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Research Output 2004 2019

  • 3253 Citations
  • 17 h-Index
  • 39 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Editorial
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Article
2019

Characterization of Fibrinogen as a Key Modulator in Patients with Wilson's Diseases with Functional Proteomic Tools

Wang, P. W., Lin, T. Y., Hung, Y. C., Chang, W. N., Yang, P. M., Chen, M. H., Yeh, C. T. & Pan, T. L., Sep 12 2019, In : International Journal of Molecular Sciences. 20, 18

Research output: Contribution to journalArticle

Open Access
fibrinogen
Hepatolenticular Degeneration
Proteomics
Fibrinogen
Modulators
Pituitary Neoplasms
Oncogenes
Renal Cell Carcinoma
Computer Simulation
Neoplasms
Open Access
gemcitabine
Computational Biology
Cell Cycle
Adenocarcinoma
Therapeutics

In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells

Chen, J. C., Hsieh, Y. Y., Lo, H. L., Li, A., Chou, C. J. & Yang, P. M., Sep 9 2019, In : Biomolecules. 9, 9

Research output: Contribution to journalArticle

Open Access
Drug Resistance
Computer Simulation
Colorectal Neoplasms
Etoposide
Topoisomerase Inhibitors
2018
2 Citations (Scopus)

Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining

Liu, T. P., Hsieh, Y. Y., Chou, C. J. & Yang, P. M., Nov 1 2018, In : Royal Society Open Science. 5, 11, 181321.

Research output: Contribution to journalArticle

Polypharmacology
Drug Repositioning
Databases
Pharmaceutical Preparations
Topoisomerase Inhibitors
7 Citations (Scopus)

Ten-eleven translocation 1 (TET1) gene is a potential target of miR-21-5p in human colorectal cancer

Cheng, Y. W., Chou, C. J. & Yang, P. M., Mar 1 2018, In : Surgical Oncology. 27, 1, p. 76-81 6 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
5-Methylcytosine
Genes
3' Untranslated Regions
DNA Methylation
2017
14 Citations (Scopus)
Apigenin
Computational Biology
Uterine Cervical Neoplasms
Interferon-gamma
Squamous Cell Carcinoma
2 Citations (Scopus)

In silico and in vitro identification of inhibitory activities of sorafenib on histone deacetylases in hepatocellular carcinoma cells

Liu, T. P., Hong, Y. H. & Yang, P. M., Oct 17 2017, In : Oncotarget. 8, 49, p. 86168-86180 13 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Computer Simulation
Hepatocellular Carcinoma
Polypharmacology
Histone Deacetylase Inhibitors

The Chinese Herbal Mixture Tien-Hsien Liquid Augments the Anticancer Immunity in Tumor Cell-Vaccinated Mice

Yang, P. M., Du, J. L., Wang, G. N. K., Chia, J. S., Hsu, W. B., Pu, P. C., Sun, A., Chiang, C. P. & Wang, W. B., Sep 1 2017, In : Integrative Cancer Therapies. 16, 3, p. 319-328 10 p.

Research output: Contribution to journalArticle

Immunity
Neoplasms
Natural Killer Cells
Cytotoxic T-Lymphocytes
Colonic Neoplasms
2016
15 Citations (Scopus)
Unfolded Protein Response
Autophagy
Colorectal Neoplasms
Up-Regulation
Endoplasmic Reticulum Stress
6 Citations (Scopus)
AT-Hook Motifs
HSP90 Heat-Shock Proteins
Epithelial-Mesenchymal Transition
Hooks
colorectal neoplasms
9 Citations (Scopus)
Metallothionein
Computer Simulation
Hepatocellular Carcinoma
Genes
Therapeutics
10 Citations (Scopus)
Cyclin-Dependent Kinases
Colorectal Neoplasms
Diphosphates
Deoxyribonucleosides
Ribonucleosides
5 Citations (Scopus)

Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: Identification of functional disparities between azacytidine and decitabine

Hsieh, Y. Y., Huang, T. C., Lo, H. L., Jhan, J. Y., Chen, S. T. & Yang, P. M., May 10 2016, In : Oncotarget. 7, 19, p. 27363-27378 16 p.

Research output: Contribution to journalArticle

decitabine
Azacitidine
Drug Discovery
Genomics
Polypharmacology
2015

Autophagic effect of SAM-competitive EZH2 inhibitors on cancer cells

Liu, T. P. & Yang, P-M., 2015, In : Cancer Cell & Microenvironment. 2, p. e551-e551

Research output: Contribution to journalArticle

S-Adenosylmethionine
Autophagy
Neoplasms
Epigenomics
Enhancer of Zeste Homolog 2 Protein
29 Citations (Scopus)
Berberine
Epithelial-Mesenchymal Transition
Prostatic Neoplasms
Genes
Neoplasm Metastasis
27 Citations (Scopus)

S-adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells

Liu, T. P., Lo, H. L., Wei, L. S., Hsiao, H. H. Y. & Yang, P. M., 2015, In : Anti-Cancer Drugs. 26, 2, p. 139-147 9 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Autophagy
Pharmaceutical Preparations
Neoplasms
Antineoplastic Agents
2014
27 Citations (Scopus)

A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine

Lee, K. H., Lo, H. L., Tang, W. C., Hsiao, H. H. Y. & Yang, P. M., 2014, In : Scientific Reports. 4, 6394.

Research output: Contribution to journalArticle

Berberine
Herbal Medicine
Transcriptome
Histone Deacetylases
Sirolimus
7 Citations (Scopus)

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine

Tsai, C. T., Yang, P. M., Chern, T. R., Chuang, S. H., Lin, J. H., Klemm, L., Müschen, M. & Chen, C. C., 2014, In : Oncotarget. 5, 1, p. 211-223 13 p.

Research output: Contribution to journalArticle

Deoxycytidine
Down-Regulation
pyrimidin-2-one beta-ribofuranoside
AICDA (activation-induced cytidine deaminase)
Neoplasms
26 Citations (Scopus)

Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells

Huang, Y. H., Yang, P. M., Chuah, Q. Y., Lee, Y. J., Hsieh, Y. F., Peng, C. W. & Chiu, S. J., 2014, In : Autophagy. 10, 7, p. 1212-1228 17 p.

Research output: Contribution to journalArticle

Bystander Effect
Autophagy
Radiation
Breast Neoplasms
Neoplasms
41 Citations (Scopus)

Radiation induces senescence and a bystander effect through metabolic alterations.

Liao, E. C., Hsu, Y. T., Chuah, Q. Y., Lee, Y. J., Hu, J. Y., Huang, T. C., Yang, P. M. & Chiu, S. J., 2014, In : Cell Death and Disease. 5

Research output: Contribution to journalArticle

Bystander Effect
Radiation
Glycolysis
Lactic Acid
Anaphase
2013
38 Citations (Scopus)

Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways

Yu, Y. C., Yang, P. M., Chuah, Q. Y., Huang, Y. H., Peng, C. W., Lee, Y. J. & Chiu, S. J., 2013, In : Scientific Reports. 3, 1675.

Research output: Contribution to journalArticle

Securin
Platelet-Derived Growth Factor Receptors
Interleukin-6
Conditioned Culture Medium
Radiation
13 Citations (Scopus)

Upregulation of endocan by epstein-barr virus latent membrane protein 1 and its clinical significance in nasopharyngeal Carcinoma

Yu, P. H., Chou, S. F., Chen, C. L., Hung, H., Lai, C. Y., Yang, P. M., Jeng, Y. M., Liaw, S. F., Kuo, H. H., Hsu, H. C., Chen, J. Y. & Wang, W. B., Dec 5 2013, In : PLoS One. 8, 12, e82254.

Research output: Contribution to journalArticle

Human herpesvirus 4
membrane proteins
carcinoma
Membrane Proteins
Up-Regulation
45 Citations (Scopus)

Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress

Yang, P. M., Lin, Y. T., Shun, C. T., Lin, S. H., Wei, T. T., Chuang, S. H., Wu, M. S. & Chen, C. C., Nov 14 2013, In : Scientific Reports. 3, 3219.

Research output: Contribution to journalArticle

pyrimidin-2-one beta-ribofuranoside
Endoplasmic Reticulum Stress
Colorectal Neoplasms
Carcinogenesis
Unfolded Protein Response
2012
15 Citations (Scopus)

CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1

Yang, P. M., Lin, P. J. & Chen, C. C., Apr 2012, In : Epigenetics. 7, 4, p. 390-399 10 p.

Research output: Contribution to journalArticle

trichostatin A
Histone Deacetylase Inhibitors
Luciferases
Neoplasms
Acetylation
58 Citations (Scopus)

Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy

Yang, P. M., Tseng, H. H., Peng, C. W., Chen, W. S. & Chiu, S. J., Feb 2012, In : International Journal of Oncology. 40, 2, p. 469-478 10 p.

Research output: Contribution to journalArticle

Caspase 7
MCF-7 Cells
Autophagy
Flavonoids
Caspase 3
9 Citations (Scopus)

Securin enhances the anti-cancer effects of 6-methoxy-3-(3′,4′,5′-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells

Tseng, H. H., Chuah, Q. Y., Yang, P. M., Chen, C. T., Chao, J. C., Lin, M. D. & Chiu, S. J., Apr 26 2012, In : PLoS One. 7, 4, e36006.

Research output: Contribution to journalArticle

Securin
indoles
colorectal neoplasms
cell death
Colorectal Neoplasms
2011
32 Citations (Scopus)

Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2

Huang, W. Y., Yang, P. M., Chang, Y. F., Marquez, V. E. & Chen, C. C., Feb 15 2011, In : Biochemical Pharmacology. 81, 4, p. 510-517 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cadherins
Methotrexate
Down-Regulation
Apoptosis
25 Citations (Scopus)

Securin depletion sensitizes human colon cancer cells to fisetin-induced apoptosis

Yu, S. H., Yang, P. M., Peng, C. W., Yu, Y. C. & Chiu, S. J., Jan 1 2011, In : Cancer Letters. 300, 1, p. 96-104 9 p.

Research output: Contribution to journalArticle

Securin
Colonic Neoplasms
Apoptosis
Null Lymphocytes
HCT116 Cells
2010
128 Citations (Scopus)

Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma

Liu, Y. L., Yang, P. M., Shun, C. T., Wu, M. S., Weng, J. R. & Chen, C. C., Nov 16 2010, In : Autophagy. 6, 8, p. 1057-1065 9 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Autophagy
Hepatocellular Carcinoma
Neoplasms
Tumor Suppressor Genes
100 Citations (Scopus)

Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies

Yang, P. M., Liu, Y. L., Lin, Y. C., Shun, C. T., Wu, M. S. & Chen, C. C., Oct 1 2010, In : Cancer Research. 70, 19, p. 7699-7709 11 p.

Research output: Contribution to journalArticle

Autophagy
AMP-Activated Protein Kinases
Neoplasms
Endoplasmic Reticulum Stress
Hepatocellular Carcinoma
14 Citations (Scopus)

Inhibition of histone deacetylase activity is a novel function of the antifolate drug methotrexate

Yang, P. M., Lin, J. H., Huang, W. Y., Lin, Y. C., Yeh, S. H. & Chen, C. C., Jan 15 2010, In : Biochemical and Biophysical Research Communications. 391, 3, p. 1396-1399 4 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Histone Deacetylases
Methotrexate
Pharmaceutical Preparations
Histone Deacetylase Inhibitors
17 Citations (Scopus)

Loss of IKKβ activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis

Yang, P. M., Huang, W. C., Lin, Y. C., Huang, W. Y., Wu, H. A., Chen, W. L., Chang, Y. F., Chou, C. W., Tzeng, C. C., Chen, Y. L. & Chen, C. C., Mar 2010, In : Journal of Cellular and Molecular Medicine. 14, 3, p. 687-698 12 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Apoptosis
Small Interfering RNA
Neoplasms
Protein Stability
2009
22 Citations (Scopus)

Attenuation of cadmium-induced necrotic cell death by necrostatin-1: Potential necrostatin-1 acting sites

Hsu, T. S., Yang, P. M., Tsai, J. S. & Lin, L. Y., Mar 1 2009, In : Toxicology and Applied Pharmacology. 235, 2, p. 153-162 10 p.

Research output: Contribution to journalArticle

Cell death
Cadmium
Cell Death
Necrosis
U937 Cells
32 Citations (Scopus)

Comparison of organic and inorganic germanium compounds in cellular radiosensitivity and preparation of germanium nanoparticles as a radiosensitizer

Lin, M. H., Hsu, T. S., Yang, P. M., Tsai, M. Y., Perng, T. P. & Lin, L. Y., Mar 2009, In : International Journal of Radiation Biology. 85, 3, p. 214-226 13 p.

Research output: Contribution to journalArticle

Germanium
Radiation Tolerance
Nanoparticles
Comet Assay
DNA Damage
2008

實證醫學操作應用常見問題探討-分析2007年實證醫學文獻查證應用競賽資料

Lo, H. L., Chiu, Y-W., Kuo, K. N., Shen, WH., Yang, P-M., Chen, C-F., Hsiao, SY. & 廖熏香, 2008, In : 醫療品質雜誌. 2, 4, p. 89-93 5 p.

Research output: Contribution to journalArticle

2007
54 Citations (Scopus)
Calpain
Depolarization
Cell death
Cadmium
Reactive Oxygen Species
2005
10 Citations (Scopus)

Differential effects of salen and manganese-salen complex (EUK-8) on the regulation of cellular cadmium uptake and toxicity

Yang, P. M., Chiu, S. J. & Lin, L. Y., May 2005, In : Toxicological Sciences. 85, 1, p. 551-559 9 p.

Research output: Contribution to journalArticle

Cadmium
Toxicity
Cytotoxicity
Cells
Reactive Oxygen Species
2004
49 Citations (Scopus)

Effect of cadmium on cell cycle progression in chinese hamster ovary cells

Yang, P. M., Chiu, S. J., Lin, K. A. & Lin, L. Y., Oct 15 2004, In : Chemico-Biological Interactions. 149, 2-3, p. 125-136 12 p.

Research output: Contribution to journalArticle

Cricetulus
Cadmium
Ovary
Cell Cycle
Cells