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Personal profile

Education

  • 2012 Ph.D., Pharmacology Institute, National Taiwan University

Experience

  • 2014- Assistant Professor, Taipei Medical University
  • 2013-2014 postdoc., Taipei Medical University
  • 2012-2013 postdoc., National Taiwan University

Awards

  • 2013 Outstanding Research Award for Scholar-in-Training, National Taiwan University

Research Interests

  • Cancer Biology, Mechanism study of anticancer drugs

URL

Fingerprint Dive into the research topics where Mei-Chuan Chen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 14 Similar Profiles
Histone Deacetylase Inhibitors Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Histone Deacetylases Medicine & Life Sciences
Cells Chemical Compounds
Neoplasms Medicine & Life Sciences
Non-Small Cell Lung Carcinoma Medicine & Life Sciences
Inhibitory Concentration 50 Medicine & Life Sciences
HCT116 Cells Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2020

天然物對鉑類抗藥性膀胱癌之治療潛力及其分子作用機轉探討(1/3)

Chen, M.

8/1/197/1/20

Project: A - Government Institutionb - Ministry of Science and Technology

發展抗肺纖維化劑-治療肺部纖維化小分子藥物之藥理活性機轉探討

Chen, M.

1/1/1912/1/19

Project: A - Government Institutiond - Ministry of Education

雙氫青蒿素衍生物在大腸直腸癌中抗癌作用與機制之探討

Chen, M.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

Tegafur衍生物在大腸直腸癌中抗癌作用之新藥開發與機制之探討(3/3)

Chen, M.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

Anticancer Drug Discovery of New Tegafur-Derivatives for Colorectal Cancer Therapy

Chen, M.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

Research Output 2011 2020

  • 320 Citations
  • 11 h-Index
  • 31 Article
1 Citation (Scopus)

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

Research output: Contribution to journalArticle

Anilides
HSP90 Heat-Shock Proteins
Histone Deacetylase Inhibitors
Histone Deacetylases
Down-Regulation

Synthesis and biological evaluation of 2-quinolineacrylamides

Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., Feb 1 2020, In : Bioorganic and Medicinal Chemistry. 28, 3, 115250.

Research output: Contribution to journalArticle

Protein Isoforms
HCT116 Cells
Ether
Western Blotting
A549 Cells
5 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
Growth Inhibitors
Amides
Prostatic Neoplasms
Cells
Lead compounds

Correction: Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and akt activation in non-small cell lung cancer cells (Oncotarget (2017) 8 (28342–28358) DOI: 10.18632/oncotarget.16058)

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., May 1 2019, In : Oncotarget. 10, 36, 1 p.

Research output: Contribution to journalArticle

Open Access
Taiwan
Non-Small Cell Lung Carcinoma
Rehabilitation
Apoptosis
artocarpin flavonoid