Research Output per year
Research Output 2008 2016
- 644 Citations
- 7 h-Index
- 7 Article
2016
22
Citations
(Scopus)
Structural analysis of disease-related TDP-43 D169G mutation: Linking enhanced stability and caspase cleavage efficiency to protein accumulation
Chiang, C. H., Grauffel, C., Wu, L. S., Kuo, P. H., Doudeva, L. G., Lim, C., Shen, C. K. J. & Yuan, H. S., Feb 17 2016, In : Scientific Reports. 6, 21581.Research output: Contribution to journal › Article
Open Access
Caspases
Amyotrophic Lateral Sclerosis
Mutation
Proteins
Caspase 3
2014
16
Citations
(Scopus)
Curcumin abolishes mutant TDP-43 induced excitability in a motoneuron-like cellular model of ALS
Dong, H., Xu, L., Wu, L., Wang, X., Duan, W., Li, H. & Li, C., Jul 11 2014, In : Neuroscience. 272, p. 141-153 13 p.Research output: Contribution to journal › Article
Curcumin
DNA-Binding Proteins
Motor Neurons
Action Potentials
Oxidative Stress
2013
7
Citations
(Scopus)
Similar dose-dependence of motor neuron cell death caused by wild type human TDP-43 and mutants with ALS-associated amino acid substitutions
Wu, L. S., Cheng, W. C. & Shen, C. K. J., Jun 3 2013, In : Journal of Biomedical Science. 20, 1, 33.Research output: Contribution to journal › Article
Open Access
Motor Neurons
Cell death
Amino Acid Substitution
Neurons
Cell Death
2012
86
Citations
(Scopus)
Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice
Wu, L. S., Cheng, W. C. & Shen, C. K. J., Aug 10 2012, In : Journal of Biological Chemistry. 287, 33, p. 27335-27344 10 p.Research output: Contribution to journal › Article
Open Access
TDP-43 Proteinopathies
Amyotrophic Lateral Sclerosis
Motor Neurons
Neurons
Spinal Cord
2010
177
Citations
(Scopus)
TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis
Wu, L. S., Cheng, W., Hou, S. C., Yan, Y. T., Jiang, S. T. & Shen, C. K. J., Jan 1 2010, In : Genesis. 48, 1, p. 56-62 7 p.Research output: Contribution to journal › Article
Embryonic Development
Biological Phenomena
Neuronal Plasticity
Gene Targeting
Amyotrophic Lateral Sclerosis
2008
81
Citations
(Scopus)
TDP-43: an emerging new player in neurodegenerative diseases
Wang, I. F., Wu, L. S. & Shen, C. K. J., Nov 1 2008, In : Trends in Molecular Medicine. 14, 11, p. 479-485 7 p.Research output: Contribution to journal › Article
DNA-Binding Proteins
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Synucleins
Neurons
255
Citations
(Scopus)
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
Wang, I. F., Wu, L. S., Chang, H. Y. & Shen, C. K. J., May 1 2008, In : Journal of Neurochemistry. 105, 3, p. 797-806 10 p.Research output: Contribution to journal › Article
Frontotemporal Lobar Degeneration
RNA-Binding Proteins
Messenger RNA
Neurons
RNA