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Lien-Szu Wu

Research Fellow

 https://orcid.org/0000-0003-0216-882X
  • 643 Citations
  • 7 h-Index
20082016
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Fingerprint Dive into the research topics where Lien-Szu Wu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Motor Neurons Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Neurons Chemical Compounds
DNA-Binding Proteins Medicine & Life Sciences
Frontotemporal Lobar Degeneration Medicine & Life Sciences
Neurodegenerative Diseases Medicine & Life Sciences
TDP-43 Proteinopathies Medicine & Life Sciences
RNA-Binding Proteins Medicine & Life Sciences

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Research Output 2008 2016

  • 643 Citations
  • 7 h-Index
  • 7 Article
22 Citations (Scopus)

Structural analysis of disease-related TDP-43 D169G mutation: Linking enhanced stability and caspase cleavage efficiency to protein accumulation

Chiang, C. H., Grauffel, C., Wu, L. S., Kuo, P. H., Doudeva, L. G., Lim, C., Shen, C. K. J. & Yuan, H. S., Feb 17 2016, In : Scientific Reports. 6, 21581.

Research output: Contribution to journal › Article

Open Access
Caspases
Amyotrophic Lateral Sclerosis
Mutation
Proteins
Caspase 3
16 Citations (Scopus)

Curcumin abolishes mutant TDP-43 induced excitability in a motoneuron-like cellular model of ALS

Dong, H., Xu, L., Wu, L., Wang, X., Duan, W., Li, H. & Li, C., Jul 11 2014, In : Neuroscience. 272, p. 141-153 13 p.

Research output: Contribution to journal › Article

Curcumin
DNA-Binding Proteins
Motor Neurons
Action Potentials
Oxidative Stress
7 Citations (Scopus)

Similar dose-dependence of motor neuron cell death caused by wild type human TDP-43 and mutants with ALS-associated amino acid substitutions

Wu, L. S., Cheng, W. C. & Shen, C. K. J., Jun 3 2013, In : Journal of Biomedical Science. 20, 1, 33.

Research output: Contribution to journal › Article

Open Access
Motor Neurons
Cell death
Amino Acid Substitution
Neurons
Cell Death
86 Citations (Scopus)

Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice

Wu, L. S., Cheng, W. C. & Shen, C. K. J., Aug 10 2012, In : Journal of Biological Chemistry. 287, 33, p. 27335-27344 10 p.

Research output: Contribution to journal › Article

Open Access
TDP-43 Proteinopathies
Amyotrophic Lateral Sclerosis
Motor Neurons
Neurons
Spinal Cord
177 Citations (Scopus)

TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis

Wu, L. S., Cheng, W., Hou, S. C., Yan, Y. T., Jiang, S. T. & Shen, C. K. J., Jan 1 2010, In : Genesis. 48, 1, p. 56-62 7 p.

Research output: Contribution to journal › Article

Embryonic Development
Biological Phenomena
Neuronal Plasticity
Gene Targeting
Amyotrophic Lateral Sclerosis