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Research Output

  • 2701 Citations
  • 29 h-Index
  • 111 Article
  • 2 Review article
  • 1 Comment/debate
2008

Further Evidence for Expression and Function of the VEGF-C/VEGFR-3 Axis in Cancer Cells

Su, J. L., Chen, P. S., Chien, M. H., Chen, P. B., Chen, Y. H., Lai, C. C., Hung, M. C. & Kuo, M. L., Jun 10 2008, In : Cancer Cell. 13, 6, p. 557-560 4 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2009

Diversity-oriented synthesis of angular bis-benzimidazole derivatives under microwave irradiation

Chen, C. H., Chien, M. H., Kuo, M. L., Chou, C. T., Lai, J. J., Lin, S. F., Thummanagoti, S. & Sun, C. M., Nov 9 2009, In : Journal of Combinatorial Chemistry. 11, 6, p. 1038-1046 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway

Chien, M. H., Ku, C. C., Johansson, G., Chen, M. W., Hsiao, M., Su, J. L., Inoue, H., Hua, K. T., Wei, L. H. & Kuo, M. L., Oct 13 2009, In : Carcinogenesis. 30, 12, p. 2005-2013 9 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)
2010

CYR61 regulates BMP-2-dependent osteoblast differentiation through the αvβ3 integrin/integrin-linked kinase/ERK pathway

Su, J. L., Chiou, J., Tang, C. H., Zhao, M., Tsai, C. H., Chen, P. S., Chang, Y. W., Chien, M. H., Peng, C. Y., Hsiao, M., Kuo, M. L. & Yenk, M. L., Oct 8 2010, In : Journal of Biological Chemistry. 285, 41, p. 31325-31336 12 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Effect of CC chemokine ligand 5 and CC chemokine receptor 5 genes polymorphisms on the risk and clinicopathological development of oral cancer

Weng, C. J., Chien, M. H., Lin, C. W., Chung, T. T., Zavras, A. I., Tsai, C. M., Chen, M. K. & Yang, S. F., Oct 2010, In : Oral Oncology. 46, 10, p. 767-772 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM

Chen, M. W., Hua, K. T., Kao, H. J., Chi, C. C., Wei, L. H., Johansson, G., Shiah, S. G., Chen, P. S., Jeng, Y. M., Cheng, T. Y., Lai, T. C., Chang, J. S., Jan, Y. H., Chien, M. H., Yang, C. J., Huang, M. S., Hsiao, M. & Kuo, M. L., Oct 15 2010, In : Cancer Research. 70, 20, p. 7830-7840 11 p.

Research output: Contribution to journalArticle

216 Citations (Scopus)

Involvement of phosphatidylcholine-phospholipase C and protein kinase C in peptidoglycan-induced nuclear factor-κB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages

Tzeng, J. I., Chen, B. C., Chang, H. M., Wang, J. J., Sureshbabu, M., Chien, M. H., Hsu, M. J., Bien, M. Y., Chiu, W. T., Hong, C. Y. & Lin, C. H., Feb 2010, In : Pharmacological Research. 61, 2, p. 162-166 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Re: Cyclooxygenase-2, prostaglandin E2 and acute myeloid leukemia

Chien, M. H., Kuo, M. L. & Wei, L. H., Mar 18 2010, In : Carcinogenesis. 31, 5, p. 954 1 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2011

Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathological development of hepatocellular carcinoma

Chien, M. H., Yeh, K. T., Li, Y. C., Hsieh, Y. H., Lin, C-H., Weng, M. S., Kuo, W. H. & Yang, S. F., Sep 1 2011, In : Journal of Surgical Oncology. 104, 3, p. 299-304 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

N-α-Acetyltransferase 10 Protein Suppresses Cancer Cell Metastasis by Binding PIX Proteins and Inhibiting Cdc42/Rac1 Activity

Hua, K. T., Tan, C. T., Johansson, G., Lee, J. M., Yang, P. W., Lu, H. Y., Chen, C. K., Su, J. L., Chen, P. B., Wu, Y. L., Chi, C. C., Kao, H. J., Shih, H. J., Chen, M. W., Chien, M. H., Chen, P. S., Lee, W. J., Cheng, T. Y., Rosenberger, G., Chai, C. Y. & 6 others, Yang, C. J., Huang, M. S., Lai, T. C., Chou, T. Y., Hsiao, M. & Kuo, M. L., Feb 15 2011, In : Cancer Cell. 19, 2, p. 218-231 14 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Polymer supported synthesis of novel benzoxazole linked benzimidazoles under microwave conditions: In vitro evaluation of VEGFR-3 kinase inhibition activity

Chanda, K., Maiti, B., Yellol, G. S., Chien, M. H., Kuo, M. L. & Sun, C. M., Mar 21 2011, In : Organic and Biomolecular Chemistry. 9, 6, p. 1917-1926 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Relationship of interleukin-8 gene polymorphisms with hepatocellular carcinoma susceptibility and pathological development

Chien, M. H., Yeh, C. B., Li, Y. C., Wei, L. H., Chang, J. H., Peng, Y. T., Yang, S. F. & Kuo, W. H., Dec 2011, In : Journal of Surgical Oncology. 104, 7, p. 798-803 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2012

Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-Kb activity

Yeh, C. B., Hsieh, M. J., Hsieh, Y. H., Chien, M. H., Chiou, H. L. & Yang, S. F., Feb 7 2012, In : PLoS One. 7, 2, e31055.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Dioscorea nipponica Makino inhibits migration and invasion of human oral cancer HSC-3 cells by transcriptional inhibition of matrix metalloproteinase-2 through modulation of CREB and AP-1 activity

Chien, M. H., Ying, T. H., Hsieh, Y. S., Chang, Y. C., Yeh, C. M., Ko, J. L., Lee, W. S., Chang, J. H. & Yang, S. F., Mar 2012, In : Food and Chemical Toxicology. 50, 3-4, p. 558-566 9 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features

Chung, T. T., Yeh, C. B., Li, Y. C., Su, S. C., Chien, M. H., Yang, S. F. & Hsieh, Y. H., Mar 12 2012, In : PLoS One. 7, 3, e33517.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer

Chien, M. H., Chou, L. S. S., Chung, T. T., Lin, C. H., Chou, M. Y., Weng, M. S., Yang, S. F. & Chen, M. K., Mar 2012, In : Head and Neck. 34, 3, p. 405-411 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Effects of NFKB1 and NFKBIA gene polymorphisms on susceptibility to environmental factors and the clinicopathologic development of oral cancer

Lin, C. W., Hsieh, Y. S., Hsin, C. H., Su, C. W., Lin, C-H., Wei, L. H., Yang, S. F. & Chien, M. H., 2012, In : PLoS One. 7, 4, e35078.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Elevated plasma matrix metalloproteinase-9 protein and its gene polymorphism in patients with community-acquired pneumonia

Chiang, T. Y., Shyu, L. Y., Tsao, T. C. Y., Chien, M. H., Tsao, S. M., Lee, Y. T. & Yang, S. F., Mar 1 2012, In : Clinical Chemistry and Laboratory Medicine. 50, 3, p. 449-454 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Expression of carbonic anhydrases I/II and the correlation to clinical aspects of oral squamous cell carcinoma analyzed using tissue microarray

Liu, C. M., Lin, Y. M., Yeh, K. T., Chen, M. K., Chang, J. H., Chen, C. J., Chou, M. Y., Yang, S. F. & Chien, M. H., Aug 2012, In : Journal of Oral Pathology and Medicine. 41, 7, p. 533-539 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Impact of interleukin-8 gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan

Liu, C. M., Yeh, C. J., Yu, C. C., Chou, M. Y., Lin, C-H., Wei, L. H., Lin, C. W., Yang, S. F. & Chien, M. H., Apr 2012, In : Oral Diseases. 18, 3, p. 307-314 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Impacts of CA9 Gene Polymorphisms and Environmental Factors on Oral-Cancer Susceptibility and Clinicopathologic Characteristics in Taiwan

Chien, M. H., Yang, J. S., Chu, Y. H., Lin, C-H., Wei, L. H., Yang, S. F. & Lin, C. W., Dec 4 2012, In : PLoS One. 7, 12, e51051.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Impacts of microRNA gene polymorphisms on the susceptibility of environmental factors leading to carcinogenesis in oral cancer

Chu, Y. H., Tzeng, S. L., Lin, C. W., Chien, M. H., Chen, M. K. & Yang, S. F., Jun 28 2012, In : PLoS One. 7, 6, e39777.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility

Chien, M. H., Hsin, C. H., Shih-Shen Chou, L., Chung, T. T., Lin, C. H., Weng, M. S., Chou, M. Y., Chen, M. K. & Yang, S. F., Apr 2012, In : Head and Neck. 34, 4, p. 551-556 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Lipocalin-2 Induces Apoptosis in Human Hepatocellular Carcinoma Cells Through Activation of Mitochondria Pathways

Chien, M. H., Ying, T. H., Yang, S. F., Yu, J. K., Hsu, C. W., Hsieh, S. C. & Hsieh, Y. H., 2012, In : Cell Biochemistry and Biophysics. 64, 3, p. 177-186 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-κB-mediated matrix metalloproteinase-9 expression

Kao, S. J., Su, J. L., Chen, C. K., Yu, M. C., Bai, K. J., Chang, J. H., Bien, M. Y., Yang, S. F. & Chien, M. H., May 15 2012, In : Toxicology and Applied Pharmacology. 261, 1, p. 105-115 11 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer

Lin, C. W., Tseng, S. W., Yang, S. F., Ko, C. P., Lin, C-H., Wei, L. H., Chien, M. H. & Hsieh, Y. S., Nov 2012, In : Oral Diseases. 18, 8, p. 734-740 7 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury

Chien, M. H., Bien, M. Y., Ku, C. C., Chang, Y. C., Pao, H. Y., Yang, Y. L., Hsiao, M., Chen, C. L. & Ho, J. H., Apr 2012, In : Critical Care Medicine. 40, 4, p. 1245-1253 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Terbinafine inhibits oral squamous cell carcinoma growth through anti-cancer cell proliferation and anti-angiogenesis

Chien, M. H., Lee, T. S., Kao, C., Yang, S. F. & Lee, W. S., May 2012, In : Molecular Carcinogenesis. 51, 5, p. 389-399 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
28 Citations (Scopus)

Tumor-associated carbonic anhydrase XII is linked to the growth of primary oral squamous cell carcinoma and its poor prognosis

Chien, M. H., Ying, T. H., Hsieh, Y. H., Lin, C-H., Shih, C. H., Wei, L. H. & Yang, S. F., May 2012, In : Oral Oncology. 48, 5, p. 417-423 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2013

Circulating level of lipocalin 2 as a predictor of severity in patients with community-acquired pneumonia

Yeh, Y. H., Chang, J. L., Hsiao, P. C., Tsao, S. M., Lin, C. H., Kao, S. J., Chou, M. C., Yang, S. F. & Chien, M. H., Jul 2013, In : Journal of Clinical Laboratory Analysis. 27, 4, p. 253-260 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Combined Effects of ICAM-1 Single-Nucleotide Polymorphisms and Environmental Carcinogens on Oral Cancer Susceptibility and Clinicopathologic Development

Lin, C. W., Chuang, C. Y., Tang, C. H., Chang, J. L., Lee, L-M., Lee, W-J., Chow, J-M., Yang, S. F. & Chien, M-H., Sep 12 2013, In : PLoS One. 8, 9, e72940.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway

Lin, C. H., Yu, M. C., Tung, W. H., Chen, T. T., Yu, C. C., Weng, C. M., Tsai, Y. J., Bai, K. J., Hong, C. Y., Chien, M. H. & Chen, B. C., Dec 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 12, p. 2823-2833 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Effects of metallothionein-1 genetic polymorphism and cigarette smoking on the development of hepatocellular carcinoma

Wong, R. H., Huang, C. H., Yeh, C. B., Lee, H. S., Chien, M. H. & Yang, S. F., Jun 2013, In : Annals of Surgical Oncology. 20, 6, p. 2088-2095 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Effects of NFKB1 and NFKBIA Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathological Features

Cheng, C. W., Su, J. L., Lin, C. W., Su, C. W., Shih, C. H., Yang, S. F. & Chien, M. H., Feb 14 2013, In : PLoS One. 8, 2, e56130.

Research output: Contribution to journalArticle

34 Citations (Scopus)
30 Citations (Scopus)

Impact of VEGF-C Gene Polymorphisms and Environmental Factors on Oral Cancer Susceptibility in Taiwan

Chien, M. H., Liu, Y. F., Hsin, C. H., Lin, C-H., Shih, C. H., Yang, S. F., Cheng, C. W. & Lin, C. W., Apr 4 2013, In : PLoS One. 8, 4, e60283.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Inhibition of metastatic potential in breast carcinoma in vivo and in vitro through targeting VEGFRs and FGFRs

Chien, M. H., Lee, L. M., Hsiao, M., Wei, L. H., Chen, C. H., Lai, T. C., Hua, K. T., Chen, M. W., Sun, C. M. & Kuo, M. L., 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 718380.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Matrix metalloproteinase-2 as a target for head and neck cancer therapy

Chien, M. H., Lin, C. W., Cheng, C. W., Wen, Y-C. & Yang, S. F., Feb 2013, In : Expert Opinion on Therapeutic Targets. 17, 2, p. 203-216 14 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol

Yu, Y. H., Chen, H. A., Chen, P. S., Cheng, Y. J., Hsu, W. H., Chang, Y. W., Chen, Y. H., Jan, Y., Hsiao, M., Chang, T. Y., Liu, Y. H., Jeng, Y. M., Wu, C. H., Huang, M. T., Su, Y-H., Hung, M. C., Chien, M. H., Chen, C. Y., Kuo, M. L. & Su, J. L., Jan 24 2013, In : Oncogene. 32, 4, p. 431-443 13 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

New markers in pneumonia

Cheng, C. W., Chien, M. H., Su, S. C. & Yang, S. F., Apr 8 2013, In : Clinica Chimica Acta. 419, p. 19-25 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Plasma long pentraxin 3 (PTX3) concentration is a novel marker of disease activity in patients with community-acquired pneumonia

Kao, S. J., Yang, H. W., Tsao, S. M., Cheng, C. W., Bien, M. Y., Yu, M. C., Bai, K. J., Yang, S. F. & Chien, M. H., Apr 2013, In : Clinical Chemistry and Laboratory Medicine. 51, 4, p. 907-913 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
28 Citations (Scopus)
2014

Associations of VEGF-C genetic polymorphisms with urothelial cell carcinoma susceptibility differ between smokers and non-smokers in Taiwan

Tung, M. C., Hsieh, M. J., Wang, S. S., Yang, S. F., Chen, S. S., Wang, S. W., Lee, L. M., Lee, W. J. & Chien, M. H., Mar 7 2014, In : PLoS One. 9, 3, e91147.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Clinical implications of aldo-keto reductase family 1 member C3 and its relationship with lipocalin 2 in cancer of the uterine cervix

Wu, C. H., Ko, J. L., Chen, S. C., Lin, Y. W., Han, C. P., Yang, T. Y., Chien, M. H. & Wang, P. H., Feb 2014, In : Gynecologic Oncology. 132, 2, p. 474-482 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Correlation of chitinase 3-like 1 single nucleotide polymorphisms and haplotypes with uterine cervical cancer in Taiwanese women

Lin, Y. S., Liu, Y. F., Chou, Y. E., Yang, S. F., Chien, M. H., Wu, C. H., Chou, C. H., Cheng, C. W. & Wang, P. H., 2014, In : PLoS One. 9, 9, p. e104038

Research output: Contribution to journalArticle

10 Citations (Scopus)

Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells

Huang, H. L., Hsieh, M. J., Chien, M. H., Chen, H. Y., Yang, S. F. & Hsiao, P. C., Jun 5 2014, In : PLoS One. 9, 6, e98943.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma

Yang, J. S., Chen, M. K., Yang, S. F., Chang, Y. C., Su, S. C., Chiou, H. L., Chien, M. H. & Lin, C. W., Sep 1 2014, In : Clinical Chemistry and Laboratory Medicine. 52, 9, p. 1367-1377 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Induction of p21Waf1/Cip1 by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer

Yu, S. Y., Liao, C. H., Chien, M. H., Tsai, T. Y., Lin, J. K. & Weng, M. S., Mar 5 2014, In : Journal of Agricultural and Food Chemistry. 62, 9, p. 2085-2095 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)