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Research Output 2003 2018

  • 1271 Citations
  • 16 h-Index
  • 25 Article
2018
2 Citations (Scopus)

Hypermethylation of CCND2 in Lung and Breast Cancer Is a Potential Biomarker and Drug Target

Hung, C. S., Wang, S. C., Yen, Y. T., Lee, T. H., Wen, W. C. & Lin, R. K., Oct 10 2018, In : International Journal of Molecular Sciences. 19, 10

Research output: Contribution to journalArticle

biomarkers
Biomarkers
breast
lungs
Lung Neoplasms
2017
14 Citations (Scopus)

Bioactive constituents from the termite nest-derived medicinal fungus Xylaria nigripes

Chang, J. C., Hsiao, G., Lin, R. K., Kuo, Y. H., Ju, Y. M. & Lee, T. H., Jan 27 2017, In : Journal of Natural Products. 80, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

Isoptera
Fungi
Alcohols
Sleep Initiation and Maintenance Disorders
Nitric Oxide Synthase Type II
1 Citation (Scopus)

Hypermethylation of BEND5 contributes to cell proliferation and is a prognostic marker of colorectal cancer

Lin, R. K., Hung, W. Y., Huang, Y. F., Chang, Y. J., Lin, C. H., Chen, W. Y., Chiu, S. F., Chang, S. C. & Tsai, S. F., Jan 1 2017, In : Oncotarget. 8, 69, p. 113431-113443 13 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Cell Proliferation
Tumor Suppressor Genes
Taiwan
Survival
2016
13 Citations (Scopus)

Alterations in histone deacetylase 8 lead to cell migration and poor prognosis in breast cancer

Hsieh, C. L., Ma, H. P., Su, C-M., Chang, Y. J., Hung, W. Y., Ho, Y. S., Huang, W. J. & Lin, R. K., Apr 15 2016, In : Life Sciences. 151, p. 7-14 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cell Movement
Breast Neoplasms
Atlases
Assays
17 Citations (Scopus)

Angiogenesis Inhibitors and Anti-Inflammatory Agents from Phoma sp. NTOU4195

Lee, M. S., Wang, S. W., Wang, G. J., Pang, K. L., Lee, C. K., Kuo, Y. H., Cha, H. J., Lin, R. K. & Lee, T. H., Dec 23 2016, In : Journal of Natural Products. 79, 12, p. 2983-2990 8 p.

Research output: Contribution to journalArticle

Angiogenesis Inhibitors
Macrophages
Endothelial cells
Inhibitory Concentration 50
Lipopolysaccharides
2 Citations (Scopus)

Synthesis and biological evaluation of lovastatin-derived aliphatic hydroxamates that induce reactive oxygen species

Lin, R. K., Lin, Y. F., Hsu, M. J., Hsieh, C. L., Wang, C. Y., Huang, C. C. & Huang, W. J., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5528-5533 6 p.

Research output: Contribution to journalArticle

Lovastatin
Reactive Oxygen Species
Cytotoxicity
Cells
Cell death
1 Citation (Scopus)

Terpenoids from the fermented broths of coprinellus radians

Lee, M. S., Hsiao, C. J., Ju, Y. M., Kuo, Y. H., Lin, R. K. & Lee, T. H., 2016, In : Natural Product Communications. 11, 9, p. 1229-1230 2 p.

Research output: Contribution to journalArticle

Coprinellus
Terpenes
Candida albicans
terpenoids
fluorouracil
5 Citations (Scopus)

Thrombomodulin influences the survival of patients with non-metastatic colorectal cancer through epithelial-to-mesenchymal transition (EMT)

Chang, Y. J., Cheng, Y. W., Lin, R. K., Huang, C. C., Chen, W. T. L., Ke, T. W. & Wei, P. L., Aug 1 2016, In : PLoS One. 11, 8, e0160550.

Research output: Contribution to journalArticle

Thrombomodulin
Epithelial-Mesenchymal Transition
colorectal neoplasms
Colorectal Neoplasms
Survival
2015
7 Citations (Scopus)

FCGR2A promoter methylation and risks for intravenous immunoglobulin treatment responses in kawasaki disease

Kuo, H. C., Hsu, Y. W., Wu, M. S., Woon, P. Y., Wong, H. S. C., Tsai, L. J., Lin, R. K., Klahan, S., Hsieh, K. S. & Chang, W. C., 2015, In : Mediators of Inflammation. 2015, 564625.

Research output: Contribution to journalArticle

Mucocutaneous Lymph Node Syndrome
Intravenous Immunoglobulins
Methylation
Therapeutics
IgG Receptors
2014
26 Citations (Scopus)

Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential

Wang, S. C., Li, Z-H., Hsu, C. H., Chang, Y. J., Chang, M. S., Wang, Y. C., Ho, Y. S., Wen, W. C. & Lin, R. K., Jun 18 2014, In : Journal of Agricultural and Food Chemistry. 62, 24, p. 5625-5635 11 p.

Research output: Contribution to journalArticle

Antrodia
Taiwanofungus camphoratus
methyltransferases
Methyltransferases
breast neoplasms
14 Citations (Scopus)

DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer

Yang, Y. C., Tang, Y. A., Shieh, J. M., Lin, R. K., Hsu, H. S. & Wang, Y. C., 2014, In : Journal of Thoracic Oncology. 9, 9, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Doxorubicin
Chromatin
DNA methyltransferase 3B
Forkhead Transcription Factors
38 Citations (Scopus)

Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer

Lin, R. K. & Wang, Y. C., Aug 19 2014, In : Cell and Bioscience. 4, 1, 46.

Research output: Contribution to journalArticle

Methyltransferases
DNA
Neoplasms
Carcinogenesis
Genes
2012
31 Citations (Scopus)

MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer

Tang, Y. A., Lin, R. K., Tsai, Y. T., Hsu, H. S., Yang, Y. C., Chen, C. Y. & Wang, Y. C., Aug 15 2012, In : Clinical Cancer Research. 18, 16, p. 4325-4333 9 p.

Research output: Contribution to journalArticle

DNA (Cytosine-5-)-Methyltransferase
Lung Neoplasms
Tumor Suppressor Genes
Methylation
DNA Methylation
166 Citations (Scopus)

TET1 Suppresses Cancer Invasion by Activating the Tissue Inhibitors of Metalloproteinases

Hsu, C-H., Peng, K-L., Kang, M-L., Chen, Y-R., Yang, Y-C., Tsai, C-H., Chu, C-S., Jeng, Y-M., Chen, Y-T., Lin, F-M., Huang, H-D., Lu, Y-Y., Teng, Y-C., Lin, S-T., Lin, R. K., Tang, F-M., Lee, S-B., Hsu, H-M., Yu, J-C., Hsiao, P-W. & 1 others, Juan, L-J., Sep 27 2012, In : Cell Reports. 2, 3, p. 568-579 12 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinases
Tumors
Dioxygenases
Methylation
Cytosine
2010
104 Citations (Scopus)

Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer

Lin, R. K., Wu, C. Y., Chang, J. W., Juan, L. J., Hsu, H. S., Chen, C. Y., Lu, Y. Y., Tang, Y. A., Yang, Y. C., Yang, P. C. & Wang, Y. C., Jul 15 2010, In : Cancer Research. 70, 14, p. 5807-5817 11 p.

Research output: Contribution to journalArticle

Methyltransferases
Lung Neoplasms
DNA
Proteins
DNA (Cytosine-5-)-Methyltransferase
63 Citations (Scopus)

hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

Lee, C-F., Ou, D. S. C., Lee, S-B., Chang, L-H., Lin, R. K., Li, Y-S., Upadhyay, A. K., Cheng, X., Wang, Y-C., Hsu, H-S., Hsiao, M., Wu, C-W. & Juan, L-J., Aug 2 2010, In : Journal of Clinical Investigation. 120, 8, p. 2920-2930 11 p.

Research output: Contribution to journalArticle

Methyltransferases
Gene Silencing
Tumor Suppressor Genes
Carcinogenesis
Cadherins
142 Citations (Scopus)

The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients

Lin, R. K., Hsieh, Y. S., Lin, P., Hsu, H. S., Chen, C. Y., Tang, Y. A., Lee, C. F. & Wang, Y. C., Feb 1 2010, In : Journal of Clinical Investigation. 120, 2, p. 521-532 12 p.

Research output: Contribution to journalArticle

Methyltransferases
Tumor Suppressor Genes
Carcinogens
Tobacco
Lung Neoplasms
2008
44 Citations (Scopus)

A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells

Chen, C. T., Munot, Y. S., Salunke, S. B., Wang, Y. C., Lin, R. K., Lin, C. C., Chen, C. C. & Liu, Y. H., Feb 22 2008, In : Advanced Functional Materials. 18, 4, p. 527-540 14 p.

Research output: Contribution to journalArticle

Galactosides
Fluorescent Dyes
lungs
cancer
Cells
31 Citations (Scopus)

Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type β-catenin nuclear accumulation in lung tumorigenesis

Tseng, R. C., Lin, R. K., Wen, C. K., Tseng, C., Hsu, H. S., Hsu, W. H. & Wang, Y. C., Jul 24 2008, In : Oncogene. 27, 32, p. 4488-4496 9 p.

Research output: Contribution to journalArticle

beta-Transducin Repeat-Containing Proteins
Catenins
Epigenomics
Carcinogenesis
Lung
2007
170 Citations (Scopus)

Alteration of DNA methyltransferases contributes to 5′CpG methylation and poor prognosis in lung cancer

Lin, R. K., Hsu, H. S., Chang, J. W., Chen, C. Y., Chen, J. T. & Wang, Y. C., Feb 2007, In : Lung Cancer. 55, 2, p. 205-213 9 p.

Research output: Contribution to journalArticle

Methyltransferases
Methylation
Lung Neoplasms
Tumor Suppressor Genes
Protein Methyltransferases
116 Citations (Scopus)

Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma

Hsu, H. S., Chen, T. P., Hung, C. H., Wen, C. K., Lin, R. K., Lee, H. C. & Wang, Y. C., Nov 1 2007, In : Cancer. 110, 9, p. 2019-2026 8 p.

Research output: Contribution to journalArticle

Epigenomics
Methylation
Lung Neoplasms
p16 Genes
Genes
43 Citations (Scopus)

Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells

Lin, R. K., Hsu, C. H. & Wang, Y. C., Nov 2007, In : Anti-Cancer Drugs. 18, 10, p. 1157-1164 8 p.

Research output: Contribution to journalArticle

Methyltransferases
Lung Neoplasms
Neoplasm Metastasis
CpG Islands
DNA
2005
55 Citations (Scopus)

Promoter hypermethylation is the predominant mechanism in hMLH1 and hMSH2 deregulation and is a poor prognostic factor in nonsmoking lung cancer

Hsu, H. S., Wen, C. K., Tang, Y. A., Lin, R. K., Li, W. Y., Hsu, W. H. & Wang, Y. C., Aug 1 2005, In : Clinical Cancer Research. 11, 15, p. 5410-5416 7 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Non-Small Cell Lung Carcinoma
Genes
Proteins
DNA Mismatch Repair
55 Citations (Scopus)

Wild-type p53 overexpression and its correlation with MDM2 and p14ARF alterations: An alternative pathway to non-small-cell lung cancer

Wang, Y. C., Lin, R. K., Tan, Y. H., Chen, J. T., Chen, C. Y. & Wang, Y. C., Jan 1 2005, In : Journal of Clinical Oncology. 23, 1, p. 154-164 11 p.

Research output: Contribution to journalArticle

Tumor Suppressor Protein p14ARF
Non-Small Cell Lung Carcinoma
Proteins
p53 Genes
Neoplasms
2003
111 Citations (Scopus)

Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples

Wang, Y. C., Lu, Y. P., Tseng, R. C., Lin, R. K., Chang, J. W., Chen, J. T., Shih, C. M. & Chen, C. Y., Mar 2003, In : Journal of Clinical Investigation. 111, 6, p. 887-895 9 p.

Research output: Contribution to journalArticle

Sputum
Methylation
Lung
Non-Small Cell Lung Carcinoma
Genes