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Research Output 2008 2019

  • 2329 Citations
  • 27 h-Index
  • 108 Article
  • 2 Review article
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Article
2019

Association of EGFR mutations and HMGB1 genetic polymorphisms in lung adenocarcinoma patients

Wu, Y. L., Chien, M. H., Chou, Y. E., Chang, J. H., Liu, T. C., Tsao, T. C. Y., Chou, M. C. & Yang, S. F., Jan 1 2019, In : Journal of Cancer. 10, 13, p. 2907-2914 8 p.

Research output: Contribution to journalArticle

Open Access
HMGB1 Protein
Genetic Polymorphisms
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
1 Citation (Scopus)
Open Access
Penfluridol
Unfolded Protein Response
Lung Neoplasms
Cell Death
Adenosine Triphosphate
Open Access
Spermatic Cord Torsion
Sperm Motility
Stem cells
Mesenchymal Stromal Cells
Metabolism
1 Citation (Scopus)
Open Access
Penfluridol
fms-Like Tyrosine Kinase 3
Protein Phosphatase 2
Autophagy
Mitogen-Activated Protein Kinases
1 Citation (Scopus)
Open Access
Osteonectin
Apigenin
Gastropoda
Epithelial-Mesenchymal Transition
Snails
2018
6 Citations (Scopus)

Associations of genetic variations of the endothelial nitric oxide synthase gene and environmental carcinogens with oral cancer susceptibility and development

Su, C. W., Chien, M. H., Lin, C. W., Chen, M. K., Chow, J. M., Chuang, C. Y., Chou, C. H., Liu, Y. C. & Yang, S. F., Sep 1 2018, In : Nitric Oxide - Biology and Chemistry. 79, p. 1-7 7 p.

Research output: Contribution to journalArticle

Environmental Carcinogens
Nitric Oxide Synthase Type III
Mouth Neoplasms
Polymorphism
Genes
7 Citations (Scopus)

Cantharidic acid induces apoptosis of human leukemic HL-60 cells via c-Jun N-terminal kinase-regulated caspase-8/-9/-3 activation pathway

Wang, S. C., Chow, J. M., Chien, M. H., Lin, C. W., Chen, H. Y., Hsiao, P. C. & Yang, S. F., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

Caspase 9
Caspase 8
JNK Mitogen-Activated Protein Kinases
HL-60 Cells
apoptosis
1 Citation (Scopus)

Dopamine receptor D2 genetic variations is associated with the risk and clinicopathological variables of urothelial cell carcinoma in a taiwanese population

Tung, M. C., Wen, Y. C., Wang, S. S., Lin, Y. W., Liu, Y. C., Yang, S. F. & Chien, M. H., Jul 30 2018, In : International Journal of Medical Sciences. 15, 11, p. 1187-1193 7 p.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Dopamine Receptors
Carcinoma
Population
Odds Ratio
9 Citations (Scopus)
Dipeptidyl Peptidase 4
Apigenin
Gastropoda
Epidermal Growth Factor Receptor
Lung Neoplasms
2 Citations (Scopus)
Chemotactic Factors
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Leukocytes
Lewis Lung Carcinoma
7 Citations (Scopus)

Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway

Lu, K. H., Su, S. C., Lin, C. W., Hsieh, Y. H., Lin, Y. C., Chien, M. H., Reiter, R. J. & Yang, S. F., Jan 1 2018, (Accepted/In press) In : Journal of Pineal Research.

Research output: Contribution to journalArticle

CC Chemokines
JNK Mitogen-Activated Protein Kinases
Osteosarcoma
Melatonin
Ligands

Niclosamide, an oral antihelmintic drug, exhibits antimetastatic activity in hepatocellular carcinoma cells through downregulating twist-mediated CD10 expression

Chien, M. H., Ho, Y. C., Yang, S. F., Yang, Y. C., Lai, S. Y., Chen, W. S., Chen, M. J. & Yeh, C. B., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

Niclosamide
Anthelmintics
motility
Hepatocellular Carcinoma
drug
6 Citations (Scopus)

Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress

Yang, Y. C., Chien, M. H., Liu, H. Y., Chang, Y. C., Chen, C. K., Lee, W. J., Kuo, T. C., Hsiao, M., Hua, K. T. & Cheng, T. Y., May 1 2018, In : Cancer Letters. 421, p. 28-40 13 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Pyruvate Kinase
Neoplastic Stem Cells
Glucose
Physiological Stress
2 Citations (Scopus)

N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas

Chien, M. H., Lee, W. J., Yang, Y. C., Tan, P., Pan, K. F., Liu, Y. C., Tsai, H. C., Hsu, C. H., Wen, Y. C., Hsiao, M. & Hua, K. T., Oct 1 2018, In : Cancer Letters. 433, p. 86-98 13 p.

Research output: Contribution to journalArticle

Acetyltransferases
Matrix Metalloproteinase 2
Osteosarcoma
Neoplasm Metastasis
Proteins
Acupressure
Stem Cell Factor
Blood Cells
Drug Therapy
Hemoglobins
2 Citations (Scopus)

Stimulation of Fas/FasL-mediated apoptosis by luteolin through enhancement of histone H3 acetylation and c-Jun activation in HL-60 leukemia cells

Wang, S. W., Chen, Y. R., Chow, J. M., Chien, M. H., Yang, S. F., Wen, Y. C., Lee, W. J. & Tseng, T. H., Jan 1 2018, (Accepted/In press) In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

Luteolin
Fas Ligand Protein
HL-60 Cells
Acetylation
Histones
4 Citations (Scopus)

The disruption of the β-catenin/TCF-1/STAT3 signaling axis by 4-acetylantroquinonol b inhibits the tumorigenesis and cancer stem-cell-like properties of glioblastoma cells, in vitro and in vivo

Liu, H. W., Su, Y-K., Bamodu, O. A., Hueng, D. Y., Lee, W. H., Huang, C. C., Deng, L., Hsiao, M., Chien, M. H., Yeh, C. T. & Lin, C. M., Dec 1 2018, In : Cancers. 10, 12, 491.

Research output: Contribution to journalArticle

Catenins
Neoplastic Stem Cells
Glioblastoma
Carcinogenesis
Glioma
2017
22 Citations (Scopus)

3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma

Hua, K. T., Liu, Y. F., Hsu, C. L., Cheng, T. Y., Yang, C. Y., Chang, J. S., Lee, W. J., Hsiao, M., Juan, H. F., Chien, M. H. & Yang, S. F., Dec 1 2017, In : Scientific Reports. 7, 1, 4466.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Alleles
Carbonic Anhydrase IX
Neoplasms
RNA Stability
4 Citations (Scopus)

A Fas Ligand (FasL)-fused humanized antibody against tumor-Associated glycoprotein 72 selectively exhibits the cytotoxic effect against oral cancer cells with a low FasL/Fas ratio

Chien, M. H., Chang, W. M., Lee, W. J., Chang, Y. C., Lai, T. C., Chan, D. V., Sharma, R., Lin, Y. F. & Hsiao, M., Jun 1 2017, In : Molecular Cancer Therapeutics. 16, 6, p. 1102-1113 12 p.

Research output: Contribution to journalArticle

Antibodies, Monoclonal, Humanized
Fas Ligand Protein
Mouth Neoplasms
Squamous Cell Carcinoma
Neoplasms

Corrigendum to "Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells" [383 (2016) 282-294]

Kuo, T. C., Chen, C. K., Hua, K. T., Yu, P., Lee, W. J., Chen, M. W., Jeng, Y. M., Chien, M. H., Kuo, K. T., Hsiao, M. & Kuo, M. L., 2017, (Accepted/In press) In : Cancer Letters.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Genetic variations of melatonin receptor type 1a are associated with the clinicopathologic development of urothelial cell carcinoma

Lin, Y. W., Wang, S. S., Wen, Y. C., Tung, M. C., Lee, L. M., Yang, S. F. & Chien, M. H., Sep 4 2017, In : International Journal of Medical Sciences. 14, 11, p. 1130-1135 6 p.

Research output: Contribution to journalArticle

Melatonin Receptors
Carcinoma
Neoplasms
Single Nucleotide Polymorphism
Disease Susceptibility
5 Citations (Scopus)

KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer

Chien, M. H., Lee, W. J., Yang, Y. C., Li, Y. L., Chen, B. R., Cheng, T. Y., Yang, P. W., Wang, M. Y., Jan, Y. H., Lin, Y. K., Lee, J. M., Hsiao, M., Chen, J. S. & Hua, K. T., Oct 1 2017, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1860, 10, p. 1013-1024 12 p.

Research output: Contribution to journalArticle

Protein Splicing
RNA Stability
Non-Small Cell Lung Carcinoma
Cells
Neoplasm Metastasis
11 Citations (Scopus)

Overexpression of carbonic anhydrase IX induces cell motility by activating matrix metalloproteinase-9 in human oral squamous cell carcinoma cells

Yang, J. S., Lin, C. W., Hsieh, Y. H., Chien, M. H., Chuang, C. Y. & Yang, S. F., 2017, In : Oncotarget. 8, 47, p. 83088-83099 12 p.

Research output: Contribution to journalArticle

Cell Movement
Squamous Cell Carcinoma
Mouth Neoplasms
Matrix Metalloproteinase 9
Focal Adhesion Protein-Tyrosine Kinases
9 Citations (Scopus)
Cell Cycle Resting Phase
HL-60 Cells
Quercetin
Autophagy
apoptosis
11 Citations (Scopus)
Quercetin
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Disintegrins
21 Citations (Scopus)
JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
apoptosis
Non-Small Cell Lung Carcinoma
cancer
38 Citations (Scopus)

The STAT3-miRNA-92-Wnt signaling pathway regulates spheroid formation and malignant progression in ovarian cancer

Chen, M. W., Yang, S. T., Chien, M. H., Hua, K. T., Wu, C. J., Hsiao, S. M., Lin, H., Hsiao, M., Su, J. L. & Wei, L. H., Apr 15 2017, In : Cancer Research. 77, 8, p. 1955-1967 13 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
MicroRNAs
Ovarian Neoplasms
Catenins
Neoplastic Stem Cells
5 Citations (Scopus)
JNK Mitogen-Activated Protein Kinases
HL-60 Cells
apoptosis
Cell death
Reactive Oxygen Species
4 Citations (Scopus)

Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts

Chien, M. H., Lee, T. H., Lee, W. J., Yeh, Y. H., Li, T. K., Wang, P. C., Chen, J. J., Chow, J. M., Lin, Y. W., Hsiao, M., Wang, S. W. & Hua, K. T., Mar 1 2017, In : Cancer Letters. 388, p. 249-261 13 p.

Research output: Contribution to journalArticle

Trichodermin
JNK Mitogen-Activated Protein Kinases
Pancreatic Neoplasms
Heterografts
DNA Damage
2016
1 Citation (Scopus)
snails
Snails
Prostatectomy
Prostatic Neoplasms
Hazards
13 Citations (Scopus)

Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells

Kuo, T. C., Chen, C. K., Hua, K. T., Yu, P., Lee, W-J., Chen, M. W., Jeng, Y. M., Chien, M-H., Kuo, K., Hsiao, M. & Kuo, M. L., Dec 28 2016, In : Cancer Letters. 383, 2, p. 282-294 13 p.

Research output: Contribution to journalArticle

Glutaminase
Hepatocellular Carcinoma
Neoplasm Metastasis
Snails
Neoplasms
35 Citations (Scopus)
Apigenin
Acetylation
Cell proliferation
tumor
Histones
28 Citations (Scopus)

Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis

Lin, C. W., Yang, W. E., Lee, W. J., Hua, K. T., Hsieh, F. K., Hsiao, M., Chen, C. C., Chow, J. M., Chen, M. K., Yang, S. F. & Chien, M. H., Jul 1 2016, In : Carcinogenesis. 37, 7, p. 712-722 11 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Squamous Cell Carcinoma
Neoplasm Metastasis
Cell Movement
MicroRNAs
72 Citations (Scopus)

Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity

Lin, Y. W., Lee, L. M., Lee, W. J., Chu, C. Y., Tan, P., Yang, Y. C., Chen, W. Y., Yang, S. F., Hsiao, M. & Chien, M. H., Apr 1 2016, In : Journal of Pineal Research. 60, 3, p. 277-290 14 p.

Research output: Contribution to journalArticle

Melatonin
Matrix Metalloproteinases
Renal Cell Carcinoma
Transcriptional Activation
Neoplasm Metastasis
54 Citations (Scopus)

Melatonin suppresses TPA-induced metastasis by downregulating matrix metalloproteinase-9 expression through JNK/SP-1 signaling in nasopharyngeal carcinoma

Ho, H. Y., Lin, C. W., Chien, M. H., Reiter, R. J., Su, S. C., Hsieh, Y. H. & Yang, S. F., Nov 1 2016, In : Journal of Pineal Research. 61, 4, p. 479-492 14 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Melatonin
Down-Regulation
Neoplasm Metastasis
Proteins
2 Citations (Scopus)

Plasma levels of soluble intercellular adhesion molecule-1 as a biomarker for disease severity of patients with community-acquired pneumonia

Chang, P. Y., Tsao, S. M., Chang, J. H., Chien, M-H., Hung, W. Y., Huang, Y. W. & Yang, S. F., Dec 1 2016, In : Clinica Chimica Acta. 463, p. 174-180 7 p.

Research output: Contribution to journalArticle

Biomarkers
Intercellular Adhesion Molecule-1
Pneumonia
Plasmas
Macrophages
7 Citations (Scopus)

Plasma monocyte chemoattractant protein-1 level as a predictor of the severity of community-acquired pneumonia

Yong, K. K., Chang, J. H., Chien, M. H., Tsao, S. M., Yu, M. C., Bai, K. J., Tsao, T. C. Y. & Yang, S. F., Jan 29 2016, In : International Journal of Molecular Sciences. 17, 2

Research output: Contribution to journalArticle

monocytes
pneumonia
Chemokine CCL2
Blood Proteins
Pneumonia

Utility of plasma osteopontin levels in management of community-acquired pneumonia

Chang, J. H., Hung, W. Y., Bai, K. J., Yang, S. F. & Chien, M. H., Aug 10 2016, In : International Journal of Medical Sciences. 13, 9, p. 673-679 7 p.

Research output: Contribution to journalArticle

Osteopontin
Pneumonia
APACHE
C-Reactive Protein
Length of Stay
2015
35 Citations (Scopus)

By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer

Wen, Y-C., Lee, W. J., Tan, P., Yang, S. F., Hsiao, M., Lee, L. M. & Chien, M. H., 2015, In : Oncotarget. 6, 25, p. 21120-21136 17 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Snails
Cadherins
Prostatic Neoplasms
Androgens
Terminalia
Evidence-Based Medicine
Matrix Metalloproteinase 9
Transcription Factor AP-1
Complementary Therapies
10 Citations (Scopus)

G2/M cell cycle arrest and tumor selective apoptosis of acute leukemia cells by a promising benzophenone thiosemicarbazone compound

Cabrera, M., Gomez, N., Lenicov, F. R., Echeverría, E., Shayo, C., Moglioni, A., Fernández, N., Davio, C. & Chien, M. H., Sep 11 2015, In : PLoS One. 10, 9, 0136878.

Research output: Contribution to journalArticle

G2 Phase Cell Cycle Checkpoints
Thiosemicarbazones
benzophenone
leukemia
Tumors
10 Citations (Scopus)

Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development

Lin, F. Y., Lin, C. W., Yang, S. F., Lee, W. J., Lin, Y. W., Lee, L. M., Chang, J. L., Weng, W. C., Lin, C. H. & Chien, M. H., Mar 25 2015, In : PLoS One. 10, 3, e0121677.

Research output: Contribution to journalArticle

Melatonin Receptors
Mouth Neoplasms
melatonin
Polymorphism
genetic polymorphism
17 Citations (Scopus)

Keap1-Nrf2 interaction suppresses cell motility in lung adenocarcinomas by targeting the S100P protein

Chien, M. H., Lee, W. J., Hsieh, F. K., Li, C. F., Cheng, T. Y., Wang, M. Y., Chen, J. S., Chow, J. M., Jan, Y. H., Hsiao, M., Hua, K. T. & Kuo, M. L., Oct 15 2015, In : Clinical Cancer Research. 21, 20, p. 4719-4732 14 p.

Research output: Contribution to journalArticle

Protein Transport
Cell Movement
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Kelch-Like ECH-Associated Protein 1
31 Citations (Scopus)
Endoplasmic Reticulum Stress
Curcumin
Reactive Oxygen Species
Prostatic Neoplasms
Cell Death
38 Citations (Scopus)

Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft

Lee, W-J., Hsiao, M., Chang, J. L., Yang, S. F., Tseng, T. H., Cheng, C-W., Chow, J-M., Lin, K. H., Lin, Y. W., Liu, C. C., Lee, L-M. & Chien, M-H., Jul 15 2015, In : Archives of Toxicology. 89, 7, p. 1103-1117 15 p.

Research output: Contribution to journalArticle

HL-60 Cells
Quercetin
Extracellular Signal-Regulated MAP Kinases
Heterografts
Reactive Oxygen Species
27 Citations (Scopus)

RAGE gene polymorphism and environmental factor in the risk of oral cancer

Su, S., Chien, M., Lin, C., Chen, M. & Yang, S., Mar 16 2015, In : Journal of Dental Research. 94, 3, p. 403-411 9 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Glycosylation
Confidence Intervals
Environmental Carcinogens
Genes
14 Citations (Scopus)

The H3K9 Methyltransferase G9a Represses E-cadherin and is Associated with Myometrial Invasion in Endometrial Cancer

Hsiao, S. M., Chen, M. W., Chen, C. A., Chien, M. H., Hua, K. T., Hsiao, M., Kuo, M. L. & Wei, L. H., Dec 1 2015, In : Annals of Surgical Oncology. 22, p. 1556-1565 10 p.

Research output: Contribution to journalArticle

Methyltransferases
Cadherins
Endometrial Neoplasms
RNA Interference
Epigenomics
12 Citations (Scopus)

Timosaponin AIII mediates caspase activation and induces apoptosis through JNK1/2 pathway in human promyelocytic leukemia cells

Huang, H. L., Chiang, W. L., Hsiao, P. C., Chien, M. H., Chen, H. Y., Weng, W. C., Hsieh, M. J. & Yang, S. F., May 2015, In : Tumor Biology. 36, 5, p. 3489-3497 9 p.

Research output: Contribution to journalArticle

Caspases
Leukemia
Apoptosis
Acute Myeloid Leukemia
Caspase 8
12 Citations (Scopus)
Matrix Metalloproteinase 2
Glioblastoma
Modulation
Matrix Metalloproteinases
Proteins
65 Citations (Scopus)
Matrix Metalloproteinase 2
Osteosarcoma
MicroRNAs
Up-Regulation
DNA