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Personal profile

Education

  • 1997, Ph.D. (Biochemistry), National Taiwan University
  • 1993, M.S. (Biochemistry), National Taiwan University
  • 1989, B.S. (Chemistry), National Taiwan Normal University

Experience

  • 1998 – 2000    Postdoctoral Fellow, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
  • 2001 – 2002    Postdoctoral Fellow, Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan
  • 2003 – 2004    Visiting Scholarship, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan
  • 2002 – 2006    Assistant Professor, Department of Biochemistry and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2009               Visiting Scholarship, the Stem Cell Core, NTU Research Center for Medical Excellence, National Taiwan University, Taipei, Taiwan
  • 2007- 2012     Associate Professor, Department of Biochemistry and Graduate Institute of   Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2010~now      Deputy Director, Center for Teeth Bank and Dental Stem Cell Biotechnology, Taipei Medical University, Taipei, Taiwan
  • 2011~2013     Secretary General, Taiwan Society for Stem Cell Research (TSSCR), Taiwan
  • 2013~now      Professor, Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2014~now      Professor and Director, Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2014~now      Member of Director Board, Taiwan Society for Stem Cell Research (TSSCR), Taiwan
  • 2014~now      Member of Director Board, Taiwan Association for Cell Therapy (TACT)
  • 2014~now      Committee member of JIRB, Taipei Medical University (TMU-JIRB), Taiwan
  • 2014~now      Committee member of Regeneration Medicine Board, Food and Drug Administration, Taiwan (TFDA 再生醫學諮議小組委員會)
  • 2015~now      Director, TMU Center for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan
  • 2015~now      Committee Member of Regeneration Medicine and Cell Therapy Development Board, Ministry of Health and Welfare (MOWH衛生福利部再生醫學及細胞治療發展諮議會委員)
  • 2016~now      Director, TMU GTP Laboratory, Taipei Medical University, Taipei, Taiwan
  • 2016~now      Distinguished Professor, Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2016~now      Director, Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2016~now      Member of Director Board, TaiGen Biotechnology (Presenter for National Development Fund, Executive Yuan, Taiwan 行政院國家發展基金會)

Awards

2017

  • 2017 Project Review Board, Food and Health Bureau (FHB) of The Government of the HKSAR, Hong Kong
  • 2017 The Best Paper Award, “IGF-1R Promotes Symmetric Self-Renewal and Migration of Alkaline Phosphatase-Positive Germ Stem Cells”, 2017 International Conference of Development Biology, Stem Cells and Regenerative Medicine-From Basic Research to Applications (2017 DBSRM), Taipei, Taiwan
  • 2017 The Best Paper Award, “IL-6 Upregulates the OCT4 Expression through STAT3-Dependent DNMT3b-OCT4-DNMT1 Axis in HBV-related Hepatocellular Carcinoma”, 2017 International Conference of Development Biology, Stem Cells and Regenerative Medicine-From Basic Research to Applications (2017 DBSRM), Taipei, Taiwan

2016

  • 2016 臺北醫學大學特聘教授
  • 2016 Distinguished Professor, Taipei Medical University, Taipei, Taiwan       
  • 2016 台灣癌症醫學會 董大成博士癌症基礎醫學研究傑出獎
  • 2016 The Outstanding Basic Research Award for Cancer Medicine of Dr. Da-Cheng Tung, The Chinese Oncology Society (COS).
  • 2016 The Prize Poster Award, “Niche ECM Laminin Mediates the Expressions of Pluripotent Transcription Factor Oct4 through IGF-IR- HIF-2α- CD49f Circuit Loop in Mouse Germline Stem Cells” 2016 Taiwan Society for Stem Cell Research (2016 TSSCR), Taipei, Taiwan
  • 2016 科技部105年度補助大專校院獎勵特殊優秀人才獎勵
  • 2016 臺灣女科技人群像介紹

2015

  • 2015臺北醫學大學國際頂尖論文獎  2015 The International Top Journal Research Award of Taipei Medical University
  • 2015   臺北醫學大學研究論文獎­—優良獎  2015 The Excellent Prize Research Award of Taipei Medical University
  • 2015   科技部104年度補助大專校院獎勵特殊優秀人才獎勵
  • 2015   The Prize Oral Award, “Insulin-like Growth Factor I Stimulates Cell Migration Through SDF-1/CXCR4 Regulation in Mouse Germline Stem Cells”, 2015 Taiwan Society For Stem Cell Research (2015 TSSCR), Taipei, Taiwan
  • 2015   The Prize Poster Award, “Insulin-like Growth Factor I Stimulates the Expressions of HIF-2α and Oct-4 Requiring α6 Integrin in Mouse Germline Stem Cells”, 2014 Taiwan Society For Stem Cell Research (2015 TSSCR), Taipei, Taiwan

2014  

  • 2014 The Prize Poster Award, “Insulin-like Growth Factor I Stimulates the Expressions of HIF-2α and Oct-4 Requiring α6 Integrin in Mouse Germline Stem Cells”, 2014 Taiwan Society For Stem Cell Research (2014 TSSCR), Taipei, Taiwan
  • 2014 科技部103年度補助大專校院獎勵特殊優秀人才獎勵

2013   

  • 2013 臺北醫學大學師鐸獎  2013 Faculty Award of Taipei Medical University in Excellence of Teaching, Administration, and Research.
  • 2013    The First Prize Oral Award, “IGF-1R-HIF-2 Signal Loop Supports the Proliferation and Oct-4 Maintenance of Alkaline Phosphatase Positive Mouse Germline Stem Cells Under Hypoxia. 2013 TSRM, Annual Meeting of Taiwan Society for Reproductive Medicine
  • 2013    The Prize Poster Award, “Interleukin-6 Regulates Stemness Expression and Early Recurrence of HBV-related Hepatocellular Carcinoma via IGF-IR Activation” & “Role of IGF-1R Signaling in Oct-4 Maintenance of Alkaline Phosphatase Positive Germline Stem Cells”. 2013 The 27th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.
  • 2013    The Excellent Research Paper Award,” Interleukin-6 Regulates Stemness Expression and Early Recurrence of HBV-related Hepatocellular Carcinoma via IGF-IR Activation “. 2013 Teachers and Students Joint Academic Research Symposium,Taipei Medical University, Taipei, Taiwan
  • 2013    The Prize Poster Award, “ IGF-IR-HIF-2 Signaling Loop Supports the Cell Proliferation and Oct4 Maintenance of Alkaline Phosphatase Positive Mouse Germline Stem Cell. 2013 Taiwan Society for Stem Cell Research (2013 TSSCR), Taipei, Taiwan.
  • 2013    The Prize Poster Award, “ HBx Stimulates the Expression of Stemness-related Properties through SENP1in HBV-related Hepatocellular Carcinomas. 2013 Taiwan Society for Stem Cell Research (2013 TSSCR), Taipei, Taiwan.
  • 2013    2013 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2012   

  • 2012 The Prize Poster Award, “ IL-6 stimulates stemness properties and early recurrence of HCC through IGF-IR activation. 2012 Taiwan Society for Stem Cell Research (2012 TSSCR), Taipei, Taiwan.
  • 2012    2012 The Second Prize Award of Excellent Research, Taipei Medical University, Taipei, Taiwan
  • 2012    The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2011       

  • 2011 The Second Prize Oral Award, “ SENP1 Regulates OCT4 Under Hypoxia: Effect of Sumoylation on Protein Stability and Drug Susceptibility of Human Pluripotent Germ Cell Tumors” 2011 International Symposium on Recent Advances in Pluripotent Stem Cells &  7th Annual Meeting of Taiwan Society for Stem Cell Research (2011 TSSCR).
  • 2011   The First Prize Oral Award, “Inflammation enhances the transformation of epithelial-like endometrium stem cells and initiates endometriosis”. 2011 Taiwan Society for Reproductive Medicine, Taipei, Taiwan (2011 TSRM)
  • 2011    The First Prize Award of Excellent Research, “Role of IL-6-IGF-1R Signaling in Early Recurrence and OCT4/NANOG Expression of HBV-related HCCs”. Taipei Medical University, Taipei, Taiwan
  • 2011    The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2010  

  • 2010 臺北醫學大學第一屆校級優良教師
  • 2010   2010 Prize Poster Award, “Crosstalking of Hypoxia and IGF-1 Signaling in Transformation of Mouse Germline Stem Cells”. The 18th Conference of The Chinese Society of Cell and Molecular Biology, Kaoshung, Taiwan
  • 2010 The First Prize Poster Award, “Role of inflammation in transformation of epithelial-like endometrium stem cells and it’s implication on endometriosis”. 2010 Taiwan Society for Reproductive Medicine, Taipei, Taiwan (2010 TSRM)
  • 2010 The First Prize Award of Excellent Research, “Role of Inflammation in Transformation of Epithelial-like Endometrium Stem Cells and its Implication on Endometriosis”, Taipei Medical University, Taipei, Taiwan
  • 2010 The Second Prize Award of Excellent Research, “IGF-1 is Required for Maintenance of Pluripotency of Mouse Spermatogonial Stem Cells”, Taipei Medical University, Taipei, Taiwan
  • 2010 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2009

  • 2009 Prize Award, The 7th Conference of the Pacific Rim Society for Fertility and Sterility (PRSFS 2009) – “ Hypoxia Stress Enhances the IGF-1 Signaling in Pluripotent Mouse Germline Stem Cells” , Taipei, Taiwan (2009 PRSFS)
  • 2009 Prize Award, The 7th Conference of the Pacific Rim Society for Fertility and Sterility (PRSFS 2009)- “Role of IGF-1/IGF-1R Signaling in Mouse Germline Stem Cells’ Pluripotency and Tumorigenesis”, Taipei, Taiwan  (2009 PRSFS)
  • 2009 Prize Poster Award, “Insulin-like Growth Factor 1 is Required for Pluripotency of Mouse Spermatogonial Stem Cells”. The 17th Conference of The Chinese Society of Cell and Molecular Biology, Kaoshung, Taiwan
  • 2009 The First Prize Award of Excellent Research,“Cross-talking of Hypoxia and IGF-1 Signaling in Pluripotent Spermatogonial Stem Cells“, Taipei Medical University, Taipei, Taiwan
  • 2009 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2008

  • 2008 Travel Award of theInternational Society for Stem Cell Research 6th Annual Meeting, Philadephia, USA
  • 2008 Prize Poster Award, The 17th Conference of Cell and Molecular Biology- “IGF-1 is Required for Maintenance of Pluripotency in Mouse Germ Line Stem Cells”. Kaoshing, Taiwan
  • 2008 The First Prize Award of Excellent Research, “IGF-1 is Required for Maintenance of Pluripotency of Mouse Spermatogonial Stem Cells”, Taipei Medical University, Taipei, Taiwan
  • 2008 The Second Prize Award of Excellent Research, Taipei Medical University, Taipei, Taiwan
  • 2008 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2007

  • 2007 The First Prize Award of Excellent Research, “Functional Characterization of a Novel Human Guanylyl Cyclase in Sperm“, Taipei Medical University, Taipei, Taiwan
  • 2007 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2006

  • 2006 The Second Prize Award of Excellent Research, “Functional Characterization of an Orphan Receptor, Gguanylyl Cyclase G, in Mouse Sperm”, Taipei Medical University, Taipei, Taiwan
  • 2006 Travel Award of theInternational Society for Stem Cell Research 4th Annual Meeting, Toronto, Canada
  • 2006 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2005   

  • 2005 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2004   

  • 2004 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2004 Visiting Scholarship, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan

2003

  • 2003 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
  • 2003 Visiting Scholarship, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan

2002

  • 2002 Visiting Scholarship, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan

2001

  • 2001 Postdoctoral Fellowship Award, Academia Sinica, Taipei, Taiwan

2000

  • 2000 The Prize Award of The 8th K.T.Li General Scientific Composition of K.T.Li Foundation for the Development of Science and Technology, Taipei, Taiwan
  • 2000 Postdoctoral Fellowship Award, Academia Sinica, Taipei, Taiwan

1999

  • 1999 The Prize Award of The 7th K.T.Li General Scientific Composition of K.T.Li Foundation for the Development of Science and Technology, Taipei, Taiwan
  • Postdoctoral Fellowship Award, Academia Sinica, Taipei, Taiwan 

1998

  • 1998 Postdoctoral Fellowship Award, Academia Sinica, Taipei, Taiwan

Research Interests

  • Stem cells and cancer stem cytology, Stem cell therapy, cytology, biochemistry, molecular biology

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Transforming Growth Factor beta Chemical Compounds
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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2010 2018

Research Output 1995 2018

  • 936 Citations
  • 17 h-Index
  • 41 Article
  • 1 Comment/debate

IGF-1R Promotes Symmetric Self-Renewal and Migration of Alkaline Phosphatase+ Germ Stem Cells through HIF-2α-OCT4/CXCR4 Loop under Hypoxia

Kuo, Y. C., Au, H. K., Hsu, J. L., Wang, H. F., Lee, C. J., Peng, S. W., Lai, S. C., Wu, Y. C., Ho, H. N. & Huang, Y. H. Feb 13 2018 In : Stem Cell Reports. 10, 2, p. 524-537

Research output: Contribution to journalArticle

Germ Cells
Alkaline Phosphatase
Stem Cells
Insulin-Like Growth Factor I
Cell Movement

Correction: Inflammation promotes expression of stemness-related properties in hbv-related hepatocellular carcinoma (PLoS ONE (2016)11:2 (e0149897) DOI: 10.1371/journal.pone.0149897)

Chang, T. S., Chen, C. L., Wu, Y. C., Liu, J. J., Kuo, Y. C., Lee, K. F., Lin, S. Y., Lin, S. E., Tung, S. Y., Kuo, L. M., Tsai, Y. H. & Huang, Y. H. Jan 1 2017 In : PLoS ONE. 12, 1, e0171176

Research output: Contribution to journalComment/debate

Organized Financing
hepatoma
funding
Hepatocellular Carcinoma
inflammation
9 Citations

Elevation of YAP promotes the epithelial-mesenchymal transition and tumor aggressiveness in colorectal cancer

Ling, H. H., Kuo, C. C., Lin, B. X., Huang, Y. H. & Lin, C. W. Jan 1 2017 In : Experimental Cell Research. 350, 1, p. 218-225 8 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Neoplasms
Proteins
Neoplasm Metastasis
4 Citations

Fluorescent nanodiamonds enable quantitative tracking of human mesenchymal stem cells in miniature pigs

Su, L. J., Wu, M. S., Hui, Y. Y., Chang, B. M., Pan, L., Hsu, P. C., Chen, Y. T., Ho, H. N., Huang, Y. H., Ling, T. Y., Hsu, H. H. & Chang, H. C. Mar 30 2017 In : Scientific Reports. 7, 45607

Research output: Contribution to journalArticle

Nanodiamonds
Mesenchymal Stromal Cells
Swine
Placenta
Stem Cells
1 Citations

Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ

Lee, W. Y., Chen, P. C., Wu, W. S., Wu, H. C., Lan, C. H., Huang, Y. H., Cheng, C. H., Chen, K. C. & Lin, C. W. 2017 (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Histone Deacetylase Inhibitors
gefitinib
panobinostat

Press / Media

Kun-yen Huangphysician, deanof medical school Kun-yen...

Yen-Hua Huang

3/22/12

1 item of media coverage

Press/Media: Press / Media