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Research Output 1991 2019

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Article
2019
Open Access
Electronic Health Records
Human Influenza
Incidence
Taiwan
Centers for Disease Control and Prevention (U.S.)

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

Lu, W-J., Lin, K-H., Tseng, M-F., Yuan, K-C., Huang, H-C., Sheu, J-R. & Chen, R-J., Mar 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1723-1734 12 p.

Research output: Contribution to journalArticle

Hemorrhagic Shock
Liver
Wounds and Injuries
Resuscitation
Therapeutics
2018
5 Citations (Scopus)
Clinical Decision Support Systems
Medical Order Entry Systems
Physicians
Health Facilities
Drug-Related Side Effects and Adverse Reactions
2 Citations (Scopus)

Acute hypoxic preconditioning prevents palmitic acid-induced cardiomyocyte apoptosis via switching metabolic GLUT4-glucose pathway back to CD36-fatty acid dependent

Chen, Y. P., Kuo, W. W., Baskaran, R., Day, C. H., Chen, R. J., Wen, S. Y., Ho, T. J., Padma, V. V., Kuo, C. H. & Huang, C. Y., Apr 1 2018, In : Journal of Cellular Biochemistry. 119, 4, p. 3363-3372 10 p.

Research output: Contribution to journalArticle

Glucose Transporter Type 4
Palmitic Acid
Cardiac Myocytes
Fatty Acids
Apoptosis

Alpinate Oxyphyllae extracts enhance the longevity and homing of mesenchymal stem cells and augment their protection against senescence in H9c2 cells

Chang, Y. M., Asokan Shibu, M., Tsai, C. T., Tsai, C. C., Lin, S. L., Chang, C. C., Viswanadha, V. P., Chen, R. J., Chang, J. H. M. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Stem Cells
Doxorubicin
CXC Chemokines

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., Nov 14 2018, In : Journal of Clinical Medicine. 7, 11

Research output: Contribution to journalArticle

Phospholipase D
Blood Platelets
Platelet Activation
Platelet Aggregation
Thrombosis
2 Citations (Scopus)

Cardiac apoptosis induced under high glucose condition involves activation of IGF2R signaling in H9c2 cardiomyoblasts and streptozotocin-induced diabetic rat hearts

Feng, C. C., Pandey, S., Lin, C. Y., Shen, C. Y., Chang, R. L., Chang, T. T., Chen, R. J., Viswanadha, V. P., Lin, Y. M. & Huang, C. Y., Jan 1 2018, In : Biomedicine and Pharmacotherapy. 97, p. 880-885 6 p.

Research output: Contribution to journalArticle

IGF Type 2 Receptor
Streptozocin
Apoptosis
Glucose
Cardiomegaly
Colistin
Carbapenems
Taiwan
Intensive Care Units
Emergency Medicine
2 Citations (Scopus)

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure

Huang, C. Y., Kuo, C. H., Pai, P. Y., Ho, T. J., Lin, Y. M., Chen, R. J., Tsai, F. J., Vijaya Padma, V., Kuo, W. W. & Huang, C. Y., Feb 1 2018, In : Data in Brief. 16, p. 521-526 6 p.

Research output: Contribution to journalArticle

Angiotensin II
Heart Failure
Cardiomegaly
Hypertension
Sumoylation
2 Citations (Scopus)

E4BP4 inhibits AngII-induced apoptosis in H9c2 cardiomyoblasts by activating the PI3K-Akt pathway and promoting calcium uptake

Chen, B. C., Shibu, M. A., Kuo, C. H., Shen, C. Y., Chang-Lee, S. N., Lai, C. H., Chen, R. J., Yao, C. H., Viswanadha, V. P., Liu, J. S., Chen, W. K. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Experimental Cell Research.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Angiotensin II
Apoptosis
Calcium
Insulin-Like Growth Factor II

Epithelioid Angiomyolipoma of the Liver

Huang, Y. M., Wei, P. L. & Chen, R. J., Jan 1 2018, In : Journal of Gastrointestinal Surgery. 22, 1, p. 175-176 2 p.

Research output: Contribution to journalArticle

Angiomyolipoma
Liver

Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats

Chen, W. K., Tsai, Y. L., Shibu, M. A., Shen, C. Y., Chang-Lee, S. N., Chen, R. J., Yao, C. H., Ban, B., Kuo, W. W. & Huang, C. Y., Dec 1 2018, In : Aging. 10, 12, p. 4166-4174 9 p.

Research output: Contribution to journalArticle

Galactose
Exercise
Inflammation
Hematoxylin
Eosine Yellowish-(YS)
3 Citations (Scopus)

Fenofibrate induced PPAR alpha expression was attenuated by oestrogen receptor alpha overexpression in Hep3B cells

Jeng, L. B., Velmurugan, B. K., Hsu, H. H., Wen, S. Y., Shen, C. Y., Lin, C. H., Lin, Y. M., Chen, R. J., Kuo, W. W. & Huang, C. Y., Feb 1 2018, In : Environmental Toxicology. 33, 2, p. 234-247 14 p.

Research output: Contribution to journalArticle

Fenofibrate
PPAR alpha
Estrogen Receptor alpha
apoptosis
plasmid

GABA tea attenuates cardiac apoptosis in spontaneously hypertensive rats (SHR) by enhancing PI3K/Akt-mediated survival pathway and suppressing Bax/Bak dependent apoptotic pathway

Chen, B. C., Hung, M. Y., Wang, H. F., Yeh, L. J., Pandey, S., Chen, R. J., Chang, R. L., Viswanadha, V. P., Lin, K. H. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

apoptosis
tea
Tea
Inbred SHR Rats
Phosphatidylinositol 3-Kinases
8 Citations (Scopus)

HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy

Huang, C. Y., Lee, F. L., Peng, S. F., Lin, K. H., Chen, R. J., Ho, T. J., Tsai, F. J., Padma, V. V., Kuo, W. W. & Huang, C. Y., Feb 2018, In : Journal of Cellular Physiology. 233, 2, p. 979-989

Research output: Contribution to journalArticle

IGF Type 2 Receptor
Phosphorylation
Extracellular Signal-Regulated MAP Kinases
Cardiac Myocytes
Angiotensin II
6 Citations (Scopus)

Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy

Huang, C. Y., Kuo, C. H., Pai, P. Y., Ho, T. J., Lin, Y. M., Chen, R. J., Tsai, F. J., Vijaya Padma, V., Kuo, W. W. & Huang, C. Y., Apr 15 2018, In : International Journal of Cardiology. 257, p. 283-290

Research output: Contribution to journalArticle

Sumoylation
Cardiomegaly
Up-Regulation
Hypertension
Heart Failure

Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest

Lu, W. J., Wu, G. J., Chen, R. J., Chang, C. C., Lien, L. M., Chiu, C. C., Tseng, M. F., Huang, L. T. & Lin, K. H., Aug 1 2018, In : Food and Function. 9, 8, p. 4500-4507 8 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Glioma
cell growth
licorice
neoplasms
4 Citations (Scopus)

Lipoteichoic acid upregulates plasminogen activator inhibitor-1 expression in parapneumonic effusions

Lee, K. L., Chen, W. L., Chen, R. J., Lai, K. S. & Chung, C. L., Jan 1 2018, In : Respirology. 23, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Up-Regulation
Gram-Positive Bacteria
Toll-Like Receptor 2
lipoteichoic acid
3 Citations (Scopus)

Lupeol alters ER stress-signaling pathway by downregulating ABCG2 expression to induce Oxaliplatin-resistant LoVo colorectal cancer cell apoptosis

Chen, M. C., Hsu, H. H., Chu, Y. Y., Cheng, S. F., Shen, C. Y., Lin, Y. J., Chen, R. J., Viswanadha, V. P., Lin, Y. M. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

oxaliplatin
Endoplasmic Reticulum Stress
apoptosis
Colorectal Neoplasms
cancer
5 Citations (Scopus)

Machine learning–based radiomics for molecular subtyping of gliomas

Lu, C-F., Hsu, F-T., Hsieh, KL-C., Kao, Y-CJ., Cheng, S-J., Hsu, JB-K., Tsai, P-H., Chen, R-J., Huang, C-C., Yen, Y. & Chen, C-Y., Sep 15 2018, In : Clinical Cancer Research. 24, 18, p. 4429-4436 8 p.

Research output: Contribution to journalArticle

Glioma
Isocitrate Dehydrogenase
Histology
Phenotype
Glioblastoma
8 Citations (Scopus)

Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p-JNK mediated hypertrophy and enhancing P-IGF1R, p-akt, and p-Badser136 activity and by fortifying NRF2 antioxidation system

Shibu, M. A., Kuo, C. H., Chen, B. C., Ju, D. T., Chen, R. J., Lai, C. H., Huang, P. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Feb 1 2018, In : Environmental Toxicology. 33, 2, p. 220-233

Research output: Contribution to journalArticle

tea
Tea
hypoxia
Cardiac Myocytes
Hypertrophy

Overexpression of IGF-IIRα regulates cardiac remodeling and aggravates high salt induced apoptosis and fibrosis in transgenic rats

Chang, R. L., Nithiyanantham, S., Kuo, W. W., Pai, P. Y., Chang, T. T., Lai, C. H., Chen, R. J., Vijaya Padma, V., Huang, C. Y. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

Transgenic Rats
apoptosis
Rats
Fibrosis
Salts
1 Citation (Scopus)
Gastrectomy
Coronary Disease
Morbid Obesity
Comorbidity
Diabetes Mellitus
9 Citations (Scopus)

Synergistic effect of HIF-1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition

Chen, Y. F., Pandey, S., Day, C. H., Chen, Y. F., Jiang, A. Z., Ho, T. J., Chen, R. J., Padma, V. V., Kuo, W. W. & Huang, C. Y., Apr 2018, In : Journal of Cellular Physiology. 233, 4, p. 3660-3671

Research output: Contribution to journalArticle

Cardiac Myocytes
Ischemia
Apoptosis
Glucose
Polymerase chain reaction
Amphotericin B
Drug Therapy
Neoplasms
Ethanol
Cinnamomum
14 Citations (Scopus)

The multifaceted link between inflammation and human diseases

Rajendran, P., Chen, Y. F., Chen, Y. F., Chung, L. C., Tamilselvi, S., Shen, C. Y., Day, C. H., Chen, R. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Inflammation
Tissue
Phagocytes
Lymphocytes
Macrophages
3 Citations (Scopus)

The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple-transgenic Alzheimer's disease model mice

Lin, K. H., Chiu, C. H., Kuo, W. W., Ju, D. T., Shen, C. Y., Chen, R. J., Lin, C. C., Viswanadha, V. P., Liu, J. S., Huang, R. F. S. & Huang, C. Y., Jan 2018, In : Environmental Toxicology. 33, 1, p. 83-92

Research output: Contribution to journalArticle

apoptosis
Folic Acid
Cardiac Myocytes
Alzheimer Disease
Apoptosis

Tumorous imaginal disc 1 (TID1) inhibits isoproterenol-induced cardiac hypertrophy and apoptosis by regulating c-terminus of hsc70-interacting protein (CHIP) mediated degradation of Gαs

Feng, C. C., Liao, P. H., Tsai, H. I., Cheng, S. M., Yang, L. Y., PadmaViswanadha, V., Pan, L. F., Chen, R. J., Lo, J. F. & Huang, C. Y., Jan 1 2018, In : International Journal of Medical Sciences. 15, 13, p. 1537-1546 10 p.

Research output: Contribution to journalArticle

HSC70 Heat-Shock Proteins
Imaginal Discs
Cardiomegaly
Isoproterenol
Proteolysis
2017
7 Citations (Scopus)

Alpinia oxyphylla Miq. fruit extract activates IGFR-PI3K/Akt signaling to induce Schwann cell proliferation and sciatic nerve regeneration

Chang, Y. M., Chang, H. H., Tsai, C. C., Lin, H. J., Ho, T. J., Ye, C. X., Chiu, P. L., Chen, Y. S., Chen, R. J., Huang, C. Y. & Lin, C. C., Mar 31 2017, In : BMC Complementary and Alternative Medicine. 17, 1, 184.

Research output: Contribution to journalArticle

Alpinia
Nerve Regeneration
Schwann Cells
Sciatic Nerve
Phosphatidylinositol 3-Kinases
5 Citations (Scopus)
gemcitabine
Chemotherapy
Tumor Burden
Pancreatic Neoplasms
Heterografts
Enterobacter cloacae
Carbapenems
Klebsiella pneumoniae
Taiwan
Intensive Care Units

Development of benzimidazole derivatives as novel anti-platelet drugs

Yao, W. C., Yuan, L. T., Yang, W. B., Hsia, C. H., Huang, L. T., Lee, T. Y., Sheu, J. R., Lu, W-J., Jayakumar, T. & Chen, R. J., Jan 1 2017, In : Current Pharmaceutical Biotechnology. 18, 7, p. 594-605 12 p.

Research output: Contribution to journalArticle

Thrombin
Blood Platelets
Platelet Aggregation
Pharmaceutical Preparations
Epinephrine
5 Citations (Scopus)

E2/ER β enhances calcineurin protein degradation and PI3k/Akt/MDM2 signal transduction to inhibit ISO-induced myocardial cell apoptosis

Lin, K. H., Kuo, W. W., Shibu, M. A., Day, C. H., Hsieh, Y. L., Chung, L. C., Chen, R. J., Wen, S. Y., Viswanadha, V. P. & Huang, C. Y., Apr 24 2017, In : International Journal of Molecular Sciences. 18, 4, 892.

Research output: Contribution to journalArticle

estrogens
Signal transduction
Calcineurin
apoptosis
Cell death
2 Citations (Scopus)

Elevated Phosphate Levels Trigger Autophagy-Mediated Cellular Apoptosis in H9c2 Cardiomyoblasts

Liu, Y. L., Lin, K. H., Tamilselvi, S., Chen, W. K., Shen, C. Y., Chen, R. J., Day, C. H., Wu, H. C., Viswanadha, V. P. & Huang, C. Y., Sep 30 2017, (Accepted/In press) In : CardioRenal Medicine. p. 31-40 10 p.

Research output: Contribution to journalArticle

Autophagy
Phosphates
Apoptosis
Fluorescein-5-isothiocyanate
Annexin A5
5 Citations (Scopus)

Enhancement of beta-catenin in cardiomyocytes suppresses survival protein expression but promotes apoptosis and fibrosis

Lin, J. C., Kuo, W. W., Baskaran, R., Chen, M. C., Ho, T. J., Chen, R. J., Chen, Y. F., Padma, V. V., Lay, I. S. & Huang, C. Y., 2017, In : Cardiology Journal. 24, 2, p. 195-205 11 p.

Research output: Contribution to journalArticle

Catenins
beta Catenin
Cardiac Myocytes
Fibrosis
Apoptosis
2 Citations (Scopus)

High density lipoprotein (HDL) reverses palmitic acid induced energy metabolism imbalance by switching CD36 and GLUT4 signaling pathways in cardiomyocyte

Wen, S. Y., Velmurugan, B. K., Day, C. H., Shen, C. Y., Chun, L. C., Tsai, Y. C., Lin, Y. M., Chen, R. J., Kuo, C. H. & Huang, C. Y., 2017, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Palmitic Acid
HDL Lipoproteins
Cardiac Myocytes
Energy Metabolism
Metabolic Networks and Pathways

How motorcycle helmets affect trauma mortality: Clinical and policy implications

Lee, J. L., Chen, T. C., Huang, H. C. & Chen, R. J., Aug 18 2017, In : Traffic Injury Prevention. 18, 6, p. 666-671 6 p.

Research output: Contribution to journalArticle

Motorcycles
Head Protective Devices
motorcycle
trauma
mortality
1 Citation (Scopus)

Identification of epidermal growth factor receptor-positive glioblastoma using lipid-encapsulated targeted superparamagnetic iron oxide nanoparticles in vitro

Chen, H. L., Hsu, F. T., Kao, Y. C. J., Liu, H. S., Huang, W. Z., Lu, C. F., Tsai, P. H., Ali, A. A. A., Lee, G. A., Chen, R. J. & Chen, C. Y., Nov 22 2017, In : Journal of Nanobiotechnology. 15, 1, 86.

Research output: Contribution to journalArticle

Glioblastoma
Iron oxides
Epidermal Growth Factor Receptor
Nanoparticles
Lipids
1 Citation (Scopus)
Diabetes Mellitus
Cohort Studies
Mortality
Odds Ratio
Population
3 Citations (Scopus)

Increased β-catenin accumulation and nuclear translocation are associated with concentric hypertrophy in cardiomyocytes

Lee, C. Y., Kuo, W. W., Baskaran, R., Day, C. H., Pai, P. Y., Lai, C. H., Chen, Y. F., Chen, R. J., Padma, V. V. & Huang, C. Y., Nov 1 2017, In : Cardiovascular Pathology. 31, p. 9-16 8 p.

Research output: Contribution to journalArticle

Catenins
Cardiac Myocytes
Hypertrophy
Infarction
Cardiomegaly
3 Citations (Scopus)

Inhibition of cardiac hypertrophy effects in d-galactose-induced senescent hearts by alpinate oxyphyllae fructus treatment

Chang, Y. M., Chang, H. H., Lin, H. J., Tsai, C. C., Tsai, C. T., Chang, H. N., Lin, S. L., Padmaviswanadha, V., Chen, R. J. & Huang, C. Y., 2017, In : Evidence-based Complementary and Alternative Medicine. 2017, 2624384.

Research output: Contribution to journalArticle

Cardiomegaly
Galactose
Hypertrophy
Alpinia
Physiological Phenomena
3 Citations (Scopus)

Interleukin 15 activates Akt to protect astrocytes from oxygen glucose deprivation-induced cell death

Lee, G. A., Lai, Y. G., Chen, R. J. & Liao, N. S., Apr 1 2017, In : Cytokine. 92, p. 68-74 7 p.

Research output: Contribution to journalArticle

Interleukin-15
Cell death
Astrocytes
Cell Death
Oxygen

Lactobacillus paracasei GMNL-32 exerts a therapeutic effect on cardiac abnormalities in NZB/W F1 mice

Hu, W. S., Rajendran, P., Tzang, B. S., Yeh, Y. L., Shen, C. Y., Chen, R. J., Ho, T. J., Padma, V. V., Chen, Y. H. & Huang, C. Y., Sep 1 2017, In : PLoS One. 12, 9, e0185098.

Research output: Contribution to journalArticle

Lactobacillus paracasei
Inbred NZB Mouse
Therapeutic Uses
Systemic Lupus Erythematosus
lupus erythematosus
5 Citations (Scopus)

Licochalcone a prevents platelet activation and thrombus formation through the inhibition of PLCγ2-PKC, Akt, and MAPK pathways

Lien, L. M., Lin, K. H., Huang, L. T., Tseng, M. F., Chiu, H. C., Chen, R. J. & Lu, W. J., Jul 12 2017, In : International Journal of Molecular Sciences. 18, 7, 1500.

Research output: Contribution to journalArticle

Platelet Activation
Platelets
platelets
Thrombosis
Chemical activation
2 Citations (Scopus)

Major pancreatic duct continuity is the crucial determinant in the management of blunt pancreatic injury: a pancreatographic classification

Lin, B. C., Wong, Y-C., Chen, R. J., Liu, N. J., Wu, C. H., Hwang, T. L. & Hsu, Y. P., Mar 9 2017, (Accepted/In press) In : Surgical Endoscopy and Other Interventional Techniques. p. 1-10 10 p.

Research output: Contribution to journalArticle

Nonpenetrating Wounds
Pancreatic Ducts
Wounds and Injuries
Pancreatectomy
Splenectomy
12 Citations (Scopus)

Prostaglandin E2-induced COX-2 expressions via EP2 and EP4 signaling pathways in human LoVo colon cancer cells

Hsu, H. H., Lin, Y. M., Shen, C. Y., Shibu, M. A., Li, S. Y., Chang, S. H., Lin, C. C., Chen, R. J., Viswanadha, V. P., Shih, H. N. & Huang, C. Y., Jun 1 2017, In : International Journal of Molecular Sciences. 18, 6, A1132.

Research output: Contribution to journalArticle

prostaglandins
Dinoprostone
Colonic Neoplasms
cancer
Cells
1 Citation (Scopus)

Protective effect of HDL on NADPH oxidase-derived super oxide anion mediates hypoxia-induced cardiomyocyte apoptosis

Wen, S. Y., Tamilselvi, S., Shen, C. Y., Day, C. H., Chun, L. C., Cheng, L. Y., Ou, H. C., Chen, R. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Jun 1 2017, In : PLoS One. 12, 6, e0179492.

Research output: Contribution to journalArticle

NADPH Oxidase
high density lipoprotein
HDL Lipoproteins
Cardiac Myocytes
superoxide anion
6 Citations (Scopus)

Relation of polymorphism of arsenic metabolism genes to arsenic methylation capacity and developmental delay in preschool children in Taiwan

Hsieh, R. L., Su, C. T., Shiue, H. S., Chen, W. J., Huang, S. R., Lin, Y. C., Lin, M. I., Mu, S. C., Chen, R. J. & Hsueh, Y. M., Apr 15 2017, In : Toxicology and Applied Pharmacology. 321, p. 37-47 11 p.

Research output: Contribution to journalArticle

Methylation
Arsenic
Preschool Children
Polymorphism
Taiwan
3 Citations (Scopus)
national surveys
antineoplaston A10
Spinal Cord Injuries
Taiwan
spinal cord
4 Citations (Scopus)

Tanshinone IIA inhibits β-catenin nuclear translocation and IGF-2R activation via estrogen receptors to suppress angiotensin II-induced H9c2 cardiomyoblast cell apoptosis

Chen, Y. F., Day, C. H., Lee, N. H., Chen, Y. F., Yang, J. J., Lin, C. H., Chen, R. J., Rajendran, P., Viswanadha, V. P. & Huang, C. Y., Sep 30 2017, In : International Journal of Medical Sciences. 14, 12, p. 1284-1291 8 p.

Research output: Contribution to journalArticle

IGF Type 2 Receptor
Catenins
Angiotensin II
Estrogen Receptors
Apoptosis