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1975 …2018
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Research Output 1975 2018

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Article
2018
5 Citations (Scopus)

Inhibitory effect of Anoectochilus formosanus extract on hyperglycemia-related PD-L1 expression and cancer proliferation

Ho, Y., Chen, Y. F., Wang, L. H., Hsu, K. Y., Chin, Y. T., Yang, Y. C. S. H., Wang, S. H., Chen, Y. R., Shih, Y. J., Liu, L. F., Wang, K., Whang-Peng, J., Tang, H. Y., Lin, H. Y., Liu, H. L. & Lin, S. J., Aug 2 2018, In : Frontiers in Pharmacology. 9, AUG, 807.

Research output: Contribution to journalArticle

Obese Mice
Hyperglycemia
Blood Glucose
Metformin
Hypoglycemic Agents
5 Citations (Scopus)

Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers

Nana, A. W., Wu, S. Y., Yang, Y. C. S., Chin, Y. T., Cheng, T. M., Ho, Y., Li, W. S., Liao, Y. M., Chen, Y. R., Shih, Y. J., Liu, Y. R., Pedersen, J., Incerpi, S., Hercbergs, A., Liu, L. F., Whang-Peng, J., Davis, P. J. & Lin, H. Y., Oct 1 2018, In : Hormones and Cancer. 9, 5, p. 349-360 12 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Oxidoreductases
Neoplasms
Integrins
Stilbenes
11 Citations (Scopus)

Tetrac downregulates β-catenin and HMGA2 to promote the effect of resveratrol in colon cancer

Nana, A. W., Chin, Y. T., Lin, C. Y., Ho, Y., Bennett, J. A., Shih, Y. J., Chen, Y. R., Changou, C. A., Pedersen, J. Z., Incerpi, S., Liu, L. F., Whang-Peng, J., Fu, E., Li, W. S., Mousa, S. A., Lin, H. Y. & Davis, P. J., Mar 1 2018, In : Endocrine-Related Cancer. 25, 3, p. 279-293 15 p.

Research output: Contribution to journalArticle

High Mobility Group Proteins
Catenins
varespladib methyl
Colonic Neoplasms
Down-Regulation
2017
16 Citations (Scopus)

Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells

Hsieh, M. T., Wang, L. M., Changou, C. A., Chin, Y. T., Yang, Y. C. S. H., Lai, H. Y., Lee, S. Y., Yang, Y. N., Whang-Peng, J., Liu, L. F., Lin, H. Y., Mousa, S. A. & Davis, P. J., 2017, In : Oncotarget. 8, 15, p. 24237-24249 13 p.

Research output: Contribution to journalArticle

Thyroid Hormones
Integrins
Ovarian Neoplasms
Estrogen Receptors
Phosphorylation
2016
12 Citations (Scopus)

2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J. & Liu, L. F., 2016, In : Mediators of Inflammation. 2016, 6953459.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Periodontitis
Ligation
Lipopolysaccharides
AMP-Activated Protein Kinases
7 Citations (Scopus)

Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin

Yang, Y. C. S. H., Chin, Y. T., Hsieh, M. T., Lai, H. Y., Ke, C. C., Crawford, D. R., Lee, O. K., Fu, E., Mousa, S. A., Grasso, P., Liu, L-F., Chang, H-Y., Tang, H. Y., Lin, H-Y. & Davis, P. J., May 10 2016, In : Oncotarget. 7, 19, p. 27641-27654 14 p.

Research output: Contribution to journalArticle

leptin (116-130)
Leptin
Thyroid Neoplasms
Adipose Tissue
Cell Proliferation
2 Citations (Scopus)

Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma

Lee, C. C., Lee, Y. L., Wang, C. N., Tsai, H. C., Chiu, C. L., Liu, L. F., Lin, H. Y. & Wu, R., Feb 1 2016, In : American Journal of Chinese Medicine. 44, 1, p. 133-147 15 p.

Research output: Contribution to journalArticle

Asthma
Ovalbumin
Cytokines
Respiratory Hypersensitivity
Transcription Factor 3
12 Citations (Scopus)

The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status

Lee, Y. S., Chin, Y. T., Yang, Y. C. S. H., Wei, P. L., Wu, H. C., Shih, A., Lu, Y. T., Pedersen, J. Z., Incerpi, S., Liu, L. F., Lin, H. Y. & Davis, P. J., 2016, In : Steroids. p. 63-70

Research output: Contribution to journalArticle

Cell proliferation
Colorectal Neoplasms
Cell Proliferation
HCT116 Cells
Cyclin D1
3 Citations (Scopus)

The cytokine-cosmc signaling axis upregulates the tumorassociated carbohydrate antigen Tn

Ho, C. W., Lin, C. Y., Liaw, Y. W., Chiang, H. L., Chin, Y. T., Huang, R. L., Lai, H. C., Hsu, Y. W., Kuo, P. J., Chen, C. E., Lin, H. Y., Whang-Peng, J., Nieh, S., Fu, E., Liu, L. F. & Hwang, J., 2016, In : Oncotarget. 7, 38, p. 61930-61944 15 p.

Research output: Contribution to journalArticle

Up-Regulation
Carbohydrates
Cytokines
Conditioned Culture Medium
Inflammation
2015
23 Citations (Scopus)

Mechanisms of dihydrotestosterone action on resveratrolinduced anti-proliferation in breast cancer cells with different ER status

Chin, Y. T., Yang, S. H., Chang, T. C., Changou, C. A., Lai, H. Y., Fu, E., HuangFu, W. C., Davis, P. J., Lin, H. Y. & Liu, L. F., 2015, In : Oncotarget. 6, 34, p. 35866-35879 14 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Breast Neoplasms
Apoptosis
p53 Genes
Integrins
2014
42 Citations (Scopus)

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, In : Oncotarget. 5, 24, p. 12891-12907 17 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Gene Expression
Stilbenes
Cell Proliferation
Perfusion
21 Citations (Scopus)

A vaccine targeted at CETP alleviates high fat and high cholesterol diet-induced atherosclerosis and non-alcoholic steatohepatitis in rabbit

Liaw, Y. W., Lin, C. Y., Lai, Y. S., Yang, T. C., Wang, C. J., Whang-Peng, J., Liu, L. F., Lin, C. P., Nieh, S., Lu, S. C. & Hwang, J., Dec 8 2014, In : PLoS One. 9, 12, e111529.

Research output: Contribution to journalArticle

cholesteryl ester transfer protein
Cholesterol Ester Transfer Proteins
High Fat Diet
Fatty Liver
high fat diet
11 Citations (Scopus)

Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells

Li, Y., Hao, H., Tzatzalos, E., Lin, R. K., Doh, S., Liu, L-F., Lyu, Y. L. L. & Cai, L., Feb 15 2014, In : Biology Open. 3, 2, p. 172-184 13 p.

Research output: Contribution to journalArticle

retina
cell viability
Retina
Cell Survival
Cells
2013
16 Citations (Scopus)

Activation of a novel ubiquitin-independent proteasome pathway when RNA polymerase II encounters a protein roadblock

Ban, Y., Ho, C. W., Lin, R. K., Lyu, Y. L. & Liu, L-F., 2013, In : Molecular and Cellular Biology. 33, 20, p. 4008-4016 9 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Proteasome Endopeptidase Complex
Ubiquitin
Adenosine Triphosphatases
Type II DNA Topoisomerase
10 Citations (Scopus)

Macrocyclic biphenyl tetraoxazoles: Synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity

Blankson, G. A., Pilch, D. S., Liu, A. A., Liu, L-F., Rice, J. E. & Lavoie, E. J., Aug 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 15, p. 4511-4520 10 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Tumors
Cells
Ligands
DNA
5 Citations (Scopus)

Macrocyclic pyridyl polyoxazoles: Structure-activity studies of the aminoalkyl side-chain on G-quadruplex stabilization and cytotoxic activity

Blankson, G., Rzuczek, S. G., Bishop, C., Pilch, D. S., Liu, A., Liu, L-F., LaVoie, E. J. & Rice, J. E., Oct 2013, In : Molecules. 18, 10, p. 11938-11963 26 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Amines
Macrocyclic Lactams
Stabilization
stabilization
27 Citations (Scopus)

Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol

Lin, H. Y., Delmas, D., Vang, O., Hsieh, T. C., Lin, S., Cheng, G. Y., Chiang, H. L., Chen, C. E., Tang, H. Y., Crawford, D. R., Whang-Peng, J., Hwang, J., Liu, L. F. & Wu, J. M., Aug 2013, In : Journal of Cellular Biochemistry. 114, 8, p. 1940-1954 15 p.

Research output: Contribution to journalArticle

Ceramides
Cyclooxygenase 2
Ovarian Neoplasms
Apoptosis
Caspase 7
6 Citations (Scopus)

Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis

Lin, R. K., Ho, C. W., Liu, L-F. & Lyu, Y. L., Mar 8 2013, In : Journal of Biological Chemistry. 288, 10, p. 7182-7192 11 p.

Research output: Contribution to journalArticle

Camptothecin
Type II DNA Topoisomerase
Drug Delivery Systems
Apoptosis
RNA Polymerase II
2012
6 Citations (Scopus)

A novel synthetic bipartite carrier protein for developing glycotope-based vaccines

Chiang, H. L., Lin, C. Y., Jan, F. D., Lin, Y. S., Hsu, C. T., Whang-Peng, J., Liu, L. F., Nieh, S., Lin, C. C. & Hwang, J., Dec 14 2012, In : Vaccine. 30, 52, p. 7573-7581 9 p.

Research output: Contribution to journalArticle

transport proteins
Carrier Proteins
Vaccines
vaccines
antigens
87 Citations (Scopus)

Chemotherapeutics and radiation stimulate MHC class i expression through elevated interferon-beta signaling in breast cancer cells

Wan, S., Pestka, S., Jubin, R. G., Lyu, Y. L., Tsai, Y. C. & Liu, L-F., Mar 1 2012, In : PLoS One. 7, 3, e32542.

Research output: Contribution to journalArticle

interferon-beta
Topotecan
Interferon-beta
major histocompatibility complex
breast neoplasms
684 Citations (Scopus)

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

Zhang, S., Liu, X., Bawa-Khalfe, T., Lu, L. S., Lyu, Y. L., Liu, L-F. & Yeh, E. T. H., Nov 2012, In : Nature Medicine. 18, 11, p. 1639-1642 4 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Doxorubicin
Type II DNA Topoisomerase
Reactive Oxygen Species
Organelle Biogenesis
43 Citations (Scopus)

ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells

Desai, S. D., Reed, R. E., Burks, J., Wood, L. M., Pullikuth, A. K., Haas, A. L., Liu, L-F., Breslin, J. W., Meiners, S. & Sankar, S., Jan 2012, In : Experimental Biology and Medicine. 237, 1, p. 38-49 12 p.

Research output: Contribution to journalArticle

Interferons
Genes
Cells
Breast Neoplasms
Cell Movement
24 Citations (Scopus)

Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity

Su, Y. F., Yang, T., Huang, H., Liu, L-F. & Hwang, J., Apr 3 2012, In : PLoS One. 7, 4, e34250.

Research output: Contribution to journalArticle

Sumoylation
Cyclin B
Phosphorylation
cyclins
phosphorylation
2011
29 Citations (Scopus)

A novel role for ATM in regulating proteasome- mediated protein degradation through suppression of the ISG15 conjugation pathway

Wood, L. M., Sankar, S., Reed, R. E., Haas, A. L., Liu, L-F., McKinnon, P. & Desai, S. D., 2011, In : PLoS One. 6, 1, e16422.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
proteasome endopeptidase complex
Automatic teller machines
Proteasome Endopeptidase Complex
protein degradation
31 Citations (Scopus)

Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα

Lin, R. K., Zhou, N., Lyu, Y. L., Tsai, Y. C., Lu, C. H., Kerrigan, J., Chen, Y. T., Guan, Z., Hsieh, T. S. & Liu, L. F., Sep 23 2011, In : Journal of Biological Chemistry. 286, 38, p. 33591-33600 10 p.

Research output: Contribution to journalArticle

Isothiocyanates
Type II DNA Topoisomerase
Sulfhydryl Compounds
Apoptosis
Detoxification
21 Citations (Scopus)

Interferon-β signaling contributes to ras transformation

Tsai, Y. C., Pestka, S., Wang, L. H., Runnels, L. W., Wan, S., Lyu, Y. L. & Liu, L-F., Aug 29 2011, In : PLoS One. 6, 8, e24291.

Research output: Contribution to journalArticle

Interferon Type I
interferons
Oncogenes
Interferons
oncogenes
2010
35 Citations (Scopus)

Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia

Azarova, A. M., Lin, R. K., Tsai, Y. C., Liu, L. F., Lin, C. P. & Lyu, Y. L., Aug 2010, In : Biochemical and Biophysical Research Communications. 399, 1, p. 66-71 6 p.

Research output: Contribution to journalArticle

Gene Rearrangement
Genistein
DNA sequences
Proteasome Endopeptidase Complex
Leukemia
23 Citations (Scopus)

Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity

Satyanarayana, M., Kim, Y. A., Rzuczek, S. G., Pilch, D. S., Liu, A. A., Liu, L-F., Rice, J. E. & LaVoie, E. J., May 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 10, p. 3150-3154 5 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Cytotoxicity
Heterografts
Nude Mice
Tumors
67 Citations (Scopus)

Macrocyclic pyridyl polyoxazoles: Selective RNA and DNA G-quadruplex ligands as antitumor agents

Rzuczek, S. G., Pilch, D. S., Liu, A., Liu, L-F., Lavoie, E. J. & Rice, J. E., May 13 2010, In : Journal of Medicinal Chemistry. 53, 9, p. 3632-3644 13 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Antineoplastic Agents
Ligands
Nude Mice
KB Cells
2009
16 Citations (Scopus)

12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents

Feng, W., Satyanarayana, M., Tsai, Y. C., Liu, A. A., Liu, L. F. & LaVoie, E. J., Apr 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 7, p. 2877-2885 9 p.

Research output: Contribution to journalArticle

Phenanthridines
Type I DNA Topoisomerase
Antineoplastic Agents
Cell growth
Growth
40 Citations (Scopus)

A G-quadruplex stabilizer induces M-phase cell cycle arrest

Tsai, Y. C., Qi, H., Lin, C. P., Lin, R. K., Kerrigan, J. E., Rzuczek, S. G., LaVoie, E. J., Rice, J. E., Pilch, D. S., Lyu, Y. L. & Liu, L. F., Aug 21 2009, In : Journal of Biological Chemistry. 284, 34, p. 22535-22543 9 p.

Research output: Contribution to journalArticle

G-Quadruplexes
M Phase Cell Cycle Checkpoints
Telomerase
Cells
Cell Division
7 Citations (Scopus)
Cytotoxicity
Bioactivity
Derivatives
dimethylacetamide
16 Citations (Scopus)
Type I DNA Topoisomerase
Iodides
Ammonium Compounds
Antineoplastic Agents
Derivatives
41 Citations (Scopus)

Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks

Lin, C. P., Ban, Y., Lyu, Y. L. & Liu, L-F., Oct 9 2009, In : Journal of Biological Chemistry. 284, 41, p. 28084-28092 9 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
Double-Stranded DNA Breaks
DNA Adducts
Proteasome Endopeptidase Complex
2008
10 Citations (Scopus)

11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents

Feng, W., Satyanarayana, M., Tsai, Y. C., Liu, A. A., Liu, L. F. & LaVoie, E. J., Sep 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 18, p. 8598-8606 9 p.

Research output: Contribution to journalArticle

Phenanthridines
Type I DNA Topoisomerase
Cytotoxicity
Derivatives
Tumor Cell Line
64 Citations (Scopus)

A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes

Lin, C. P., Ban, Y., Lyu, Y. L., Desai, S. D. & Liu, L-F., Jul 25 2008, In : Journal of Biological Chemistry. 283, 30, p. 21074-21083 10 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Proteasome Endopeptidase Complex
Ubiquitin
Repair
Camptothecin
110 Citations (Scopus)

Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation

Fu, X., Wan, S., Lyu, Y. L., Liu, L-F. & Qi, H., Apr 23 2008, In : PLoS One. 3, 4, e2009.

Research output: Contribution to journalArticle

AMP-activated protein kinase
Ataxia Telangiectasia
AMP-Activated Protein Kinases
Organelle Biogenesis
Etoposide
9 Citations (Scopus)
Ammonium Compounds
Derivatives
Structure-Activity Relationship
Salts
Water
1772 Citations (Scopus)

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., Bamber, B. A., Bassham, D. C., Bergamini, E., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Bredesen, D. E., Brodsky, J. L., Brumell, J. H., Brunk, U. T. & 216 others, Bursch, W., Camougrand, N., Cebollero, E., Cecconi, F., Chen, Y., Chin, L. S., Choi, A., Chu, C. T., Chung, J., Clarke, P. G. H., Clark, R. S. B., Clarke, S. G., Clavé, C., Cleveland, J. L., Codogno, P., Colombo, M. I., Cotomontes, A., Cregg, J. M., Cuervo, A. M., Debnath, J., Demarchi, F., Dennis, P. B., Dennis, P. A., Deretic, V., Devenish, R. J., Di Sano, F., Dice, J. F., DiFiglia, M., Dinesh-Kumar, S., Distelhorst, C. W., Djavaheri-Mergny, M., Dorsey, F. C., Dröge, W., Dron, M., Dunn, W. A., Duszenko, M., Eissa, N. T., Elazar, Z., Esclatine, A., Eskelinen, E. L., Fésüs, L., Finley, K. D., Fuentes, J. M., Fueyo, J., Fujisaki, K., Galliot, B., Gao, F. B., Gewirtz, D. A., Gibson, S. B., Gohla, A., Goldberg, A. L., Gonzalez, R., González-Estévez, C., Gorski, S., Gottlieb, R. A., Häussinger, D., He, Y. W., Heidenreich, K., Hill, J. A., Høyer-Hansen, M., Hu, X., Huang, W. P., Iwasaki, A., Jäättelä, M., Jackson, W. T., Jiang, X., Jin, S., Johansen, T., Jung, J. U., Kadowaki, M., Kang, C., Kelekar, A., Kessel, D. H., Kiel, J. A. K. W., Hong, P. K., Kimchi, A., Kinsella, T. J., Kiselyov, K., Kitamoto, K., Knecht, E., Komatsu, M., Kominami, E., Kondo, S., Kovács, A. L., Kroemer, G., Kuan, C. Y., Kumar, R., Kundu, M., Landry, J., Laporte, M., Le, W., Lei, H. Y., Lenardo, M. J., Levine, B., Lieberman, A., Lim, K. L., Lin, F. C., Liou, W., Liu, L-F., Lopez-Berestein, G., López-Otín, C., Lu, B., Macleod, K. F., Malorni, W., Martinet, W., Matsuoka, K., Mautner, J., Meijer, A. J., Meléndez, A., Michels, P., Miotto, G., Mistiaen, W. P., Mizushima, N., Mograbi, B., Monastyrska, I., Moore, M. N., Moreira, P. I., Moriyasu, Y., Motyl, T., Münz, C., Murphy, L. O., Naqvi, N. I., Neufeld, T. P., Nishino, I., Nixon, R. A., Noda, T., Nürnberg, B., Ogawa, M., Oleinick, N. L., Olsen, L. J., Ozpolat, B., Paglin, S., Palmer, G. E., Papassideri, I., Parkes, M., Perlmutter, D. H., Perry, G., Piacentini, M., Pinkas-Kramarski, R., Prescott, M., Proikascezanne, T., Raben, N., Rami, A., Reggiori, F., Rohrer, B., Rubinsztein, D. C., Ryan, K. M., Sadoshima, J., Sakagami, H., Sakai, Y., Sandri, M., Sasakawa, C., Sass, M., Schneider, C., Seglen, P. O., Seleverstov, O., Settleman, J., Shacka, J. J., Shapiro, I. M., Sibirny, A., Silva-Zacarin, E. C. M., Simon, H. U., Simone, C., Simonsen, A., Smith, M. A., Spanel-Borowski, K., Srinivas, V., Steeves, M., Stenmark, H., Stromhaug, P. E., Subauste, C. S., Sugimoto, S., Sulzer, D., Suzuki, T., Swanson, M. S., Tabas, I., Takeshita, F., Talbot, N. J., Tallóczy, Z., Tanaka, K., Tanaka, K., Tanida, I., Taylor, G. S., Taylor, J. P., Terman, A., Tettamanti, G., Thompson, C. B., Thumm, M., Tolkovsky, A. M., Tooze, S. A., Truant, R., Tumanovska, L. V., Uchiyama, Y., Ueno, T., Uzcátegui, N. L., Van Der Klei, I., Vaquero, E. C., Vellai, T., Vogel, M. W., Wang, H. G., Webster, P., Wiley, J. W., Xi, Z., Xiao, G., Yahalom, J., Yang, J. M., Yap, G., Yin, X. M., Yoshimori, T., Yu, L., Yue, Z., Yuzaki, M., Zabirnyk, O., Zheng, X., Zhu, X. & Deter, R. L., Feb 16 2008, In : Autophagy. 4, 2, p. 151-175 25 p.

Research output: Contribution to journalArticle

Autophagy
Eukaryota
Guidelines
Vacuoles
Lysosomes
44 Citations (Scopus)

ISG15 as a novel tumor biomarker for drug sensitivity

Desai, S. D., Wood, L. M., Tsai, Y. C., Hsieh, T. S., Marks, J. R., Scott, G. L., Giovanella, B. C. & Liu, L-F., 2008, In : Molecular Cancer Therapeutics. 7, 6, p. 1430-1439 10 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Pharmaceutical Preparations
Genes
Proteasome Endopeptidase Complex
irinotecan
28 Citations (Scopus)

Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency

Satyanarayana, M., Rzuczek, S. G., LaVoie, E. J., Pilch, D. S., Liu, A., Liu, L-F. & Rice, J. E., Jul 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 13, p. 3802-3804 3 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Cytotoxicity
Inhibitory Concentration 50
Cell Line
DNA
11 Citations (Scopus)

Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31)

Satyanarayana, M., Feng, W., Cheng, L., Liu, A. A., Tsai, Y. C., Liu, L. F. & LaVoie, E. J., Aug 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 16, p. 7824-7831 8 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Nude Mice
Antineoplastic Agents
Cytotoxicity
Heterografts
13 Citations (Scopus)

Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents

Feng, W., Satyanarayana, M., Cheng, L., Liu, A., Tsai, Y. C., Liu, L. F. & LaVoie, E. J., Oct 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 20, p. 9295-9301 7 p.

Research output: Contribution to journalArticle

Naphthyridines
Type I DNA Topoisomerase
Bioactivity
Antineoplastic Agents
Substitution reactions
8 Citations (Scopus)

TOR regulates cell death induced by telomere dysfunction in budding yeast

Qi, H., Chen, Y., Fu, X., Lin, C. P., Zheng, X. F. S. & Liu, L-F., Oct 24 2008, In : PLoS One. 3, 10, e3520.

Research output: Contribution to journalArticle

Saccharomycetales
telomeres
Telomere
Cell death
Sirolimus
2007
147 Citations (Scopus)

Autophagy regulates ageing in C. elegans

Hars, E. S., Qi, H., Ryazanov, A. G., Jin, S., Cai, L., Hu, C. & Liu, L-F., Mar 2007, In : Autophagy. 3, 2, p. 93-95 3 p.

Research output: Contribution to journalArticle

Autophagy
RNA Interference
Genes
Yeasts
Beclin-1
16 Citations (Scopus)

Protection of DNA ends by telomeric 3′ G-tail sequences

Tsai, Y. C., Qi, H. & Liu, L. F., Jun 29 2007, In : Journal of Biological Chemistry. 282, 26, p. 18786-18792 7 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Conformations
Tail
DNA
DNA sequences
25 Citations (Scopus)

Role of DNA topoisomerase IIβ in neurite outgrowth

Nur-E-Kamal, A., Meiners, S., Ahmed, I., Azarova, A., Lin, C. P., Lyu, Y. L. & Liu, L-F., Jun 18 2007, In : Brain Research. 1154, 1, p. 50-60 11 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Neurons
Knockout Mice
Growth Cones
Neuromuscular Junction
181 Citations (Scopus)

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies

Azarova, A. M., Lyu, Y. L., Lin, C. P., Tsai, Y. C., Lau, J. Y. N., Wang, J. C. & Liu, L. F., Jun 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 26, p. 11014-11019 6 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Etoposide
Isoenzymes
Drug Therapy
Neoplasms
312 Citations (Scopus)

Targeting mammalian target of rapamycin (mTOR) for health and diseases

Tsang, C. K., Qi, H., Liu, L-F. & Zheng, X. F. S., Feb 2007, In : Drug Discovery Today. 12, 3-4, p. 112-124 13 p.

Research output: Contribution to journalArticle

Sirolimus
Health
Macrolides
Graft Rejection
Growth
159 Citations (Scopus)

The role of autophagy in mitochondria maintenance: Characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains

Zhang, Y., Qi, H., Taylor, R., Xu, W., Liu, L-F. & Jin, S., Jul 2007, In : Autophagy. 3, 4, p. 337-346 10 p.

Research output: Contribution to journalArticle

Autophagy
Saccharomyces cerevisiae
Mitochondria
Maintenance
Mitochondrial Membrane Potential