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Ming-Heng Wu

Associate Professor

 https://orcid.org/0000-0002-5740-9144
  • 995 Citations
  • 13 h-Index
20072020
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Research Output 2007 2019

  • 995 Citations
  • 13 h-Index
  • 20 Article
2019

Glycidamide promotes the growth and migratory ability of prostate cancer cells by changing the protein expression of cell cycle regulators and epithelial-to-mesenchymal transition (EMT)- associated proteins with prognostic relevance

Ekanem, T. I., Huang, C. C., Wu, M. H., Lin, D. Y., Lai, W. F. T. & Lee, K. H., May 1 2019, In : International Journal of Molecular Sciences. 20, 9, 2199.

Research output: Contribution to journal › Article

Open Access
Cell Cycle Proteins
Epithelial-Mesenchymal Transition
regulators
Prostatic Neoplasms
genes
2018
4 Citations (Scopus)

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation

Chiang, W. F., Cheng, T. M., Chang, C. C., Pan, S. H., Changou, C. A., Chang, T. H., Lee, K. H., Wu, S. Y., Chen, Y. F., Chuang, K. H., Shieh, D. B., Chen, Y. L., Tu, C. C., Tsui, W. L. & Wu, M. H., Jan 4 2018, In : Oncogene. 37, 1, p. 116-127 12 p.

Research output: Contribution to journal › Article

Carcinoembryonic Antigen
Cell Adhesion Molecules
Glycosylation
Epidermal Growth Factor Receptor
Squamous Cell Carcinoma
3 Citations (Scopus)

Risk analysis of malignant potential of oral verrucous hyperplasia: A follow-up study of 269 patients and copy number variation analysis

Wu, M. H., Luo, J. D., Wang, W. C., Chang, T. H., Hwang, W. L., Lee, K. H., Liu, S. Y., Yang, J. W., Chiou, C. T., Chang, C. H. & Chiang, W. F., Jan 1 2018, (Accepted/In press) In : Head and Neck.

Research output: Contribution to journal › Article

Hyperplasia
Oral Submucous Fibrosis
Mastication
Survival Rate
Gene Amplification
2017
6 Citations (Scopus)

Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells

Huang, T. C., Lee, P. T., Wu, M. H., Huang, C. C., Ko, C. Y., Lee, Y. C., Lin, D. Y., Cheng, Y. W. & Lee, K. H., Aug 1 2017, In : PLoS One. 12, 8, e0181034.

Research output: Contribution to journal › Article

RNA Isoforms
colorectal neoplasms
Colorectal Neoplasms
Catenins
Cells
8 Citations (Scopus)

Glycosylation-dependent galectin-1/neuropilin-1 interactions promote liver fibrosis through activation of TGF-β-and PDGF-like signals in hepatic stellate cells

Wu, M. H., Chen, Y. L., Lee, K. H., Chang, C. C., Cheng, T. M., Wu, S. Y., Tu, C. C. & Tsui, W. L., Dec 1 2017, In : Scientific Reports. 7, 1, 11006.

Research output: Contribution to journal › Article

Neuropilin-1
Galectin 1
Hepatic Stellate Cells
Platelet-Derived Growth Factor
Transforming Growth Factors
43 Citations (Scopus)

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Shih, J. W., Chiang, W. F., Wu, A. T. H., Wu, M. H., Wang, L. Y., Yu, Y. L., Hung, Y. W., Wang, W. C., Chu, C. Y., Hung, C. L., Changou, C. A., Yen, Y. & Kung, H. J., Jun 22 2017, In : Nature Communications. 8, 15874.

Research output: Contribution to journal › Article

Long Noncoding RNA
Mouth Neoplasms
progressions
hypoxia
cancer
2016
6 Citations (Scopus)

Heat shock protein 90 is involved in the regulation of HMGA2-driven growth and epithelial-to-mesenchymal transition of colorectal cancer cells

Kao, C. Y., Yang, P. M., Wu, M. H., Huang, C. C., Lee, Y. C. & Lee, K. H., 2016, In : PeerJ. 2016, 2, 1683.

Research output: Contribution to journal › Article

AT-Hook Motifs
HSP90 Heat-Shock Proteins
Epithelial-Mesenchymal Transition
Hooks
colorectal neoplasms
2015
29 Citations (Scopus)

Berberine inhibits the metastatic ability of prostate cancer cells by suppressing epithelial-to-mesenchymal transition (EMT)-associated genes with predictive and prognostic relevance

Liu, C. H., Tang, W. C., Sia, P., Huang, C. C., Yang, P. M., Wu, M. H., Lai, I. L. & Lee, K. H., Jan 1 2015, In : International Journal of Medical Sciences. 12, 1, p. 63-71 9 p.

Research output: Contribution to journal › Article

Berberine
Epithelial-Mesenchymal Transition
Prostatic Neoplasms
Genes
Neoplasm Metastasis
2 Citations (Scopus)

Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues

Lee, Y. C., Lee, J. W., Huang, C. C., Wu, M. H. & Lee, K. H., 2015, In : Data in Brief. 4, p. 235-238 4 p.

Research output: Contribution to journal › Article

cancer
statistical significance
system development
Disease
26 Citations (Scopus)

Galectin-1 accelerates wound healing by regulating the neuropilin-1/Smad3/NOX4 pathway and ROS production in myofibroblasts

Lin, Y. T., Chen, J. S., Wu, M. H., Hsieh, I. S., Liang, C. H., Hsu, C. L., Hong, T. M. & Chen, Y. L., Jan 1 2015, In : Journal of Investigative Dermatology. 135, 1, p. 258-268 11 p.

Research output: Contribution to journal › Article

Neuropilin-1
Galectin 1
Myofibroblasts
NADPH Oxidase
Wound Healing
21 Citations (Scopus)

Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer

Su, Y-H., Tang, W. C., Cheng, Y. W., Sia, P., Huang, C. C., Lee, Y. C., Jiang, H. Y., Wu, M. H., Lai, I. L., Lee, J. W. & Lee, K. H., Oct 1 2015, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 10, p. 2261-2272 12 p.

Research output: Contribution to journal › Article

Berberine
HSP90 Heat-Shock Proteins
Colorectal Neoplasms
Chemical Databases
Catenins
2014
15 Citations (Scopus)

Galectin-1 induces vascular permeability through the neuropilin-1/vascular endothelial growth factor receptor-1 complex

Wu, M. H., Ying, N. W., Hong, T. M., Chiang, W. F., Lin, Y. T. & Chen, Y. L., Oct 1 2014, In : Angiogenesis. 17, 4, p. 839-849 11 p.

Research output: Contribution to journal › Article

Neuropilin-1
Galectin 1
Vascular Endothelial Growth Factor Receptor-1
Capillary Permeability
Tumors
2012
70 Citations (Scopus)

Hepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikis

Ma, W. L., Hsu, C. L., Yeh, C. C., Wu, M. H., Huang, C. K., Jeng, L. B., Hung, Y. C., Lin, T. Y., Yeh, S. & Chang, C., Jul 2012, In : Hepatology. 56, 1, p. 176-185 10 p.

Research output: Contribution to journal › Article

Anoikis
Androgen Receptors
Cell Movement
Hepatocellular Carcinoma
Neoplasm Metastasis
2011
82 Citations (Scopus)

Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis by downregulating MCP-1/CCL2 expression

Wu, M. H., Hong, H. C., Hong, T. M., Chiang, W. F., Jin, Y. T. & Chen, Y. L., Mar 15 2011, In : Clinical Cancer Research. 17, 6, p. 1306-1316 11 p.

Research output: Contribution to journal › Article

Galectin 1
Squamous Cell Carcinoma
Down-Regulation
Fibroblasts
Neoplasm Metastasis
2010
113 Citations (Scopus)

Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription

Wu, M. H., Ma, W. L., Hsu, C. L., Chen, Y. L., Ou, J. H. J., Ryan, C. K., Hung, Y. C., Yeh, S. & Chang, C., 2010, In : Science Translational Medicine. 2, 32

Research output: Contribution to journal › Article

Androgen Receptors
Hepatitis B virus
RNA
Hepatocellular Carcinoma
Androgens
2009
105 Citations (Scopus)

Galectin-1-Mediated tumor invasion and metastasis, Up-Regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons

Wu, M. H., Hong, T. M., Cheng, H. W., Pan, S. H., Liang, Y. R., Hong, H. C., Chiang, W. F., Wong, T. Y., Shieh, D. B., Shiau, A. L., Jin, Y. T. & Chen, Y. L., Mar 1 2009, In : Molecular Cancer Research. 7, 3, p. 311-318 8 p.

Research output: Contribution to journal › Article

Galectin 1
Matrix Metalloproteinases
Actin Cytoskeleton
Neoplasm Metastasis
Neoplasms
2008
139 Citations (Scopus)

Androgen Receptor Is a New Potential Therapeutic Target for the Treatment of Hepatocellular Carcinoma

Ma, C. L., Hsu, C. L., Wu, M. H., Wu, C. T., Wu, C. C., Lai, J. J., Jou, Y. S., Chen, C. W., Yeh, S. & Chang, C., Sep 2008, In : Gastroenterology. 135, 3

Research output: Contribution to journal › Article

Androgen Receptors
Hepatocellular Carcinoma
Therapeutics
Androgens
DNA Damage
142 Citations (Scopus)

Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells

Hsieh, S. H., Ying, N. W., Wu, M. H., Chiang, W. F., Hsu, C. L., Wong, T. Y., Jin, Y. T., Hong, T. M. & Chen, Y. L., Jun 12 2008, In : Oncogene. 27, 26, p. 3746-3753 8 p.

Research output: Contribution to journal › Article

Neuropilin-1
Galectin 1
Vascular Endothelial Growth Factor Receptor-2
Endothelial Cells
Ligands
54 Citations (Scopus)

Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma

Chiang, W. F., Liu, S. Y., Fang, L. Y., Lin, C. N., Wu, M. H., Chen, Y. C., Chen, Y. L. & Jin, Y. T., Apr 2008, In : Oral Oncology. 44, 4, p. 325-334 10 p.

Research output: Contribution to journal › Article

Oral Stage
Galectin 1
Squamous Cell Carcinoma
Neoplasms
Neoplasm Metastasis
2007
127 Citations (Scopus)

Targeting neuropilin 1 as an antitumor strategy in lung cancer

Hong, T. M., Chen, Y. L., Wu, Y. Y., Yuan, A., Chao, Y. C., Chung, Y. C., Wu, M. H., Yang, S. C., Pan, S. H., Shih, J. Y., Chan, W. K. & Yang, P. C., Aug 15 2007, In : Clinical Cancer Research. 13, 16, p. 4759-4768 10 p.

Research output: Contribution to journal › Article

Neuropilin-1
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Neoplasms
Carcinogenesis