• 34347 Citations
  • 88 h-Index
1975 …2018

Research output per year

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Research Output

1975

On the degree of unwinding of the DNA helix by ethidium. II. Studies by electron microscopy

Liu, L-F. & Wang, J. C., Jul 23 1975, In : BBA Section Nucleic Acids And Protein Synthesis. 395, 4, p. 405-412 8 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
1976

Knotted single-stranded DNA rings: A novel topological isomer of circular single-stranded DNA formed by treatment with Escherichia coli ω protein

Liu, L-F., Depew, R. E. & Wang, J. C., Sep 15 1976, In : Journal of Molecular Biology. 106, 2, p. 439-452 14 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)
1978

DNA-DNA gyrase complex: the wrapping of the DNA duplex outside the enzyme

Liu, L-F. & Wang, J. C., 1978, In : Cell. 15, 3, p. 979-984 6 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

Interaction between DNA and Escherichia coli protein ω. Formation of a complex between single-stranded DNA and ω protein

Depew, R. E., Liu, L-F. & Wang, J. C., 1978, In : Journal of Biological Chemistry. 253, 2, p. 511-518 8 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)
148 Citations (Scopus)

Nonhistone proteins HMG1 and HMG2 change the DNA helical structure

Javaherian, K., Liu, L-F. & Wang, J. C., 1978, In : Science. 199, 4335, p. 1345-1346 2 p.

Research output: Contribution to journalArticle

175 Citations (Scopus)

Nonhistone proteins HMG1 and HMG2 unwind DNA double helix

Javaherian, K., Sadeghi, M. & Liu, L-F., Aug 10 1979, In : Nucleic Acids Research. 6, 11, p. 3569-3580 12 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

T4 DNA topoisomerase: A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

Liu, L-F., Liu, C. C. & Alberts, B. M., 1979, In : Nature. 281, 5731, p. 456-461 6 p.

Research output: Contribution to journalArticle

156 Citations (Scopus)
1980

Type II DNA topoisomerases: Enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break

Liu, L-F., Liu, C. C. & Alberts, B. M., 1980, In : Cell. 19, 3, p. 697-707 11 p.

Research output: Contribution to journalArticle

372 Citations (Scopus)
1981

A homogeneous type II DNA topoisomerase from HeLa cell nuclei.

Miller, K. G., Liu, L. F. & Englund, P. T., Sep 10 1981, In : Journal of Biological Chemistry. 256, 17, p. 9334-9339 6 p.

Research output: Contribution to journalArticle

272 Citations (Scopus)
328 Citations (Scopus)

Knotted DNA from bacteriophage capsids

Liu, L-F., Perkocha, L., Calendar, R. & Wang, J. C., 1981, In : Proceedings of the National Academy of Sciences of the United States of America. 78, 9 II, p. 5498-5502 5 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Novel topologically knotted DNA from bacteriophage P4 capsids: Studies with DNA topoisomerases

Liu, L-F., Davis, J. L. & Calender, R., 1981, In : Nucleic Acids Research. 9, 16, p. 3979-3989 11 p.

Research output: Contribution to journalArticle

174 Citations (Scopus)
1982

Intra- and intermolecular strand transfer by HeLa DNA topoisomerase I.

Halligan, B. D., Davis, J. L., Edwards, K. A. & Liu, L-F., Apr 10 1982, In : Journal of Biological Chemistry. 257, 7, p. 3995-4000 6 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Recognition sites of eukaryotic DNA topoisomerase I: DNA nucleotide sequencing analysis of topo I cleavage sites on SV40 DNA

Edwards, K. A., Halligan, B. D., Davis, J. L., Nivera, N. L. & Liu, L-F., Apr 24 1982, In : Nucleic Acids Research. 10, 8, p. 2565-2576 12 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)
1983

Association of eukaryotic DNA topoisomerase I with nucleosomes and chromosomal proteins

Javaherian, K. & Liu, L-F., Jan 25 1983, In : Nucleic Acids Research. 11, 2, p. 461-472 12 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Cleavage of DNA by mammalian DNA topoisomerase II.

Liu, L. F., Rowe, T. C., Yang, L., Tewey, K. M. & Chen, G. L., Dec 25 1983, In : Journal of Biological Chemistry. 258, 24, p. 15365-15370 6 p.

Research output: Contribution to journalArticle

471 Citations (Scopus)

DNA topoisomerases--enzymes that catalyse the breaking and rejoining of DNA.

Liu, L-F., 1983, In : CRC critical reviews in biochemistry. 15, 1, p. 1-24 24 p.

Research output: Contribution to journalArticle

166 Citations (Scopus)

HeLa topoisomerase I

Liu, L-F., 1983, In : Methods in Enzymology. Vol. 100, p. 133-137 5 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
1984

Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D. & Liu, L-F., 1984, In : Science. 226, 4673, p. 466-468 3 p.

Research output: Contribution to journalArticle

1195 Citations (Scopus)

Identification of the breakage-reunion subunit of T4 DNA topoisomerase

Rowe, T. C., Tewey, K. M. & Liu, L-F., 1984, In : Journal of Biological Chemistry. 259, 14, p. 9177-9181 5 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

Tewey, K. M., Chen, G. L., Nelson, E. M. & Liu, L-F., 1984, In : Journal of Biological Chemistry. 259, 14, p. 9182-9187 6 p.

Research output: Contribution to journalArticle

513 Citations (Scopus)

Mechanism of antitumor drug action: Poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

Nelson, E. M., Tewey, K. M. & Liu, L-F., 1984, ISOTOPENPRAXIS. 1 ed. Vol. 20. p. 1361-1365 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

578 Citations (Scopus)

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

Chen, G. L., Yang, L., Rowe, T. C., Halligan, B. D., Tewey, K. M. & Liu, L-F., 1984, In : Journal of Biological Chemistry. 259, 21, p. 13560-13566 7 p.

Research output: Contribution to journalArticle

622 Citations (Scopus)

Role of Topoisomerase II in Mediating Epipodophyllotoxin-induced DNA Cleavage

Ross, W., Glisson, B., Yalowich, J., Rowe, T. & Liu, L-F., Dec 1 1984, In : Cancer Research. 44, p. 5857-5860 4 p.

Research output: Contribution to journalArticle

441 Citations (Scopus)
1985

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

Hsiang, Y. H., Hertzberg, R., Hecht, S. & Liu, L-F., 1985, In : Journal of Biological Chemistry. 260, 27, p. 14873-14878 6 p.

Research output: Contribution to journalArticle

2062 Citations (Scopus)

In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin

Yang, L., Rowe, T. C., Nelson, E. M. & Liu, L-F., 1985, In : Cell. 41, 1, p. 127-132 6 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

Purification and characterization of a type II DNA topoisomerase from bovine calf thymus

Halligan, B. D., Edwards, K. A. & Liu, L-F., 1985, In : Journal of Biological Chemistry. 260, 4, p. 2475-2482 8 p.

Research output: Contribution to journalArticle

196 Citations (Scopus)

Topoisomerase II is a structural component of mitotic chromosome scaffolds

Earnshaw, W. C., Halligan, B., Cooke, C. A., Heck, M. M. S. & Liu, L-F., May 1 1985, In : Journal of Cell Biology. 100, 5, p. 1706-1715 10 p.

Research output: Contribution to journalArticle

574 Citations (Scopus)
1986

Chapter 24. DNA Topoisomerases as Therapeutic Targets in Cancer Chemotherapy

Chen, G. L. & Liu, L-F., 1986, In : Annual Reports in Medicinal Chemistry. 21, C, p. 257-262 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II

Rowe, T. C., Chen, G. L., Hsiang, Y. H. & Liu, L-F., 1986, In : Cancer Research. 46, 4 II, p. 2021-2026 6 p.

Research output: Contribution to journalArticle

236 Citations (Scopus)

Induction of sister chromatid exchanges by inhibitors of topoisomerases

Lim, M., Liu, L-F., Jacobson-Kram, D. & Williams, J. R., Dec 1986, In : Cell Biology and Toxicology. 2, 4, p. 485-494 10 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

In vivo localization of DNA topoisomerase II cleavage sites on Drosophila heat shock chromatin

Rowe, T. C., Wang, J. C. & Liu, L. F., 1986, In : Molecular and Cellular Biology. 6, 4, p. 985-992 8 p.

Research output: Contribution to journalArticle

Open Access
75 Citations (Scopus)

Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells

Nelson, W. G., Liu, L-F. & Coffey, D. S., 1986, In : Nature. 322, 6075, p. 187-189 3 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)
1987

DNA topoisomerase II as a potential factor in drug resistance of human malignancies

Potmesil, M., Hsiang, Y. H., Liu, L-F., Wu, H. Y., Traganos, F., Bank, B. & Silber, R., 1987, In : NCI Monographs. 4, p. 105-109 5 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Involvement of intracellular ATP in cytotoxicity of topoisomerase II-targeting antitumor drugs

Kupfer, G., Bodley, A. L. & Liu, L-F., 1987, NCI Monographs. 4 ed. p. 37-40 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

40 Citations (Scopus)

Metabolic activation of N-acylanthracyclines precedes their interaction with DNA topoisomerase II

Silber, R., Liu, L-F., Israel, M., Bodley, A. L., Hsiang, Y. H., Kirschenbaum, S., Sweatman, T. W., Seshadri, R. & Potmesil, M., 1987, In : NCI Monographs. 4, p. 111-115 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Regulation of DNA topoisomerases during cellular differentiation

Bodley, A. L., Wu, H. Y. & Liu, L-F., 1987, NCI Monographs. 4 ed. p. 31-35 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

29 Citations (Scopus)

Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro

Yang, L., Wold, M. S., Li, J. J., Kelly, T. J. & Liu, L-F., 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 4, p. 950-954 5 p.

Research output: Contribution to journalArticle

233 Citations (Scopus)

Supercoiling of the DNA template during transcription.

Liu, L-F. & Wang, J. C., Oct 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 20, p. 7024-7027 4 p.

Research output: Contribution to journalArticle

1362 Citations (Scopus)
1988

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

Tsai-Pflugfelder, M., Liu, L. F., Liu, A. A., Tewey, K. M., Whang-Peng, J., Knutsen, T., Huebner, K., Croce, C. M. & Wang, J. C., 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 19, p. 7177-7181 5 p.

Research output: Contribution to journalArticle

365 Citations (Scopus)

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2

Juan, C. C., Hwang, J., Liu, A. A., Whang-Peng, J., Knutsen, T., Huebner, K., Croce, C. M., Zhang, H., Wang, J. C. & Liu, L. F., 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 23, p. 8910-8913 4 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin

Hsiang, Y. H. & Liu, L-F., 1988, In : Cancer Research. 48, 7, p. 1722-1726 5 p.

Research output: Contribution to journalArticle

827 Citations (Scopus)

Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

Zhang, H., Wang, J. C. & Liu, L-F., Feb 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 4, p. 1060-1064 5 p.

Research output: Contribution to journalArticle

251 Citations (Scopus)

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells

Hsiang, Y. H., Wu, H. Y. & Liu, L-F., 1988, In : Cancer Research. 48, 11, p. 3230-3235 6 p.

Research output: Contribution to journalArticle

249 Citations (Scopus)

Topoisomerases: Novel therapeutic targets in cancer chemotherapy

Hsiang, Y. H., Wu, H. Y. & Liu, L-F., May 1 1988, In : Biochemical Pharmacology. 37, 9, p. 1801-1802 2 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Topoisomerases as novel targets for cancer chemotherapy

Bodley, A. L. & Liu, L-F., 1988, In : Bio/Technology. 6, 11, p. 1315-1319 5 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Transcription generates positively and negatively supercoiled domains in the template

Wu, H. Y., Shyy, S., Wang, J. C. & Liu, L-F., May 6 1988, In : Cell. 53, 3, p. 433-440 8 p.

Research output: Contribution to journalArticle

503 Citations (Scopus)
1989

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

Hsiang, Y. H., Lihou, M. G. & Liu, L-F., 1989, In : Cancer Research. 49, 18, p. 5077-5082 6 p.

Research output: Contribution to journalArticle

980 Citations (Scopus)