Y-R., Yang, Y-C., Tsai, C-H., Chu, C-S., Jeng, Y-M., Chen, Y-T., Lin, F-M., Huang, H-D., Lu, Y-Y., Teng, Y-C., Lin, S-T., Lin, R. K., Tang, F-M., Lee, S-B., Hsu, H-M., Yu, J-C., Hsiao, P-W. & 1 others, Juan, L-J., Sep 27 2012, In : Cell Reports. 2, 3, p. 568-579 12 p.

Research output: Contribution to journalArticle

175 Citations (Scopus)
2010

Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer

Lin, R. K., Wu, C. Y., Chang, J. W., Juan, L. J., Hsu, H. S., Chen, C. Y., Lu, Y. Y., Tang, Y. A., Yang, Y. C., Yang, P. C. & Wang, Y. C., Jul 15 2010, In : Cancer Research. 70, 14, p. 5807-5817 11 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)

hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

Lee, C-F., Ou, D. S. C., Lee, S-B., Chang, L-H., Lin, R. K., Li, Y-S., Upadhyay, A. K., Cheng, X., Wang, Y-C., Hsu, H-S., Hsiao, M., Wu, C-W. & Juan, L-J., Aug 2 2010, In : Journal of Clinical Investigation. 120, 8, p. 2920-2930 11 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients

Lin, R. K., Hsieh, Y. S., Lin, P., Hsu, H. S., Chen, C. Y., Tang, Y. A., Lee, C. F. & Wang, Y. C., Feb 1 2010, In : Journal of Clinical Investigation. 120, 2, p. 521-532 12 p.

Research output: Contribution to journalArticle

145 Citations (Scopus)
2008

A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells

Chen, C. T., Munot, Y. S., Salunke, S. B., Wang, Y. C., Lin, R. K., Lin, C. C., Chen, C. C. & Liu, Y. H., Feb 22 2008, In : Advanced Functional Materials. 18, 4, p. 527-540 14 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type β-catenin nuclear accumulation in lung tumorigenesis

Tseng, R. C., Lin, R. K., Wen, C. K., Tseng, C., Hsu, H. S., Hsu, W. H. & Wang, Y. C., Jul 24 2008, In : Oncogene. 27, 32, p. 4488-4496 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2007

Alteration of DNA methyltransferases contributes to 5′CpG methylation and poor prognosis in lung cancer

Lin, R. K., Hsu, H. S., Chang, J. W., Chen, C. Y., Chen, J. T. & Wang, Y. C., Feb 2007, In : Lung Cancer. 55, 2, p. 205-213 9 p.

Research output: Contribution to journalArticle

171 Citations (Scopus)

Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma

Hsu, H. S., Chen, T. P., Hung, C. H., Wen, C. K., Lin, R. K., Lee, H. C. & Wang, Y. C., Nov 1 2007, In : Cancer. 110, 9, p. 2019-2026 8 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)

Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells

Lin, R. K., Hsu, C. H. & Wang, Y. C., Nov 2007, In : Anti-Cancer Drugs. 18, 10, p. 1157-1164 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2005

Promoter hypermethylation is the predominant mechanism in hMLH1 and hMSH2 deregulation and is a poor prognostic factor in nonsmoking lung cancer

Hsu, H. S., Wen, C. K., Tang, Y. A., Lin, R. K., Li, W. Y., Hsu, W. H. & Wang, Y. C., Aug 1 2005, In : Clinical Cancer Research. 11, 15, p. 5410-5416 7 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Wild-type p53 overexpression and its correlation with MDM2 and p14ARF alterations: An alternative pathway to non-small-cell lung cancer

Wang, Y. C., Lin, R. K., Tan, Y. H., Chen, J. T., Chen, C. Y. & Wang, Y. C., Jan 1 2005, In : Journal of Clinical Oncology. 23, 1, p. 154-164 11 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)
2003

Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples

Wang, Y. C., Lu, Y. P., Tseng, R. C., Lin, R. K., Chang, J. W., Chen, J. T., Shih, C. M. & Chen, C. Y., Mar 2003, In : Journal of Clinical Investigation. 111, 6, p. 887-895 9 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)