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2020

A population-based cohort study of mortality of intensive care unit patients with liver cirrhosis

Huang, Y. F., Lin, C. S., Cherng, Y. G., Yeh, C. C., Chen, R. J., Chen, T. L. & Liao, C. C., Jan 16 2020, In : BMC Gastroenterology. 20, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Orally administered resveratrol enhances the therapeutic effect of autologous transplanted adipose-derived stem cells on rats with diabetic hepatopathy

Chen, T. S., Lai, C. H., Shen, C. Y., Pai, P. Y., Chen, R. J., PadmaViswanadha, V., Yang, C. K., Chen, M. C., Lin, Y. M. & Huang, C. Y., Jan 2 2020, In : Biotechnic and Histochemistry. 95, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The development an artificial intelligence algorithm for early sepsis diagnosis in the intensive care unit

Yuan, K. C., Tsai, L. W., Lee, K. H., Cheng, Y. W., Hsu, S. C., Lo, Y. S. & Chen, R. J., Sep 2020, In : International Journal of Medical Informatics. 141, 104176.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2019
Open Access
3 Citations (Scopus)

Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats

Lin, K. H., Shibu, M. A., Peramaiyan, R., Chen, Y. F., Shen, C. Y., Hsieh, Y. L., Chen, R. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Jan 1 2019, In : Journal of Functional Foods. 52, p. 212-218 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Blockchain-enabled iWellChain framework integration with the national medical referral system: Development and usability study

Lo, Y. S., Yang, C. Y., Chien, H. F., Chang, S. S., Lu, C. Y. & Chen, R. J., Jan 1 2019, In : Journal of Medical Internet Research. 21, 12, e13563.

Research output: Contribution to journalArticle

Open Access

CHIP attenuates lipopolysaccharide-induced cardiac hypertrophy and apoptosis by promoting NFATc3 proteasomal degradation

Chao, C. N., Lai, C. H., Badrealam, K. F., Lo, J. F., Shen, C. Y., Chen, C. H., Chen, R. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Nov 1 2019, In : Journal of Cellular Physiology. 234, 11, p. 20128-20138 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Deep sea minerals ameliorate diabetic-induced inflammation via inhibition of TNFα signaling pathways

Lu, C. H., Ou, H. C., Day, C. H., Chen, H. I., Pai, P. Y., Lee, C. Y., Chen, R. J., Chang, R. L., PadmaViswanadha, V., Hsieh, D. J. Y. & Huang, C. Y., Jan 1 2019, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

Embelin as a Novel Inhibitor of PKC in the Prevention of Platelet Activation and Thrombus Formation

Li, J. Y., Chen, R. J., Huang, L. T., Lee, T. Y., Lu, W. J. & Lin, K. H., Oct 18 2019, In : Journal of Clinical Medicine. 8, 10

Research output: Contribution to journalArticle

Insulin-like growth factor II receptor-α is a novel stress-inducible contributor to cardiac damage underpinning doxorubicin-induced oxidative stress and perturbed mitochondrial autophagy

Pandey, S., Kuo, W. W., Shen, C. Y., Yeh, Y. L., Ho, T. J., Chen, R. J., Chang, R. L., Pai, P. Y., Viswanadha, V. P., Huang, C. Y. & Huang, C. Y., Aug 2019, In : American Journal of Physiology - Cell Physiology. 317, 2, p. C235-C243

Research output: Contribution to journalArticle

4 Citations (Scopus)

Lessons learned from isolated blunt major pancreatic injury: Surgical experience in one trauma centre

Lin, B. C., Chen, R. J. & Hwang, T. L., Jan 1 2019, In : Injury.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

Lu, W-J., Lin, K-H., Tseng, M-F., Yuan, K-C., Huang, H-C., Sheu, J-R. & Chen, R-J., Mar 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1723-1734 12 p.

Research output: Contribution to journalArticle

Protective effect of autologous transplantation of resveratrol preconditioned adipose-derived stem cells in the treatment of diabetic liver dysfunction in rat model

Chen, T. S., Ju, D. T., Day, C. H., Yeh, Y. L., Chen, R. J., Viswanadha, V. P., Chang, R. L., Lin, Y. C., Yao, C. H. & Huang, C. Y., Sep 1 2019, In : Journal of Tissue Engineering and Regenerative Medicine. 13, 9, p. 1629-1640 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats

Chen, Y. P., Sivalingam, K., Shibu, M. A., Peramaiyan, R., Day, C. H., Shen, C. Y., Lai, C. H., Chen, R. J., Viswanadha, V. P., Chen, Y. F. & Huang, C. Y., Apr 1 2019, In : Phytomedicine. 57, p. 1-8 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Resveratrol increases stem cell function in the treatment of damaged pancreas

Chen, T. S., Kuo, C. H., Day, C. H., Pan, L. F., Chen, R. J., Chen, B. C., Padma, V. V., Lin, Y. M. & Huang, C. Y., Nov 2019, In : Journal of Cellular Physiology. 234, 11, p. 20443-20452 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Synergistic cardiac pathological hypertrophy induced by high-salt diet in IGF-IIRα cardiac-specific transgenic rats

Chang, R. L., Nithiyanantham, S., Huang, C. Y., Pai, P. Y., Chang, T. T., Hu, L. C., Chen, R. J., VijayaPadma, V., Kuo, W. W. & Huang, C. Y., Jun 1 2019, In : PLoS ONE. 14, 6, e0216285.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Tid1-S attenuates LPS-induced cardiac hypertrophy and apoptosis through ER-a mediated modulation of p-PI3K/p-Akt signaling cascade

Chao, C. N., Lo, J. F., Khan, F. B., Day, C. H., Lai, C. H., Chen, C. H., Chen, R. J., Viswanadha, V. P., Kuo, C. H. & Huang, C. Y., Jan 1 2019, In : Journal of Cellular Biochemistry. 120, 10, p. 16703-16710 8 p.

Research output: Contribution to journalArticle

Two-vessel occlusion mouse model of cerebral ischemia-reperfusion

Chen, C. Y., Chen, R. J. & Lee, G. A., Mar 1 2019, In : Journal of Visualized Experiments. 2019, 145, e59078.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Upregulation of IGF-IIRα intensifies doxorubicin-induced cardiac damage

Pandey, S., Kuo, W. W., Ho, T. J., Yeh, Y. L., Shen, C. Y., Chen, R. J., Chang, R. L., Pai, P. Y., Padma, V. V., Huang, C. Y. & Huang, C. Y., Jan 1 2019, In : Journal of Cellular Biochemistry. 120, 10, p. 16956-16966 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC

Lu, W. J., Li, J. Y., Chen, R. J., Huang, L. T., Lee, T. Y. & Lin, K. H., Dec 1 2019, In : Scientific Reports. 9, 1, 18852.

Research output: Contribution to journalArticle

Open Access

β-catenin/LEF1/IGF-IIR Signaling Axis Galvanizes the Angiotensin-II-induced Cardiac Hypertrophy

Lai, C. H., Pandey, S., Day, C. H., Ho, T. J., Chen, R. J., Chang, R. L., Pai, P. Y., Padma, V. V., Kuo, W. W. & Huang, C. Y., Sep 1 2019, In : International Journal of Molecular Sciences. 20, 17, 4288.

Research output: Contribution to journalArticle

Open Access
2018
9 Citations (Scopus)

Acute hypoxic preconditioning prevents palmitic acid-induced cardiomyocyte apoptosis via switching metabolic GLUT4-glucose pathway back to CD36-fatty acid dependent

Chen, Y. P., Kuo, W. W., Baskaran, R., Day, C. H., Chen, R. J., Wen, S. Y., Ho, T. J., Padma, V. V., Kuo, C. H. & Huang, C. Y., Apr 1 2018, In : Journal of Cellular Biochemistry. 119, 4, p. 3363-3372 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Alpinate Oxyphyllae extracts enhance the longevity and homing of mesenchymal stem cells and augment their protection against senescence in H9c2 cells

Chang, Y. M., Asokan Shibu, M., Tsai, C. T., Tsai, C. C., Lin, S. L., Chang, C. C., Viswanadha, V. P., Chen, R. J., Chang, J. H. M. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

1 Citation (Scopus)

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., Nov 14 2018, In : Journal of Clinical Medicine. 7, 11

Research output: Contribution to journalArticle

Cardiac apoptosis induced under high glucose condition involves activation of IGF2R signaling in H9c2 cardiomyoblasts and streptozotocin-induced diabetic rat hearts

Feng, C. C., Pandey, S., Lin, C. Y., Shen, C. Y., Chang, R. L., Chang, T. T., Chen, R. J., Viswanadha, V. P., Lin, Y. M. & Huang, C. Y., Jan 1 2018, In : Biomedicine and Pharmacotherapy. 97, p. 880-885 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2 Citations (Scopus)

C-terminus of Hsc70-interacting protein (CHIP) enhances stemness properties of human Wharton’s jelly mesenchymal stem cell

Yang, C. K., Feng, C. C., Lo, J. F., Chen, J. W., Padma, V. V., Lai, C. H., Chen, T. S., Chen, R. J., Liao, P. H. & Huang, C. Y., Nov 17 2018, In : Biotechnic and Histochemistry. 93, 8, p. 632-639 8 p.

Research output: Contribution to journalArticle

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure

Huang, C. Y., Kuo, C. H., Pai, P. Y., Ho, T. J., Lin, Y. M., Chen, R. J., Tsai, F. J., Vijaya Padma, V., Kuo, W. W. & Huang, C. Y., Feb 1 2018, In : Data in Brief. 16, p. 521-526 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

E4BP4 inhibits AngII-induced apoptosis in H9c2 cardiomyoblasts by activating the PI3K-Akt pathway and promoting calcium uptake

Chen, B. C., Shibu, M. A., Kuo, C. H., Shen, C. Y., Chang-Lee, S. N., Lai, C. H., Chen, R. J., Yao, C. H., Viswanadha, V. P., Liu, J. S., Chen, W. K. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Experimental Cell Research.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Epithelioid Angiomyolipoma of the Liver

Huang, Y. M., Wei, P. L. & Chen, R. J., Jan 1 2018, In : Journal of Gastrointestinal Surgery. 22, 1, p. 175-176 2 p.

Research output: Contribution to journalArticle

Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats

Chen, W. K., Tsai, Y. L., Shibu, M. A., Shen, C. Y., Chang-Lee, S. N., Chen, R. J., Yao, C. H., Ban, B., Kuo, W. W. & Huang, C. Y., Dec 1 2018, In : Aging. 10, 12, p. 4166-4174 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Fenofibrate induced PPAR alpha expression was attenuated by oestrogen receptor alpha overexpression in Hep3B cells

Jeng, L. B., Velmurugan, B. K., Hsu, H. H., Wen, S. Y., Shen, C. Y., Lin, C. H., Lin, Y. M., Chen, R. J., Kuo, W. W. & Huang, C. Y., Feb 1 2018, In : Environmental Toxicology. 33, 2, p. 234-247 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

GABA tea attenuates cardiac apoptosis in spontaneously hypertensive rats (SHR) by enhancing PI3K/Akt-mediated survival pathway and suppressing Bax/Bak dependent apoptotic pathway

Chen, B. C., Hung, M. Y., Wang, H. F., Yeh, L. J., Pandey, S., Chen, R. J., Chang, R. L., Viswanadha, V. P., Lin, K. H. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

6 Citations (Scopus)

HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy

Huang, C. Y., Lee, F. L., Peng, S. F., Lin, K. H., Chen, R. J., Ho, T. J., Tsai, F. J., Padma, V. V., Kuo, W. W. & Huang, C. Y., Feb 2018, In : Journal of Cellular Physiology. 233, 2, p. 979-989

Research output: Contribution to journalArticle

18 Citations (Scopus)

Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy

Huang, C. Y., Kuo, C. H., Pai, P. Y., Ho, T. J., Lin, Y. M., Chen, R. J., Tsai, F. J., Vijaya Padma, V., Kuo, W. W. & Huang, C. Y., Apr 15 2018, In : International Journal of Cardiology. 257, p. 283-290

Research output: Contribution to journalArticle

10 Citations (Scopus)

Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest

Lu, W. J., Wu, G. J., Chen, R. J., Chang, C. C., Lien, L. M., Chiu, C. C., Tseng, M. F., Huang, L. T. & Lin, K. H., Aug 1 2018, In : Food and Function. 9, 8, p. 4500-4507 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Lipoteichoic acid upregulates plasminogen activator inhibitor-1 expression in parapneumonic effusions

Lee, K. L., Chen, W. L., Chen, R. J., Lai, K. S. & Chung, C. L., Jan 1 2018, In : Respirology. 23, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Lupeol alters ER stress-signaling pathway by downregulating ABCG2 expression to induce Oxaliplatin-resistant LoVo colorectal cancer cell apoptosis

Chen, M. C., Hsu, H. H., Chu, Y. Y., Cheng, S. F., Shen, C. Y., Lin, Y. J., Chen, R. J., Viswanadha, V. P., Lin, Y. M. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Machine learning–based radiomics for molecular subtyping of gliomas

Lu, C-F., Hsu, F-T., Hsieh, KL-C., Kao, Y-CJ., Cheng, S-J., Hsu, JB-K., Tsai, P-H., Chen, R-J., Huang, C-C., Yen, Y. & Chen, C-Y., Sep 15 2018, In : Clinical Cancer Research. 24, 18, p. 4429-4436 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p-JNK mediated hypertrophy and enhancing P-IGF1R, p-akt, and p-Badser136 activity and by fortifying NRF2 antioxidation system

Shibu, M. A., Kuo, C. H., Chen, B. C., Ju, D. T., Chen, R. J., Lai, C. H., Huang, P. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Feb 1 2018, In : Environmental Toxicology. 33, 2, p. 220-233

Research output: Contribution to journalArticle

15 Citations (Scopus)

Overexpression of IGF-IIRα regulates cardiac remodeling and aggravates high salt induced apoptosis and fibrosis in transgenic rats

Chang, R. L., Nithiyanantham, S., Kuo, W. W., Pai, P. Y., Chang, T. T., Lai, C. H., Chen, R. J., Vijaya Padma, V., Huang, C. Y. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2 Citations (Scopus)

Synergistic effect of HIF-1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition

Chen, Y. F., Pandey, S., Day, C. H., Chen, Y. F., Jiang, A. Z., Ho, T. J., Chen, R. J., Padma, V. V., Kuo, W. W. & Huang, C. Y., Apr 2018, In : Journal of Cellular Physiology. 233, 4, p. 3660-3671

Research output: Contribution to journalArticle

17 Citations (Scopus)

The multifaceted link between inflammation and human diseases

Rajendran, P., Chen, Y. F., Chen, Y. F., Chung, L. C., Tamilselvi, S., Shen, C. Y., Day, C. H., Chen, R. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

30 Citations (Scopus)

The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple-transgenic Alzheimer's disease model mice

Lin, K. H., Chiu, C. H., Kuo, W. W., Ju, D. T., Shen, C. Y., Chen, R. J., Lin, C. C., Viswanadha, V. P., Liu, J. S., Huang, R. F. S. & Huang, C. Y., Jan 2018, In : Environmental Toxicology. 33, 1, p. 83-92

Research output: Contribution to journalArticle

8 Citations (Scopus)

Tumorous imaginal disc 1 (TID1) inhibits isoproterenol-induced cardiac hypertrophy and apoptosis by regulating c-terminus of hsc70-interacting protein (CHIP) mediated degradation of Gαs

Feng, C. C., Liao, P. H., Tsai, H. I., Cheng, S. M., Yang, L. Y., PadmaViswanadha, V., Pan, L. F., Chen, R. J., Lo, J. F. & Huang, C. Y., Jan 1 2018, In : International Journal of Medical Sciences. 15, 13, p. 1537-1546 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Alpinia oxyphylla Miq. fruit extract activates IGFR-PI3K/Akt signaling to induce Schwann cell proliferation and sciatic nerve regeneration

Chang, Y. M., Chang, H. H., Tsai, C. C., Lin, H. J., Ho, T. J., Ye, C. X., Chiu, P. L., Chen, Y. S., Chen, R. J., Huang, C. Y. & Lin, C. C., Mar 31 2017, In : BMC Complementary and Alternative Medicine. 17, 1, 184.

Research output: Contribution to journalArticle

13 Citations (Scopus)
7 Citations (Scopus)