• 1589 Citations
  • 26 h-Index
20002020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 1589 Citations
  • 26 h-Index
  • 59 Article
  • 1 Poster
  • 1 Review article
2020

Lovastatin-mediated MCF-7 cancer cell death involves LKB1-AMPK-p38MAPK-p53-survivin signalling cascade

Huang, S. W., Chyuan, I. T., Shiue, C., Yu, M. C., Hsu, Y. F. & Hsu, M. J., Jan 1 2020, In : Journal of Cellular and Molecular Medicine. 24, 2, p. 1822-1836 15 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2019

A novel 2-aminobenzimidazole-based compound Jzu 17 exhibits anti-angiogenesis effects by targeting VEGFR-2 signalling

Lien, J. C., Chung, C. L., Huang, T. F., Chang, T. C., Chen, K. C., Gao, G. Y., Hsu, M. J. & Huang, S. W., Oct 1 2019, In : British Journal of Pharmacology. 176, 20, p. 4034-4049 16 p.

Research output: Contribution to journalArticle

WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin Signaling Cascade

Huang, S. W., Yang, H. Y., Huang, W. J., Chen, W. C., Yu, M. C., Wang, S. W., Hsu, Y. F. & Hsu, M. J., Nov 6 2019, In : Frontiers in Oncology. 9, 1188.

Research output: Contribution to journalArticle

Open Access
2018

A novel hydroxamate-based compound WMJ-J-09 causes head and neck squamous cell carcinoma cell death via LKB1-AMPK-p38MAPK-p63-survivin cascade

Yen, C. S., Choy, C. S., Huang, W. J., Huang, S. W., Lai, P. Y., Yu, M. C., Shiue, C., Hsu, Y. F. & Hsu, M. J., Mar 1 2018, In : Frontiers in Pharmacology. 9, MAR, p. 1-17 17 p., 167.

Research output: Contribution to journalArticle

2 Citations (Scopus)

CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation

Sheu, J. R., Chen, Z. C., Hsu, M. J., Wang, S. H., Jung, K. W., Wu, W. F., Pan, S. H., Teng, R. D., Yang, C. H. & Hsieh, C. Y., Feb 1 2018, In : Journal of Cellular and Molecular Medicine. 22, 2, p. 999-1013 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2017

Ketamine, a clinically used anesthetic, inhibits vascular smooth muscle cell proliferation via PP2A-activated PI3K/Akt/ERK inhibition

Chang, Y., Li, J. Y., Jayakumar, T., Hung, S. H., Lee, W. C., Manubolu, M., Sheu, J. R. & Hsu, M. J., Dec 1 2017, In : International Journal of Molecular Sciences. 18, 12, 2545.

Research output: Contribution to journalArticle

5 Citations (Scopus)

WMJ-8-B, a novel hydroxamate derivative, induces MDA-MB-231 breast cancer cell death via the SHP-1-STAT3-survivin cascade

Chuang, Y. F., Huang, S. W., Hsu, Y. F., Yu, M. C., Ou, G., Huang, W. J. & Hsu, M. J., 2017, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2016
30 Citations (Scopus)

Interleukin-6 induces vascular endothelial growth factor-C expression via Src-FAK-STAT3 signaling in lymphatic endothelial cells

Huang, Y. H., Yang, H. Y., Huang, S. W., Ou, G., Hsu, Y. F. & Hsu, M. J., Jul 1 2016, In : PLoS One. 11, 7, e0158839.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade

Yen, C. S., Chen, J. C., Chang, Y. F., Hsu, Y. F., Chiu, P. T., Shiue, C., Chuang, Y. F., Ou, G. & Hsu, M. J., Apr 28 2016, In : Scientific Reports. 6, 25082.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Synthesis and biological evaluation of lovastatin-derived aliphatic hydroxamates that induce reactive oxygen species

Lin, R. K., Lin, Y. F., Hsu, M. J., Hsieh, C. L., Wang, C. Y., Huang, C. C. & Huang, W. J., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5528-5533 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

Antiproliferative activity of hinokitiol, a tropolone derivative, is mediated via the inductions of p-JNK and p-PLCγ1 signaling in PDGF-BB-Stimulated vascular smooth muscle cells

Yang, P. S., Wang, M. J., Jayakumar, T., Chou, D. S., Ko, C. Y., Hsu, M. J. & Hsieh, C. Y., May 1 2015, In : Molecules. 20, 5, p. 8198-8212 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Protein phosphatase 2A in lipopolysaccharide-induced cyclooxygenase-2 expression in murine lymphatic endothelial cells

Chuang, Y. F., Chen, M. C., Huang, S. W., Hsu, Y. F., Ou, G., Tsai, Y. J. & Hsu, M. J., Aug 28 2015, In : PLoS One. 10, 8, e0137177.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death

Huang, Y. H., Huang, S. W., Hsu, Y. F., Ou, G., Huang, W. J. & Hsu, M. J., Oct 29 2015, In : Scientific Reports. 5, 15900.

Research output: Contribution to journalArticle

6 Citations (Scopus)

WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-angiogenic activities via Src-homology-2-domaincontaining protein tyrosine phosphatase 1

Chang, Y. F., Hsu, Y. F., Chiu, P. T., Huang, W. J., Huang, S. W., Ou, G., Sheu, J. R. & Hsu, M. J., 2015, In : Oncotarget. 6, 1, p. 85-100 16 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-inflammatory properties via MKP-1 in LPS-stimulated RAW264.7 macrophages

Chen, W. C., Yen, C. S., Huang, W. J., Hsu, Y. F., Ou, G. & Hsu, M. J., 2015, In : British Journal of Pharmacology. 172, 7, p. 1894-1908 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2014

Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade

Chen, Y. Y., Hsieh, C. Y., Jayakumar, T., Lin, K. H., Chou, D. S., Lu, W-J., Hsu, M. J. & Sheu, J. R., Jul 10 2014, In : Scientific Reports. 4, 5651.

Research output: Contribution to journalArticle

23 Citations (Scopus)
14 Citations (Scopus)
9 Citations (Scopus)

Src contributes to IL6-induced vascular endothelial growth factor-C expression in lymphatic endothelial cells

Huang, Y. H., Yang, H-Y., Hsu, Y. F., Chiu, P. T., Ou, G. & Hsu, M-J., Apr 1 2014, In : Angiogenesis. 17, 2, p. 407-418 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells

Chuang, Y. F., Yang, H. Y., Ko, T. L., Hsu, Y. F., Sheu, J. R., Ou, G. & Hsu, M. J., Apr 1 2014, In : Biochemical Pharmacology. 88, 3, p. 372-383 12 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2013
21 Citations (Scopus)

Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: Targeting vascular endothelial growth factor receptor signaling and angiogenesis

Yang, H. Y., Hsu, Y. F., Chiu, P. T., Ho, S. J., Wang, C. H., Chi, H. N., Huang, Y. H., Lee, C. F., Li, Y. S., Ou, G. & Hsu, M. J., Nov 27 2013, In : PLoS One. 8, 11, e81592.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Denbinobin induces human glioblastoma multiforme cell apoptosis through the IKKα-Akt-FKHR signaling cascade

Weng, H. Y., Hsu, M. J., Chen, C. C., Chen, B. C., Hong, C. Y., Teng, C. M., Pan, S. L., Chiu, W. T. & Lin, C. H., Jan 5 2013, In : European Journal of Pharmacology. 698, 1-3, p. 103-109 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade

Chang, H. L., Chen, C. Y., Hsu, Y. F., Kuo, W. S., Ou, G., Chiu, P. T., Huang, Y. H. & Hsu, M. J., 2013, In : Biochimica et Biophysica Acta - General Subjects. 1830, 8, p. 4053-4064 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Thrombin-induced CCN2 expression in human lung fibroblasts requires the c-Src/ JAK2/STAT3 pathway

Bai, K. J., Chen, B. C., Pai, H. C., Weng, C. M., Yu, C. C., Hsu, M. J., Yu, M. C., Ma, H. P., Wu, C. H., Hong, C. Y., Kuo, M. L. & Lin, C. H., Jan 2013, In : Journal of Leukocyte Biology. 93, 1, p. 101-112 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2012

Antihyperglycemic and antioxidant effects of a flavanone, naringenin, in streptozotocin-nicotinamide-induced experimental diabetic rats

Annadurai, T., Muralidharan, A. R., Joseph, T., Hsu, M. J., Thomas, P. A. & Geraldine, P., Sep 2012, In : Journal of Physiology and Biochemistry. 68, 3, p. 307-318 12 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)
8 Citations (Scopus)
45 Citations (Scopus)

Thrombin induced connective tissue growth factor expression in rat vascular smooth muscle cells via the PAR-1/JNK/AP-1 pathway

Ko, W. C., Chen, B. C., Hsu, M. J., Tsai, C. T., Hong, C. Y. & Lin, C. H., Jan 2012, In : Acta Pharmacologica Sinica. 33, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells

Hsu, Y. F., Sheu, J. R., Lin, C-H., Yang, D. S., Hsiao, G., Ou, G., Chiu, P. T., Huang, Y. H., Kuo, W. H. & Hsu, M. J., Feb 2012, In : Biochimica et Biophysica Acta - General Subjects. 1820, 2, p. 104-115 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
29 Citations (Scopus)
2011

Andrographolide enhances nuclear factor-κB subunit p65 Ser 536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells

Hsieh, C. Y., Hsu, M. J., Hsiao, G., Wang, Y. H., Huang, C. W., Chen, S. W., Jayakumar, T., Chiu, P. T., Chiu, Y. H. & Sheu, J. R., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 5942-5955 14 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
14 Citations (Scopus)
1 Citation (Scopus)

Molecular mechanisms in peptidoglycan-induced human umbilical vascular endothelial cell apoptosis

Jang, T. N., Chiu, P. T., Chen, W. C. & Hsu, M. J., Jun 2011, In : Journal of Food and Drug Analysis. 19, 2

Research output: Contribution to journalArticle

p53 in trichostatin A induced C6 glioma cell death

Hsu, Y. F., Sheu, J. R., Hsiao, G., Lin, C-H., Chang, T. H., Chiu, P. T., Wang, C. Y. & Hsu, M. J., May 2011, In : Biochimica et Biophysica Acta - General Subjects. 1810, 5, p. 504-513 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2010

Apoptosis signal-regulating kinase 1 in peptidoglycan-induced COX-2 expression in macrophages

Hsu, M. J., Chang, C. K., Chen, M. C., Chen, B. C., Ma, H. P., Hong, C. Y. & Lin, C-H., Jun 2010, In : Journal of Leukocyte Biology. 87, 6, p. 1069-1082 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Histone deacetylase inhibitor CBHA attenuates the expression of plasminogen activator inhibitor-1 in human pleural mesothelial cells

Chung, C-L., Chen, W-L., Cheng, Y-W., Chou, Y-C., Hsu, M-J., Hsiao, C-J., Sheu, J-R. & Hsiao, G., 2010, p. A105-A106. 2 p.

Research output: Contribution to conferencePoster

10 Citations (Scopus)

Involvement of phosphatidylcholine-phospholipase C and protein kinase C in peptidoglycan-induced nuclear factor-κB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages

Tzeng, J. I., Chen, B. C., Chang, H. M., Wang, J. J., Sureshbabu, M., Chien, M. H., Hsu, M. J., Bien, M. Y., Chiu, W. T., Hong, C. Y. & Lin, C. H., Feb 2010, In : Pharmacological Research. 61, 2, p. 162-166 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Mitochondrial mechanisms in amyloid beta peptide-induced cerebrovascular degeneration

Hsu, M. J., Sheu, J. R., Lin, C. H., Shen, M. Y. & Hsu, C-Y., Mar 2010, In : Biochimica et Biophysica Acta - General Subjects. 1800, 3, p. 290-296 7 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)

Nuclear-targeted inhibition of NF-κB on MMP-9 production by N-2-(4-bromophenyl) ethyl caffeamide in human monocytic cells

Chou, Y. C., Sheu, J. R., Chung, C. L., Chen, C. Y., Lin, F. L., Hsu, M. J., Kuo, Y. H. & Hsiao, G., Mar 2010, In : Chemico-Biological Interactions. 184, 3, p. 403-412 10 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2009

Apoptosis signal-regulating kinase 1 mediates denbinobin-induced apoptosis in human lung adenocarcinoma cells

Kuo, C. T., Chen, B. C., Yu, C. C., Weng, C. M., Hsu, M. J., Chen, C. C., Chen, M. C., Teng, C. M., Pan, S. L., Bien, M. Y., Shih, C. H. & Lin, C. H., 2009, In : Journal of Biomedical Science. 16, 1, 43.

Research output: Contribution to journalArticle

30 Citations (Scopus)
19 Citations (Scopus)
33 Citations (Scopus)

Thrombin-induced connective tissue growth factor expression in human lung fibroblasts requires the ASK1/JNK/AP-1 pathway

Yu, C. C., Hsu, M. J., Kuo, M. L., Chen, R. F. C., Chen, M. C., Bai, K. J., Yu, M. C., Chen, B. C. & Lin, C-H., Jun 15 2009, In : Journal of Immunology. 182, 12, p. 7916-7927 12 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2008

Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction

Kuo, C. T., Hsu, M. J., Chen, B. C., Chen, C. C., Teng, C. M., Pan, S. L. & Lin, C. H., Feb 28 2008, In : Toxicology Letters. 177, 1, p. 48-58 11 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2007

Apoptosis signal-regulating kinase 1 in amyloid β peptide-induced cerebral endothelial cell apoptosis

Hsu, M. J., Hsu, C-Y., Chen, B. C., Chen, M. C., Ou, G. & Lin, C. H., May 23 2007, In : Journal of Neuroscience. 27, 21, p. 5719-5729 11 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
52 Citations (Scopus)