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Research Output

  • 3470 Citations
  • 18 h-Index
  • 47 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Editorial
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Article
2020
Open Access

Sorafenib inhibits ribonucleotide reductase regulatory subunit M2 (RRM2) in hepatocellular carcinoma cells

Yang, P. M., Lin, L. S. & Liu, T. P., Jan 2020, In : Biomolecules. 10, 1, 117.

Research output: Contribution to journalArticle

Open Access
2019
Open Access
2 Citations (Scopus)

Characterization of Fibrinogen as a Key Modulator in Patients with Wilson's Diseases with Functional Proteomic Tools

Wang, P. W., Lin, T. Y., Hung, Y. C., Chang, W. N., Yang, P. M., Chen, M. H., Yeh, C. T. & Pan, T. L., Sep 12 2019, In : International Journal of Molecular Sciences. 20, 18

Research output: Contribution to journalArticle

Open Access

Comparison of the biological impact of UVA and UVB upon the skin with functional proteomics and immunohistochemistry

Wang, P. W., Hung, Y. C., Lin, T. Y., Fang, J. Y., Yang, P. M., Chen, M. H. & Pan, T. L., Dec 2019, In : Antioxidants. 8, 12, 569.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Differential effect of herbal tea extracts on free fatty acids-, ethanol- and acetaminophen-induced hepatotoxicity in FL83B hepatocytes

Chen, G. W., Chen, T. Y. & Yang, P. M., Jan 1 2019, (Accepted/In press) In : Drug and Chemical Toxicology.

Research output: Contribution to journalArticle

Open Access
Open Access

In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells

Chen, J. C., Hsieh, Y. Y., Lo, H. L., Li, A., Chou, C. J. & Yang, P. M., Sep 9 2019, In : Biomolecules. 9, 9

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining

Liu, T. P., Hsieh, Y. Y., Chou, C. J. & Yang, P. M., Nov 1 2018, In : Royal Society Open Science. 5, 11, 181321.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Ten-eleven translocation 1 (TET1) gene is a potential target of miR-21-5p in human colorectal cancer

Cheng, Y. W., Chou, C. J. & Yang, P. M., Mar 1 2018, In : Surgical Oncology. 27, 1, p. 76-81 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2017
16 Citations (Scopus)

In silico and in vitro identification of inhibitory activities of sorafenib on histone deacetylases in hepatocellular carcinoma cells

Liu, T. P., Hong, Y. H. & Yang, P. M., Oct 17 2017, In : Oncotarget. 8, 49, p. 86168-86180 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The Chinese Herbal Mixture Tien-Hsien Liquid Augments the Anticancer Immunity in Tumor Cell-Vaccinated Mice

Yang, P. M., Du, J. L., Wang, G. N. K., Chia, J. S., Hsu, W. B., Pu, P. C., Sun, A., Chiang, C. P. & Wang, W. B., Sep 1 2017, In : Integrative Cancer Therapies. 16, 3, p. 319-328 10 p.

Research output: Contribution to journalArticle

2016
17 Citations (Scopus)
6 Citations (Scopus)
9 Citations (Scopus)
11 Citations (Scopus)

Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: Identification of functional disparities between azacytidine and decitabine

Hsieh, Y. Y., Huang, T. C., Lo, H. L., Jhan, J. Y., Chen, S. T. & Yang, P. M., May 10 2016, In : Oncotarget. 7, 19, p. 27363-27378 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2015

Autophagic effect of SAM-competitive EZH2 inhibitors on cancer cells

Liu, T. P. & Yang, P-M., 2015, In : Cancer Cell & Microenvironment. 2, p. e551-e551

Research output: Contribution to journalArticle

34 Citations (Scopus)

S-adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells

Liu, T. P., Lo, H. L., Wei, L. S., Hsiao, H. H. Y. & Yang, P. M., 2015, In : Anti-Cancer Drugs. 26, 2, p. 139-147 9 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2014

A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine

Lee, K. H., Lo, H. L., Tang, W. C., Hsiao, H. H. Y. & Yang, P. M., 2014, In : Scientific Reports. 4, 6394.

Research output: Contribution to journalArticle

29 Citations (Scopus)

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine

Tsai, C. T., Yang, P. M., Chern, T. R., Chuang, S. H., Lin, J. H., Klemm, L., Müschen, M. & Chen, C. C., 2014, In : Oncotarget. 5, 1, p. 211-223 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells

Huang, Y. H., Yang, P. M., Chuah, Q. Y., Lee, Y. J., Hsieh, Y. F., Peng, C. W. & Chiu, S. J., 2014, In : Autophagy. 10, 7, p. 1212-1228 17 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Radiation induces senescence and a bystander effect through metabolic alterations.

Liao, E. C., Hsu, Y. T., Chuah, Q. Y., Lee, Y. J., Hu, J. Y., Huang, T. C., Yang, P. M. & Chiu, S. J., 2014, In : Cell Death and Disease. 5

Research output: Contribution to journalArticle

41 Citations (Scopus)
2013

Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways

Yu, Y. C., Yang, P. M., Chuah, Q. Y., Huang, Y. H., Peng, C. W., Lee, Y. J. & Chiu, S. J., 2013, In : Scientific Reports. 3, 1675.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Upregulation of endocan by epstein-barr virus latent membrane protein 1 and its clinical significance in nasopharyngeal Carcinoma

Yu, P. H., Chou, S. F., Chen, C. L., Hung, H., Lai, C. Y., Yang, P. M., Jeng, Y. M., Liaw, S. F., Kuo, H. H., Hsu, H. C., Chen, J. Y. & Wang, W. B., Dec 5 2013, In : PLoS One. 8, 12, e82254.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress

Yang, P. M., Lin, Y. T., Shun, C. T., Lin, S. H., Wei, T. T., Chuang, S. H., Wu, M. S. & Chen, C. C., Nov 14 2013, In : Scientific Reports. 3, 3219.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2012

CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1

Yang, P. M., Lin, P. J. & Chen, C. C., Apr 2012, In : Epigenetics. 7, 4, p. 390-399 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy

Yang, P. M., Tseng, H. H., Peng, C. W., Chen, W. S. & Chiu, S. J., Feb 2012, In : International Journal of Oncology. 40, 2, p. 469-478 10 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Securin enhances the anti-cancer effects of 6-methoxy-3-(3′,4′,5′-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells

Tseng, H. H., Chuah, Q. Y., Yang, P. M., Chen, C. T., Chao, J. C., Lin, M. D. & Chiu, S. J., Apr 26 2012, In : PLoS One. 7, 4, e36006.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2011

Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2

Huang, W. Y., Yang, P. M., Chang, Y. F., Marquez, V. E. & Chen, C. C., Feb 15 2011, In : Biochemical Pharmacology. 81, 4, p. 510-517 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Securin depletion sensitizes human colon cancer cells to fisetin-induced apoptosis

Yu, S. H., Yang, P. M., Peng, C. W., Yu, Y. C. & Chiu, S. J., Jan 1 2011, In : Cancer Letters. 300, 1, p. 96-104 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2010

Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma

Liu, Y. L., Yang, P. M., Shun, C. T., Wu, M. S., Weng, J. R. & Chen, C. C., Nov 16 2010, In : Autophagy. 6, 8, p. 1057-1065 9 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies

Yang, P. M., Liu, Y. L., Lin, Y. C., Shun, C. T., Wu, M. S. & Chen, C. C., Oct 1 2010, In : Cancer Research. 70, 19, p. 7699-7709 11 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)

Inhibition of histone deacetylase activity is a novel function of the antifolate drug methotrexate

Yang, P. M., Lin, J. H., Huang, W. Y., Lin, Y. C., Yeh, S. H. & Chen, C. C., Jan 15 2010, In : Biochemical and Biophysical Research Communications. 391, 3, p. 1396-1399 4 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Loss of IKKβ activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis

Yang, P. M., Huang, W. C., Lin, Y. C., Huang, W. Y., Wu, H. A., Chen, W. L., Chang, Y. F., Chou, C. W., Tzeng, C. C., Chen, Y. L. & Chen, C. C., Mar 2010, In : Journal of Cellular and Molecular Medicine. 14, 3, p. 687-698 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2009

Attenuation of cadmium-induced necrotic cell death by necrostatin-1: Potential necrostatin-1 acting sites

Hsu, T. S., Yang, P. M., Tsai, J. S. & Lin, L. Y., Mar 1 2009, In : Toxicology and Applied Pharmacology. 235, 2, p. 153-162 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Comparison of organic and inorganic germanium compounds in cellular radiosensitivity and preparation of germanium nanoparticles as a radiosensitizer

Lin, M. H., Hsu, T. S., Yang, P. M., Tsai, M. Y., Perng, T. P. & Lin, L. Y., Mar 2009, In : International Journal of Radiation Biology. 85, 3, p. 214-226 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2008

實證醫學操作應用常見問題探討-分析2007年實證醫學文獻查證應用競賽資料

Lo, H. L., Chiu, Y-W., Kuo, K. N., Shen, WH., Yang, P-M., Chen, C-F., Hsiao, SY. & 廖熏香, 2008, In : 醫療品質雜誌. 2, 4, p. 89-93 5 p.

Research output: Contribution to journalArticle

2007
56 Citations (Scopus)
2005

Differential effects of salen and manganese-salen complex (EUK-8) on the regulation of cellular cadmium uptake and toxicity

Yang, P. M., Chiu, S. J. & Lin, L. Y., May 2005, In : Toxicological Sciences. 85, 1, p. 551-559 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2004

Effect of cadmium on cell cycle progression in chinese hamster ovary cells

Yang, P. M., Chiu, S. J., Lin, K. A. & Lin, L. Y., Oct 15 2004, In : Chemico-Biological Interactions. 149, 2-3, p. 125-136 12 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)