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Research Output

  • 2583 Citations
  • 28 h-Index
  • 110 Article
  • 2 Review article
  • 1 Comment/debate
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Article
2020

Dual targeting of the p38 MAPK‐HO‐1 axis and cIAP1/XIAP by demethoxycurcumin triggers caspase‐mediated apoptotic cell death in oral squamous cell carcinoma cells

Chien, M. H., Yang, W. E., Yang, Y. C., Ku, C. C., Lee, W. J., Tsai, M. Y., Lin, C. W. & Yang, S. F., Mar 2020, In : Cancers. 12, 3, 703.

Research output: Contribution to journalArticle

Open Access
2019

Association of EGFR mutations and HMGB1 genetic polymorphisms in lung adenocarcinoma patients

Wu, Y. L., Chien, M. H., Chou, Y. E., Chang, J. H., Liu, T. C., Tsao, T. C. Y., Chou, M. C. & Yang, S. F., Jan 1 2019, In : Journal of Cancer. 10, 13, p. 2907-2914 8 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
1 Citation (Scopus)

Loss of TIMP3 by promoter methylation of Sp1 binding site promotes oral cancer metastasis

Su, C. W., Chang, Y. C., Chien, M. H., Hsieh, Y. H., Chen, M. K., Lin, C. W. & Yang, S. F., Nov 1 2019, In : Cell Death and Disease. 10, 11, 793.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
Open Access
Open Access
1 Citation (Scopus)
Open Access
4 Citations (Scopus)
2018

Associations of genetic variations of the endothelial nitric oxide synthase gene and environmental carcinogens with oral cancer susceptibility and development

Su, C. W., Chien, M. H., Lin, C. W., Chen, M. K., Chow, J. M., Chuang, C. Y., Chou, C. H., Liu, Y. C. & Yang, S. F., Sep 1 2018, In : Nitric Oxide - Biology and Chemistry. 79, p. 1-7 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Cantharidic acid induces apoptosis of human leukemic HL-60 cells via c-Jun N-terminal kinase-regulated caspase-8/-9/-3 activation pathway

Wang, S. C., Chow, J. M., Chien, M. H., Lin, C. W., Chen, H. Y., Hsiao, P. C. & Yang, S. F., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Dopamine receptor D2 genetic variations is associated with the risk and clinicopathological variables of urothelial cell carcinoma in a taiwanese population

Tung, M. C., Wen, Y. C., Wang, S. S., Lin, Y. W., Liu, Y. C., Yang, S. F. & Chien, M. H., Jul 30 2018, In : International Journal of Medical Sciences. 15, 11, p. 1187-1193 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
15 Citations (Scopus)
3 Citations (Scopus)

Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway

Lu, K. H., Su, S. C., Lin, C. W., Hsieh, Y. H., Lin, Y. C., Chien, M. H., Reiter, R. J. & Yang, S. F., Jan 1 2018, (Accepted/In press) In : Journal of Pineal Research.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Niclosamide, an oral antihelmintic drug, exhibits antimetastatic activity in hepatocellular carcinoma cells through downregulating twist-mediated CD10 expression

Chien, M. H., Ho, Y. C., Yang, S. F., Yang, Y. C., Lai, S. Y., Chen, W. S., Chen, M. J. & Yeh, C. B., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress

Yang, Y. C., Chien, M. H., Liu, H. Y., Chang, Y. C., Chen, C. K., Lee, W. J., Kuo, T. C., Hsiao, M., Hua, K. T. & Cheng, T. Y., May 1 2018, In : Cancer Letters. 421, p. 28-40 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas

Chien, M. H., Lee, W. J., Yang, Y. C., Tan, P., Pan, K. F., Liu, Y. C., Tsai, H. C., Hsu, C. H., Wen, Y. C., Hsiao, M. & Hua, K. T., Oct 1 2018, In : Cancer Letters. 433, p. 86-98 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Stimulation of Fas/FasL-mediated apoptosis by luteolin through enhancement of histone H3 acetylation and c-Jun activation in HL-60 leukemia cells

Wang, S. W., Chen, Y. R., Chow, J. M., Chien, M. H., Yang, S. F., Wen, Y. C., Lee, W. J. & Tseng, T. H., Jan 1 2018, (Accepted/In press) In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The disruption of the β-catenin/TCF-1/STAT3 signaling axis by 4-acetylantroquinonol b inhibits the tumorigenesis and cancer stem-cell-like properties of glioblastoma cells, in vitro and in vivo

Liu, H. W., Su, Y-K., Bamodu, O. A., Hueng, D. Y., Lee, W. H., Huang, C. C., Deng, L., Hsiao, M., Chien, M. H., Yeh, C. T. & Lin, C. M., Dec 1 2018, In : Cancers. 10, 12, 491.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma

Hua, K. T., Liu, Y. F., Hsu, C. L., Cheng, T. Y., Yang, C. Y., Chang, J. S., Lee, W. J., Hsiao, M., Juan, H. F., Chien, M. H. & Yang, S. F., Dec 1 2017, In : Scientific Reports. 7, 1, 4466.

Research output: Contribution to journalArticle

25 Citations (Scopus)
4 Citations (Scopus)

Corrigendum to "Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells" [383 (2016) 282-294]

Kuo, T. C., Chen, C. K., Hua, K. T., Yu, P., Lee, W. J., Chen, M. W., Jeng, Y. M., Chien, M. H., Kuo, K. T., Hsiao, M. & Kuo, M. L., 2017, (Accepted/In press) In : Cancer Letters.

Research output: Contribution to journalArticle

Genetic variations of melatonin receptor type 1a are associated with the clinicopathologic development of urothelial cell carcinoma

Lin, Y. W., Wang, S. S., Wen, Y. C., Tung, M. C., Lee, L. M., Yang, S. F. & Chien, M. H., Sep 4 2017, In : International Journal of Medical Sciences. 14, 11, p. 1130-1135 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer

Chien, M. H., Lee, W. J., Yang, Y. C., Li, Y. L., Chen, B. R., Cheng, T. Y., Yang, P. W., Wang, M. Y., Jan, Y. H., Lin, Y. K., Lee, J. M., Hsiao, M., Chen, J. S. & Hua, K. T., Oct 1 2017, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1860, 10, p. 1013-1024 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Overexpression of carbonic anhydrase IX induces cell motility by activating matrix metalloproteinase-9 in human oral squamous cell carcinoma cells

Yang, J. S., Lin, C. W., Hsieh, Y. H., Chien, M. H., Chuang, C. Y. & Yang, S. F., 2017, In : Oncotarget. 8, 47, p. 83088-83099 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
9 Citations (Scopus)
20 Citations (Scopus)
24 Citations (Scopus)

The STAT3-miRNA-92-Wnt signaling pathway regulates spheroid formation and malignant progression in ovarian cancer

Chen, M. W., Yang, S. T., Chien, M. H., Hua, K. T., Wu, C. J., Hsiao, S. M., Lin, H., Hsiao, M., Su, J. L. & Wei, L. H., Apr 15 2017, In : Cancer Research. 77, 8, p. 1955-1967 13 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
7 Citations (Scopus)

Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts

Chien, M. H., Lee, T. H., Lee, W. J., Yeh, Y. H., Li, T. K., Wang, P. C., Chen, J. J., Chow, J. M., Lin, Y. W., Hsiao, M., Wang, S. W. & Hua, K. T., Mar 1 2017, In : Cancer Letters. 388, p. 249-261 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016
1 Citation (Scopus)

Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells

Kuo, T. C., Chen, C. K., Hua, K. T., Yu, P., Lee, W-J., Chen, M. W., Jeng, Y. M., Chien, M-H., Kuo, K., Hsiao, M. & Kuo, M. L., Dec 28 2016, In : Cancer Letters. 383, 2, p. 282-294 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
44 Citations (Scopus)

Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis

Lin, C. W., Yang, W. E., Lee, W. J., Hua, K. T., Hsieh, F. K., Hsiao, M., Chen, C. C., Chow, J. M., Chen, M. K., Yang, S. F. & Chien, M. H., Jul 1 2016, In : Carcinogenesis. 37, 7, p. 712-722 11 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity

Lin, Y. W., Lee, L. M., Lee, W. J., Chu, C. Y., Tan, P., Yang, Y. C., Chen, W. Y., Yang, S. F., Hsiao, M. & Chien, M. H., Apr 1 2016, In : Journal of Pineal Research. 60, 3, p. 277-290 14 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Melatonin suppresses TPA-induced metastasis by downregulating matrix metalloproteinase-9 expression through JNK/SP-1 signaling in nasopharyngeal carcinoma

Ho, H. Y., Lin, C. W., Chien, M. H., Reiter, R. J., Su, S. C., Hsieh, Y. H. & Yang, S. F., Nov 1 2016, In : Journal of Pineal Research. 61, 4, p. 479-492 14 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Plasma levels of soluble intercellular adhesion molecule-1 as a biomarker for disease severity of patients with community-acquired pneumonia

Chang, P. Y., Tsao, S. M., Chang, J. H., Chien, M-H., Hung, W. Y., Huang, Y. W. & Yang, S. F., Dec 1 2016, In : Clinica Chimica Acta. 463, p. 174-180 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Plasma monocyte chemoattractant protein-1 level as a predictor of the severity of community-acquired pneumonia

Yong, K. K., Chang, J. H., Chien, M. H., Tsao, S. M., Yu, M. C., Bai, K. J., Tsao, T. C. Y. & Yang, S. F., Jan 29 2016, In : International Journal of Molecular Sciences. 17, 2

Research output: Contribution to journalArticle

8 Citations (Scopus)

Utility of plasma osteopontin levels in management of community-acquired pneumonia

Chang, J. H., Hung, W. Y., Bai, K. J., Yang, S. F. & Chien, M. H., Aug 10 2016, In : International Journal of Medical Sciences. 13, 9, p. 673-679 7 p.

Research output: Contribution to journalArticle

2015

By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer

Wen, Y-C., Lee, W. J., Tan, P., Yang, S. F., Hsiao, M., Lee, L. M. & Chien, M. H., 2015, In : Oncotarget. 6, 25, p. 21120-21136 17 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

G2/M cell cycle arrest and tumor selective apoptosis of acute leukemia cells by a promising benzophenone thiosemicarbazone compound

Cabrera, M., Gomez, N., Lenicov, F. R., Echeverría, E., Shayo, C., Moglioni, A., Fernández, N., Davio, C. & Chien, M. H., Sep 11 2015, In : PLoS One. 10, 9, 0136878.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development

Lin, F. Y., Lin, C. W., Yang, S. F., Lee, W. J., Lin, Y. W., Lee, L. M., Chang, J. L., Weng, W. C., Lin, C. H. & Chien, M. H., Mar 25 2015, In : PLoS One. 10, 3, e0121677.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Keap1-Nrf2 interaction suppresses cell motility in lung adenocarcinomas by targeting the S100P protein

Chien, M. H., Lee, W. J., Hsieh, F. K., Li, C. F., Cheng, T. Y., Wang, M. Y., Chen, J. S., Chow, J. M., Jan, Y. H., Hsiao, M., Hua, K. T. & Kuo, M. L., Oct 15 2015, In : Clinical Cancer Research. 21, 20, p. 4719-4732 14 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
32 Citations (Scopus)

Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft

Lee, W-J., Hsiao, M., Chang, J. L., Yang, S. F., Tseng, T. H., Cheng, C-W., Chow, J-M., Lin, K. H., Lin, Y. W., Liu, C. C., Lee, L-M. & Chien, M-H., Jul 15 2015, In : Archives of Toxicology. 89, 7, p. 1103-1117 15 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

RAGE gene polymorphism and environmental factor in the risk of oral cancer

Su, S., Chien, M., Lin, C., Chen, M. & Yang, S., Mar 16 2015, In : Journal of Dental Research. 94, 3, p. 403-411 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

The H3K9 Methyltransferase G9a Represses E-cadherin and is Associated with Myometrial Invasion in Endometrial Cancer

Hsiao, S. M., Chen, M. W., Chen, C. A., Chien, M. H., Hua, K. T., Hsiao, M., Kuo, M. L. & Wei, L. H., Dec 1 2015, In : Annals of Surgical Oncology. 22, p. 1556-1565 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Timosaponin AIII mediates caspase activation and induces apoptosis through JNK1/2 pathway in human promyelocytic leukemia cells

Huang, H. L., Chiang, W. L., Hsiao, P. C., Chien, M. H., Chen, H. Y., Weng, W. C., Hsieh, M. J. & Yang, S. F., May 2015, In : Tumor Biology. 36, 5, p. 3489-3497 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)