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Research Output 2008 2016

  • 644 Citations
  • 7 h-Index
  • 7 Article
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Article
2016
22 Citations (Scopus)

Structural analysis of disease-related TDP-43 D169G mutation: Linking enhanced stability and caspase cleavage efficiency to protein accumulation

Chiang, C. H., Grauffel, C., Wu, L. S., Kuo, P. H., Doudeva, L. G., Lim, C., Shen, C. K. J. & Yuan, H. S., Feb 17 2016, In : Scientific Reports. 6, 21581.

Research output: Contribution to journalArticle

Open Access
Caspases
Amyotrophic Lateral Sclerosis
Mutation
Proteins
Caspase 3
2014
16 Citations (Scopus)

Curcumin abolishes mutant TDP-43 induced excitability in a motoneuron-like cellular model of ALS

Dong, H., Xu, L., Wu, L., Wang, X., Duan, W., Li, H. & Li, C., Jul 11 2014, In : Neuroscience. 272, p. 141-153 13 p.

Research output: Contribution to journalArticle

Curcumin
DNA-Binding Proteins
Motor Neurons
Action Potentials
Oxidative Stress
2013
7 Citations (Scopus)
Open Access
Motor Neurons
Cell death
Amino Acid Substitution
Neurons
Cell Death
2012
86 Citations (Scopus)

Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice

Wu, L. S., Cheng, W. C. & Shen, C. K. J., Aug 10 2012, In : Journal of Biological Chemistry. 287, 33, p. 27335-27344 10 p.

Research output: Contribution to journalArticle

Open Access
TDP-43 Proteinopathies
Amyotrophic Lateral Sclerosis
Motor Neurons
Neurons
Spinal Cord
2010
177 Citations (Scopus)

TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis

Wu, L. S., Cheng, W., Hou, S. C., Yan, Y. T., Jiang, S. T. & Shen, C. K. J., Jan 1 2010, In : Genesis. 48, 1, p. 56-62 7 p.

Research output: Contribution to journalArticle

Embryonic Development
Biological Phenomena
Neuronal Plasticity
Gene Targeting
Amyotrophic Lateral Sclerosis
2008
81 Citations (Scopus)

TDP-43: an emerging new player in neurodegenerative diseases

Wang, I. F., Wu, L. S. & Shen, C. K. J., Nov 1 2008, In : Trends in Molecular Medicine. 14, 11, p. 479-485 7 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Synucleins
Neurons
255 Citations (Scopus)

TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

Wang, I. F., Wu, L. S., Chang, H. Y. & Shen, C. K. J., May 1 2008, In : Journal of Neurochemistry. 105, 3, p. 797-806 10 p.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
RNA-Binding Proteins
Messenger RNA
Neurons
RNA