Research Output per year
Research Output
- 683 Citations
- 7 h-Index
- 9 Article
2020
A robust TDP-43 knock-in mouse model of ALS
Huang, S. L., Wu, L. S., Lee, M., Chang, C. W., Cheng, W. C., Fang, Y. S., Chen, Y. R., Cheng, P. L. & Shen, C. K. J., Jan 21 2020, In : Acta neuropathologica communications. 8, 1, 3.Research output: Contribution to journal › Article
Open Access
2
Citations
(Scopus)
2019
Transcriptomopathies of pre- and post-symptomatic frontotemporal dementia-like mice with TDP-43 depletion in forebrain neurons
Wu, L. S., Cheng, W. C., Chen, C. Y., Wu, M. C., Wang, Y. C., Tseng, Y. H., Chuang, T. J. & Shen, C-K., Mar 29 2019, In : Acta neuropathologica communications. 7, 1, 1 p.Research output: Contribution to journal › Article
Open Access
2016
Structural analysis of disease-related TDP-43 D169G mutation: Linking enhanced stability and caspase cleavage efficiency to protein accumulation
Chiang, C. H., Grauffel, C., Wu, L. S., Kuo, P. H., Doudeva, L. G., Lim, C., Shen, C. K. J. & Yuan, H. S., Feb 17 2016, In : Scientific Reports. 6, 21581.Research output: Contribution to journal › Article
Open Access
27
Citations
(Scopus)
2014
Curcumin abolishes mutant TDP-43 induced excitability in a motoneuron-like cellular model of ALS
Dong, H., Xu, L., Wu, L., Wang, X., Duan, W., Li, H. & Li, C., Jul 11 2014, In : Neuroscience. 272, p. 141-153 13 p.Research output: Contribution to journal › Article
24
Citations
(Scopus)
2013
Similar dose-dependence of motor neuron cell death caused by wild type human TDP-43 and mutants with ALS-associated amino acid substitutions
Wu, L. S., Cheng, W. C. & Shen, C. K. J., Jun 3 2013, In : Journal of Biomedical Science. 20, 1, 33.Research output: Contribution to journal › Article
Open Access
8
Citations
(Scopus)
2012
Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice
Wu, L. S., Cheng, W. C. & Shen, C. K. J., Aug 10 2012, In : Journal of Biological Chemistry. 287, 33, p. 27335-27344 10 p.Research output: Contribution to journal › Article
Open Access
92
Citations
(Scopus)
2010
TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis
Wu, L. S., Cheng, W., Hou, S. C., Yan, Y. T., Jiang, S. T. & Shen, C. K. J., Jan 1 2010, In : Genesis. 48, 1, p. 56-62 7 p.Research output: Contribution to journal › Article
185
Citations
(Scopus)
2008
TDP-43: an emerging new player in neurodegenerative diseases
Wang, I. F., Wu, L. S. & Shen, C. K. J., Nov 1 2008, In : Trends in Molecular Medicine. 14, 11, p. 479-485 7 p.Research output: Contribution to journal › Article
84
Citations
(Scopus)
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
Wang, I. F., Wu, L. S., Chang, H. Y. & Shen, C. K. J., May 1 2008, In : Journal of Neurochemistry. 105, 3, p. 797-806 10 p.Research output: Contribution to journal › Article
261
Citations
(Scopus)