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Research Output

2020

Mangosteen pericarp components alleviate progression of prostatic hyperplasia and mitochondrial dysfunction in rats

Tsai, H. H., Chen, C. W., Yu, P. L., Lin, Y. L. & Hsieh, R. H., Dec 1 2020, In : Scientific Reports. 10, 1, 322.

Research output: Contribution to journalArticle

Open Access

Mevalonate pathway enzyme HMGCS1 contributes to gastric cancer progression

Wang, I. H., Huang, T. T., Chen, J. L., Chu, L. W., Ping, Y. H., Hsu, K. W., Huang, K. H., Fang, W. L., Lee, H. C., Chen, C. F., Liao, C. C., Hsieh, R. H. & Yeh, T. S., May 2020, In : Cancers. 12, 5, 1088.

Research output: Contribution to journalArticle

Open Access
2019

Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model

Kurniawan, A. L., Lee, Y. C., Shih, C. K., Hsieh, R. H., Chen, S. H. & Chang, J. S., Jul 17 2019, In : Food and Function. 10, 7, p. 4113-4123 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Assessing causality between childhood adiposity and early puberty: A bidirectional Mendelian randomization and longitudinal study

Chen, Y. C., Fan, H. Y., Yang, C., Hsieh, R. H., Pan, W. H. & Lee, Y. L., Nov 1 2019, In : Metabolism: Clinical and Experimental. 100, 153961.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Body mass index growth trajectories, early pubertal maturation, and short stature

Fan, H. Y., Lee, Y. L., Hsieh, R. H., Yang, C. & Chen, Y. C., Jan 1 2019, (Accepted/In press) In : Pediatric Research.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Evaluation of a technological image-based dietary assessment tool for children during pubertal growth: A pilot study

Wang, J. S., Hsieh, R. H., Tung, Y. T., Chen, Y. C., Chen, Y. H. & Yang, C., Oct 20 2019, In : Nutrients. 11, 10, 2527.

Research output: Contribution to journalArticle

Open Access
2018

Birthweight, time-varying adiposity growth and early menarche in girls: A Mendelian randomisation and mediation analysis

Fan, H. Y., Huang, Y. T., Hsieh, R. H., Chao, J. C. J., Tung, Y. C., Lee, Y. L. & Chen, Y. C., Jan 1 2018, (Accepted/In press) In : Obesity Research and Clinical Practice.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Curcumin Supplementation Ameliorated Vascular Dysfunction and Antioxidant Status in High Sucrose, High Fat Fed Rats

Tsai, I-J., Chen, C-W., Tsai, S-Y., Wang, P-Y., Owaga, E. & Hsieh, R-H., Jan 29 2018, In : Applied Physiology, Nutrition and Metabolism.

Research output: Contribution to journalArticle

5 Citations (Scopus)
1 Citation (Scopus)
2017

Notch1-promoted TRPA1 expression in erythroleukemic cells suppresses erythroid but enhances megakaryocyte differentiation

Chen, J. L., Ping, Y. H., Tseng, M. J., Chang, Y. I., Lee, H. C., Hsieh, R. H. & Yeh, T. S., Feb 21 2017, In : Scientific Reports. 7, 42883.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis

Tsai, S. Y., Chung, P. C., Owaga, E. E., Tsai, I. J., Wang, P. Y., Tsai, J. I., Yeh, T. S. & Hsieh, R-H., Dec 1 2016, In : Nutrition and Metabolism. 13, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression

Hsu, K. W., Fang, W. L., Huang, K. H., Huang, T. T., Lee, H. C., Hsieh, R. H., Chi, C. W. & Tsai, T-S., 2016, In : Oncotarget. 7, 25, p. 38036-38051 16 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2015

Effects of a probiotic preparation on the human faecal microflora and biochemical and haematological parameters

Lan, A., Hsieh, R. H., Tsai, C. C. & Huang, C. C., Jun 1 2015, In : ScienceAsia. 41, 3, p. 155-161 7 p.

Research output: Contribution to journalArticle

RRM2B-mediated regulation of mitochondrial activity and inflammation under oxidative stress

Cho, E. C., Kuo, M. L., Cheng, J. H., Cheng, Y. C., Hsieh, Y. C., Liu, Y. R., Hsieh, R. H. & Yen, Y., 2015, In : Mediators of Inflammation. 2015, 287345.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Th17 cells as potential probiotic therapeutic targets in inflammatory bowel diseases

Owaga, E., Hsieh, R. H., Mugendi, B., Masuku, S., Shih, C. K. & Chang, J. S., Sep 1 2015, In : International Journal of Molecular Sciences. 16, 9, p. 20841-20858 18 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2014

Multifunctional effects of mangosteen pericarp on cognition in C57BL/6J and triple transgenic alzheimer's mice

Huang, H. J., Chen, W. L., Hsieh, R. H. & Hsieh-Li, H. M., 2014, In : Evidence-based Complementary and Alternative Medicine. 2014, 813672.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Oral toxicity evaluation of kefir-isolated Lactobacillus kefiranofaciens M1 in Sprague-Dawley rats

Owaga, E. E., Chen, M. J., Chen, W. Y., Chen, C. W. & Hsieh, R. H., 2014, In : Food and Chemical Toxicology. 70, p. 157-162 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

產生動物脂肪肝模式之套組

Translated title of the contribution: KIT OF GENERATING ANIMAL FATTY LIVER MODELHsieh, R-H. & 林聖玫, Nov 11 2014, Patent No. TWI459907B

Research output: Patent

2013

營養與免疫

Hsieh, R-H., Feb 2013, 華格那出版社.

Research output: Book/ReportBook

2012

Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression

Hsu, K. W., Hsieh, R. H., Huang, K. H., Li, A. F. Y., Chi, C. W., Wang, T. Y., Tseng, M. J., Wu, K. J. & Tsai, T-S., Aug 2012, In : Carcinogenesis. 33, 8, p. 1459-1467 9 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Notch2-induced COX-2 expression enhancing gastric cancer progression

Tseng, Y. C., Tsai, Y. H., Tseng, M. J., Hsu, K. W., Yang, M. C., Huang, K. H., Li, A. F. Y., Chi, C. W., Hsieh, R. H., Ku, H. H. & Tsai, T-S., Dec 2012, In : Molecular Carcinogenesis. 51, 12, p. 939-951 13 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2011

Method to induce fatty liver in animal

Hsieh, R-H., Jul 21 2011, Patent No. US08138166B2

Research output: Patent

2009

Functional modulation of mitochondria by eicosapentaenoic acid provides protection against ceramide toxicity to C6 glioma cells

Jeng, J. Y., Lee, W. H., Tsai, Y-H., Chen, C. Y., Chao, S. Y. & Hsieh, R. H., Dec 23 2009, In : Journal of Agricultural and Food Chemistry. 57, 24, p. 11455-11462 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Linoleic acid promotes mitochondrial biogenesis and maintains mitochondrial structure for prevention of streptozotocin damage in RIN-m5F cells

Jeng, J. Y., Tsai, T-S., Chiu, Y. H., Lee, Y. C., Cheng, H-H. & Hsieh, R. H., 2009, In : Bioscience, Biotechnology and Biochemistry. 73, 6, p. 1262-1267 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2

Hsu, K. W., Hsieh, R. H., Wu, C. W., Chi, C. W., Lee, Y. H. W., Kuo, M. L., Wu, K. J. & Tsai, T-S., 2009, In : Molecular Biology of the Cell. 20, 24, p. 5127-5137 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2008
10 Citations (Scopus)

Maintenance of mitochondrial DNA copy number and expression are essential for preservation of mitochondrial function and cell growth

Jeng, J. Y., Tsai, T-S., Lee, J. W., Lin, S-H., Fong, T-H. & Hsieh, R-H., Feb 1 2008, In : Journal of Cellular Biochemistry. 103, 2, p. 347-357 11 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

The activated Notch1 receptor cooperates with α-enolase and MBP-1 in modulating c-myc activity

Hsu, K. W., Hsieh, R-H., Lee, Y. H. W., Chao, C. H., Wu, K. J., Tseng, M. J. & Tsai, T-S., Aug 2008, In : Molecular and Cellular Biology. 28, 15, p. 4829-4842 14 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2007

A follow-up study in a Taiwanese family with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes syndrome

Li, J. Y., Hsieh, R. H., Peng, N. J., Lai, P. H., Lee, C. F., Lo, Y. K. & Wei, Y. H., Jul 2007, In : Journal of the Formosan Medical Association = Taiwan yi zhi. 106, 7, p. 528-536 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1

Liao, W. R., Hsieh, R. H., Hsu, K. W., Wu, M. Z., Tseng, M. J., Mai, R. T., Wu lee, Y. H. & Tsai, T-S., Sep 2007, In : Carcinogenesis. 28, 9, p. 1867-1876 10 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2005
47 Citations (Scopus)
35 Citations (Scopus)
2 Citations (Scopus)

Calcium stimulates mitochondrial biogenesis in human granulosa cells

Tsai, T-S., Ho, J. D., Yang, V. W. C., Tzeng, C. R. & Hsieh, R. H., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 157-162 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Deleted mitochondrial DNA in human luteinized granulosa cells

Au, H. K., Lin, S. H., Huang, S. Y., Tsai, T-S., Tzeng, C. R. & Hsieh, R. H., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 136-141 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Effects of glucose and α-tocopherol on low-density lipoprotein oxidation and glycation

Chang, C. J., Hsieh, R. H., Wang, H. F., Chin, M. Y. & Huang, S. Y., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 294-302 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells

Tsai, N. M., Hsieh, R. H., Au, H. K., Hsieh, M-C., Huang, S. Y. & Tzeng, C. R., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 531-537 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Oxidative damage and mitochondrial DNA mutations with endometriosis

Kao, S. H., Huang, H. C., Hsieh, R. H., Chen, S. C., Tsai, M-C. & Tzeng, C. R., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 186-194 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Oxidative stress-induced depolymerization of microtubules and alteration of mitochondrial mass in human cells

Lee, C. F., Liu, C. Y., Hsieh, R. H. & Wei, Y. H., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 246-254 9 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)
2004

Decreased expression of mitochondrial genes in human unfertilized oocytes and arrested embryos

Hsieh, R. H., Au, H. K., Yeh, T. S., Chang, S. J., Cheng, Y. F. & Tzeng, C. R., Mar 2004, In : Fertility and Sterility. 81, SUPPL. 1, p. 912-918 7 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Nuclear βII-tubulin associates with the activated notch receptor to modulate notch signaling

Tsai, T-S., Hsieh, R-H., Shen, S-C., Wang, S. H., Tseng, M. J., Shih, C-M. & Lin, J. J., Nov 15 2004, In : Cancer Research. 64, 22, p. 8334-8340 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice

Chang, S. L., Chang, C. L., Chiang, Y. M., Hsieh, R-H., Tzeng, C-R., Wu, T. K., Sytwu, H. K., Shyur, L. F. & Yang, W. C., Nov 2004, In : Planta Medica. 70, 11, p. 1045-1051 7 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2003

Association of Transcription Factor YY1 with the High Molecular Weight Notch Complex Suppresses the Transactivation Activity of Notch

Tsai, T-S., Lin, Y. M., Hsieh, R-H. & Tseng, M. J., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 41963-41969 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

The Role of Mitochondria in the Aging Ovary

Hsieh, R. H., Au, H. K., Wang, R. S., Yang, P. S. & Tzeng, C. R., Dec 18 2003, The Ovary: Second Edition. Elsevier Inc., p. 569-575 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2002

Multiple rearrangements of mitochondrial DNA in unfertilized human oocytes

Hsieh, R. H., Tsai, N. M., Au, H. K., Chang, S. J., Wei, Y. H. & Tzeng, C. R., 2002, In : Fertility and Sterility. 77, 5, p. 1012-1017 6 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2001

A novel mutation in the mitochondrial 16S rRNA gene in a patient with MELAS syndrome, diabetes mellitus, hyperthyroidism and cardiomyopathy

Hsieh, R-H., Li, J. Y., Pang, C. Y. & Wei, Y. H., 2001, In : Journal of Biomedical Science. 8, 4, p. 328-335 8 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
1998

Large-scale mitochondrial DNA deletions in patients with CPEO syndrome in Taiwan

Wang, E. K., Kao, K. P., Hsieh, R. H., Lu, C. Y., Pang, C. Y. & Wei, Y. H., 1998, In : Journal of Biochemistry, Molecular Biology and Biophysics. 1, 3, p. 165-170 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Mitochondrial cardiomyopathy: biochemical and molecular analysis

Hsieh, R-H., Harn, HJ. & Lee, WH., 1998, In : Medical Digest. 27, p. 124-128

Research output: Contribution to journalArticle

1996

Age-related 4,977 bp deletion in human lung mitochondrial DNA

Fahn, H. J., Wang, L. S., Hsieh, R. H., Chang, S. C., Kao, S. H., Huang, M. H. & Wei, Y. H., 1996, In : American Journal of Respiratory and Critical Care Medicine. 154, 4 I, p. 1141-1145 5 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
1994

Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria

Hsieh, R. H., Hou, J. H., Hsu, H. S. & Wei, Y. H., 1994, In : Biochemistry and Molecular Biology International. 32, 6, p. 1009-1022 14 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)