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Research Output 1992 2019

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2019

Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model

Kurniawan, A. L., Lee, Y. C., Shih, C. K., Hsieh, R. H., Chen, S. H. & Chang, J. S., Jul 1 2019, In : Food and Function. 10, 7, p. 4113-4123 11 p.

Research output: Contribution to journalArticle

sex hormones
Gonadal Steroid Hormones
testosterone
Testosterone
Iron
2018

Birthweight, time-varying adiposity growth and early menarche in girls: A Mendelian randomisation and mediation analysis

Fan, H. Y., Huang, Y. T., Hsieh, R. H., Chao, J. C. J., Tung, Y. C., Lee, Y. L. & Chen, Y. C., Jan 1 2018, (Accepted/In press) In : Obesity Research and Clinical Practice.

Research output: Contribution to journalArticle

Mendelian Randomization Analysis
Menarche
Adiposity
Growth
Genes
1 Citation (Scopus)

Curcumin Supplementation Ameliorated Vascular Dysfunction and Antioxidant Status in High Sucrose, High Fat Fed Rats

Tsai, I-J., Chen, C-W., Tsai, S-Y., Wang, P-Y., Owaga, E. & Hsieh, R-H., Jan 29 2018, In : Applied Physiology, Nutrition and Metabolism.

Research output: Contribution to journalArticle

Curcumin
Blood Vessels
Sucrose
High Fat Diet
Antioxidants
Hemoglobin
hemoglobin
metabolism
liver
Metabolism
2017

Notch1-promoted TRPA1 expression in erythroleukemic cells suppresses erythroid but enhances megakaryocyte differentiation

Chen, J. L., Ping, Y. H., Tseng, M. J., Chang, Y. I., Lee, H. C., Hsieh, R. H. & Yeh, T. S., Feb 21 2017, In : Scientific Reports. 7, 42883.

Research output: Contribution to journalArticle

Ankyrins
Erythroid Cells
Megakaryocytes
Notch1 Receptor
K562 Cells
2016
17 Citations (Scopus)

Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis

Tsai, S. Y., Chung, P. C., Owaga, E. E., Tsai, I. J., Wang, P. Y., Tsai, J. I., Yeh, T. S. & Hsieh, R-H., Dec 1 2016, In : Nutrition and Metabolism. 13, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Garcinia mangostana
High Fat Diet
Mitochondria
Apoptosis
Liver
23 Citations (Scopus)

Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression

Hsu, K. W., Fang, W. L., Huang, K. H., Huang, T. T., Lee, H. C., Hsieh, R. H., Chi, C. W. & Tsai, T-S., 2016, In : Oncotarget. 7, 25, p. 38036-38051 16 p.

Research output: Contribution to journalArticle

MicroRNAs
Stomach Neoplasms
Focal Adhesion Protein-Tyrosine Kinases
Notch1 Receptor
Stomach
2015

Effects of a probiotic preparation on the human faecal microflora and biochemical and haematological parameters

Lan, A., Hsieh, R. H., Tsai, C. C. & Huang, C. C., Jun 1 2015, In : ScienceAsia. 41, 3, p. 155-161 7 p.

Research output: Contribution to journalArticle

Probiotics
Placebos
Bacteria
Healthy Volunteers
Streptococcus thermophilus
6 Citations (Scopus)

RRM2B-mediated regulation of mitochondrial activity and inflammation under oxidative stress

Cho, E. C., Kuo, M. L., Cheng, J. H., Cheng, Y. C., Hsieh, Y. C., Liu, Y. R., Hsieh, R. H. & Yen, Y., 2015, In : Mediators of Inflammation. 2015, 287345.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Oxidative Stress
Inflammation
Mitochondrial Genes
DNA Damage
31 Citations (Scopus)

Th17 cells as potential probiotic therapeutic targets in inflammatory bowel diseases

Owaga, E., Hsieh, R. H., Mugendi, B., Masuku, S., Shih, C. K. & Chang, J. S., Sep 1 2015, In : International Journal of Molecular Sciences. 16, 9, p. 20841-20858 18 p.

Research output: Contribution to journalArticle

Th17 Cells
Probiotics
Inflammatory Bowel Diseases
cells
pathogenesis
2014
15 Citations (Scopus)

Multifunctional effects of mangosteen pericarp on cognition in C57BL/6J and triple transgenic alzheimer's mice

Huang, H. J., Chen, W. L., Hsieh, R. H. & Hsieh-Li, H. M., 2014, In : Evidence-based Complementary and Alternative Medicine. 2014, 813672.

Research output: Contribution to journalArticle

Garcinia mangostana
Cognition
Transgenic Mice
Dietary Supplements
Diet
10 Citations (Scopus)

Oral toxicity evaluation of kefir-isolated Lactobacillus kefiranofaciens M1 in Sprague-Dawley rats

Owaga, E. E., Chen, M. J., Chen, W. Y., Chen, C. W. & Hsieh, R. H., 2014, In : Food and Chemical Toxicology. 70, p. 157-162 6 p.

Research output: Contribution to journalArticle

Lactobacillus kefiri
drug toxicity
Urinalysis
Lactobacillus
Hematology
2012
77 Citations (Scopus)

Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression

Hsu, K. W., Hsieh, R. H., Huang, K. H., Li, A. F. Y., Chi, C. W., Wang, T. Y., Tseng, M. J., Wu, K. J. & Tsai, T-S., Aug 2012, In : Carcinogenesis. 33, 8, p. 1459-1467 9 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Stomach Neoplasms
Notch1 Receptor
Neoplasms
Stomach
41 Citations (Scopus)

Notch2-induced COX-2 expression enhancing gastric cancer progression

Tseng, Y. C., Tsai, Y. H., Tseng, M. J., Hsu, K. W., Yang, M. C., Huang, K. H., Li, A. F. Y., Chi, C. W., Hsieh, R. H., Ku, H. H. & Tsai, T-S., Dec 2012, In : Molecular Carcinogenesis. 51, 12, p. 939-951 13 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Stomach Neoplasms
Neoplasms
Notch2 Receptor
Signal Transduction
2009
13 Citations (Scopus)

Functional modulation of mitochondria by eicosapentaenoic acid provides protection against ceramide toxicity to C6 glioma cells

Jeng, J. Y., Lee, W. H., Tsai, Y-H., Chen, C. Y., Chao, S. Y. & Hsieh, R. H., Dec 23 2009, In : Journal of Agricultural and Food Chemistry. 57, 24, p. 11455-11462 8 p.

Research output: Contribution to journalArticle

ceramides
Mitochondria
Eicosapentaenoic Acid
Ceramides
eicosapentaenoic acid
9 Citations (Scopus)

Linoleic acid promotes mitochondrial biogenesis and maintains mitochondrial structure for prevention of streptozotocin damage in RIN-m5F cells

Jeng, J. Y., Tsai, T-S., Chiu, Y. H., Lee, Y. C., Cheng, H-H. & Hsieh, R. H., 2009, In : Bioscience, Biotechnology and Biochemistry. 73, 6, p. 1262-1267 6 p.

Research output: Contribution to journalArticle

Organelle Biogenesis
Linoleic Acid
Streptozocin
Mitochondrial DNA
Insulin
28 Citations (Scopus)

MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2

Hsu, K. W., Hsieh, R. H., Wu, C. W., Chi, C. W., Lee, Y. H. W., Kuo, M. L., Wu, K. J. & Tsai, T-S., 2009, In : Molecular Biology of the Cell. 20, 24, p. 5127-5137 11 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Stomach Neoplasms
Carrier Proteins
Neoplasm Metastasis
Growth
2008
10 Citations (Scopus)
Retinoid X Receptors
Mitochondria
Transcription
Mitochondrial DNA
Membranes
69 Citations (Scopus)

Maintenance of mitochondrial DNA copy number and expression are essential for preservation of mitochondrial function and cell growth

Jeng, J. Y., Tsai, T-S., Lee, J. W., Lin, S-H., Fong, T-H. & Hsieh, R-H., Feb 1 2008, In : Journal of Cellular Biochemistry. 103, 2, p. 347-357 11 p.

Research output: Contribution to journalArticle

Cell growth
Mitochondrial DNA
Maintenance
Clone Cells
Growth
45 Citations (Scopus)

The activated Notch1 receptor cooperates with α-enolase and MBP-1 in modulating c-myc activity

Hsu, K. W., Hsieh, R-H., Lee, Y. H. W., Chao, C. H., Wu, K. J., Tseng, M. J. & Tsai, T-S., Aug 2008, In : Molecular and Cellular Biology. 28, 15, p. 4829-4842 14 p.

Research output: Contribution to journalArticle

Notch1 Receptor
Phosphopyruvate Hydratase
Carrier Proteins
Response Elements
YY1 Transcription Factor
2007
14 Citations (Scopus)

A follow-up study in a Taiwanese family with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes syndrome

Li, J. Y., Hsieh, R. H., Peng, N. J., Lai, P. H., Lee, C. F., Lo, Y. K. & Wei, Y. H., Jul 2007, In : Journal of the Formosan Medical Association = Taiwan yi zhi. 106, 7, p. 528-536 9 p.

Research output: Contribution to journalArticle

MELAS Syndrome
Mitochondrial DNA
Mutation
Stroke
rRNA Genes
40 Citations (Scopus)

The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1

Liao, W. R., Hsieh, R. H., Hsu, K. W., Wu, M. Z., Tseng, M. J., Mai, R. T., Wu lee, Y. H. & Tsai, T-S., Sep 2007, In : Carcinogenesis. 28, 9, p. 1867-1876 10 p.

Research output: Contribution to journalArticle

Notch1 Receptor
Signal Transduction
Transcription Factors
Response Elements
K562 Cells
2005
45 Citations (Scopus)
Mitochondria
Oocytes
Embryonic Structures
Embryonic Development
Mitochondrial Size
34 Citations (Scopus)
Experimental Diabetes Mellitus
Streptozocin
Medical problems
Rats
Tissue
2 Citations (Scopus)
Granulosa Cells
Up-Regulation
Electrons
Calcium
Gene Expression
5 Citations (Scopus)

Calcium stimulates mitochondrial biogenesis in human granulosa cells

Tsai, T-S., Ho, J. D., Yang, V. W. C., Tzeng, C. R. & Hsieh, R. H., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 157-162 6 p.

Research output: Contribution to journalArticle

Granulosa Cells
Organelle Biogenesis
Calcimycin
Calcium
Gene expression
4 Citations (Scopus)

Deleted mitochondrial DNA in human luteinized granulosa cells

Au, H. K., Lin, S. H., Huang, S. Y., Tsai, T-S., Tzeng, C. R. & Hsieh, R. H., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 136-141 6 p.

Research output: Contribution to journalArticle

Granulosa Cells
Mitochondrial DNA
Fertilization
Oocytes
Embryonic Development
9 Citations (Scopus)

Effects of glucose and α-tocopherol on low-density lipoprotein oxidation and glycation

Chang, C. J., Hsieh, R. H., Wang, H. F., Chin, M. Y. & Huang, S. Y., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 294-302 9 p.

Research output: Contribution to journalArticle

Tocopherols
LDL Lipoproteins
Glucose
Oxidation
Malondialdehyde
10 Citations (Scopus)

Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells

Tsai, N. M., Hsieh, R. H., Au, H. K., Hsieh, M-C., Huang, S. Y. & Tzeng, C. R., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 531-537 7 p.

Research output: Contribution to journalArticle

Granulosa Cells
Gonadotropin-Releasing Hormone
Apoptosis
Buserelin
Leuprolide
33 Citations (Scopus)

Oxidative damage and mitochondrial DNA mutations with endometriosis

Kao, S. H., Huang, H. C., Hsieh, R. H., Chen, S. C., Tsai, M-C. & Tzeng, C. R., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 186-194 9 p.

Research output: Contribution to journalArticle

Endometriosis
Mitochondrial DNA
Deoxyguanosine
Lipid Peroxides
Mutation
66 Citations (Scopus)

Oxidative stress-induced depolymerization of microtubules and alteration of mitochondrial mass in human cells

Lee, C. F., Liu, C. Y., Hsieh, R. H. & Wei, Y. H., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 246-254 9 p.

Research output: Contribution to journalArticle

Depolymerization
Mitochondria
Oxidative stress
Mitochondrial DNA
Microtubules
2004
50 Citations (Scopus)

Decreased expression of mitochondrial genes in human unfertilized oocytes and arrested embryos

Hsieh, R. H., Au, H. K., Yeh, T. S., Chang, S. J., Cheng, Y. F. & Tzeng, C. R., Mar 2004, In : Fertility and Sterility. 81, SUPPL. 1, p. 912-918 7 p.

Research output: Contribution to journalArticle

Mitochondrial Genes
Oocytes
Embryonic Structures
Carbon Monoxide
Fertilization in Vitro
19 Citations (Scopus)

Nuclear βII-tubulin associates with the activated notch receptor to modulate notch signaling

Tsai, T-S., Hsieh, R-H., Shen, S-C., Wang, S. H., Tseng, M. J., Shih, C-M. & Lin, J. J., Nov 15 2004, In : Cancer Research. 64, 22, p. 8334-8340 7 p.

Research output: Contribution to journalArticle

Notch1 Receptor
Notch Receptors
Tubulin
Ankyrins
Two-Hybrid System Techniques
49 Citations (Scopus)

Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice

Chang, S. L., Chang, C. L., Chiang, Y. M., Hsieh, R-H., Tzeng, C-R., Wu, T. K., Sytwu, H. K., Shyur, L. F. & Yang, W. C., Nov 2004, In : Planta Medica. 70, 11, p. 1045-1051 7 p.

Research output: Contribution to journalArticle

Bidens
Bidens pilosa
Butanols
Inbred NOD Mouse
T-cells
2003
34 Citations (Scopus)

Association of Transcription Factor YY1 with the High Molecular Weight Notch Complex Suppresses the Transactivation Activity of Notch

Tsai, T-S., Lin, Y. M., Hsieh, R-H. & Tseng, M. J., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 41963-41969 7 p.

Research output: Contribution to journalArticle

Notch1 Receptor
Transcriptional Activation
Transcription Factors
Molecular Weight
Molecular weight
2002
46 Citations (Scopus)

Multiple rearrangements of mitochondrial DNA in unfertilized human oocytes

Hsieh, R. H., Tsai, N. M., Au, H. K., Chang, S. J., Wei, Y. H. & Tzeng, C. R., 2002, In : Fertility and Sterility. 77, 5, p. 1012-1017 6 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Oocytes
Embryonic Structures
Fertilization in Vitro
Fertilization
2001
47 Citations (Scopus)

A novel mutation in the mitochondrial 16S rRNA gene in a patient with MELAS syndrome, diabetes mellitus, hyperthyroidism and cardiomyopathy

Hsieh, R-H., Li, J. Y., Pang, C. Y. & Wei, Y. H., 2001, In : Journal of Biomedical Science. 8, 4, p. 328-335 8 p.

Research output: Contribution to journalArticle

Lactic Acidosis
Brain Diseases
Muscular Diseases
Hyperthyroidism
Medical problems
1998
2 Citations (Scopus)

Large-scale mitochondrial DNA deletions in patients with CPEO syndrome in Taiwan

Wang, E. K., Kao, K. P., Hsieh, R. H., Lu, C. Y., Pang, C. Y. & Wei, Y. H., 1998, In : Journal of Biochemistry, Molecular Biology and Biophysics. 1, 3, p. 165-170 6 p.

Research output: Contribution to journalArticle

Chronic Progressive External Ophthalmoplegia
Mitochondrial DNA
Taiwan
Muscle
Muscles

Mitochondrial cardiomyopathy: biochemical and molecular analysis

Hsieh, R-H., Harn, HJ. & Lee, WH., 1998, In : Medical Digest. 27, p. 124-128

Research output: Contribution to journalArticle

1996
36 Citations (Scopus)

Age-related 4,977 bp deletion in human lung mitochondrial DNA

Fahn, H. J., Wang, L. S., Hsieh, R. H., Chang, S. C., Kao, S. H., Huang, M. H. & Wei, Y. H., 1996, In : American Journal of Respiratory and Critical Care Medicine. 154, 4 I, p. 1141-1145 5 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Base Pairing
Lung
Age Groups
Mutation
1994
85 Citations (Scopus)

Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria

Hsieh, R. H., Hou, J. H., Hsu, H. S. & Wei, Y. H., 1994, In : Biochemistry and Molecular Biology International. 32, 6, p. 1009-1022 14 p.

Research output: Contribution to journalArticle

Muscle Mitochondrion
Mitochondria
Mitochondrial DNA
Muscle
Muscles
1992
38 Citations (Scopus)

Age dependent 6KB deletion in human liver mitochondrial DNA

Yen, T. C., Pang, C. Y., Hsieh, R. H., Su, C. H., King, K. L. & Wei, Y. H., 1992, In : Biochemistry International. 26, 3, p. 457-468 12 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Liver
Nucleotides
Restriction Mapping
Stillbirth