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Research Output 2011 2019

  • 307 Citations
  • 11 h-Index
  • 28 Article
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Article
2019
4 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
Growth Inhibitors
Amides
Prostatic Neoplasms
Cells
Lead compounds

Correction: Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and akt activation in non-small cell lung cancer cells (Oncotarget (2017) 8 (28342–28358) DOI: 10.18632/oncotarget.16058)

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., May 1 2019, In : Oncotarget. 10, 36, 1 p.

Research output: Contribution to journalArticle

Open Access
Taiwan
Non-Small Cell Lung Carcinoma
Rehabilitation
Apoptosis
artocarpin flavonoid
1 Citation (Scopus)

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Chen, M. C., Wang, G. J., Kuo, Y. H., Chiang, Y. R., Cho, T. Y., Ju, Y. M. & Lee, T. H., Jan 1 2019, In : Journal of Food and Drug Analysis. 27, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

Open Access
Xylaria
Isoptera
termite mounds
Ethers
nitric oxide
2017
19 Citations (Scopus)

Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., 2017, In : Oncotarget. 8, 17, p. 28342-28358 17 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Reactive Oxygen Species
Apoptosis
Noxae
Protein Kinases
4 Citations (Scopus)
Autophagy
Colorectal Neoplasms
Cell Death
HCT116 Cells
Cyclin B1
2 Citations (Scopus)

Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea

Chen, M. C., Cho, T. Y., Kuo, Y. H. & Lee, T. H., Sep 22 2017, In : Journal of Natural Products. 80, 9, p. 2439-2446 8 p.

Research output: Contribution to journalArticle

Antrodia
Fungi
antroquinonol
Alcoholic Intoxication
Structure-Activity Relationship
7 Citations (Scopus)

Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms

Nepali, K., Lee, H-Y., Lai, M-J., Ojha, R., Wu, T. Y., Wu, G. X., Chen, M-C. & Liou, J-P., Feb 15 2017, In : European Journal of Medicinal Chemistry. 127, p. 115-127 13 p.

Research output: Contribution to journalArticle

Carbolines
Histone Deacetylases
Cytotoxicity
Hydroxamic Acids
Indoles

The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells

Chen, M. C., Kuo, Y. C., Hsu, C. M., Chen, Y. L., Shen, C. C., Teng, C. M. & Pan, S. L., Apr 7 2017, In : Scientific Reports. 7, 46149.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Apoptosis
Mitochondrial Membrane Potential
G2 Phase
G1 Phase
2016
2 Citations (Scopus)

Chemical Constituents from Termite-associated Xylaria acuminatilongissima YMJ623

Cho, T. Y., Wang, G. J., Ju, Y. M., Chen, M. C. & Lee, T. H., May 1 2016, In : Journal of the Chinese Chemical Society. 63, 5, p. 404-409 6 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Benzofurans
Optical rotation
Macrophages
Natural resources
5 Citations (Scopus)

LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Huang, H. L., Chao, M. W., Chen, C. C., Cheng, C. C., Chen, M. C., Lin, C. F., Liou, J. P., Teng, C. M. & Pan, S. L., Jun 9 2016, In : Scientific Reports. 6, 27794.

Research output: Contribution to journalArticle

Antimitotic Agents
Pancreatic Neoplasms
Polyploidy
Microtubules
Growth
5 Citations (Scopus)
Antineoplastic Agents
Ovarian Neoplasms
Cisplatin
Apoptosis
Pharmaceutical Preparations
14 Citations (Scopus)

Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma

Chen, M-C., Huang, H-H., Lai, C-Y., Lin, Y-J., Liou, J-P., Lai, M-J., Li, Y-H., Teng, C-M. & Yang, C-R., Jan 5 2016, In : Oncotarget. 7, 1, p. 402-17 16 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Hepatocellular Carcinoma
Tumor Necrosis Factor-alpha
Apoptosis
Ligands
2015
7 Citations (Scopus)

New whitening constituents from taiwan-native Pyracantha koidzumii: Structures and tyrosinase inhibitory analysis in human epidermalmelanocytes

Lin, R. D., Chen, M. C., Liu, Y. L., Lin, Y. T., Lu, M. K., Hsu, F-L. & Lee, M. H., Dec 2 2015, In : International Journal of Molecular Sciences. 16, 12, p. 28598-28613 16 p.

Research output: Contribution to journalArticle

Pyracantha
Monophenol Monooxygenase
Cosmetics
Taiwan
inhibitors
16 Citations (Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., Aug 27 2015, In : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Tubulin
Phosphorylation
Polymerization
Antineoplastic Agents
7 Citations (Scopus)

Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells

Liu, Y-M., Lee, H. Y., Lai, M-J., Pan, S. L., Huang, H-L., Kuo, F-C., Chen, M. C. & Liou, J. P., Aug 17 2015, In : Organic and Biomolecular Chemistry. 13, 40, p. 10226-10235 10 p.

Research output: Contribution to journalArticle

HCT116 Cells
Histone Deacetylase Inhibitors
Histone Deacetylases
Oncology
Poisons
1 Citation (Scopus)

R173W mutation of hydroxymethylbilane synthetase is associated with acute intermittent porphyria complicated with rhabdomyolysis: The first report

Chen, M. C., Chang, C. J., Lu, Y. H., Niu, D. M., Lou, H. Y. & Chang, C. C., Mar 13 2015, In : Journal of Clinical Gastroenterology. 49, 3, p. 256-257 2 p.

Research output: Contribution to journalArticle

DNA Mutational Analysis
Hydroxymethylbilane Synthase
Acute Intermittent Porphyria
Rhabdomyolysis
Pedigree
11 Citations (Scopus)

The novel ribonucleotide reductase inhibitor COH29 inhibits DNA repair in vitros

Chen, M. C., Zhou, B., Zhang, K., Yuan, Y. C., Un, F., Hu, S., Chou, C. M., Chen, C. H., Wu, J., Wang, Y., Liu, X., Smith, D. L., Li, H., Liu, Z., Warden, C. D., Su, L., Malkas, L. H., Chung, Y. M., Hu, M. C. T. & Yen, Y., Jun 1 2015, In : Molecular Pharmacology. 87, 6, p. 996-1005 10 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
DNA Repair
DNA Damage
gemcitabine
Deoxyribonucleotides
2014
32 Citations (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., May 22 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

Research output: Contribution to journalArticle

HCT116 Cells
Histone Deacetylases
Colorectal Neoplasms
Histone Deacetylase Inhibitors
Heterografts
5 Citations (Scopus)

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents

Mehndiratta, S., Chiang, Y-F., Lai, M-J., Lee, H. Y., Chen, M. C., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., Sep 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 17, p. 4917-4923 7 p.

Research output: Contribution to journalArticle

Antimitotic Agents
Blood Vessels
Cells
Cell Line
G2 Phase
9 Citations (Scopus)

NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells

Wu, S. Y., Pan, S. L., Xiao, Z. Y., Hsu, J. L., Chen, M. C., Lee, K. H. & Teng, C. M., Nov 5 2014, In : PLoS One. 9, 11, e112220.

Research output: Contribution to journalArticle

DNA topoisomerase (ATP-hydrolysing)
Type II DNA Topoisomerase
Poisons
Renal Cell Carcinoma
DNA damage
31 Citations (Scopus)

Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo

Chen, C. H., Chen, M. C., Wang, J. C., Tsai, A. C., Chen, C. S., Liou, J. P., Pan, S. L. & Teng, C. M., 2014, In : Clinical Cancer Research. 20, 5, p. 1274-1287 14 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Liver Neoplasms
Heterografts
Cell Survival
Histone Code
2013
43 Citations (Scopus)

The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells

Chen, M. C., Chen, C. H., Wang, J. C., Tsai, A. C., Liou, J. P., Pan, S. L. & Teng, C. M., Sep 2013, In : Cell Death and Disease. 4, 9, e810.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Epidermal Growth Factor Receptor
Cell Death
Protein-Tyrosine Kinases
erbB-1 Genes
12 Citations (Scopus)

TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells

Chen, M. C., Chen, C. H., Liu, Y. N., Wang, H. P., Pan, S. L. & Teng, C. M., Aug 19 2013, In : Cancer Letters. 336, 2, p. 370-378 9 p.

Research output: Contribution to journalArticle

3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione
Autophagy
Non-Small Cell Lung Carcinoma
G2 Phase
Cell Division
2012
21 Citations (Scopus)

Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo

Lai, C. Y., Tsai, A. C., Chen, M. C., Chang, L. H., Sun, H. L., Chang, Y. L., Chen, C. C., Teng, C. M. & Pan, S. L., Aug 13 2012, In : PLoS One. 7, 8, e42192.

Research output: Contribution to journalArticle

DNA damage
apoptosis
Cells
Apoptosis
Chrysopogon aciculatus
10 Citations (Scopus)

QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells

Chen, M. C., Pan, S. L., Shi, Q., Xiao, Z., Lee, K. H., Li, T. K. & Teng, C. M., Jan 2012, In : Cancer Science. 103, 1, p. 80-87 8 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Non-Small Cell Lung Carcinoma
Apoptosis
DNA Damage
DNA
2011
17 Citations (Scopus)

Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression

Chen, C-H., Huang, P. H., Chu, P. C., Chen, M. C., Chou, C. C., Wang, D., Kulp, S. K., Teng, C. M., Wang, Q. & Chen, C. S., Mar 25 2011, In : Journal of Biological Chemistry. 286, 12, p. 9968-9976 9 p.

Research output: Contribution to journalArticle

Kruppel-Like Transcription Factors
Tumor Suppressor Genes
Epigenomics
Gene expression
Histones
22 Citations (Scopus)

Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells

Chen, M. C., Chen, C-H., Chuang, H. C., Kulp, S. K., Teng, C. M. & Chen, C. S., Jan 2011, In : Hepatology. 53, 1, p. 148-159 12 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Histone Deacetylase Inhibitors
Hepatocellular Carcinoma
Phosphorylation
F-Box Proteins